Tohoku Journal of Experimental Medicine最新文献_第3页

1,25(OH)2D3 is Involved in the Regulation of Caspase-3/GSDME Pathway-Mediated Cellular Pyroptosis on Kidneys of Rats with Diabetic Nephropathy. 1.25(OH)2D3参与调节Caspase-3/GSDME通路介导的糖尿病肾病大鼠肾脏细胞焦亡

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-13 Epub Date: 2025-03-20 DOI: 10.1620/tjem.2025.J041

Yuxin Lu, Xi Chen, Lu Wan, Yuchi Qian, Yin Yu, Qin Gao, Lei Liu, Lijuan Yang

{"title":"1,25(OH)2D3 is Involved in the Regulation of Caspase-3/GSDME Pathway-Mediated Cellular Pyroptosis on Kidneys of Rats with Diabetic Nephropathy.","authors":"Yuxin Lu, Xi Chen, Lu Wan, Yuchi Qian, Yin Yu, Qin Gao, Lei Liu, Lijuan Yang","doi":"10.1620/tjem.2025.J041","DOIUrl":"10.1620/tjem.2025.J041","url":null,"abstract":"This study sought to investigate the presence of caspase-3/Gasdermin E (GSDME) pathway-induced cellular pyroptosis in diabetic nephropathy (DN), and to clarify the mode of action of this pathway and the regulatory role of 1,25(OH)2D3. A rat model of DN was constructed using Streptozotocin (STZ) in combination with a high-fat, high-sugar diet. The results show that 1,25(OH)2D3 reduces pyroptosis, protects kidney tissues, reduces renal cells damage, and decreases serum creatinine, blood urea nitrogen, and 24-hour urine protein (24hUpro) in rats with DN. Pathological changes such as glomerular mesangial stroma, glomerular basement membrane thickening, tubular vacuolar degeneration, and interstitial fibrosis in the kidney tissue of rats with DN were significantly ameliorated by the intervention of 1,25(OH)2D3. In addition, 1,25(OH)2D3 down-regulated the activation of the inflammatory factor NF-κB, down-regulation of caspase-8 expression and inhibition of protein expression of DN rat focal death-associated protein cleavage caspase-3, GSDME and GSDME-N. These findings support the protective effect of 1,25(OH)2D3 on kidney tissues of rats with diabetic nephropathy may be related to the inhibition of the caspase-3/GSDME pathway in the presence of pyroptosis.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"21-31"},"PeriodicalIF":1.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Image Quality and Safety Profile between Ethiodol and Ioversol Contrast Medium for Hysterosalpingography: A Meta-Analysis. 子宫输卵管造影术中乙碘和 Ioversol 造影剂的图像质量和安全性比较：元分析。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-12 Epub Date: 2024-10-10 DOI: 10.1620/tjem.2024.J106

Yun Tian, Zhenglong Chen, Peng Chen, Faling Song

{"title":"Comparison of Image Quality and Safety Profile between Ethiodol and Ioversol Contrast Medium for Hysterosalpingography: A Meta-Analysis.","authors":"Yun Tian, Zhenglong Chen, Peng Chen, Faling Song","doi":"10.1620/tjem.2024.J106","DOIUrl":"10.1620/tjem.2024.J106","url":null,"abstract":"The selection of an hysterosalpingography (HSG) contrast medium is quite essential due to the different imaging performances and safety profiles among contrast medium during the HSG procedure. Ethiodol and ioversol are the most common contrast mediums, whose superiority of imaging performance and safety profile during HSG is controversial. This meta-analysis aimed to comprehensively compare image quality and safety between infertility patients who received HSG with ethiodol and ioversol. PubMed, Web of Science (WOS), Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang, and Chongqing VIP (CQVIP) were utilized for literature searching until September 1, 2023. Twelve cohort studies containing 3,622 patients who underwent HSG with ioversol (N = 1,693) or ethiodol (N = 1,929) were included. Ethiodol realized an elevated rate of good and excellent image quality compared to ioversol (risk ratio (RR) = 0.94, 95% confidence intervals (CI): 0.89-1.00, P = 0.035). Whereas the incidence of overall adverse events (AEs) was reduced in patients receiving HSG with ioversol than ethiodol (RR = 0.53, 95% CI: 0.32-0.86, P = 0.011). Nevertheless, incidences of each adverse event, including reflux of contrast medium, abdominal pain, nausea and vomiting, and cough, were not different between patients receiving HSG with ioversol and ethiodol (all P > 0.050). The risk of bias was low, and there was no evidence of publication bias. Meanwhile, sensitivity analysis revealed that the result of image quality was affected by omitting some studies, but most other results were robust. Conclusively, ethiodol realizes improved image quality but ioversol realizes fewer overall AEs for HSG in infertility patients, suggesting that their clinical selection can refer to actual demands.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Analysis of Novel Variants Located in the Tetramerization Loop of ACAT1. 位于 ACAT1 四聚合环的新型变体的功能分析

