Tohoku Journal of Experimental Medicine最新文献_第4页

Bacillus Licheniformis Capsules 1 (Live) Modulates Gut Microbiota and Enhances Immune Function in Chemotherapy Patients with Non-Small Cell Lung Cancer. 地衣芽孢杆菌胶囊1（活）调节非小细胞肺癌化疗患者肠道微生物群并增强免疫功能

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J076

Jie Yu, Hongcan Shi, Xiaolin Wang, Shichun Lu, Chao Sun, Weiguo Jin, Yusheng Shu

引用次数: 0

Immunolocalization of CD28, CTLA-4 and CD80 in Non-Small Cell Lung Carcinoma: Combined CD28/CTLA-4/CD80 Status is a Potent Prognostic Factor of These Patients. CD28、CTLA-4和CD80在非小细胞肺癌中的免疫定位：CD28/CTLA-4/CD80联合状态是这些患者预后的一个重要因素。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J078

Takashi Sato, Kiyoshi Takagi, Chihiro Inoue, Mitsunori Higuchi, Nobuko Sakuma, Michie Kojimahara, Miho Sagawa, Megumi Tanaki, Hiroshi Hojo, Takashi Suzuki, Osamu Suzuki

引用次数: 0

Cimetidine for Pediatric Use in Japan: Rising Prescriptions for a New Indication. 西咪替丁在日本的儿科应用：新适应症的处方增加。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J075

Karin Oshima, Eisuke Inage, Shun Toriumi, Kenji Oishi, Hiromichi Yamada, Yosuke Baba, Takahiro Kudo, Yoshikazu Ohtsuka, Ryuta Nishikomori, Hidefumi Nakamura, Nobuaki Michihata, Hiromichi Shoji

引用次数: 0

HSPA1B Regulates the Expression of Blood Pressure Related Genes in Human Umbilical Vein Endothelial Cells (HUVEC) and Its Mechanism. HSPA1B调控人脐静脉内皮细胞（HUVEC）血压相关基因的表达及其机制

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J079

Li Zhong, Bing Zhang, Kadeer Nafeisha, Wushouer Xilinguli, Yunusi Kurexi

引用次数: 0

Circular RNA Hsa_circ_0007376 Promotes Malignancy of Gastric Cancer Cells by Regulating MiR-556-5p/CREB5 Axis. 环状RNA Hsa_Circ_0007376通过调节miR-556-5p/CREB5轴促进胃癌细胞恶性。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 Epub Date: 2024-12-12 DOI: 10.1620/tjem.2024.J145

Chao Liu, Xin Zhou, Guangsheng Wang, Chenyu Zhu, Rui Xu

{"title":"Circular RNA Hsa_circ_0007376 Promotes Malignancy of Gastric Cancer Cells by Regulating MiR-556-5p/CREB5 Axis.","authors":"Chao Liu, Xin Zhou, Guangsheng Wang, Chenyu Zhu, Rui Xu","doi":"10.1620/tjem.2024.J145","DOIUrl":"10.1620/tjem.2024.J145","url":null,"abstract":"Gastric cancer (GC) is one deadly malignancy globally. The potential clinical values of circular RNAs (circRNAs) in cancer diagnosis, prognosis, and treatment have been demonstrated in increasing studies. This research aimed at delving into the specific role of circRNA hsa_circ_0007376 (circMAP2K2) in GC development. CircMAP2K2, miR-556-5p, and CREB5 levels in GC cells and tissues were tested by RT-qPCR. Subcellular fractionation assay was employed for determining the distribution of circMAP2K2 in GC cell cytoplasm and nucleus. The binding potentials between circMAP2K2 (or CREB5) and miR-556-5p were confirmed through luciferase reporter assay. GC cell viability, growth, and metastasis were examined via CCK-8, colony formation, and Transwell assays. CREB5 protein level was assessed via western blot analysis. CircMAP2K2 was upregulated in GC cells and tissues vs. normal controls. CircMAP2K2 depletion hindered GC cell growth, migration, and invasion. Mechanically, circMAP2K2 elevated CREB5 level by completely binding with miR-556-5p. Overexpressing CREB5 abrogated the suppression of circMAP2K2 silencing on GC cell malignant behaviors. CircMAP2K2/miR-556-5p/CREB5 axis plays an oncogenic role in GC tumorigenesis.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"173-184"},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone Deacetylase 4 as a Potential Biomarker for Post-Stroke Cognitive Impairment. 组蛋白去乙酰化酶 4 是中风后认知障碍的潜在生物标记物

