Tohoku Journal of Experimental Medicine最新文献_第10页

Cyanoacrylate is still an Effective Surgical strategy for Homeostasis: A Rodent Model of Liver Trauma and Evaluation of Early Wound Healing. 氰基丙烯酸酯仍然是一种有效的手术策略：一种啮齿动物肝损伤模型和早期伤口愈合的评估。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-05 DOI: 10.1620/tjem.2025.J067

Anıl Orhan, Süleyman Demiryas, Engin Hatipoğlu, Karolin Yanar, Nuray Kepil, Salih Pekmezci

引用次数: 0

Detection of Cataract with a New Perimetry Method Using Retinal Projection Technology. 利用视网膜投影技术检测白内障的新方法。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-05 DOI: 10.1620/tjem.2025.J066

Takeshi Yabana, Naoko Takada, Satoru Tsuda, Makoto Ishikawa, Mai Yamazaki, Masataka Sato, Takahiro Ninomiya, Yu Yokoyama, Noriko Himori, Kazuki Hashimoto, Aki Osanai, Seiji Morino, Makoto Suzuki, Mitsuru Sugawara, Hiroshi Kunikata, Toru Nakazawa

引用次数: 0

An Indolent Aldosterone-Producing Adenoma in a Young Hypertensive Patient Manifested during 7-Year Follow-up. 一例年轻高血压患者在7年随访中表现为惰性醛固酮分泌腺瘤。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-29 DOI: 10.1620/tjem.2025.J060

Yuta Tezuka, Yoshikiyo Ono, Yuto Yamazaki, Satoshi Higuchi, Jun Nishikawa, Kei Omata, Sota Oguro, Hideki Ota, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Takashi Suzuki, Hironobu Sasano, Tetsuhiro Tanaka, Fumitoshi Satoh

引用次数: 0

Predictive Value of Abnormally Expressed Serum MiR-204-5p in Pregnancy during Second Trimester on Subclinical Hypothyroidism. 妊娠中期血清MiR-204-5p异常表达对亚临床甲状腺功能减退的预测价值

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-29 DOI: 10.1620/tjem.2025.J063

Qian Wang, Jingsong Cheng, Wenjing He, Xiaofeng Li, Jun Ma, Xiaoyan Wang, Xing Wu, Lin Ma, Lin Guo

引用次数: 0

Effect of Serum MiR-106a-5p on Vascular Calcification in Dialysis Patients. 血清MiR-106a-5p对透析患者血管钙化的影响

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-29 DOI: 10.1620/tjem.2025.J064

Hong Zhang, Zhihang Jiang, Lei Xu, Jihong Zhang, Yawei Yuan, Xuanlin Lu

引用次数: 0

Curcumin Nano-Formulations with Enhanced Bioavailability and Therapeutic Efficacy for Osteoarthritis Treatment. 姜黄素纳米制剂与提高生物利用度和治疗骨关节炎的疗效。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-29 DOI: 10.1620/tjem.2025.J062

Fan Zhong, Jinyi Zhang, Lin Teng, Dahai Liu, Yongchuan Xiao, Gang Zhong

引用次数: 0

Effects of SCN2A Gene Polymorphism on Drug Response in Han Chinese Children with Epilepsy. SCN2A基因多态性对汉族癫痫患儿药物反应的影响

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-29 DOI: 10.1620/tjem.2025.J061

Lin Xu, Jie Fan, Yongbiao Zou

引用次数: 0

Association Between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: The Ohasama Study. 考虑到亚临床脑血管疾病的存在，分娩次数与认知障碍之间的关系：Ohasama 研究。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-28 Epub Date: 2024-11-28 DOI: 10.1620/tjem.2024.J139

Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

{"title":"Association Between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: The Ohasama Study.","authors":"Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo","doi":"10.1620/tjem.2024.J139","DOIUrl":"10.1620/tjem.2024.J139","url":null,"abstract":"Although the association between the number of deliveries and cognitive impairment has been previously examined, the influence of subclinical cerebrovascular diseases (SCDs), such as silent cerebrovascular lesions and carotid atherosclerosis, on this association remains unclear. This cross-sectional study aimed to examine whether SCDs mediated the association between the number of deliveries and cognitive impairment. Among 627 Japanese women with a mean age of 73 years, the number of deliveries was collected in the 1998 survey and classified into four groups (0-1, 2, 3, ≥ 4), with two deliveries as the reference. At the annual comprehensive medical examinations, cognitive function was assessed using the Mini-Mental State Examination (MMSE), and SCDs were evaluated using brain magnetic resonance imaging and ultrasonography. Each participant's latest data on these variables and covariates between 1992 and 2018 were used. MMSE scores were divided into three ordinal categories: ≥ 28 (normal), 24-27 (mild cognitive impairment; MCI), and ≤ 23 (severe cognitive impairment). Ordinal logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive impairment. The ORs for cognitive impairment associated with the number of deliveries were 2.13 (95% CI, 1.21-3.76) in the lowest (0-1) group and 1.45 (0.95-2.23) in the highest (≥ 4) group. These association estimates remained similar after adjusting for SCDs but were weaker in the more recent birth year group. We demonstrated a U-shaped association between the number of deliveries and cognitive impairment, independent of SCDs, and the cohort effect confounded the association.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"69-79"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-Sectional Study of the Association Between Plasma Brain Natriuretic Peptide Levels and Left Ventricular Shortening Fraction in Fukuyama Congenital Muscular Dystrophy. 福山先天性肌营养不良症患者血浆脑钠肽水平与左心室缩短率之间关系的横断面研究

