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Trends in pharmacological sciences最新文献

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Leveraging human microbiomes for disease prediction and treatment. 利用人类微生物组进行疾病预测和治疗。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.tips.2024.11.007
Henok Ayalew Tegegne, Tor C Savidge
{"title":"Leveraging human microbiomes for disease prediction and treatment.","authors":"Henok Ayalew Tegegne, Tor C Savidge","doi":"10.1016/j.tips.2024.11.007","DOIUrl":"10.1016/j.tips.2024.11.007","url":null,"abstract":"<p><p>The human microbiome consists of diverse microorganisms that inhabit various body sites. As these microbes are increasingly recognized as key determinants of health, there is significant interest in leveraging individual microbiome profiles for early disease detection, prevention, and drug efficacy prediction. However, the complexity of microbiome data, coupled with conflicting study outcomes, has hindered its integration into clinical practice. This challenge is partially due to demographic and technological biases that impede the development of reliable disease classifiers. Here, we examine recent advances in 16S rRNA and shotgun-metagenomics sequencing, along with bioinformatics tools designed to enhance microbiome data integration for precision diagnostics and personalized treatments. We also highlight progress in microbiome-based therapies and address the challenges of establishing causality to ensure robust diagnostics and effective treatments for complex diseases.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"32-44"},"PeriodicalIF":13.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic targeting of exportin-1 beyond nuclear export. 核出口以外的export -1治疗靶点。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.tips.2024.11.002
Yi Fan Chen, Drew J Adams
{"title":"Therapeutic targeting of exportin-1 beyond nuclear export.","authors":"Yi Fan Chen, Drew J Adams","doi":"10.1016/j.tips.2024.11.002","DOIUrl":"10.1016/j.tips.2024.11.002","url":null,"abstract":"<p><p>Exportin-1 (XPO1), also known as chromosome region maintenance 1 (CRM1), directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking nuclear export by the selective inhibitors of nuclear export (SINEs) is a validated therapeutic axis in cancer and an active area of research. However, a growing body of evidence implicates XPO1 in biological functions beyond nuclear export that include the regulation of mitosis and the epigenome. Additionally, new pharmacological classes of small molecules have emerged that degrade XPO1 or induce distinct cellular activity profiles. Here, we discuss the canonical model of nuclear export and XPO1's emergence as an anticancer target. We also spotlight the key evidence for underappreciated XPO1 functions and discuss the use of chemical probes to uncover new cellular roles for XPO1. With these growing trends, the field is poised to extend XPO1 therapeutic targeting to indications beyond oncology.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"20-31"},"PeriodicalIF":13.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging therapeutic strategies for optic nerve regeneration. 视神经再生的新治疗策略。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1016/j.tips.2024.11.008
Qi Zhang, Jiahui Tang, Liyan Liu, Zhe Liu, Jingfei Xue, Jian Ge, Yehong Zhuo, Yiqing Li
{"title":"Emerging therapeutic strategies for optic nerve regeneration.","authors":"Qi Zhang, Jiahui Tang, Liyan Liu, Zhe Liu, Jingfei Xue, Jian Ge, Yehong Zhuo, Yiqing Li","doi":"10.1016/j.tips.2024.11.008","DOIUrl":"10.1016/j.tips.2024.11.008","url":null,"abstract":"<p><p>The optic nerve, comprising axons from retinal ganglion cells (RGCs), is a component of the central nervous system (CNS) that generally exhibits a limited regeneration capacity following injury in mature mammals, resulting in permanent vision loss. Here, we summarize recent advances in interventions targeting cell-intrinsic and cell-extrinsic mechanisms to enhance RGC axon regeneration. Additionally, we summarize strategies for guiding the reconnection of regenerating axons with brain visual targets, aiming to restore partial visual function. Given the advent of high-throughput screening techniques and multiomics analyses, we discuss how these emerging methodologies deepen our understanding of regenerative mechanisms and expedite the development of innovative therapeutic approaches. Lastly, we explore the translational potential of these strategies in achieving clinically meaningful vision recovery.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"45-61"},"PeriodicalIF":13.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics. ACK1/TNK2激酶：分子机制和新兴的癌症治疗。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.1016/j.tips.2024.11.006
Dhivya Sridaran, Nupam P Mahajan
{"title":"ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics.","authors":"Dhivya Sridaran, Nupam P Mahajan","doi":"10.1016/j.tips.2024.11.006","DOIUrl":"10.1016/j.tips.2024.11.006","url":null,"abstract":"<p><p>Activated CDC42-associated kinase 1 (ACK1), encoded by the TNK2 gene, is a cytoplasmic non-receptor tyrosine kinase whose aberrant activation correlates positively with cancer severity. Recent research has revealed the functional relevance of this oncokinase - it is an epigenetic regulator that drives cancer progression in multiple malignancies. Although ACK1 is an attractive target for therapeutic intervention, incomplete knowledge of its diverse signaling mechanisms and the lack of specific inhibitors have challenged its clinical success. We summarize recent breakthroughs in understanding ACK1 regulation and cellular signaling, and shed light on its immunomodulatory role in balancing T cell activation. We provide a comprehensive overview of preclinical, proof-of-concept studies of potent ACK1-targeting small-molecule inhibitors that are expected to enter clinical trials for cancer patients.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"62-77"},"PeriodicalIF":13.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poxvirus vaccines: the evolution of an 18th-century vaccine to the 21st century. 痘病毒疫苗：从 18 世纪的疫苗发展到 21 世纪。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1016/j.tips.2024.10.015