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J120

Xinfei Duan, Zhongbo Zhang, Jundong Jia, Jingjing Jiang, Jianfei Li, Ke Hu, Runting Niu

{"title":"Histone Deacetylase 4 as a Potential Biomarker for Post-Stroke Cognitive Impairment.","authors":"Xinfei Duan, Zhongbo Zhang, Jundong Jia, Jingjing Jiang, Jianfei Li, Ke Hu, Runting Niu","doi":"10.1620/tjem.2024.J120","DOIUrl":"10.1620/tjem.2024.J120","url":null,"abstract":"Histon deacetylase 4 (HDAC4) modulates memory and cognitive impairment, but its association with post-stroke cognitive impairment (PSCI) is unclear. This study aimed to investigate the potential of HDAC4 for predicting PSCI risk. Sixty-nine PSCI patients and 70 control post-stroke (CPS) patients were enrolled in this case-control study. In all stroke patients, HDAC4 in peripheral blood mononuclear cells was detected by quantitative polymerase chain reaction; T-helper 17 (Th17) cells were detected by flow cytometry, and interleukin-17A was detected by enzyme-linked immunosorbent assay. HDAC4 was reduced in PSCI patients compared with CPS patients (P = 0.001). In total stroke patients, HDAC4 showed negative linkages with age (P = 0.003), history of diabetes (P = 0.012), stroke recurrence (P = 0.001), Th17 cells (P = 0.027), and interleukin-17A (P = 0.002). Additionally, multivariate logistic regression analysis revealed that HDAC4 (per unit) [odds ratio (OR) = 0.438, P = 0.024] was independently associated with a lower PSCI risk, but age (per unit) (OR = 1.061, P = 0.016) and multifocal disease (yes vs. no) (OR = 2.490, P = 0.014) were independently associated with a higher PSCI risk. By receiver operator characteristic curves, HDAC4 had an acceptable value for predicting PSCI risk [area under the curve (AUC) = 0.656, 95% confidence interval = 0.566-0.746]. The combination of HDAC4, age, and multifocal disease showed a good value for predicting PSCI risk (AUC = 0.728, 95% confidence interval = 0.644-0.811). HDAC4 may serve as a potential biomarker for predicting PSCI risk, which could facilitate the early screening and prevention of PSCI, thus promoting the management of stroke.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"153-160"},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Older Patients at the Start of Medical and Long-Term Care at the Place of Discharge After Acute Care Who Needed Continuous Medical Care: Analysis of a Nationwide Administrative Database in Japan. 需要持续医疗护理的急性病后出院地老年患者在开始接受医疗和长期护理时的特征：日本全国行政数据库分析》。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 Epub Date: 2024-10-10 DOI: 10.1620/tjem.2024.J107

Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi

{"title":"Characteristics of Older Patients at the Start of Medical and Long-Term Care at the Place of Discharge After Acute Care Who Needed Continuous Medical Care: Analysis of a Nationwide Administrative Database in Japan.","authors":"Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi","doi":"10.1620/tjem.2024.J107","DOIUrl":"10.1620/tjem.2024.J107","url":null,"abstract":"Japan has the largest aged population globally, and the number of older people requiring medical and long-term care is increasing yearly. Therefore, providing older people with appropriate medical and long-term care in their living setting is essential. This study will clarify the characteristics of older patients who started medical and long-term care in their place of living following acute inpatient treatment, focusing on the differences between their homes and nursing homes. The analysis was conducted using Japan's nationwide administrative database. We collected discharge records of patients aged 65 and older who received acute inpatient treatment. Those who started medical and long-term care at home or admission a nursing home at the time of discharge were selected and categorized into the home group and the nursing home group. Patient characteristics were shown by group, and factors determining group differences were estimated using univariate and multivariate logistic regression analysis. We selected 89,705 people in the home group and 92,969 in the nursing home group. The home group had a significantly higher rate of cancer, while the nursing home group had a significantly higher age, long-term care need level, and dementia. It became clear that the home group was highly dependent on medical care, and the nursing home group was highly reliant on long-term care. Furthermore, the age group of those admissions to nursing homes varied by sex. These results are expected to provide basic information useful in practice for medical professionals, care workers, and policymakers.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"161-171"},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and Comparison of Intervertebral Disc Degeneration Models Induced by Cervical Instability in Rats. 颈椎不稳致大鼠椎间盘退变模型的评价与比较。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J077

Yutao Wang, Jiaxin Chen, Dinghao Zhang, Haoshan Lin, Xinjun Fan, Shenyi Lu, Yiqi Huang, Weizheng Guo, Jianlang Liang, Zhaoke Huang, Hailan Hu, Qi Liu

引用次数: 0

The Potential of CAR-T cells for Treating Heart Diseases: Current Status and Hurdles in Clinical Translation. CAR-T 细胞治疗心脏病的潜力：临床转化的现状与障碍。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-13 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J116

Ruxia Zhang, Ganggang Si, Jianjun Li, Xiangbing Li, Huahua Cui, Sancong Pan

{"title":"The Potential of CAR-T cells for Treating Heart Diseases: Current Status and Hurdles in Clinical Translation.","authors":"Ruxia Zhang, Ganggang Si, Jianjun Li, Xiangbing Li, Huahua Cui, Sancong Pan","doi":"10.1620/tjem.2024.J116","DOIUrl":"10.1620/tjem.2024.J116","url":null,"abstract":"Traditional treatments for heart disease, including pharmacotherapy and surgical interventions, are effective in managing symptoms and preventing complications but often fail to fully restore cardiac function or halt the progression of the disease. Additionally, these approaches are frequently associated with significant adverse effects. Inspired by the success of CAR-T cell therapy in oncology, this review examines the potential of CAR-T cell technology for treating heart diseases, detailing how CAR-T cells, engineered by merging antibody-derived targeting domains with T-cell signaling domains. The technology's core includes an extracellular antigen-binding domain, hinge region, transmembrane domain, and intracellular signaling domain, with the single-chain variable fragment (scFv) playing a crucial role in antigen recognition. The paper delves into the immune mechanisms in cardiovascular diseases like heart failure, hypertension, and myocardial infarction, focusing on the roles of T cells in promoting myocardial fibrosis and the therapeutic potential of regulatory T cells (Tregs) in recovery phases. Additionally, it explores the use of lipid nanoparticles (LNPs) carrying mRNA to produce transient, non-integrative CAR-T cells targeting fibroblast activation protein (FAP) to reduce myocardial fibrosis, a method showing promise in preclinical models by enhancing cardiac function and reducing ventricular fibrosis. Despite its potential, the study acknowledges challenges in clinical translation, such as limited therapeutic effects and severe inflammatory responses, highlighting the need for further optimization and research in CAR-T cell technology for cardiovascular disease treatment.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"145-152"},"PeriodicalIF":1.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Specific Trends and Health Status of Children Aged 12-19 Years with Specified Chronic Pediatric Diseases in Japan - Insights from a National Database Study. 日本患有特定慢性儿科疾病的12-19岁儿童的年龄特定趋势和健康状况——来自国家数据库研究的见解

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-12 DOI: 10.1620/tjem.2025.J073

Erika Kuwahara, Akinori Moriichi, Hitoshi Kato

引用次数: 0