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-12 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J132

Yue Xiao, Hideo Sasai, Hideki Matsumoto, Mai Mori, Yuka Aoyama, Norio Kawamoto, Drago Bratkovic, Hidenori Ohnishi

{"title":"Functional Analysis of Novel Variants Located in the Tetramerization Loop of ACAT1.","authors":"Yue Xiao, Hideo Sasai, Hideki Matsumoto, Mai Mori, Yuka Aoyama, Norio Kawamoto, Drago Bratkovic, Hidenori Ohnishi","doi":"10.1620/tjem.2024.J132","DOIUrl":"10.1620/tjem.2024.J132","url":null,"abstract":"Patients with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency, a rare inborn error of ketone body metabolism, sometimes experience severe ketoacidosis crises. The etiology of T2 deficiency is related to pathogenic variants of ACAT1. Typically, T2 homodimers form homotetramers through dimeric polymerization. Although the \"tetramerization loop\" comprising amino acid residues 160-177 is expected to be crucial for the formation and stabilization of tetramers, no functional analysis of this loop has been reported. We identified a novel homozygous ACAT1 c.508T>C (p.Y170H) variant in siblings with recurrent ketoacidosis, and further investigated the previously reported but not functionally analyzed heterozygous variant c.481T>C (p.Y161H), both of which are located in the T2 tetramerization loop. We evaluated T2 enzymatic activities and protein expression levels in patient-derived dermal fibroblasts expressing Y170H and in dermal fibroblasts with transient expression of variants Y161H and Y170H cultured at 37°C and 40°C. A silkworm expression system was used to confirm T2 enzymatic activity and evaluate the protein-stoichiometry of the two variants, which showed decreased enzymatic activity and protein stability. Native-polyacrylamide gel electrophoresis immunoblotting revealed structural differences between the wild-type and variant T2 proteins. Tetramerization loop variants Y161H and Y170H were found to be temperature sensitive, with compromised protein stability and obstruction of homotetramer formation. This study provides new insights into the functional importance of the T2 tetramerization loop in patients with T2 deficiency.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"11-19"},"PeriodicalIF":1.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Biallelic TECRL Gene Variants Associated with Familial Catecholaminergic Polymorphic Ventricular Tachycardia in a Chinese Family with a History of Sudden Cardiac Death. 有心源性猝死史的中国家庭中与家族儿茶酚胺能多态性室性心动过速相关的新型双等位基因TECRL变异

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-11 DOI: 10.1620/tjem.2025.J109

Ruihua Li, Ning Li, Chengxun Lv, Xingya Xu, Jianshu Song, Rujiang Bai, Xiangting Hua

引用次数: 0

Anti-TNF-α Treatment Improves the Live Birth Rate and Reduces the Risk of Premature Delivery in Patients with Recurrent Spontaneous Abortion. 抗tnf -α治疗可提高复发性自然流产患者的活产率并降低早产风险。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-04 DOI: 10.1620/tjem.2025.J103

Shuxia Chen, Yuan Li, Chao Sun, Jiecheng Yang, Shaoying Li, Qiang Feng, Xin Feng, Zhe Li, Kejuan Zhang, Yuejun Liu

