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Trends in pharmacological sciences最新文献

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GlycoRNAs as emerging drug targets. glycorna作为新兴的药物靶点。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-08-22 DOI: 10.1016/j.tips.2025.07.018
Bingzhi Li, Xiaolong Zheng, Xing Zhang, He Huang
{"title":"GlycoRNAs as emerging drug targets.","authors":"Bingzhi Li, Xiaolong Zheng, Xing Zhang, He Huang","doi":"10.1016/j.tips.2025.07.018","DOIUrl":"10.1016/j.tips.2025.07.018","url":null,"abstract":"<p><p>GlycoRNAs are glycosylated noncoding RNAs displayed on the cell surface. Emerging studies reveal their roles in intercellular communication and their dysregulation in inflammation and cancer, highlighting therapeutic potential. This review summarizes disease-related insights into glycoRNAs and outlines current strategies and challenges in developing glycoRNA-targeted interventions.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"832-835"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nemolizumab (Nemluvio®) for prurigo nodularis. Nemolizumab (Nemluvio®)用于结节性皮炎。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-07-05 DOI: 10.1016/j.tips.2025.06.004
Svenja Royeck, Sonja Ständer
{"title":"Nemolizumab (Nemluvio®) for prurigo nodularis.","authors":"Svenja Royeck, Sonja Ständer","doi":"10.1016/j.tips.2025.06.004","DOIUrl":"10.1016/j.tips.2025.06.004","url":null,"abstract":"","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"922-923"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-derived brain T cells modulate behavior via IFN-γ. 肠源性脑T细胞通过IFN-γ调节行为。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-07-31 DOI: 10.1016/j.tips.2025.07.009
Bingjun Ha, Xuetao Cao
{"title":"Gut-derived brain T cells modulate behavior via IFN-γ.","authors":"Bingjun Ha, Xuetao Cao","doi":"10.1016/j.tips.2025.07.009","DOIUrl":"10.1016/j.tips.2025.07.009","url":null,"abstract":"<p><p>The constitutive presence of immune cells within brain parenchyma under homeostatic conditions is debated. Recent findings by Yoshida et al. have shown that the subfornical organ harbors gut- and adipose-derived T cells that secrete IFN-γ to regulate brain homeostasis and adaptive behavior in the gut-fat-brain immune axis.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"826-828"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amphiregulin: a potential therapeutic target for tissue fibrosis. 双调节蛋白：组织纤维化的潜在治疗靶点。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1016/j.tips.2025.06.002
M H Wang, J Liu, S L Li, M Z Zheng, R Y Qu, M Xiang
{"title":"Amphiregulin: a potential therapeutic target for tissue fibrosis.","authors":"M H Wang, J Liu, S L Li, M Z Zheng, R Y Qu, M Xiang","doi":"10.1016/j.tips.2025.06.002","DOIUrl":"10.1016/j.tips.2025.06.002","url":null,"abstract":"<p><p>Amphiregulin (AREG), a ligand of the epidermal growth factor receptor (EGFR), plays critical roles in immune homeostasis, cell proliferation, and tissue repair. Recent preclinical studies have shown that AREG is markedly upregulated in various fibrotic diseases and contributes to disease progression through distinct cell sources and signaling mechanisms. These advances highlight AREG as a fibrotic mediator with cellular and organ heterogeneity, suggesting that AREG-targeted therapies can be tailored with great specificity. This review synthesizes recent insights into AREG's expression dynamics, cellular sources, target cell types, and signaling mechanisms in fibrotic diseases, and presents a novel perspective on how this emerging knowledge may inform the development of selective, context-aware antifibrotic therapies.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"877-890"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFTX-G12V: a novel KRASG12V-selective RNAi therapeutic. EFTX-G12V：一种新的krasg12v选择性RNAi治疗药物。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.tips.2025.07.004
Kostas A Papavassiliou, Alice G Vassiliou, Athanasios G Papavassiliou
{"title":"EFTX-G12V: a novel KRAS<sup>G12V</sup>-selective RNAi therapeutic.","authors":"Kostas A Papavassiliou, Alice G Vassiliou, Athanasios G Papavassiliou","doi":"10.1016/j.tips.2025.07.004","DOIUrl":"10.1016/j.tips.2025.07.004","url":null,"abstract":"<p><p>KRAS<sup>G12V</sup>-driven cancers remain therapeutically elusive. Recently, Stanland and colleagues developed EFTX-G12V, a GE11-conjugated small interfering RNA (siRNA) that selectively silences KRAS<sup>G12V</sup> and achieves tumor regression by inhibiting oncogenic signaling and angiogenesis and enhancing anti-tumor immunity. EFTX-G12V represents an innovative RNAi-based precision oncology strategy for previously undruggable oncogenic mutations.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"820-822"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human carbonic anhydrase modulators: the past, present, and future. 人类碳酸酐酶调节剂：过去，现在和未来。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.tips.2025.07.002
Simone Giovannuzzi, Claudiu T Supuran
