Tissue & cell最新文献

{"title":"FOXO3a-mediated structural and cellular remodeling in liver tissue: Implications for apoptosis and homeostasis","authors":"Heba Ibrahim Abd El-Moaty ,&nbsp;Sameh Saber ,&nbsp;Rabab S. Hamad ,&nbsp;Elsayed A. Elmorsy ,&nbsp;Alshaimaa A. Farrag ,&nbsp;Simona Cavalu ,&nbsp;Hanan Eissa ,&nbsp;Attalla F. El-kott ,&nbsp;Sally Negm ,&nbsp;Mohammed A. AlShehri ,&nbsp;Mohamed A.M. Ali ,&nbsp;Waseem Ali Hasan ,&nbsp;Anis Ahmad Chaudhary ,&nbsp;Ahmed Gaafar ,&nbsp;Fatma Elnaghy","doi":"10.1016/j.tice.2026.103375","DOIUrl":"10.1016/j.tice.2026.103375","url":null,"abstract":"<div><div>FOXO3a, a member of the forkhead box O transcription factor family, has emerged as a pivotal regulator of cellular fate in liver physiology and pathology. Its activity integrates multiple stress signals to orchestrate antioxidant defense, autophagy, and apoptosis, placing it at the intersection of survival and death pathways. Notably, FOXO3a demonstrates a dual role in apoptosis: under certain contexts, it promotes hepatocyte death through activation of pro-apoptotic genes such as Bim and PUMA, contributing to disease progression; conversely, it mitigates oxidative stress and supports cell survival by inducing antioxidant enzymes and autophagy-related genes. This paradox emphasizes FOXO3a as both a mediator of injury and a guardian of homeostasis, based on cellular and environmental cues. In liver disorders, FOXO3a influences critical processes including oxidative injury, inflammation, fibrosis, ischemia/reperfusion responses, and regeneration. Its modulation of mitochondrial function and autophagic flux underscores its importance in maintaining hepatocyte integrity, while its context-dependent activation can either exacerbate damage or promote recovery. These multifaceted actions make FOXO3a an attractive therapeutic target, with potential strategies aimed at fine-tuning its action to restore balance between apoptosis and survival. Enhancing FOXO3a function may support regeneration and protect against acute stress, whereas its inhibition may prevent excessive cell death and limit fibrosis. Overall, FOXO3a functions as a molecular switch in liver disease pathogenesis, and precision targeting of its signaling pathways holds promise for innovative interventions that maintain tissue homeostasis while preventing progression of chronic injury.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103375"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-type-specific radiosensitivity in the human parotid gland and its implications for radiotherapy-induced dysfunction","authors":"Jeong-Mi Kim ,&nbsp;Huu Hoang ,&nbsp;Eun-Jeong Jeon ,&nbsp;Jin-Mi Park ,&nbsp;Jeong-Seok Choi","doi":"10.1016/j.tice.2026.103384","DOIUrl":"10.1016/j.tice.2026.103384","url":null,"abstract":"<div><h3>Background</h3><div>The human parotid gland, vital for oral health and digestion, comprises mainly acinar and ductal cells, each with unique responses to environmental stimuli such as radiation. Understanding the differential effects of radiation on these cells is crucial for therapeutic advancements in treating radiation-induced salivary gland damage.</div></div><div><h3>Methods</h3><div>Acinar and ductal cells were isolated from human parotid glands and cultured in both 2D and 3D environments. Morphology, proliferation capacity, and transepithelial electrical resistance (TER) were assessed to characterize each cell type. To evaluate radiosensitivity, both cell types were exposed to 5 Gy of irradiation, and post-radiation cellular responses were compared. Differential gene expressions were analyzed under normal and irradiated conditions using microarray analysis. Selected genes were further validated using qRT-PCR and immunohistochemistry (IHC) to confirm cell-type-specific expression patterns and radiation-induced change.</div></div><div><h3>Results</h3><div>Acinar cells exhibited strong epithelial junctional features, including high E-cadherin and ZO-2 expression, and showed higher TER values than ductal cells. After irradiation, acinar cells demonstrated sustained proliferation loss and activation of inflammatory pathways, such as IL-17 and MAPK signaling. In contrast, ductal cells displayed early growth reduction followed by stabilization and showed increased expression of ECM- and repair-related genes, including GREM1, HAS2, SNAIL1, and CEMIP. Radiation-induced transcriptional responses were distinctly cell-type specific.