International Journal of Clinical and Diagnostic Pathology最新文献

{"title":"Rare variant of renal cell carcinoma: A case report from rural tertiary care centre","authors":"Dr. Keerthyraj N, Dr. V Sriram, Dr. Revathi G, Dr. V Vigneswaramoorthi, Dr. Erli Amel Ivan, Dr. Ramya G","doi":"10.33545/pathol.2023.v6.i3a.527","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3a.527","url":null,"abstract":"Introduction: Renal Cell Carcinoma (RCC) is the most common type of kidney cancer, accounting for 3% of all malignancies and 85% of all malignant kidney tumors. The histological classification is of utmost importance, considering the significant prognostic and therapeutic implications of these histological subtypes. Here we report rare variant of RCC which include Oncocytic variant of papillary renal cell carcinoma (OPRCC). Case report: A middle age male presented with pain in left flank and decreased urine output. CECT Abdomen revealed a well defined solid cystic mass lesion arising from inferior polar cortex of the left kidney measuring 10.9 x 9.4 x 9.8 cm. Left radical nephrectomy was performed and the specimen was sent for histopathological examination and show features of oncocytic variant of papillary renal cell carcinoma. Conclusion: The importance of this case report is to identify the rare variants of the histological subtypes of RCC as it confers high propensity of metastasis and hence less chance of survival. OPRCC is regarded as an independent subtype of PRCC not only for its distinct pathological features but also for its indolent clinical behaviour and the tumor presents with same immunophenotypic as of type 2 but same genetic features and prognosis as of type 1 PRCC.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121895674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of thrombocytopenia in patients with alcohol withdrawal and its association with clinical complications","authors":"Dr. Bansri B Patel, Dr. Sanjay V Dhotre, Dr. Hitendra Barot, Dr. Bhavesh Faldu, Dr. Amit Satasiya, Dr. Hansa Goswami","doi":"10.33545/pathol.2023.v6.i3b.541","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3b.541","url":null,"abstract":"Background: The aim of the study is to evaluate thrombocytopenia in alcohol withdrawal symptoms (AWS) as a predictive marker for non-severe alcohol withdrawal symptoms (nAWS) to severe alcohol withdrawal symptoms (sAWS) and its relationship with liver enzymes.Methodology: A 3 months (forty-three patients) prospective study during June 2023 to August 2023 was carried out in patient admitted at B. J. Medical College with complains of symptoms related with alcohol withdrawal. Detailed history and evaluation regarding alcohol dependence along with laboratory parameters like CBC, LFT, RFT at regular intervals was carried out. On achieving the diagnostic criteria of alcohol withdrawal symptoms patients was treated and discharge.Result: During the treatment period out of 43 patients, 9 (21%) were having complains of sAWS out of which 7 had reduced platelet counts and remaining 34 (79%) were having complains of nAWS. Liver enzyme (Alanine transaminase (ALT)) was higher in 28% (12/43) of patients ranging from (42-178 IU/L) which was a significant risk factor (p","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134887403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of endoscopic ultrasound: Guided fine needle core biopsy for diagnosis of pancreatic lesions: A clinicopathological study","authors":"Dr. Zainab Sattar Mohammed, Dr. Sazan Abdulwahab Mirza","doi":"10.33545/pathol.2023.v6.i3a.534","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3a.534","url":null,"abstract":"Introduction: EUS-FNB can detect pancreatic cancer. It preserves tissue for histologic grading and molecular biology. Aim: to investigate the role of endoscopic ultrasound guided fine needle core biopsy in histopathological diagnosis of pancreatic lesions, differentiating malignant from benign lesions, and correlating histopathology results with clinico-pathological parameters like age, sex, location, size, and lesion type (homogeneous or heterogeneous).Methods: EUS-FNB pancreatic core biopsy retrospective investigation of 60 patients. The Baghdad gastroenterology and hepatology teaching hospital gathered cores from March to December 2022. Histopathological findings scored histological specimens 0-3: 0: Non-representative: cores, blood clots, fibrosis, or strips of bland intestinal or stomach mucosa alone. 1. Suspicious: Typical doubtful (poorly preserved, crush artefacts, overlapping cell groupings). 