引用次数: 0

Lupus Peritonitis Development in a Patient with Coronavirus Disease 2019 on Peritoneal Dialysis: A Case Report. 2019年腹膜透析患者患上狼疮性腹膜炎：病例报告。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-08-27 Epub Date: 2024-10-24 DOI: 10.1620/tjem.2024.J110

Kosuke Yamaka, Daiki Aomura, Makoto Harada, Takayuki Nimura, Koji Hashimoto, Yuji Kamijo

{"title":"Lupus Peritonitis Development in a Patient with Coronavirus Disease 2019 on Peritoneal Dialysis: A Case Report.","authors":"Kosuke Yamaka, Daiki Aomura, Makoto Harada, Takayuki Nimura, Koji Hashimoto, Yuji Kamijo","doi":"10.1620/tjem.2024.J110","DOIUrl":"10.1620/tjem.2024.J110","url":null,"abstract":"Despite receiving immunosuppressive therapy, a 37-year-old woman with lupus nephritis experienced refractory nephrotic syndrome and severe kidney dysfunction that necessitated peritoneal dialysis. Thereafter, immunosuppressants were tapered because her lupus symptoms improved. Two weeks after prednisolone termination, she was hospitalized because of acute abdominal pain. A physical examination revealed upper abdominal tenderness. Her dialysate was cloudy and comprised an elevated neutrophil count. A coronavirus disease 2019 test yielded positive results. Infectious peritonitis was suspected, coronavirus disease 2019 was diagnosed, and antibiotic and steroid therapies were initiated. The patient's symptoms improved rapidly, and steroid therapy was discontinued on day 9. On day 10, she experienced abdominal pain and exhibited an elevated monocyte-predominant dialysate cell count despite antibiotic treatment. The dialysate culture results were negative. Lupus peritonitis was suspected because of her slightly elevated dsDNA antibodies and changes in the dialysate cell fraction. Prednisolone was resumed on day 12. Her symptoms improved immediately, and she was discharged on day 30 without complications. This case highlights unique autoimmune activation by coronavirus disease 2019 (COVID-19) that resulted in unexpected pathological shifts and challenging diagnoses. Clinicians should consider various causes of immune flare-ups in patients with COVID-19 and autoimmune conditions.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"381-386"},"PeriodicalIF":1.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Clinical Value of LINC01094/Hsa-miR-4758-5p and Their Action Mechanisms in Carotid Artery Stenosis. LINC01094/hsa-miR-4758-5p 在颈动脉狭窄中的临床价值及其作用机制

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-08-22 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J119

Junwei Xu, Xingxing Wu, Yali Zhang, Ying Jin, Caijiao Wang, Chunchun Xu, Yanfeng Zhang, Li Chen, Haining Zhen