</div></div><div><h3>Conclusion</h3><div>Acinar and ductal cells exhibit fundamentally different structural properties and radiation responses. Acinar cells appear more vulnerable to inflammation-associated injury, whereas ductal cells activate adaptive remodeling pathways. These findings support the development of cell-type-specific strategies to protect acinar cells and enhance ductal-mediated repair during radiotherapy.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103384"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cordycepin inhibits human extravillous trophoblast invasion by suppressing snail-mediated MMP2 expression","authors":"Manman Guo ,&nbsp;Siwei Luo ,&nbsp;Beibei Bi,&nbsp;Xiaoyu Han,&nbsp;Yuanyuan Jia,&nbsp;Jung-Chien Cheng,&nbsp;Lanlan Fang","doi":"10.1016/j.tice.2026.103381","DOIUrl":"10.1016/j.tice.2026.103381","url":null,"abstract":"<div><div>Invasion of extravillous trophoblast (EVT) cells is essential for establishing proper maternal-fetal circulation and ensuring successful pregnancy outcomes. Cordycepin (COR), a bioactive compound derived from <em>Cordyceps</em> spp., is an adenosine analog known to exert multiple beneficial effects on human health. Although COR has been reported to suppress invasiveness in various cancer cell types, its effect on human EVT cell invasion remains unclear. In the present study, we demonstrated that COR treatment did not affect the cell viability but significantly downregulated matrix metalloproteinase 2 (MMP2) expression in both the immortalized human EVT cell line HTR-8/SVneo and primary human EVT cells. Using specific adenosine receptor antagonists, we further showed that the inhibitory effect of COR on MMP2 expression was mediated by A₁, A_2A, and A₃ adenosine receptors. Mechanistically, COR activated ERK1/2 and AKT signaling pathways, but only AKT activation was required for the COR-induced downregulation of MMP2. In addition, COR suppressed the expression of the transcription factor Snail, which contributed to the downregulation of MMP2. Functionally, COR treatment inhibited EVT cell invasion, and this effect was mediated by MMP2 downregulation. These findings provide new insights into the molecular mechanisms by which COR regulates EVT cell invasiveness and highlight the potential implications of COR as a health supplement during pregnancy.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103381"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of polydatin on cyclophosphamide-induced ovarian and uterine damage in rats via modulation of hormonal, oxidative, inflammatory, and histopathological alterations","authors":"Ramazan Bülbül ,&nbsp;Sefa Küçükler ,&nbsp;Selim Çomaklı ,&nbsp;Özge Kandemir ,&nbsp;Elif Dalkılınç ,&nbsp;Sevda Sağ Bayav ,&nbsp;Cuneyt Caglayan ,&nbsp;Fatih Mehmet Kandemir","doi":"10.1016/j.tice.2026.103309","DOIUrl":"10.1016/j.tice.2026.103309","url":null,"abstract":"<div><div>Cyclophosphamide (Cyclo) is a chemotherapeutic agent whose clinical use is limited by its toxic effects on ovarian and uterine tissues. Polydatin (Poly), a resveratrol derivative with antioxidant and anti-inflammatory properties, was evaluated for its protective potential against Cyclo-induced reproductive toxicity. Female rats were divided into five groups: control, Poly (100 mg/kg), Cyclo, and combination groups (Cyclo + Poly 50 mg/kg, Cyclo + Poly 100 mg/kg). Poly was administered orally and Cyclo was administered intraperitoneally. Serum hormone levels (AMH, FSH, E2, LH), antioxidant parameters (SOD, CAT, GPx, GSH), inflammatory markers (<em>NF-κB, TNF-α, IL-1β</em>), gene expression <em>(Pgr, Esr1, Esr2, Cyp19a1, Foxl2, Amh, Hoxa10, Lhcgr, Hsd3b1, Cyp11a1, Sohlh2</em>), and protein levels (<em>BAX, BCL-2, ERK1/2, CREB</em>) were analyzed using ELISA, RT-PCR, Western blot and immunohistochemistry methods. Histopathological analyses were also performed. The results showed that Cyclo significantly disrupted hormonal balance, reduced antioxidant activity, increased inflammatory markers, and induced apoptosis in ovary and uterine tissues. Poly administered with Cyclo dose-dependently attenuated these changes, restoring hormone levels, gene expressions, antioxidant status, and tissue integrity. Consequently, Poly may be a potential therapeutic agent for alleviating Cyclo-induced reproductive toxicity.