Tohoku Journal of Experimental Medicine最新文献_第3页

PMILACG Model: A Predictive Model for Identifying Invasiveness of Lung Adenocarcinoma Based on High-Resolution CT-Determined Ground Glass Nodule Features. PMILACG 模型：基于高分辨率 CT 确定的磨玻璃结节特征识别肺腺癌侵袭性的预测模型。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-07 Epub Date: 2025-01-30 DOI: 10.1620/tjem.2024.J078

Bo Yan, Yifeng Jiang, Shijie Fu, Rong Li

{"title":"PMILACG Model: A Predictive Model for Identifying Invasiveness of Lung Adenocarcinoma Based on High-Resolution CT-Determined Ground Glass Nodule Features.","authors":"Bo Yan, Yifeng Jiang, Shijie Fu, Rong Li","doi":"10.1620/tjem.2024.J078","DOIUrl":"10.1620/tjem.2024.J078","url":null,"abstract":"The morphology of ground-glass nodule (GGN) under high-resolution computed tomography (HRCT) has been suggested to indicate different histological subtypes of lung adenocarcinoma (LUAD); however, existing studies only include the limited number of GGN characteristics, which lacks a systematic model for predicting invasive LUAD. This study aimed to construct a predictive model based on GGN features under HRCT for LUAD. A total of 1,189 surgical LUAD patients were enrolled, and their GGN-related features were assessed by 2 individual radiologists. The pathological diagnosis of the invasive LUAD was established by pathologic examination following surgery (including 1,073 invasive and 526 non-invasive LUAD). After adjustment by multivariate logistic regression, GGN diameter (OR = 1.382, 95% CI: 1.300-1.469), mean CT attenuation (OR = 1.007, 95% CI: 1.006-1.009), heterogeneous uniformity of density (OR = 2.151, 95% CI: 1.587-2.915), not defined nodule-lung interface (OR = 1.915, 95% CI: 1.384-2.651), GGN with spiculation (OR = 2.097, 95% CI: 1.519-2.896), type I (OR = 1.678, 95% CI: 1.216-2.371), and type II (OR = 3.577, 95% CI: 1.153-11.097) vessel changes were independent risk factors for invasive LUAD. In addition, a predictive model integrating these six independent GGN features was established (named as invasion of lung adenocarcinoma by GGN features (ILAG)), and receiver-operating characteristic curve illustrated that the ILAG model presented good predictive value for invasive LUAD (AUC: 0.905, 95% CI: 0.890-0.919). In conclusion, The ILAG predictive model, which integrates imaging features of GGN via HRCT, including diameter, mean CT attenuation, heterogeneous uniformity of density, not defined nodule-lung interface, GGN with spiculation, type I, and type II vessel changes, shows great potential for early estimation of LUAD invasiveness.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"13-20"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Auricular Acupressure on Women Psychological Distress during Controlled Ovarian Hyperstimulation for in vitro Fertilization: A Single-Blind, Randomized, and Sham-Controlled Study. 耳针指压对体外受精中控制性卵巢过度刺激妇女心理压力的影响：单盲、随机和假对照研究。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-07 Epub Date: 2025-01-30 DOI: 10.1620/tjem.2024.J076