{"title":"The Clinical Value of LINC01094/Hsa-miR-4758-5p and Their Action Mechanisms in Carotid Artery Stenosis.","authors":"Junwei Xu, Xingxing Wu, Yali Zhang, Ying Jin, Caijiao Wang, Chunchun Xu, Yanfeng Zhang, Li Chen, Haining Zhen","doi":"10.1620/tjem.2024.J119","DOIUrl":"10.1620/tjem.2024.J119","url":null,"abstract":"Carotid artery stenosis (CAS) is mostly caused by carotid atherosclerotic plaque, leading to various cardiovascular and cerebrovascular diseases that seriously threaten human lives. This study aims to explore the roles of LINC01094 and hsa-miR-4758-5p in CAS pathogenesis and provide theoretical support for its prediction and treatment. RT-qPCR was used to detect the levels of LINC01094 and hsa-miR-4758-5p. SPSS software was utilized to construct the Receiver Operating Characteristic (ROC) curves for diagnosingCAS using LINC01094 and hsa-miR-4758-5p. The interaction between LINC01094 and hsa-miR-4758-5p was tested using a dual-luciferase reporter gene assay. CCK-8 assay and flow cytometry were employed to assess cell activity and apoptotic cell ratio, respectively. The Western Blotting assay detected the expression of BAK, BCL-2, and ICAM-1. ELISA, lipid peroxidation (MDA), and reactive oxygen species (ROS) kits measured the levels of inflammatory factors (IL-6 and TNF-α), MDA, and ROS, respectively. LINC01094 expressed highly, and hsa-miR-4758-5p expressed lowly in CAS. The combination of LINC01094 and hsa-miR-4758-5p showed higher accuracy in diagnosing CAS compared to either factor alone. The hsa-miR-4758-5p mimic significantly reduced the luciferase activity of HCAECs and THP-1 cells transfected with wt-LINC01094 vectors. LINC01094 overexpression suppressed the level of hsa-miR-4758-5p. The hsa-miR-4758-5p mimic reversed cell damage induced by ox-LDL or LINC01094 overexpression. LINC01094 and hsa-miR-4758-5p had good diagnostic value in CAS. Mechanistically, LINC01094 mediated ox-LDL-induced damage of HCAECs and THP-1 cells by negatively regulating hsa-miR-4758-5p.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"371-379"},"PeriodicalIF":1.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Difference in Olfactory Interhemispheric Malformation Caused by Pax6 Haploinsufficiency. Pax6单倍不足导致嗅觉半球间畸形的性别差异。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-08-22 Epub Date: 2025-06-05 DOI: 10.1620/tjem.2025.J068

Natsumi Joko, Takako Kikkawa, Takayoshi Inoue, Noriko Osumi

{"title":"Sex-Difference in Olfactory Interhemispheric Malformation Caused by Pax6 Haploinsufficiency.","authors":"Natsumi Joko, Takako Kikkawa, Takayoshi Inoue, Noriko Osumi","doi":"10.1620/tjem.2025.J068","DOIUrl":"10.1620/tjem.2025.J068","url":null,"abstract":"Sex differences are increasingly recognized as critical factors influencing the onset and manifestation of various neurodevelopmental disorders, including autism spectrum disorder (ASD). Among ASD-associated genes, Pax6, which encodes a transcription factor, has been implicated in sex-dependent phenotypes when mutated. The anterior commissure (AC), a major commissural pathway involved in higher cognitive and social functions, exhibits structural abnormalities both in individuals with ASD and in those carrying Pax6 mutations. Anatomically, the AC consists of two principal fiber bundles: the anterior limb (aAC), connecting the olfactory bulbs and anterior olfactory nucleus, and the posterior limb (pAC), connecting the piriform cortex and amygdaloid regions, both converging at the midline. In this study, we investigated sex-specific structural abnormalities of the AC in Pax6 mutant mice. Analysis of horizontal and sagittal AC sections revealed that Pax6 haploinsufficiency in mice induces abnormal de-fasciculation in the aAC and aberrant intermingling of aAC and pAC fibers at the midline. Notably, Pax6 mutant females exhibited more diverse phenotypes. These females showed a pronounced reduction in overall AC size and disruptions in pAC shape regularity, likely due to a more severe disruption of the boundary between the aAC and pAC axon bundles. These sex-dependent alterations in AC morphology may contribute to the sexually dimorphic phenotypes observed in various neurodevelopmental disorders, including autism spectrum disorder.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"361-369"},"PeriodicalIF":1.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Up-Regulated MiR-616-5p Promotes the Progression of Nasopharynx Cancer through GSK3β. 上调的 MiR-616-5p 通过 GSK3β 促进鼻咽癌的进展

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-08-21 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J131

