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Trends in pharmacological sciences最新文献

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Endometriosis: cannabidiol therapy for symptom relief. 子宫内膜异位症：缓解症状的大麻二酚疗法。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.tips.2024.10.014
Lucy H R Whitaker, Clive Page, Charles Morgan, Andrew W Horne, Philippa T K Saunders
{"title":"Endometriosis: cannabidiol therapy for symptom relief.","authors":"Lucy H R Whitaker, Clive Page, Charles Morgan, Andrew W Horne, Philippa T K Saunders","doi":"10.1016/j.tips.2024.10.014","DOIUrl":"10.1016/j.tips.2024.10.014","url":null,"abstract":"<p><p>Endometriosis is a common, chronic, incurable condition the hallmark of which is the presence of lesions (tissue resembling endometrium) in sites outside the womb, with symptoms including chronic debilitating pain and fatigue. However, current therapeutic options are limited. Recent advances in our understanding of the mechanisms that contribute to the development of lesions and pain experience in endometriosis as well as surveys of patients have increased interest in testing recently approved formulations containing cannabidiol (CBD) in this patient group. In this review, we summarise data from patient samples and animals models focussed on the pathophysiology of endometriosis, including pathways where CBD has activity. We consider the available formulations of CBD-containing products, their pharmacokinetics (PK), and their use in ongoing clinical trials in endometriosis and other pain conditions.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1150-1161"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pegcetacoplan (SyfovreΤΜ): targeting complement C3 in geographic atrophy. Pegcetacoplan (SyfovreΤΜ)：针对地理萎缩的补体 C3。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1016/j.tips.2024.10.001
Dimitrios C Mastellos, John D Lambris
{"title":"Pegcetacoplan (Syfovre<sup>ΤΜ</sup>): targeting complement C3 in geographic atrophy.","authors":"Dimitrios C Mastellos, John D Lambris","doi":"10.1016/j.tips.2024.10.001","DOIUrl":"10.1016/j.tips.2024.10.001","url":null,"abstract":"","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1175-1176"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug repurposing for neglected and zoonotic diseases. 针对被忽视疾病和人畜共患疾病的药物再利用。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1016/j.tips.2024.10.012
Alexios-Fotios A Mentis, Helen W Hernandez, Kenneth I Kaitin
{"title":"Drug repurposing for neglected and zoonotic diseases.","authors":"Alexios-Fotios A Mentis, Helen W Hernandez, Kenneth I Kaitin","doi":"10.1016/j.tips.2024.10.012","DOIUrl":"10.1016/j.tips.2024.10.012","url":null,"abstract":"<p><p>Globalization and climate change have intensified the need to address the marginalization of R&D for neglected and zoonotic diseases. We propose that drug repurposing, using enabling technologies such as artificial intelligence, can address this need at a lower cost than de novo R&D processes.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1100-1103"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tiny but mighty: small molecules as vaccine adjuvants. 微小但强大：作为疫苗佐剂的小分子。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.tips.2024.10.011
Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner
{"title":"Tiny but mighty: small molecules as vaccine adjuvants.","authors":"Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner","doi":"10.1016/j.tips.2024.10.011","DOIUrl":"10.1016/j.tips.2024.10.011","url":null,"abstract":"<p><p>Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1097-1099"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some assembly required: a single-RNA vaccine against enterovirus-D68. 需要进行一些组装：针对肠道病毒-D68 的单核糖核酸疫苗。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1016/j.tips.2024.10.010
Noah Pollack, William T Jackson
{"title":"Some assembly required: a single-RNA vaccine against enterovirus-D68.","authors":"Noah Pollack, William T Jackson","doi":"10.1016/j.tips.2024.10.010","DOIUrl":"10.1016/j.tips.2024.10.010","url":null,"abstract":"<p><p>A single-RNA-based vaccine against enterovirus-D68, a respiratory virus and causative agent of severe paralytic disease in children, by the Erasmus group shows great promise in generating broadly cross-neutralizing antibodies in mice and macaque models of infection.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1089-1091"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in cell therapy: progress and challenges in hematological and solid tumors. 细胞疗法的进展：血液肿瘤和实体瘤的进展与挑战。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.tips.2024.10.016
Claudia D'Avanzo, Franziska Blaeschke, Memnon Lysandrou, Florian Ingelfinger, Robert Zeiser
{"title":"Advances in cell therapy: progress and challenges in hematological and solid tumors.","authors":"Claudia D'Avanzo, Franziska Blaeschke, Memnon Lysandrou, Florian Ingelfinger, Robert Zeiser","doi":"10.1016/j.tips.2024.10.016","DOIUrl":"10.1016/j.tips.2024.10.016","url":null,"abstract":"<p><p>Cell-based therapies harness the endogenous ability of the immune system to fight cancer and have shown promising results in the treatment of hematological malignancies. However, their clinical application beyond B cell malignancies is hampered by numerous hurdles, ranging from relapsed disease to a hostile tumor microenvironment (TME). Recent advances in cell engineering and TME modulation may expand the applicability of these therapies to a wider range of cancers, creating new treatment possibilities. Breakthroughs in advanced gene editing and sophisticated cell engineering, have also provided promising solutions to longstanding challenges. In this review, we examine the challenges and future directions of the most prominent cell-based therapies, including chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes (TILs), and natural killer (NK) cells, and emerging modalities. We provide a comprehensive analysis of emerging cell types and combination strategies translated into clinical trials, offering insights into the next generation of cell-based cancer treatments.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1119-1134"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to boost antibody selectivity in oncology.
