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Advisory Board and Contents 咨询委员会和内容
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-05 DOI: 10.1016/s0165-6147(24)00126-3
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(24)00126-3","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00126-3","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"15 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment. 先天免疫性双态性对 MASLD 发病机制和治疗的影响。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-01 Epub Date: 2024-06-08 DOI: 10.1016/j.tips.2024.05.004
Richell Booijink, Prakash Ramachandran, Ruchi Bansal
{"title":"Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment.","authors":"Richell Booijink, Prakash Ramachandran, Ruchi Bansal","doi":"10.1016/j.tips.2024.05.004","DOIUrl":"10.1016/j.tips.2024.05.004","url":null,"abstract":"<p><p>Growing evidence suggests that metabolic dysfunction-associated steatotic liver disease (MASLD) is significantly higher in men versus women. Increased prevalence is observed in postmenopausal women, suggesting that age and sex (hormones) influence MASLD development and progression. Molecular data further reveal that sex regulates the innate immune responses with an essential role in MASLD progression. To date, there has been limited focus on the role of innate immune sexual dimorphism in MASLD, and differences between men and women are not considered in the current drug discovery landscape. In this review, we summarize the sex disparities and innate immune sexual dimorphism in MASLD pathogenesis. We further highlight the importance of harnessing sexual dimorphism in identifying therapeutic targets, developing pharmacological therapies, and designing (pre-) clinical studies for the personalized treatment for MASLD.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"614-627"},"PeriodicalIF":13.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting extranuclear histones to alleviate acute and chronic inflammation. 针对核外组蛋白缓解急性和慢性炎症。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-01 Epub Date: 2024-06-08 DOI: 10.1016/j.tips.2024.05.008
Gerry A F Nicolaes, Oliver Soehnlein
{"title":"Targeting extranuclear histones to alleviate acute and chronic inflammation.","authors":"Gerry A F Nicolaes, Oliver Soehnlein","doi":"10.1016/j.tips.2024.05.008","DOIUrl":"10.1016/j.tips.2024.05.008","url":null,"abstract":"<p><p>Extracellular histones instigate an inflammatory triad - centered on cytotoxicity, immune cell stimulation, and coagulation - ultimately shaping the dynamics and outcome of various inflammatory pathologies. Given the virtual absence of beneficial functions of histones in the extracellular space, in recent years a number of interference strategies have emerged. In this review we summarize pathogenic functions of extracellular histones and highlight current developments of therapeutic interference. Finally, we elaborate on the current status of preclinical attempts to interfere with extracellular histones in the context of a focus on sepsis and cardiovascular diseases, both of which are leading causes of mortality worldwide.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"651-662"},"PeriodicalIF":13.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide libraries: from epitope mapping to in-depth high-throughput analysis. 多肽文库：从表位图谱到深入的高通量分析。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-01 Epub Date: 2024-05-08 DOI: 10.1016/j.tips.2024.04.004
Debora Iaculli, Steven Ballet
{"title":"Peptide libraries: from epitope mapping to in-depth high-throughput analysis.","authors":"Debora Iaculli, Steven Ballet","doi":"10.1016/j.tips.2024.04.004","DOIUrl":"10.1016/j.tips.2024.04.004","url":null,"abstract":"<p><p>Peptide arrays are a valuable instrument in the characterization of protein-protein interactions (PPIs) and immunogenic regions. New methods were developed to exploit the high-throughput potential of peptide arrays to obtain more in-depth information, replacing traditional resource-intensive experiments. Here, we discuss the recent advances in peptide-array-based technologies and the remaining challenges.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"579-582"},"PeriodicalIF":13.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GPCR-dependent and -independent arrestin signaling. 依赖和不依赖 GPCR 的 arrestin 信号转导。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-01 Epub Date: 2024-06-20 DOI: 10.1016/j.tips.2024.05.007
Vsevolod V Gurevich, Eugenia V Gurevich
