三萜类药物发现的进展。

IF 13.9 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI:10.1016/j.tips.2024.10.003
Zoë R Goddard, Mark Searcey, Anne Osbourn
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引用次数: 0

摘要

三萜类化合物是结构复杂的天然产物,具有广阔的治疗前景。化学合成的不稳定性阻碍了它们在药物开发中的应用。最近的研究进展使得利用工程生物学方法获取和利用三萜结构多样性成为可能,从而能够发现和优化新一代药物线索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in triterpene drug discovery.

Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.

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来源期刊
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍: Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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