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103309"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular cytokine profiles and granulosa cell integrity across ovarian response during in vitro fertilisation","authors":"Oya Korkmaz ,&nbsp;Seda Karabulut ,&nbsp;Pelin Macit","doi":"10.1016/j.tice.2026.103370","DOIUrl":"10.1016/j.tice.2026.103370","url":null,"abstract":"<div><h3>Background</h3><div>Ovarian response to controlled ovarian stimulation varies considerably among women and may be influenced by inflammatory activity within the follicular microenvironment.</div></div><div><h3>Objective</h3><div>To examine the relationship between ovarian response and follicular inflammatory activity by evaluating IL-1β, IL-17, and IL-18 levels, granulosa cell expression, and markers of chromatin integrity and apoptosis in IVF cycles.</div></div><div><h3>Methods</h3><div>A total of 150 women undergoing controlled ovarian stimulation were grouped as low, normal, or high ovarian response (n = 50 each). Follicular fluid cytokine levels were measured by ELISA/CLIA, granulosa cell cytokine expression was assessed immunohistochemically, and chromatin integrity and DNA fragmentation were evaluated using Toluidine Blue and TUNEL assays.</div></div><div><h3>Results</h3><div>Follicular fluid levels and granulosa cell immunopositivity of IL-1β, IL-17, and IL-18 increased progressively from low to high ovarian response groups (p &lt; 0.05). Chromatin integrity was best preserved in the normal responder group, whereas both Toluidine Blue–positive and TUNEL-positive granulosa cell ratios were significantly higher in low and high responders (p &lt; 0.01). IL-18 levels showed positive correlations with oocyte number, serum estradiol levels, and MII oocyte ratio (p &lt; 0.05). Notably, granulosa cell IL-18 expression was inversely correlated with DNA fragmentation, suggesting a potential cytoprotective role under physiological inflammatory conditions.</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that follicular cytokine balance is closely associated with ovarian response and granulosa cell integrity during IVF. IL-18 emerges as a key regulator linking physiological inflammation to oocyte competence, highlighting its potential relevance for individualized ovarian stimulation strategies.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103370"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropharyngeal cavity roof adaptations of the migratory black-tailed native-hen (Tribonyx ventralis): Gross, scanning electron microscopic, and histological features","authors":"Ramadan Kandyel ,&nbsp;Saeed Alasmari ,&nbsp;Salem H. Alharethi ,&nbsp;Abdulrhman A. Almadiy ,&nbsp;Bader Albogami ,&nbsp;Diaa Massoud ,&nbsp;Basma G. Hanafy ,&nbsp;Ahmed G. Nomir ,&nbsp;Mohamed Abumandour","doi":"10.1016/j.tice.2026.103333","DOIUrl":"10.1016/j.tice.2026.103333","url":null,"abstract":"<div><div>The morphological structure of the oropharyngeal cavity roof of the Black-tailed Native-Hen (<em>Tribonyx ventralis</em>) had not been previously researched. The study aimed to provide a comprehensive morphological description of the oropharyngeal cavity roofs of the Black-tailed Native-Hen using gross, SEM, and histological techniques. The oropharyngeal roof was categorized into three regions: pre-conchal, middle conchal, and infundibular. The dorsal palatine surface carried twelve papillary rows: eleven longitudinal and one transverse. These rows were presented in a manner such that one median longitudinal row was on the pre-choanal region, eight longitudinal rows were on the choanal field on each side of the choanal opening, two longitudinal rows bordered the rostral portion of the choanal opening, and one transverse row separated the rostral and caudal portions. Papillae are arranged in twelve rows on the palatine surface, with free distribution in specific lateral areas, while the caudal choanal and infundibular regions lack papillae. The choanal opening was located in the caudal palatine half, which was divided into two parts: the rostral long papillary and the caudal wide non-papillary portions. Histologically, the salivary glands were classified into five types based on their position: rostral, median, caudal, intraepithelial, and infundibular. The oropharyngeal roof, influenced by various lifestyles and environments, significantly influences food handling and direction toward the esophagus.