{"title":"GPCR-dependent and -independent arrestin signaling.","authors":"Vsevolod V Gurevich, Eugenia V Gurevich","doi":"10.1016/j.tips.2024.05.007","DOIUrl":"10.1016/j.tips.2024.05.007","url":null,"abstract":"<p><p>Biological activity of free arrestins is often overlooked. Based on available data, we compare arrestin-mediated signaling that requires and does not require binding to G-protein-coupled receptors (GPCRs). Receptor-bound arrestins activate ERK1/2, Src, and focal adhesion kinase (FAK). Yet, arrestin-3 regulation of Src family member Fgr does not appear to involve receptors. Free arrestin-3 facilitates the activation of JNK family kinases, preferentially binds E3 ubiquitin ligases Mdm2 and parkin, and facilitates parkin-dependent mitophagy. The binding of arrestins to microtubules and calmodulin and their function in focal adhesion disassembly and apoptosis also do not involve receptors. Biased GPCR ligands and the phosphorylation barcode can only affect receptor-dependent arrestin signaling. Thus, elucidation of receptor dependence or independence of arrestin functions has important scientific and therapeutic implications.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"639-650"},"PeriodicalIF":13.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-target drugs for Alzheimer's disease. 治疗阿尔茨海默病的多靶点药物。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-01 Epub Date: 2024-06-09 DOI: 10.1016/j.tips.2024.05.005
Bengisu Turgutalp, Caghan Kizil
{"title":"Multi-target drugs for Alzheimer's disease.","authors":"Bengisu Turgutalp, Caghan Kizil","doi":"10.1016/j.tips.2024.05.005","DOIUrl":"10.1016/j.tips.2024.05.005","url":null,"abstract":"<p><p>Alzheimer's disease (AD), a leading cause of dementia, increasingly challenges our healthcare systems and society. Traditional therapies aimed at single targets have fallen short owing to the complex, multifactorial nature of AD that necessitates simultaneous targeting of various disease mechanisms for clinical success. Therefore, targeting multiple pathologies at the same time could provide a synergistic therapeutic effect. The identification of new disease targets beyond the classical hallmarks of AD offers a fertile ground for the design of new multi-target drugs (MTDs), and building on existing compounds have the potential to yield in successful disease modifying therapies. This review discusses the evolving landscape of MTDs, focusing on their potential as AD therapeutics. Analysis of past and current trials of compounds with multi-target activity underscores the capacity of MTDs to offer synergistic therapeutic effects, and the flourishing genetic understanding of AD will inform and inspire the development of MTD-based AD therapies.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"628-638"},"PeriodicalIF":13.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial protein coronas: directing nanoparticles to targets. 人造蛋白质冠：将纳米粒子导向目标。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1016/j.tips.2024.05.003
Giulio Caracciolo
{"title":"Artificial protein coronas: directing nanoparticles to targets.","authors":"Giulio Caracciolo","doi":"10.1016/j.tips.2024.05.003","DOIUrl":"10.1016/j.tips.2024.05.003","url":null,"abstract":"<p><p>The protein corona surrounding nanoparticles (NPs) offers exciting possibilities for targeted drug delivery. However, realizing this potential requires direct evidence of corona-receptor interactions in vivo; a challenge hampered by the limitations of in vitro settings. This opinion proposes that utilizing engineered protein coronas can address this challenge. Artificial coronas made of selected plasma proteins retain their properties in vivo, enabling manipulation for specific receptor targeting. To directly assess corona-receptor interactions mimicking in vivo complexity, we propose testing artificial coronas with recently adapted quartz crystal microbalance (QCM) setups whose current limitations and potential advancements are critically discussed. Finally, the opinion proposes future experiments to decipher corona-receptor interactions and unlock the full potential of the protein corona for NP-based drug delivery.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"602-613"},"PeriodicalIF":13.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-06 DOI: 10.1016/s0165-6147(24)00104-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0165-6147(24)00104-4","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00104-4","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"14 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-06 DOI: 10.1016/s0165-6147(24)00108-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0165-6147(24)00108-1","DOIUrl":"https://doi.org/10.1016/s0165-6147(24)00108-1","url":null,"abstract":"No Abstract","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":"8 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141511434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tackling therapy resistance in cancer. 应对癌症的抗药性
IF 13.8 1区 医学
Trends in pharmacological sciences Pub Date : 2024-06-01 Epub Date: 2024-05-21 DOI: 10.1016/j.tips.2024.05.002
Jerry C Madukwe
{"title":"Tackling therapy resistance in cancer.","authors":"Jerry C Madukwe","doi":"10.1016/j.tips.2024.05.002","DOIUrl":"10.1016/j.tips.2024.05.002","url":null,"abstract":"","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"465-466"},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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