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Tohoku Journal of Experimental Medicine最新文献

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Background Factors that Hospital-Based Geriatricians and General Practitioners Associate with Difficulty in Treating Older People with Multimorbidity: A Cross-Sectional Survey. 医院老年病科医生和全科医生在治疗多病老人时遇到困难的背景因素：一项横断面调查。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-12-06 Epub Date: 2024-06-20 DOI: 10.1620/tjem.2024.J045
Takuma Kimura, Shinji Matsumura, Masayoshi Hashimoto, Ken Shinmura
{"title":"Background Factors that Hospital-Based Geriatricians and General Practitioners Associate with Difficulty in Treating Older People with Multimorbidity: A Cross-Sectional Survey.","authors":"Takuma Kimura, Shinji Matsumura, Masayoshi Hashimoto, Ken Shinmura","doi":"10.1620/tjem.2024.J045","DOIUrl":"10.1620/tjem.2024.J045","url":null,"abstract":"<p><p>In recent years, hospital-based geriatricians and general practitioners in Japan who frequently manage older people with multimorbidity in an acute setting have often found treating these patients difficult. In this study, we surveyed geriatricians and general practitioners who treat older people with multimorbidity in hospitals to identify patient characteristics that make treatment provision difficult in these patients. In June 2022, we mailed an anonymous questionnaire to 3,300 family medicine specialists, primary care-certified physicians, and geriatric specialists in Japan. We used a four-point Likert-type scale to score items specific to diseases, patient backgrounds, clinical factors, and important clinical strategies that make treatment provision difficult. We used logistic regression analysis to identify factors that hospital-based geriatricians and general practitioners associate with difficulty in treating older adults with multimorbidity. In total, 490 cases were included in the analysis. The factors that were associated with difficulty in treating older people with multimorbidity were experience as a physician (adjusted odds ratio [AOR]: 0.935; 95% confidence interval [95% CI]: 0.905-0.965), the overall scores for difficult disease (AOR: 1.028; 95% CI: 1.004-1.053) and difficult background (AOR: 1.065; 95% CI: 1.005-1.129), and the lack of emphasis on general practice guidelines (AOR: 2.91; 95% CI: 1.305-6.491). To facilitate the treatment of older people with multimorbidity, it is desirable to enhance education and training and strengthen support systems within Japan's healthcare system based on the characteristics of hospital physicians who find treating these patients difficult.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"61-72"},"PeriodicalIF":1.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yangfei Tongluo Decoction Alleviated Fibrosis and Inflammation in Post-Infectious Bronchiolitis Obliterans via Hedgehog Pathway. 杨飞通络煎剂通过刺猬蛋白通路缓解感染后阻塞性支气管炎的纤维化和炎症反应
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-28 DOI: 10.1620/tjem.2024.J140
Wenxia Chen, Libiao Wang, Sujing Su, Shuhua Fan
{"title":"Yangfei Tongluo Decoction Alleviated Fibrosis and Inflammation in Post-Infectious Bronchiolitis Obliterans via Hedgehog Pathway.","authors":"Wenxia Chen, Libiao Wang, Sujing Su, Shuhua Fan","doi":"10.1620/tjem.2024.J140","DOIUrl":"https://doi.org/10.1620/tjem.2024.J140","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Cellular Mechanism of Improving Inflammatory Effect of Gastrodin. 胃泌素改善炎症效应的细胞机制研究
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-28 DOI: 10.1620/tjem.2024.J141
Xue Zheng, Taowu Gong, Wanqiu Yu, Shan Xu, Chunchun Tang, Yuanping Zhong, Zhaoqiong Zhu
{"title":"Study on Cellular Mechanism of Improving Inflammatory Effect of Gastrodin.","authors":"Xue Zheng, Taowu Gong, Wanqiu Yu, Shan Xu, Chunchun Tang, Yuanping Zhong, Zhaoqiong Zhu","doi":"10.1620/tjem.2024.J141","DOIUrl":"https://doi.org/10.1620/tjem.2024.J141","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion. 磷酸八钙/明胶（OCP/Gel）复合体植入对小型猪腰椎椎间融合术的疗效。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-28 DOI: 10.1620/tjem.2024.J138
Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki
{"title":"Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion.","authors":"Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki","doi":"10.1620/tjem.2024.J138","DOIUrl":"https://doi.org/10.1620/tjem.2024.J138","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: the Ohasama Study. 考虑到亚临床脑血管疾病的存在，分娩次数与认知障碍之间的关系：Ohasama 研究。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-28 DOI: 10.1620/tjem.2024.J139
Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo
{"title":"Association between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: the Ohasama Study.","authors":"Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo","doi":"10.1620/tjem.2024.J139","DOIUrl":"https://doi.org/10.1620/tjem.2024.J139","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal Expression of lncRNA SNHG7 in Dry Eye Disease and Its Effect on Human Conjunctival Epithelial Cells. 干眼症中 lncRNA SNHG7 的异常表达及其对人类结膜上皮细胞的影响
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-21 DOI: 10.1620/tjem.2024.J134
Shuang Liu, Guang Yang, Qingnan Li, Shaohua Tang