Ying Li, Wanjia Shen, Fengyi Mo, Qing Ma, Lanfeng Xing

{"title":"The Effect of Auricular Acupressure on Women Psychological Distress during Controlled Ovarian Hyperstimulation for in vitro Fertilization: A Single-Blind, Randomized, and Sham-Controlled Study.","authors":"Ying Li, Wanjia Shen, Fengyi Mo, Qing Ma, Lanfeng Xing","doi":"10.1620/tjem.2024.J076","DOIUrl":"10.1620/tjem.2024.J076","url":null,"abstract":"There is little research on the psychological state of women in the controlled ovarian hyperstimulation (COH) stage of in vitro fertilization (IVF) treatment. This study explored the effect of auricular acupressure on relieving negative psychology in the women during the COH stage of IVF treatment. Infertile women were enrolled and randomly divided into three groups: control (n = 121), auricular acupressure (n = 126), and sham acupoint (n = 121). The group allocation was blinded to the participants. The auricular acupressure (AA) group selected four auricular points: Shenmen, Kidney, Endocrine, and Internal genitalia. The sham acupoint group (SA) used four irrelevant auricular points and the control group accepted only routine IVF treatment. The intervention lasted from the first day of COH until the day before transvaginal oocyte retrieval. Participants' psychological states were measured using the Symptom Checklist 90 (SCL-90) before and after auricular acupressure. IVF outcomes were followed up. There were significant increases in obsessive-compulsive symptoms, interpersonal sensitivity, depression, and anxiety in the control and SA groups. Additionally, the SA group showed a higher somatization symptom score, after COH. The AA group showed decreased somatization symptom, interpersonal sensitivity, obsessive-compulsive symptoms, depression, and anxiety scores after COH. The AA group showed lower obsessive-compulsive symptoms, depression, and anxiety scores compared to those in the control and SA groups. The auricular acupressure was correlated with higher IVF success. Auricular acupressure may alleviate the psychological and emotional problems of IVF participants during the COH period.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"29-37"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Home-Visiting Clinic Decreased the Emergency Transportation in Rural Japan: A Quasi-Experimental Approach. 家庭出诊减少了日本农村地区的急诊交通：准实验方法》。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-07 Epub Date: 2024-08-29 DOI: 10.1620/tjem.2024.J080

Takaaki Ikeda, Kemmyo Sugiyama, Yusuke Tanoue, Toru Tsuboya

{"title":"A Home-Visiting Clinic Decreased the Emergency Transportation in Rural Japan: A Quasi-Experimental Approach.","authors":"Takaaki Ikeda, Kemmyo Sugiyama, Yusuke Tanoue, Toru Tsuboya","doi":"10.1620/tjem.2024.J080","DOIUrl":"10.1620/tjem.2024.J080","url":null,"abstract":"This study examined whether a home-visiting clinic decreased emergency transportations in the region, using a quasi-experimental approach derived from private practice. This study employed a retrospective observational design and was conducted in suburban Tome City, Miyagi Prefecture, with a population of approximately 80,000 and an aging population rate of 35.5% in 2020. Information on ambulance services and the age distribution in Tome City was obtained as confidential data from Tome City. Data on ambulance services and age distribution across Japan was obtained from a publicly accessible dataset. We calculated the standardized emergency transportations due to sudden illness ratio (SER), based on the standardized mortality ratio. This ratio represents the relative incidence of emergency transportations due to sudden illnesses in Tome City compared to all of Japan (with 100 for Japan), adjusted for the age distribution in Tome City through an indirect method. The SER increased to 88.2% in 2011, remained high at 89.6% in 2012, and declined from 85.6% in 2013, the year the home-visit clinic was established, to 86.7%, 83.0%, 80.5%, and 78.1%. The findings suggest that home medical care is an effective means of providing medical assistance to homebound patients and may reduce the necessity for hospitalization and ambulance services.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"7-12"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLOD3 Promotes Head and Neck Squamous Cell Carcinoma Progress via Regulation of P38 MAPK Signal Pathway.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 DOI: 10.1620/tjem.2025.J035

Junxia Qiao, Na Guo, Congcong Wei

引用次数: 0

Clinical Significance and Biological Role of LncRNA HCG11 in Diabetic Retinopathy.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 DOI: 10.1620/tjem.2025.J033

Jiawen Ling, Jianli Ma, Zhencheng Wu, Xianmi Lin, Chaohui Zhu, Xiang Xiao

引用次数: 0

Impact of Downsampling Size and Interpretation Methods on Diagnostic Accuracy in Deep Learning Model for Breast Cancer Using Digital Breast Tomosynthesis Images. 使用数字乳腺断层合成图像的乳腺癌深度学习模型中，下采样大小和解释方法对诊断准确性的影响。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 Epub Date: 2024-07-25 DOI: 10.1620/tjem.2024.J071

