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Do the therapeutic effects of psilocybin involve actions in the gut? 迷幻药的治疗效果是否涉及肠道作用？
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-02-01 Epub Date: 2024-01-11 DOI: 10.1016/j.tips.2023.12.007
Felicia Reed, Claire J Foldi
{"title":"Do the therapeutic effects of psilocybin involve actions in the gut?","authors":"Felicia Reed, Claire J Foldi","doi":"10.1016/j.tips.2023.12.007","DOIUrl":"10.1016/j.tips.2023.12.007","url":null,"abstract":"<p><p>The psychedelic compound psilocybin has recently emerged as a therapeutic intervention for various mental health conditions. Psilocybin is a potent agonist of serotonin (5-HT) receptors (5-HTRs), which are expressed in the brain and throughout peripheral tissues, with particularly high expression in the gastrointestinal (GI) tract. However, no studies have investigated the possibility that peripheral actions of psilocybin may contribute to improvements in mental health outcomes. This is despite strong evidence for disturbed gut-brain signalling in conditions in which psilocybin is being tested clinically. In this Opinion, we highlight the likely actions of psychedelics in the gut and provide initial support for the premise that peripheral actions may be involved in rapid and long-term therapeutic effects. A greater understanding of all sites and modes of action will guide more targeted approaches to drug development.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-02-01 DOI: 10.1016/s0165-6147(24)00007-5
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(24)00007-5","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00007-5","url":null,"abstract":"Abstract not available","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139656466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex architecture of cardiac muscle thick filaments revealed 揭示心肌粗丝的复杂结构
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-31 DOI: 10.1016/j.tips.2024.01.006
Pradeep K. Luther, Steve B. Marston
{"title":"Complex architecture of cardiac muscle thick filaments revealed","authors":"Pradeep K. Luther, Steve B. Marston","doi":"10.1016/j.tips.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.tips.2024.01.006","url":null,"abstract":"<p>Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by <span>Dutta <em>et al</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg>. and <span>Tamborrini <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg>, discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139656328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The structure and function of olfactory receptors 嗅觉受体的结构和功能
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-31 DOI: 10.1016/j.tips.2024.01.004
Chenyang Wu, Marc Xu, Junlin Dong, Wenqiang Cui, Shuguang Yuan
{"title":"The structure and function of olfactory receptors","authors":"Chenyang Wu, Marc Xu, Junlin Dong, Wenqiang Cui, Shuguang Yuan","doi":"10.1016/j.tips.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.tips.2024.01.004","url":null,"abstract":"<p>Olfactory receptors (ORs) form the most important chemosensory receptor family responsible for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the class A G protein-coupled receptors (GPCRs). Recent research has indicated that ORs are involved in many nonolfactory physiological processes in extranasal tissue, such as the brain, pancreas, and testes, and implies the possible role of their dysregulation in various diseases. The recently released structures of OR51E2 and consensus OR52 have also unveiled the uniqueness of ORs from other class A GPCR members. In this review, we discuss these recent developments and computational modeling efforts toward understanding the structural properties of unresolved ORs, which could guide potential future OR-targeted drug discovery.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139644637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting sensitivity of senescent cells to BH3 mimetics 重新审视衰老细胞对 BH3 模拟物的敏感性
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-20 DOI: 10.1016/j.tips.2024.01.002
Nadine Martin, Anda Huna, Athanasios Tsalikis, David Bernard
{"title":"Revisiting sensitivity of senescent cells to BH3 mimetics","authors":"Nadine Martin, Anda Huna, Athanasios Tsalikis, David Bernard","doi":"10.1016/j.tips.2024.01.002","DOIUrl":"https://doi.org/10.1016/j.tips.2024.01.002","url":null,"abstract":"<p>B cell leukemia/lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics were reported to selectively kill senescent cells and improve age-related diseases. Defining why these cells show increased sensitivity to these molecules will help to identify new pharmacological compounds with senolytic activity. Here, we discuss how recent research findings provide new clues to understand this vulnerability.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139509393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor iron homeostasis and immune regulation 肿瘤铁平衡与免疫调节
