TAM-tastic：癌症从抗药性到恢复力。

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1016/j.tips.2024.09.006

Jie Ting Low, Ping-Chih Ho, Mai Matsushita

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引用次数: 0

摘要

在肿瘤微环境（TME）中，T细胞浸润稀少，而肿瘤相关巨噬细胞（TAMs）共同表达T细胞免疫球蛋白和含粘蛋白结构域的3（TIM3）和V-结构域免疫球蛋白T细胞活化抑制因子（VISTA），因此克服肿瘤免疫疗法的耐药性具有挑战性。在最近的一篇文章中，Vanmeerbeek 等人发现，阻断 IL-4 支持的 TAMs 上的 TIM3 或 VISTA 与紫杉醇（PTX）联合使用，可使 TAMs 重新编程以攻击癌细胞，这凸显了一种潜在的新治疗策略。

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TAM-tastic: from resistance to resilience in cancer.

Overcoming resistance to immunotherapy in cancer is challenging due, in part, to tumor-associated macrophages (TAMs) co-expressing T cell immunoglobulin and mucin domain-containing 3 (TIM3) and V-domain immunoglobulin suppressor of T cell activation (VISTA) in tumor microenvironments (TME) with sparse T cell infiltration. In a recent article, Vanmeerbeek et al. found that blocking TIM3 or VISTA on IL-4-supported TAMs, in combination with paclitaxel (PTX), reprogrammed TAMs to attack cancer cells, highlighting a potential new therapeutic strategy.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.