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.1016/j.tips.2024.10.005
Vincent Blay, Atanasio Pandiella
{"title":"Strategies to boost antibody selectivity in oncology.","authors":"Vincent Blay, Atanasio Pandiella","doi":"10.1016/j.tips.2024.10.005","DOIUrl":"10.1016/j.tips.2024.10.005","url":null,"abstract":"<p><p>Antibodies in oncology are being equipped with toxic cargoes and effector functions that can kill cells at very low concentrations. A key challenge is that most targets on cancer cells are also present on at least some healthy cells. Shared targets can result in off-tumor binding and compromise the safety and potential of therapeutic candidates. In this review, we survey strategies that can help direct biologics to cancer sites more selectively. These strategies are becoming increasingly feasible thanks to advances in molecular design and engineering. The objective is to create therapeutics that exploit changes in cancer and leverage the human body infrastructure, enabling therapeutics that discriminate not just self from non-self but diseased from healthy tissue.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1135-1149"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of PROTACs using computational approaches. 利用计算方法开发 PROTAC。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1016/j.tips.2024.10.006
Jingxuan Ge, Chang-Yu Hsieh, Meijing Fang, Huiyong Sun, Tingjun Hou
{"title":"Development of PROTACs using computational approaches.","authors":"Jingxuan Ge, Chang-Yu Hsieh, Meijing Fang, Huiyong Sun, Tingjun Hou","doi":"10.1016/j.tips.2024.10.006","DOIUrl":"10.1016/j.tips.2024.10.006","url":null,"abstract":"<p><p>Proteolysis-targeting chimeras (PROTACs) are drugs designed to degrade target proteins via the ubiquitin-proteasome system. With the application of computational biology/chemistry technique in drug design, numerous computer-aided drug design and artificial intelligence (AI)-driven drug design (CADD/AIDD) methods have recently emerged to facilitate the development of PROTAC drugs. We systematically review the role of in silico tools in PROTAC drug design, emphasizing how computational software can model PROTAC action and structure, predict activity, and assist in molecule design. We also discuss current challenges in the rational design of PROTACs from an in silico perspective, such as deviations from small-molecule druggability and the limited availability of training data. We provide an overview of recent discoveries and emerging research in this field, and discuss their potential impact on PROTAC design strategies.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1162-1174"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and considerations in multi-epitope vaccine design surrounding toll-like receptors. 围绕收费样受体设计多表位疫苗的挑战和考虑因素。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1016/j.tips.2024.10.013
Masaud Shah, Sobia Rafiq, Hyun G Woo
{"title":"Challenges and considerations in multi-epitope vaccine design surrounding toll-like receptors.","authors":"Masaud Shah, Sobia Rafiq, Hyun G Woo","doi":"10.1016/j.tips.2024.10.013","DOIUrl":"10.1016/j.tips.2024.10.013","url":null,"abstract":"<p><p>Epitope-based peptide vaccines elicit targeted immune responses, making them effective for diseases requiring focused immune activation, such as targeting cancer-associated antigens. Strategies like peptide cocktails and mRNA-based epitope vaccines have revolutionized the field; however, the term 'multi-epitope peptide vaccine' has been overextended, especially concerning the use of toll-like receptors (TLRs), their ligands, and peptide linkers. TLRs are often conflated with T cell receptors (TCRs) and B cell receptors (BCRs), which recognize immunogenic peptides within vaccines. This Opinion clarifies the role of TLRs and highlights challenges linked to their indiscriminate use in multi-epitope vaccine design. While peptide linkers are crucial in creating multivalent vaccines, their unsupervised application is increasing and warrants attention. After highlighting their role in advancing peptide vaccines, we discuss critical factors in linker implementation and caution against their misuse, which could undermine vaccines' efficacy.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1104-1118"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RH5 antigenic landscape shapes vaccine and antibody development. RH5 抗原结构影响疫苗和抗体的开发。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1016/j.tips.2024.10.008
Palak N Patel, Niraj H Tolia
{"title":"RH5 antigenic landscape shapes vaccine and antibody development.","authors":"Palak N Patel, Niraj H Tolia","doi":"10.1016/j.tips.2024.10.008","DOIUrl":"10.1016/j.tips.2024.10.008","url":null,"abstract":"<p><p>The essential interaction between Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) and basigin makes RH5 a prime target for broadly neutralizing antibodies. A recent study by Barrett et al. mapped the RH5 antigenic landscape from RH5.1/AS01<sub>B</sub> vaccinees and identified a potent public antibody clonotype, advancing malaria vaccine and prophylactic antibody development.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1092-1094"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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