2. Suggestive: Few diagnostic cells. Representative: definitive diagnosis. H & E-stained paraffin slides are reviewed for diagnostic criteria.Results: Regarding the sixty cases of pancreatic lesions: age range was (22-75) years, 30 (50%) of cases were males, 30 (50%) of them were females, 21 (35%) of the cases the quality of histological specimen was score 3. Twenty-one (35%) of the cases were diagnosed as adenocarcinoma (20 cases moderately differentiated and 1 case was poorly differentiated), other cases, neuroendocrine tumors 5 cases (8.3%), solid pseudo papillary neoplasm 2 cases (3.3%), chronic pancreatitis 2 cases (3.3%), mucinous cystic neoplasm one case (1.7%). Thirty-eight (63.3%) of the lesions located in the head of the pancreas, 44 (73.3%) of the lesions were heterogeneous in nature, 48 (80%) of the cases, the number of pieces taken by EUS-FNB was ≥ 5.Conclusion: EUS-FNB is effective and safe for diagnosing pancreatic lesions. 80% of cases yielded suitable samples for histological evaluation. Most lesions were in the pancreatic head (63.3%). Specimens with quality 2 or 3 had a definite diagnosis (P = 0.001). EUS-FNB showed 93.1% sensitivity and 100% specificity in diagnosing pancreatic lesions.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of immature reticulocyte fraction (IRF) and reticulocyte maturity indices in differential diagnosis of anemia","authors":"Dr. Bansari Anovadia, D. Trivedi, D. Savjiyani, Dr. Vijay C Popat","doi":"10.33545/pathol.2023.v6.i1a.505","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i1a.505","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124615998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet binding to lymphocytes and platelet activation in systemic lupus erythematosus patients","authors":"Reem Mostafa Awny, M. Abu-Zaid, A. Shahba, M. Mabrouk, N. Elwan","doi":"10.33545/pathol.2023.v6.i3a.529","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3a.529","url":null,"abstract":"Background: A condition known as systemic lupus erythematosus (SLE) is caused by the creation of multiple autoantibodies targeting various biological components, which may impact many cells, tissues, and organs. The purpose of this study was to evaluate the role of platelet-lymphocyte binding and platelet activation in pathogenesis of SLE, clarifying their relationship to the clinical and laboratory characteristics of individuals with SLE. Methods: This case-control work was performed on 30 individuals, their age was more than 18 years old, with clinical criteria of SLE, divided into SLE patient group and control health group. Each participant was exposed to flow cytometric analysis of the peripheral blood samples to detect lymphocytes bound to platelets and Enzyme-linked immune-sorbent assay (ELISA) analysis of serum, to evaluate the concentrations of soluble cluster of differentiation 40 ligand (sCD40L) and the concentrations of interleukin 10 (IL-10). Results: A substantial elevation was existed in the percentage of lymphocyte bound platelets (CD19+CD41a+ lymphocytes and CD3+CD41a+ lymphocytes), sCD40L level and IL10 level in individuals with SLE contrasted to controls. The percentage of lymphocyte bound platelets, sCD40L and IL10 expressed a significant increase in SLE patients who had hematuria and positive anti-dsDNA compared to SLE patients without hematuria and negative anti-dsDNA. Both sCD40L and IL10 had a substantial positive association with each other and with CD19+CD41a+ lymphocytes, CD3+CD41a+ lymphocytes, and albumin to creatinine ratio, SLEDAI, creatinine and urea, while they had a significant negative correlation with C3, C4, hemoglobin, platelets and leucocytic count. CD19+CD41a+ lymphocytes and CD3+CD41a+ lymphocytes had a substantial positive association with each other and with sCD40L, IL10, albumin to creatinine ratio, SLEDAI, creatinine and urea, while they had a substantial negative association with C3, C4 and platelets. Moreover, CD3+CD41a+ lymphocytes had a substantial negative association with leucocytic count. Conclusions: SLE patients had a substantial elevation in lymphocytes bound platelets contrasted to the healthy control group.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"30 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133754805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HER2/neu estimation by ISH (FISH and CISH) technique in equivocal cases (+2) by IHC in breast cancer","authors":"Reem Mazin Hilmi Wali, Mohammed Subhi Kama","doi":"10.33545/pathol.2023.v6.i3a.535","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3a.535","url":null,"abstract":"Background: The HER-2/neu oncogene, a member of the epidermal growth factor receptor family, plays a significant role in the development of human breast cancer due to its common amplification. Its detection is paramount for determining the suitability of patients for trastuzumab (Herceptin) therapy and informing treatment decisions involving