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103333"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HSPA1A-BAG5 chaperone complex promotes spermatogenesis by driving ubiquitination-mediated degradation of ATF2","authors":"Peng Yi,&nbsp;Bo Peng,&nbsp;Ying Cao,&nbsp;Xianghong Fu","doi":"10.1016/j.tice.2026.103331","DOIUrl":"10.1016/j.tice.2026.103331","url":null,"abstract":"<div><h3>Background</h3><div>Male infertility represents a major global health challenge. Heat shock protein A1A (HSPA1A), a stress-inducible molecular chaperone, shows potential importance in spermatogenesis, though its precise mechanistic role remains undefined.</div></div><div><h3>Methods</h3><div>Analysis of human sperm transcriptome data (GSE6969) revealed HSPA1A expression in fertile versus infertile samples. Functional characterization involved the overexpression of HSPA1A in spermatogonia (GC-1 spg) and its knockdown in spermatocytes (GC-2 spd(ts)), assessing apoptosis, proliferation, and cell cycle progression. HSPA1A-interacting proteins were identified through immunoprecipitation-mass spectrometry and validated by co-immunoprecipitation. Downstream targets were investigated via bioinformatic analysis and proteomics. <em>In vivo</em> validation employed a mouse model of chronic HSP70 inhibition (VER-155008).</div></div><div><h3>Results</h3><div>HSPA1A is highly expressed in fertile sperm, and its overexpression significantly inhibited apoptosis, enhanced proliferation, and induced S/G2 phase arrest, while HSPA1A knockdown produced opposite effects. BAG5 was identified as a primary HSPA1A interactor. Mechanistically, the HSPA1A-BAG5 complex promoted ubiquitination-mediated degradation of ATF2, subsequently downregulating apoptotic signaling. <em>In vivo</em> HSPA1A inhibition induced testicular atrophy, reduced sperm count, impaired sperm morphology and acrosome reaction, disrupted seminiferous tubule architecture, and elevated germ cell apoptosis. Concurrent upregulation of ATF2, p53, and reduced testosterone levels were observed.</div></div><div><h3>Conclusion</h3><div>The HSPA1A-BAG5 complex maintains spermatogenic cell survival and proliferation through ubiquitination-dependent ATF2 degradation. These findings elucidate a novel regulatory axis essential for spermatogenesis and position HSPA1A as a promising therapeutic target for male infertility.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103331"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-liposomal berberine and vildagliptin combination: A novel therapeutic approach against oxidative stress, inflammation, autophagy dysregulation, and fibrosis in diabetic nephropathy","authors":"Areej A. Eskandrani ,&nbsp;Safaa I. Khater ,&nbsp;Mahran Mohamed Abd El-Emam ,&nbsp;Rawan Altalhi ,&nbsp;Mohamed M.M. Metwally ,&nbsp;Tarek Khamis ,&nbsp;Mahmoud Mostafa ,&nbsp;Mohamed Mohamed Soliman ,&nbsp;Shatha B. Albattal ,&nbsp;Saed A. Althobaiti ,&nbsp;Ola Ali ,&nbsp;Mona I. Abdel Ati","doi":"10.1016/j.tice.2026.103355","DOIUrl":"10.1016/j.tice.2026.103355","url":null,"abstract":"<div><div>An important consequence of diabetes is diabetic nephropathy (DN), which could end up in end-stage renal failure and chronic kidney disease. Blood glucose control, reduction of inflammation, management of oxidative stress, enhancement of autophagy, and repair of renal injury and fibrosis are important strategies for the management of DN. This research examined the protective benefits of berberine hydrochloride liposomes (BHC-Lip) and/or vildagliptin (Vild) against DN in rats with high-fat diet/streptozotocin (HFD/STZ) were examined in this investigation. The rats were separated into four diabetic groups and a control group. These groups are T2DM, T2DM-BHC-Lip, T2DM-Vildagliptin (Vild), and T2DM-BHC-Lip-Vild groups. BHC-Lip or Vild treatment significantly restored antioxidant capacity, resulting in decreased MDA and elevated GPx, SOD, and GSH levels in renal tissues, with combined therapy producing the most powerful effect. The combined therapy significantly improved renal function biomarkers, including creatinine, urea, sodium, and potassium levels, restoring them to nearly control levels. Furthermore, BHC-Lip or