Ryusei Inamori, Tomofumi Kaneno, Ken Oba, Eichi Takaya, Daisuke Hirahara, Tomoya Kobayashi, Kurara Kawaguchi, Maki Adachi, Daiki Shimokawa, Kengo Takahashi, Hiroko Tsunoda, Takuya Ueda

{"title":"Impact of Downsampling Size and Interpretation Methods on Diagnostic Accuracy in Deep Learning Model for Breast Cancer Using Digital Breast Tomosynthesis Images.","authors":"Ryusei Inamori, Tomofumi Kaneno, Ken Oba, Eichi Takaya, Daisuke Hirahara, Tomoya Kobayashi, Kurara Kawaguchi, Maki Adachi, Daiki Shimokawa, Kengo Takahashi, Hiroko Tsunoda, Takuya Ueda","doi":"10.1620/tjem.2024.J071","DOIUrl":"10.1620/tjem.2024.J071","url":null,"abstract":"While deep learning (DL) models have shown promise in breast cancer diagnosis using digital breast tomosynthesis (DBT) images, the impact of varying matrix sizes and image interpolation methods on diagnostic accuracy remains unclear. Understanding these effects is essential to optimize preprocessing steps for DL models, which can lead to more efficient training processes, improved diagnostic accuracy, and better utilization of computational resources. Our institutional review board approved this retrospective study and waived the requirement for informed consent from the patients. In this study, 499 patients (29-90 years old, mean age 50.5 years) who underwent breast tomosynthesis were included. We performed downsampling to 256 × 256, 128 × 128, 64 × 64, and 32 × 32 using five image interpolation methods: Nearest (NN), Bilinear (BL), Bicubic (BC), Hamming (HM), and Lanczos (LC). The diagnostic accuracy of the DL model was assessed by mean AUC with its 95% confidence interval (CI). DL models with downsampled images to 256 × 256 pixels using the LC interpolation method showed a significantly lower AUC than the original 512 × 512 pixels model. This decrease was also observed with the 128 × 128 pixels DL models using HM and LC methods. All interpolation methods showed a significant decrease in AUC for the 64 × 64 and 32 × 32 pixels DL models. Our results highlight the significant impact of downsampling size and interpolation methods on the diagnostic performance of DL models. Understanding these effects is essential for optimizing preprocessing steps, which can enhance the accuracy and reliability of breast cancer diagnosis using DBT images.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Berberine Improves ox-LDL-Induced Macrophage Efferocytosis Dysfunction and Alleviates Inflammation via the PPARγ/LXRα Pathway.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 DOI: 10.1620/tjem.2025.J036

Xiangli Shen, Yushan Chen, Lili Yu, Junmeng Zheng, Shasha Shang, Jianru Wang

引用次数: 0

Effects of Phosphodiesterase-3 Inhibitor in the Management of Left Heart Failure in Extremely Low-Birth-Weight Infants with Simple Aortic Coarctation.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 DOI: 10.1620/tjem.2025.J034

Hideyuki Hawaka, Katsuaki Toyoshima, Tomoko Saito, Tomoyuki Shimokaze, Kazuma Tsuno, Takeshi Ikegawa, Junko Nakajima, Atsushi Uchiyama

引用次数: 0

Clinical Significance of LncRNA NNT-AS1 in the Diagnosis, Deterioration and Prognosis of Sepsis. LncRNA NNT-AS1 在败血症诊断、恶化和预后中的临床意义

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 Epub Date: 2024-06-27 DOI: 10.1620/tjem.2024.J053