anthracycline-based and hormonal regimens. The aim of the study is to HER2/neu estimation by ISH (FISH and CISH) technique in equivocal cases (+2) by IHC in breast cancer. Method: Cross-sectional analysis of 52 female breast cancer patients under FISH and 150 under CISH. CISH from Department of pathology/medical city teaching complex/oncology teaching hospital and FISH from AL SHARIQA specialized lab/diagnostic centre from January 2019 to May 2023. Both groups of females were asked their age (years) and FISH or CISH results (positive or negative). Results: Breast cancer patients average 53 ± 11 years. Table 1 shows 38.5% of females aged 50–59 and 30.8% aged 40–49. Only 21.2% of women had HER 2 Neu-positive FISH. 78.8% had HER 2 Neu-negative FISH. FISH for HER 2 Neu is 100% positive in 30-39-year-old women. 30% of women aged 50–59 had HER 2 Neu-positive FISH. 6.3% and 7.7% of women aged 40–49 and ≥ 60 had positive FISH for HER 2 Neu. Breast cancer patients average 50.9 ± 12.2. Table 3 shows 30.7% of women aged 40–49 and 28% aged 50–59. Only 27.3% of women have HER 2 Neu-positive CISH. 72.7% have HER 2 Neu-negative CISH. Age does not affect HER 2 Neu CISH. Conclusion: FISH and CISH showed various age-HER-2/neu oncogene amplification relationships. FISH showed an age-group-HER-2/neu amplification connection, whereas CISH did not. These results emphasise the relevance of the detection technique in interpreting HER-2/neu status in breast cancer and recommend additional study to improve patient classification and therapy decision.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To study the expression of cytokeratin 5 and 6 in triple negative breast carcinoma: An immunohistochemical study","authors":"Dr. Amanpreet Singh Rattan, Dr. Manisha Sharma, Dr. Arshdeep Kaur, Dr. Manas Madan, Dr. Karamjit Singh Gill","doi":"10.33545/pathol.2023.v6.i1a.508","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i1a.508","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"77 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134410574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selpercatinib induced intestinal lymphangiectasia in RET fusion positive metastatic non-small cell lung cancer","authors":"Nashwa Mansoor, Syed Yasir Andrabi, Henry Fung, Reza Nejati","doi":"10.33545/pathol.2023.v6.i3a.533","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3a.533","url":null,"abstract":"RET (Rearranged during Transfection) is a transmembrane receptor protein-tyrosine kinase commonly associated with non-small cell lung adenocarcinomas, particularly those harboring RET fusion proteins [1] . Selective kinase inhibitors, such as Selpercatinib, have been developed to target RET tyrosine kinase receptors with higher specificity, aiming to improve treatment outcomes and reduce side effects compared to multitarget tyrosine kinase inhibitors [2] . Some of the side effects that have been reported with Selpercatinib are dry mouth, diarrhea, elevated liver enzymes, hypertension, prolonged corrected QT interval, fatigue/asthenia and abdominal pain [1] . While intestinal lymphangiectasia has been reported as a rare complication of multitarget tyrosine kinase inhibitors, to our knowledge, this is the first report of intestinal lymphangiectasia in a patient receiving the new generation of kinase inhibitors (Selpercatinib), which is considered a selective kinase inhibitor. We present the clinical presentation, diagnostic evaluation, and implications of this unique case. Due to the rarity of this complication and the presence of nonspecific symptoms, diagnosis can be difficult or delayed. Raising awareness about this rare complication can facilitate early diagnosis and improve care for cancer patients receiving Selpercatinib or similar targeted therapies.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"15 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132090482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of intra-operative frozen section at tertiary care center","authors":"Dr. Chirag I Chavda, D. A. Shah, D. H. Goswami, Dr. Jayshri A Vaghani","doi":"10.33545/pathol.2023.v6.i1a.504","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i1a.504","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"IA-21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126561370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Napsin-A and TTF-1 in differentiating primary from secondary lung carcinoma","authors":"Dr. Jayesh Gojiya, Dr. Grishma Aghera, Dr. Alaknanda Atara, Dr. Kishor Dethariya","doi":"10.33545/pathol.2023.v6.i3a.531","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i3a.531","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129741330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}