硝基脂肪酸：开发癌症新疗法的有望药物。

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI:10.1016/j.tips.2024.09.009

Jessica Roos, Georg Manolikakes, Uwe Schlomann, Anna Klinke, Francisco J Schopfer, Carola A Neumann, Thorsten J Maier

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引用次数: 0

摘要

硝基脂肪酸（NO2-FAs）是一种内源性多效脂质介质，被认为是治疗炎症和纤维化疾病的有希望的候选药物。在过去的二十年里，NO2-脂肪酸的抗炎和细胞保护作用以及一些分子靶点已被确定。最近，临床前研究证明，NO2-FAs 具有良好的安全性和肿瘤选择性，有望成为癌症治疗药物。在本综述中，我们介绍了 NO2-FA 的作用机制，重点是 NO2-FA 的抗肿瘤和化疗增敏作用。我们还探讨了内源性和结构修饰的 NO2-FAs 物种在癌症治疗中的潜在治疗应用。

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Nitro-fatty acids: promising agents for the development of new cancer therapeutics.

Nitro-fatty acids (NO₂-FAs) are endogenous pleiotropic lipid mediators regarded as promising drug candidates for treating inflammatory and fibrotic diseases. Over the past two decades, the anti-inflammatory and cytoprotective actions of NO₂-FAs and several molecular targets have been identified. More recently, preclinical studies have demonstrated their potential as prospective cancer therapeutics with favorable safety and tumor-selective profiles. In this review, we describe the mechanisms of action, with a focus on NO₂-FA antineoplastic and chemosensitizing effects. We also address the potential therapeutic applications of endogenous and structurally modified NO₂-FAs species in cancer treatment.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.