{"title":"Abnormal Expression of lncRNA SNHG7 in Dry Eye Disease and Its Effect on Human Conjunctival Epithelial Cells.","authors":"Shuang Liu, Guang Yang, Qingnan Li, Shaohua Tang","doi":"10.1620/tjem.2024.J134","DOIUrl":"https://doi.org/10.1620/tjem.2024.J134","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-sectional Study of the Association between Plasma Brain Natriuretic Peptide Levels and Left Ventricular Shortening Fraction in Fukuyama Congenital Muscular Dystrophy. 福山先天性肌营养不良症患者血浆脑钠肽水平与左心室缩短率之间关系的横断面研究
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-21 DOI: 10.1620/tjem.2024.J137
Takatoshi Sato, Yuki Kihara, Kumiko Ishiguro, Minobu Shichiji, Terumi Murakami, Satoru Nagata, Eriko Shimada, Kei Inai, Atsuhito Takeda, Keiko Ishigaki
{"title":"Cross-sectional Study of the Association between Plasma Brain Natriuretic Peptide Levels and Left Ventricular Shortening Fraction in Fukuyama Congenital Muscular Dystrophy.","authors":"Takatoshi Sato, Yuki Kihara, Kumiko Ishiguro, Minobu Shichiji, Terumi Murakami, Satoru Nagata, Eriko Shimada, Kei Inai, Atsuhito Takeda, Keiko Ishigaki","doi":"10.1620/tjem.2024.J137","DOIUrl":"https://doi.org/10.1620/tjem.2024.J137","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Up-Regulated MiR-20b-5p Mitigates Cell Inflammation and Apoptosis in Allergic Rhinitis via STAT3. 上调的 MiR-20b-5p 通过 STAT3 缓解过敏性鼻炎的细胞炎症和凋亡
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-21 DOI: 10.1620/tjem.2024.J136
ZeWei Zhong, XiaoHua Huang, Qiong Lan, WeiHua Chen
{"title":"Up-Regulated MiR-20b-5p Mitigates Cell Inflammation and Apoptosis in Allergic Rhinitis via STAT3.","authors":"ZeWei Zhong, XiaoHua Huang, Qiong Lan, WeiHua Chen","doi":"10.1620/tjem.2024.J136","DOIUrl":"https://doi.org/10.1620/tjem.2024.J136","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor. 神经营养酪氨酸激酶受体 I 型 NTRK1 多态性对分娩期间使用氢吗啡酮硬膜外镇痛的影响
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-21 DOI: 10.1620/tjem.2024.J135
Kangli Lu, Yujiao Huang, Zhicai Chen, Kuncheng Cai
{"title":"Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor.","authors":"Kangli Lu, Yujiao Huang, Zhicai Chen, Kuncheng Cai","doi":"10.1620/tjem.2024.J135","DOIUrl":"https://doi.org/10.1620/tjem.2024.J135","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal Light Chain Proximal Tubulopathy Complicated by Monoclonal Gammopathy of Undetermined Significance/Smoldering Multiple Myeloma Successfully Diagnosed by Immunofluorescence on Pronase-Digested Paraffin Section: Reports of Two Cases and Review of the Literature. 通过荧光酶消化石蜡切片免疫荧光法成功诊断的由意义未定的单克隆丙种球蛋白病/夹层型多发性骨髓瘤并发的局灶性轻链近端输尿管病变：两个病例的报告和文献综述。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-11-16 Epub Date: 2024-06-20 DOI: 10.1620/tjem.2024.J047
Tetsuya Abe, Yukihiro Wada, Kazuhiro Takeuchi, Ryota Uchitsubo, Shun Sakurabayashi, Sayumi Kawamura, Mariko Kamata, Shokichi Naito, Togo Aoyama, Akira Shimizu, Yasuo Takeuchi
{"title":"Focal Light Chain Proximal Tubulopathy Complicated by Monoclonal Gammopathy of Undetermined Significance/Smoldering Multiple Myeloma Successfully Diagnosed by Immunofluorescence on Pronase-Digested Paraffin Section: Reports of Two Cases and Review of the Literature.","authors":"Tetsuya Abe, Yukihiro Wada, Kazuhiro Takeuchi, Ryota Uchitsubo, Shun Sakurabayashi, Sayumi Kawamura, Mariko Kamata, Shokichi Naito, Togo Aoyama, Akira Shimizu, Yasuo Takeuchi","doi":"10.1620/tjem.2024.J047","DOIUrl":"10.1620/tjem.2024.J047","url":null,"abstract":"<p><p>Light chain proximal tubulopathy (LCPT) is a rare type of paraprotein-related disease (PRDs) characterized by monoclonal free light chain (FLC) deposition in proximal tubular epithelial cells (PTECs). A diagnosis of LCPT requires identification of FLC deposition in PTECs; however, FLC luminescence defects in immunofluorescence staining using frozen tissue (IF-F), regarded as \"masked LCPT\", are occasionally encountered. We describe two cases of focal masked LCPT in monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM) diagnosed by IF in formalin-fixed, paraffin-embedded tissue sections following pronase digestion (IF-P) rather than by IF-F. Case 1 was a 66-year-old woman who exhibited renal dysfunction with IgG-λ monoclonal proteinemia, and Case 2 was a 69-year-old man who exhibited renal dysfunction with IgG-κ type monoclonal proteinemia. In both cases, renal pathology showed focal tubular damage consisted of swelling and desquamation of PTECs. FLC deposition in PTECs was detectable by IF-P but not by IF-F. Consequently, an appropriate diagnosis by IF-P led the patients to receive chemotherapy immediately. These two cases indicate that LCPT can be present even if tubular injury is focal and PRD is not severe. According to a literature review of 33 cases, including our 2 cases, focal LCPT complicated by MGUS/SMM is relative rare. In PRD, evaluation with IF-P is desirable for assessing LCPT when FLC deposition is undetected by IF-F despite characteristic degenerative PTECs. We consider that early and definitive diagnosis of LCPT by IF-P rather than IF-F might result in favorite outcome since physicians could smoothly decide treatment strategy.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"53-60"},"PeriodicalIF":1.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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