{"title":"Human carbonic anhydrase modulators: the past, present, and future.","authors":"Simone Giovannuzzi, Claudiu T Supuran","doi":"10.1016/j.tips.2025.07.002","DOIUrl":"10.1016/j.tips.2025.07.002","url":null,"abstract":"<p><p>Human carbonic anhydrases (hCAs) are a superfamily of metalloenzymes with considerable, though yet poorly exploited therapeutic potential. They were primarily implicated in ocular and renal diseases and are targeted by antiglaucoma and diuretic drugs. However, emerging evidence has expanded our understanding of the roles of hCA modulators in other pathologies, including obesity, inflammation, hypoxic tumors, neurodegeneration, and neuropathic pain. In this review, we trace the evolution of our knowledge of hCA modulators, from their discovery to recent advances and future prospects. We also highlight the dysregulation of CAs in various diseases and current progress in developing hCA modulators for therapeutic use.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"836-847"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of targeting macrophages and microglia in glioblastoma. 靶向巨噬细胞和小胶质细胞治疗胶质母细胞瘤的潜力。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.tips.2025.07.006
Fei Zhou, Pritha Mukherjee, Jinming Mu, Peiwen Chen
{"title":"Therapeutic potential of targeting macrophages and microglia in glioblastoma.","authors":"Fei Zhou, Pritha Mukherjee, Jinming Mu, Peiwen Chen","doi":"10.1016/j.tips.2025.07.006","DOIUrl":"10.1016/j.tips.2025.07.006","url":null,"abstract":"<p><p>Glioblastoma (GBM) is a highly aggressive and lethal form of brain tumor in human adults that resists standard of care (SOC) and immunotherapy. Tumor-associated macrophages and microglia (TAMs) represent the most abundant cell population within the GBM tumor microenvironment (TME), comprising up to 50% of the whole tumor mass. TAMs play a pivotal role in promoting tumor progression, driving immunosuppression and inducing therapy resistance. Recent advances have revealed TAM heterogeneity - including their cellular identity (e.g., bone marrow-derived macrophages versus microglia) and the presence of distinct activation/function states and subpopulations within each subtype - in GBM tumors. Targeting the context-dependent TAM infiltration, reprogramming, new subpopulations, survival, phagocytosis, and their interactions with GBM cells in the TME has emerged as a promising therapeutic strategy. Herein we review recent advances in pharmacological targeting of the TAM biology and highlight how these strategies may enhance the effectiveness of SOC and immunotherapies in GBM.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"848-862"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RARE-seq: an inflection point in cfRNA liquid biopsy. RARE-seq: cfRNA液体活检的拐点。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-08-22 DOI: 10.1016/j.tips.2025.08.001
Jonathan C M Wan, Ahmed Eldarwi, Luis A Diaz
{"title":"RARE-seq: an inflection point in cfRNA liquid biopsy.","authors":"Jonathan C M Wan, Ahmed Eldarwi, Luis A Diaz","doi":"10.1016/j.tips.2025.08.001","DOIUrl":"10.1016/j.tips.2025.08.001","url":null,"abstract":"<p><p>Historically, the clinical application of cell-free RNA (cfRNA) liquid biopsies has been limited by background noise. In a recent study, Nesselbush et al. developed a method for denoising cfRNA analysis, resulting in RARE-seq, a versatile liquid biopsy platform that enables transcriptomic profiling, and cancer detection and monitoring, unlocking the potential of this exciting analyte.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"823-825"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new angle on RGS protein modulation. RGS蛋白调控的新视角。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-08-01 DOI: 10.1016/j.tips.2025.07.012
David L Roman
{"title":"A new angle on RGS protein modulation.","authors":"David L Roman","doi":"10.1016/j.tips.2025.07.012","DOIUrl":"10.1016/j.tips.2025.07.012","url":null,"abstract":"<p><p>In most drug discovery efforts targeting regulator of G-protein signaling (RGS) proteins, inhibiting their activity is the end-goal. A recent article by Aryal et al. presents a novel strategy to stabilize RGS2 by blocking its degradation via the ubiquitin-proteasomal system rather than inhibiting its function, a shift from developing small-molecule inhibitors targeting RGS proteins to modulate G-protein-coupled receptor (GPCR) signaling.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"829-831"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Swinging the SWI/SNF complexes for cancer therapy. 将SWI/SNF复合物用于癌症治疗。
IF 19.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-09-01 Epub Date: 2025-08-14 DOI: 10.1016/j.tips.2025.07.008
Hongyan Jing, Xi Zhang, Linghua Meng
{"title":"Swinging the SWI/SNF complexes for cancer therapy.","authors":"Hongyan Jing, Xi Zhang, Linghua Meng","doi":"10.1016/j.tips.2025.07.008","DOIUrl":"10.1016/j.tips.2025.07.008","url":null,"abstract":"<p><p>SWI/SNF chromatin remodeling complexes are essential epigenetic regulators that control chromatin accessibility and transcriptional programs. Alterations in SWI/SNF components are common across a wide spectrum of human cancers, driving tumorigenesis through diverse mechanisms. Increasing insights into the oncogenic roles of aberrant SWI/SNF complexes have spurred the development of novel therapeutic strategies. In this review, we integrate large-scale cancer genomic data towards understanding tumorigenesis driven by alterations in subunits of SWI/SNF complexes. We also evaluate strategies exploiting vulnerabilities in SWI/SNF-mutant cancers, including direct targeting of residual complex components and unique dependencies in critical cellular processes. Among them, one drug has been approved, and several others are in clinical trials.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"907-921"},"PeriodicalIF":19.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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