Xin Liu, Jianyuan Huang

{"title":"Clinical Significance of LncRNA NNT-AS1 in the Diagnosis, Deterioration and Prognosis of Sepsis.","authors":"Xin Liu, Jianyuan Huang","doi":"10.1620/tjem.2024.J053","DOIUrl":"10.1620/tjem.2024.J053","url":null,"abstract":"Sepsis is a serious infectious disease that may lead to a systemic inflammatory and life-threatening condition. Early diagnosis and treatment of sepsis is important to prevent organ failure and reduce mortality. This paper investigated the expression of long non-coding RNA NNT-AS1 (lncRNA NNT-AS1) in sepsis and its relationship the development of the disease, and revealed the clinical potential of NNT-AS1 in the diagnosis and prognosis of sepsis. Clinical data of the included individuals were collected and analyzed. Acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score were performed based on the severity of the patient's condition. Inflammatory factors were measured by enzyme-linked immunosorbent assay (ELISA). NNT-AS1 expression was quantified by real-time quantitative polymerase chain reaction (RT-qPCR). The ability of NNT-AS1 to identify sepsis was evaluated using receiver operating characteristic (ROC) curve. The prognostic value of NNT-AS1 was confirmed by the Kaplan-Meier method and Cox regression analysis. Biochemical indicators, inflammatory factors, APACHE II score and SOFA score were higher in sepsis patients than in healthy individuals. Serum NNT-AS1 was actively expressed in sepsis and had a high diagnostic value. NNT-AS1 levels were positively correlated with APACHEII score, SOFA score, and inflammatory factor levels. Meanwhile, high expression of NNT-AS1 predicted shorter survival of patients. NNT-AS1 was highly expressed in sepsis and was closely related to the development of patients' conditions. By monitoring the changes of NNT-AS1 may be of key value for the diagnosis, prognosis and therapeutic prognosis of patients.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"21-27"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Low-Cost Scanning Laser Ophthalmoscope Using Semiconductor Laser Technology. 利用半导体激光技术开发低成本扫描激光眼底镜。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-06 Epub Date: 2024-08-01 DOI: 10.1620/tjem.2024.J072

Hiroki Takizawa, Hiroshi Kunikata, Takeshi Yabana, Masataka Sato, Takahiro Ninomiya, Neelam Kaushik, Parmanand Sharma, Noriko Himori, Mitsuru Sugawara, Seiji Morino, Makoto Suzuki, Makoto Ishikawa, Toru Nakazawa

{"title":"Development of a Low-Cost Scanning Laser Ophthalmoscope Using Semiconductor Laser Technology.","authors":"Hiroki Takizawa, Hiroshi Kunikata, Takeshi Yabana, Masataka Sato, Takahiro Ninomiya, Neelam Kaushik, Parmanand Sharma, Noriko Himori, Mitsuru Sugawara, Seiji Morino, Makoto Suzuki, Makoto Ishikawa, Toru Nakazawa","doi":"10.1620/tjem.2024.J072","DOIUrl":"10.1620/tjem.2024.J072","url":null,"abstract":"In recent years, the use of scanning laser ophthalmoscopy (SLO) has emerged as a valuable tool in ophthalmic diagnostics. However, its widespread adoption has been prevented by substantial costs associated with existing devices. This study reports on the development of a low-cost SLO that is safe, requires no pupil dilation and no focus adjustment, and uses semiconductor laser technology for scanning. A prototype SLO equipped with red (638 nm) and infrared (IR; 795 nm) lasers was developed, and eyes with ocular diseases including glaucoma, branch retinal vein occlusion (BRVO), and diabetic retinopathy (DR) were examined using the SLO. We examined 53 patients (average age 62.0 ± 13.0 years; 93 eyes) with glaucoma (65 eyes), BRVO (11 eyes), and DR (17 eyes) using the low-cost SLO. Successful images were obtained from 83 eyes of 47 patients. The process was non-invasive, allowing for clear observation of the optic nerve head (ONH) and retinal vessels using both red and IR lasers. Furthermore, ophthalmological findings such as ONH cupping, macular edema, and retinal hemorrhage were detectable. Using a semiconductor laser, the prototype SLO successfully obtained high-quality images of ocular morphology and pathology without requiring pupil dilation and without focus adjustment. This low-cost SLO has the potential to enhance the accessibility of ophthalmic diagnostics, particularly in resource-limited settings, and contribute to the early detection and management of various ocular diseases.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"39-45"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0