Vild treatments markedly reduced serum inflammatory cytokines and upregulated autophagy-related gene expression, with increased expression of Beclin-1 and LC3, and decreased expression of PI3K/Akt/mTOR/P62 signaling. In contrast, combination therapy produced superior autophagic activation and suppression of pro-inflammatory pathways. Furthermore, there was a noticeable improvement in kidney damage and fibrosis indicators (nephrin and higher nestin, desmin, and vimentin), especially those receiving combined treatment. Histopathological examination supported these findings, showing significant improvement in kidney architecture. Together, our findings show that Vild and BHC-Lip work in concert to prevent DN through lowering oxidative stress and inflammation, boosting autophagy, and reducing renal structural damage.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103355"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic hydrogel dressings: An integrated \"perception-response-repair\" strategy for chronic diabetic wounds","authors":"Yiran Tang ,&nbsp;Langyu He ,&nbsp;Xinyue Liu ,&nbsp;Chengbo Ran ,&nbsp;Yuen Yee Cheng ,&nbsp;Yue Kang ,&nbsp;Kun Yao ,&nbsp;Hongwei Gao ,&nbsp;Kedong Song","doi":"10.1016/j.tice.2026.103372","DOIUrl":"10.1016/j.tice.2026.103372","url":null,"abstract":"<div><div>With the dramatic increase in the global incidence of diabetes, the incidence of its complications such as chronic wounds and ulcers has also increased significantly. How to more effectively treat diabetic wounds has always been a huge challenge for clinicians and even global health systems. Diabetic wound coverage and rapid healing require multifunctional skin-mimicking wound dressings, including sufficient mechanical strength, antibacterial, antioxidant, anti-inflammatory and tissue adhesion properties. This minireview discusses in detail the current and emerging preparation ideas of hydrogel dressings, analyzes and discusses from four aspects: glucose responsiveness, antibacterial properties, antioxidant properties, and anti-inflammatory properties, and explores the advantages and challenges of natural polymers, synthetic polymers, and nanomaterials in wound dressings. This article aims to promote the further development of biomedicine by comprehensively analyzing the application potential of hydrogel dressings in diabetes treatment.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103372"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of endoplasmic reticulum stress: Insights for potential therapeutic benefits in burns","authors":"Shuhan Tang ,&nbsp;Zhiyang Ren ,&nbsp;Bin Zhu ,&nbsp;Ke Li","doi":"10.1016/j.tice.2026.103378","DOIUrl":"10.1016/j.tice.2026.103378","url":null,"abstract":"<div><div>Burns are injuries to the skin and deep tissues caused by thermal effects, which can trigger inflammation, necrosis, and systemic pathological reactions, often leading to life-threatening complications such as shock, infection, and multi-organ failure. Endoplasmic reticulum stress (ERS) is a key driving factor for tissue damage after burns. Burns are proposed to induce ERS through multiple mechanisms, including protein denaturation, inflammatory cytokine storms, and metabolic disturbances, Under stress conditions, cells can activate three key sensors, IRE1, PERK, and ATF6, to fully activate the main signaling pathway of unfolded protein response (UPR). In severe burns, sustained ERS promotes cell death via CHOP-mediated apoptosis, programmed necrosis, and ferroptosis (activated by the PERK-eIF2α-ATF4 pathway), exacerbating tissue injury. The progressive elevation of endoplasmic reticulum stress markers such as GRP78 and CHOP during burn course has been proven to be an important biological indicator for evaluating the degree of secondary organ damage. Consequently, therapeutic interventions such as propranolol (to counteract catecholamine effects) and 4-PBA (to stabilize protein folding) are under investigation as potential approaches for improving burn outcomes. This review systematically examines the pathological mechanisms of burn-induced ERS, associated modes of cell death, clinical manifestations of organ dysfunction, potential drug therapies, and other burn-related stress responses.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103378"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}