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-28 Epub Date: 2024-11-21 DOI: 10.1620/tjem.2024.J137

Takatoshi Sato, Yuki Kihara, Kumiko Ishiguro, Minobu Shichiji, Terumi Murakami, Satoru Nagata, Eriko Shimada, Kei Inai, Atsuhito Takeda, Keiko Ishigaki

{"title":"Cross-Sectional Study of the Association Between Plasma Brain Natriuretic Peptide Levels and Left Ventricular Shortening Fraction in Fukuyama Congenital Muscular Dystrophy.","authors":"Takatoshi Sato, Yuki Kihara, Kumiko Ishiguro, Minobu Shichiji, Terumi Murakami, Satoru Nagata, Eriko Shimada, Kei Inai, Atsuhito Takeda, Keiko Ishigaki","doi":"10.1620/tjem.2024.J137","DOIUrl":"10.1620/tjem.2024.J137","url":null,"abstract":"This study aimed to investigate the correlation between plasma brain natriuretic peptide levels and left ventricular shortening fraction in Fukuyama congenital muscular dystrophy. The correlation between brain natriuretic peptide levels and left ventricular shortening fraction in patients with genetically confirmed Fukuyama congenital muscular dystrophy was retrospectively investigated. The patients at Tokyo Women's Medical University were followed-up from October 2015 to October 2020. The brain natriuretic peptide level was measured using a specific immunoradiometric assay kit. Left ventricular shortening fraction was defined as a degree of left ventricular systolic function within 3 months before and after brain natriuretic peptide measurements. In addition to left ventricular shortening fraction, the ratio of early filling to early diastolic and the maximum velocity of tricuspid regurgitation, which are measures of diastolic function, were investigated. In total, 27 sets of brain natriuretic peptide levels and echocardiography results were obtained from 16 patients with Fukuyama congenital muscular dystrophy. Excellent correlations were found between the brain natriuretic peptide levels and left ventricular shortening fraction (R2 = 0.8755). Patients with a left ventricular shortening fraction of > 20% had low brain natriuretic peptide levels. However, the brain natriuretic peptide values of patients with a left ventricular shortening fraction of < 20% were > 40 pg/mL. In Fukuyama congenital muscular dystrophy, the brain natriuretic peptide level was exponentially correlated with left ventricular shortening fraction. However, it did not elevate until the advanced stage of left ventricular systolic dysfunction.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"81-85"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cornuside Ameliorates Diabetic Nephropathy Possibly by Regulating Angiogenesis and MAPK Signaling. 山茱萸苷可能通过调节血管生成和 MAPK 信号转导改善糖尿病肾病

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-28 Epub Date: 2024-10-24 DOI: 10.1620/tjem.2024.J112

Fang Xiang, Xin Li, Wei Hu

{"title":"Cornuside Ameliorates Diabetic Nephropathy Possibly by Regulating Angiogenesis and MAPK Signaling.","authors":"Fang Xiang, Xin Li, Wei Hu","doi":"10.1620/tjem.2024.J112","DOIUrl":"10.1620/tjem.2024.J112","url":null,"abstract":"Diabetic nephropathy (DN) is a prevalent diabetic complication seriously threatening patients' health and lives. Cornuside is an iridoid glycoside compound with various pharmacological properties. Nonetheless, whether cornuside has a protective effect against DN remains unillustrated. In this study, a rat model for DN was established by streptozotocin (STZ) injection. Rat podocytes were stimulated with high glucose (HG) to mimic a DN microenvironment in vitro. Several indicators linked to kidney function were evaluated. Periodic Acid-Schiff (PAS) and hematoxylin-eosin staining were implemented for renal histologic analysis. Immunofluorescence staining of CD31 was used for the detection of neovascularization. Western blotting was employed to assess levels of angiogenic factors and MAPK signaling-related proteins in the kidney or podocytes. The results showed that cornuside administration alleviated STZ-elicited renal dysfunction, as evidenced by the reduction in fasting blood glucose, proteinuria, serum creatinine, and blood urea nitrogen. Cornuside attenuated renal pathological lesions in DN rats. Cornuside repressed angiogenesis in DN rat kidney tissues and podocytes. Cornuside blocked MAPK signaling in HG-stimulated podocytes. In conclusion, cornuside alleviates renal injury in DN rats possibly by hindering angiogenesis and MAPK signaling.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"87-95"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0