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-11 DOI: 10.1016/j.tips.2023.12.003
Yan-Yu Zhang, Yi Han, Wen-Ning Li, Rui-Hua Xu, Huai-Qiang Ju
{"title":"Tumor iron homeostasis and immune regulation","authors":"Yan-Yu Zhang, Yi Han, Wen-Ning Li, Rui-Hua Xu, Huai-Qiang Ju","doi":"10.1016/j.tips.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.tips.2023.12.003","url":null,"abstract":"<p>Abnormal iron metabolism has long been regarded as a key metabolic hallmark of cancer. As a critical cofactor, iron contributes to tumor progression by participating in various processes such as mitochondrial electron transport, gene regulation, and DNA synthesis or repair. Although the role of iron in tumor cells has been widely studied, recent studies have uncovered the interplay of iron metabolism between tumor cells and immune cells, which may affect both innate and adaptive immune responses. In this review, we discuss the current understanding of the regulatory networks of iron metabolism between cancer cells and immune cells and how they contribute to antitumor immunity, and we analyze potential therapeutics targeting iron metabolism. Also, we highlight several key challenges and describe potential therapeutic approaches for future investigations.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139422780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolite-sensing GPCRs in rheumatoid arthritis 类风湿性关节炎中的代谢感应 GPCRs
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-05 DOI: 10.1016/j.tips.2023.12.001
Xuezhi Yang, Wankang Zhang, Luping Wang, Yingjie Zhao, Wei Wei
{"title":"Metabolite-sensing GPCRs in rheumatoid arthritis","authors":"Xuezhi Yang, Wankang Zhang, Luping Wang, Yingjie Zhao, Wei Wei","doi":"10.1016/j.tips.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.tips.2023.12.001","url":null,"abstract":"<p>Persistent inflammation in damaged joints results in metabolic dysregulation of the synovial microenvironment, causing pathogenic alteration of cell activity in rheumatoid arthritis (RA). Recently, the role of metabolite and metabolite-sensing G protein-coupled receptors (GPCRs) in the RA-related inflammatory immune response (IIR) has become a focus of research attention. These GPCRs participate in the progression of RA by modulating immune cell activation, migration, and inflammatory responses. Here, we discuss recent evidence implicating metabolic dysregulation in RA pathogenesis, focusing on the connection between RA-related IIR and GPCR signals originating from the synovial joint and gut. Furthermore, we discuss future directions for targeting metabolite-sensing GPCRs for therapeutic benefit, emphasizing the importance of identifying endogenous ligands and investigating the various transduction mechanisms involved.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139104397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-04 DOI: 10.1016/s0165-6147(23)00267-5
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(23)00267-5","DOIUrl":"https://doi.org/10.1016/s0165-6147(23)00267-5","url":null,"abstract":"Abstract not available","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-04 DOI: 10.1016/s0165-6147(23)00271-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0165-6147(23)00271-7","DOIUrl":"https://doi.org/10.1016/s0165-6147(23)00271-7","url":null,"abstract":"Abstract not available","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A quick guide to networking for scientists. 科学家网络快速指南。
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.1016/j.tips.2023.10.004
Heather K Beasley, Ky'Era V Actkins, Andrea G Marshall, Edgar Garza-Lopez, Celestine Wanjalla, Estevão Scudese, Annet Kirabo, Kaihua Liu, Antentor Hinton
{"title":"A quick guide to networking for scientists.","authors":"Heather K Beasley, Ky'Era V Actkins, Andrea G Marshall, Edgar Garza-Lopez, Celestine Wanjalla, Estevão Scudese, Annet Kirabo, Kaihua Liu, Antentor Hinton","doi":"10.1016/j.tips.2023.10.004","DOIUrl":"10.1016/j.tips.2023.10.004","url":null,"abstract":"<p><p>Networking is an important skill for finding social relationships relevant to one's career. However, networking can be difficult to navigate as different social situations and career levels require unique skill sets. Here, we provide tips for effective networking at conferences, dinners, and other events.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":13.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134649847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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