Yuhong Xiao, Stuart N Isaacs
{"title":"Poxvirus vaccines: the evolution of an 18th-century vaccine to the 21st century.","authors":"Yuhong Xiao, Stuart N Isaacs","doi":"10.1016/j.tips.2024.10.015","DOIUrl":"10.1016/j.tips.2024.10.015","url":null,"abstract":"<p><p>The unprecedented global spread of monkeypox (mpox) has reinvigorated the pursuit of next-generation poxvirus vaccines. Given the success of the mRNA-lipid nanoparticle (LNP) vaccine platform to vaccinate against SARS-CoV-2, candidate poxvirus mRNA vaccines, as recently reported by Zuiani et al. and Mucker et al., demonstrate success in nonhuman primate (NHP) models and provide insights into the basis of the protective immune response.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1086-1088"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis: cannabidiol therapy for symptom relief. 子宫内膜异位症：缓解症状的大麻二酚疗法。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.tips.2024.10.014
Lucy H R Whitaker, Clive Page, Charles Morgan, Andrew W Horne, Philippa T K Saunders
{"title":"Endometriosis: cannabidiol therapy for symptom relief.","authors":"Lucy H R Whitaker, Clive Page, Charles Morgan, Andrew W Horne, Philippa T K Saunders","doi":"10.1016/j.tips.2024.10.014","DOIUrl":"10.1016/j.tips.2024.10.014","url":null,"abstract":"<p><p>Endometriosis is a common, chronic, incurable condition the hallmark of which is the presence of lesions (tissue resembling endometrium) in sites outside the womb, with symptoms including chronic debilitating pain and fatigue. However, current therapeutic options are limited. Recent advances in our understanding of the mechanisms that contribute to the development of lesions and pain experience in endometriosis as well as surveys of patients have increased interest in testing recently approved formulations containing cannabidiol (CBD) in this patient group. In this review, we summarise data from patient samples and animals models focussed on the pathophysiology of endometriosis, including pathways where CBD has activity. We consider the available formulations of CBD-containing products, their pharmacokinetics (PK), and their use in ongoing clinical trials in endometriosis and other pain conditions.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1150-1161"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pegcetacoplan (SyfovreΤΜ): targeting complement C3 in geographic atrophy. Pegcetacoplan (SyfovreΤΜ)：针对地理萎缩的补体 C3。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1016/j.tips.2024.10.001
Dimitrios C Mastellos, John D Lambris
{"title":"Pegcetacoplan (Syfovre<sup>ΤΜ</sup>): targeting complement C3 in geographic atrophy.","authors":"Dimitrios C Mastellos, John D Lambris","doi":"10.1016/j.tips.2024.10.001","DOIUrl":"10.1016/j.tips.2024.10.001","url":null,"abstract":"","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1175-1176"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug repurposing for neglected and zoonotic diseases. 针对被忽视疾病和人畜共患疾病的药物再利用。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1016/j.tips.2024.10.012
Alexios-Fotios A Mentis, Helen W Hernandez, Kenneth I Kaitin
{"title":"Drug repurposing for neglected and zoonotic diseases.","authors":"Alexios-Fotios A Mentis, Helen W Hernandez, Kenneth I Kaitin","doi":"10.1016/j.tips.2024.10.012","DOIUrl":"10.1016/j.tips.2024.10.012","url":null,"abstract":"<p><p>Globalization and climate change have intensified the need to address the marginalization of R&D for neglected and zoonotic diseases. We propose that drug repurposing, using enabling technologies such as artificial intelligence, can address this need at a lower cost than de novo R&D processes.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1100-1103"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tiny but mighty: small molecules as vaccine adjuvants. 微小但强大：作为疫苗佐剂的小分子。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.tips.2024.10.011
Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner
{"title":"Tiny but mighty: small molecules as vaccine adjuvants.","authors":"Ari Joffe, Nancy Vázquez-Maldonado, Kentner L Singleton, Wolfgang W Leitner","doi":"10.1016/j.tips.2024.10.011","DOIUrl":"10.1016/j.tips.2024.10.011","url":null,"abstract":"<p><p>Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037. This compound successfully restored vaccine-induced immune responses in aged mice.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1097-1099"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some assembly required: a single-RNA vaccine against enterovirus-D68. 需要进行一些组装：针对肠道病毒-D68 的单核糖核酸疫苗。
IF 13.9 1区 医学
Trends in pharmacological sciences Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1016/j.tips.2024.10.010
Noah Pollack, William T Jackson
{"title":"Some assembly required: a single-RNA vaccine against enterovirus-D68.","authors":"Noah Pollack, William T Jackson","doi":"10.1016/j.tips.2024.10.010","DOIUrl":"10.1016/j.tips.2024.10.010","url":null,"abstract":"<p><p>A single-RNA-based vaccine against enterovirus-D68, a respiratory virus and causative agent of severe paralytic disease in children, by the Erasmus group shows great promise in generating broadly cross-neutralizing antibodies in mice and macaque models of infection.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"1089-1091"},"PeriodicalIF":13.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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