Shasha Zhang, Meiai Xu, Xuefeng Shen, Sicong Jiang, Xianming He, Juying Ke

{"title":"Up-Regulated MiR-616-5p Promotes the Progression of Nasopharynx Cancer through GSK3β.","authors":"Shasha Zhang, Meiai Xu, Xuefeng Shen, Sicong Jiang, Xianming He, Juying Ke","doi":"10.1620/tjem.2024.J131","DOIUrl":"10.1620/tjem.2024.J131","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) is a serious malignancy occurring in nasopharynx with high incidence, which is caused by excessive proliferation of nasopharyngeal cells. It has been reported that both microRNA (miR)-616-5p and glycogen synthase kinase 3β (GSK3β) are involved in multiple biological processes in various cancer cells and there is a targeting relationship between them. However, their roles in NPC remain undiscovered. This study was to investigate the prognosis and regulatory role of miR-616-5p/ GSK3β in NPC. 136 patients with NPC were enrolled and provided tissue samples. The NPC cell line SUNE-1 was used to explore the effect of miR-616-5p on NPC. Cell transfection was used to regulate gene expression and the expression levels of miR-616-5p and GSK3β were confirmed by qRT-PCR. Results confirmed that miR-616-5p was increased in both NPC tissues of patients and NPC cell lines. Further Kaplan-Meier assay showed that increased miR-616-5p was related to the poor prognosis of NPC patients. Subsequent assessment on cellular biological behavior demonstrated that up-regulated miR-616-5p facilitated cell proliferation, migration and invasion while it suppressed cell apoptosis. In addition, GSK3β was identified as a potential downstream target of miR-616-5p by dual-luciferase system. In conclusion, up-regulated miR-616-5p may promote the progression of NPC via targeting GSK3β.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"353-360"},"PeriodicalIF":1.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Online with Offline Cognitive-Behavioral Stress Caring Program in Prostate Cancer Survivors after Prostatectomy: A Prospective, Propensity Score-Matched, Cohort Study. 前列腺切除术后前列腺癌幸存者在线与离线认知行为应激护理项目的比较：一项前瞻性、倾向评分匹配的队列研究。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-08-21 Epub Date: 2025-02-27 DOI: 10.1620/tjem.2025.J030

Hong Qu, Bingbing Song, Yang Lin, Jiao Liu

{"title":"Comparison of Online with Offline Cognitive-Behavioral Stress Caring Program in Prostate Cancer Survivors after Prostatectomy: A Prospective, Propensity Score-Matched, Cohort Study.","authors":"Hong Qu, Bingbing Song, Yang Lin, Jiao Liu","doi":"10.1620/tjem.2025.J030","DOIUrl":"10.1620/tjem.2025.J030","url":null,"abstract":"Offline cognitive-behavioral stress caring program (CBSC) modifies maladaptive cognition and improves management stress skills, which relieves mental disorders in some cancer patients; however, it is limited by space and time. This study compared the effect of online and offline CBSC on mental health, spiritual well-being, fatigue, and patient satisfaction in prostate cancer survivors after prostatectomy. Totally, 147 prostate cancer survivors after prostatectomy were divided into offline (n = 89) and online (n = 58) CBSC groups. CBSC included stress management, relaxation, disease-relevant education, and weekly homework. Selection bias was adjusted by matching patients in both groups (1:1) using propensity scores (n = 58 in both groups after adjustment). Hospital Anxiety and Depression Scale (HADS)-anxiety, HADS-depression, Functional Assessment of Chronic Illness Therapy Spiritual Well-Being Scale (FACIT-SP), the brief fatigue inventory-China (BFI-C), and patient satisfaction score (PSS) were evaluated. 'Improvement' was defined as positive improvement values in indexes after a 10-week CBSC. Before and after adjustment, HADS-anxiety, HADS-depression, FACIT-SP, BFI-severity, and BFI-interference scores were improved at week 10 vs. baseline in the online or offline CBSC group. However, these scores did not vary at baseline or week 10 between groups. The improvement of HADS-anxiety, HADS-depression, and FACIT-SP scores was smaller in online CBSC group than in offline CBSC group. The improvement of BFI-severity and BFI-interference scores were non-differential between groups. PSS scores were reduced in online CBSC group vs. offline CBSC group. Overall, online CBSC alleviates mental disorders, elevates satisfaction, and relieves fatigue in prostate cancer survivors after prostatectomy, but its overall effect is less than offline CBSC.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"343-351"},"PeriodicalIF":1.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0