Tohoku Journal of Experimental Medicine最新文献_第10页

Effects of 15 Years of Continuous Treatment with Bisphosphonate on Japanese Postmenopausal Osteoporosis Patients: An Observational Study. 人猴痘病毒 (hMPXV) OPG191 基因中的最新帧移位突变。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-25 Epub Date: 2024-11-16 DOI: 10.1620/tjem.2024.J124

Kousuke Iba, Megumi Hanaka, Makoto Emori, Kenichi Takashima, Atsushi Teramoto, Junichi Takada

{"title":"Effects of 15 Years of Continuous Treatment with Bisphosphonate on Japanese Postmenopausal Osteoporosis Patients: An Observational Study.","authors":"Kousuke Iba, Megumi Hanaka, Makoto Emori, Kenichi Takashima, Atsushi Teramoto, Junichi Takada","doi":"10.1620/tjem.2024.J124","DOIUrl":"10.1620/tjem.2024.J124","url":null,"abstract":"Bisphosphonate (BP) is mainly used for the treatment of osteoporosis because of its efficacy in increasing bone mineral density (BMD) and reducing osteoporotic fractures. Previous large-scale studies indicated that continuous 10-year treatment with BP was effective for osteoporosis treatment. However, several studies indicated an increase in the risk of serious adverse events such as atypical femoral fracture on prolonged BP treatment. The benefits and risks associated with long-term BP therapy are controversial. On the other hand, the effects of BP for more than 10 years are unknown because of few previous studies. The aim of this study to investigate effects of continuous 15-year treatment with BP on Japanese postmenopausal osteoporosis patients. The study was a retrospective observational study. Fifteen of the 55 patients, who had already received a 10-year course of oral BP treatment in our previous study, continued the treatment for an additional 5 years. All patients made the choice additional BP treatment with informed consent. BMD; hip structural analysis (HSA); limbs-muscle volume; and serum total alkaline phosphatase, tartrate-resistant acid phosphatase-5b, calcium and phosphate levels were measured for 5 years in the 15 patients. BMD values at the lumbar spine were significantly increased at 15 years in comparison with that at 10 years. Section modulus of HSA for the intertrochanter was significantly increased at 15 years. No subsequent fractures or serious adverse events were observed. We demonstrated favorable effects of an additional 5 years of BP treatment in postmenopausal osteoporosis patients who had already received a continuous 10-year treatment.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"229-237"},"PeriodicalIF":1.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of miR-4638-5p in Patients with Sepsis and Its Regulatory Role in the LPS-Induced Inflammatory Response. miR-4638-5p在脓毒症患者中的临床意义及其在lps诱导的炎症反应中的调节作用

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-24 DOI: 10.1620/tjem.2025.J045

Yuanming Bai, Jing Yang, Xin Liu, Jianyuan Huang

引用次数: 0

KDM6B Regulates BMP2 to Promote Osteoblast Differentiation and Ameliorates Alcohol-Induced Osteoporosis. KDM6B调节BMP2促进成骨细胞分化，改善酒精性骨质疏松

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-24 DOI: 10.1620/tjem.2025.J046

Dechun Li, Yanguo Wang, Bo Zou, Yannan Bi, Guocen Zheng, Di Wu

引用次数: 0

Surgery within Two Days of Admission Reduces Complications and Mortality of Patients with Trochanteric Femur Fractures: A Japanese DPC Study. 入院两天内手术可降低股骨转子间骨折患者的并发症和死亡率：日本 DPC 研究

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-18 Epub Date: 2024-09-12 DOI: 10.1620/tjem.2024.J093

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

{"title":"Surgery within Two Days of Admission Reduces Complications and Mortality of Patients with Trochanteric Femur Fractures: A Japanese DPC Study.","authors":"Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa","doi":"10.1620/tjem.2024.J093","DOIUrl":"10.1620/tjem.2024.J093","url":null,"abstract":"An early surgery for older adult patients with hip fractures is recommended to avoid perioperative complications in existing clinical guidelines. Few studies have analyzed only transtrochanteric fractures. The purpose of this study was to assess whether surgery within two days of admission reduces the incidence of pneumonia, deep vein thrombosis, pulmonary embolism, pressure ulcers, and mortality during hospitalization in patients with older adult transtrochanteric femur fractures. In this retrospective study, we used the Japanese National Administrative DPC (Diagnosis Procedure Combination) database that covers April 2016 to March 2022. Transtrochanteric femur fracture was included in patients aged 65 years or older who underwent surgery. The perioperative complications with pneumonia, deep vein thrombosis, pulmonary embolism, pressure ulcers, and mortality during hospitalization were assessed after propensity score matching, focusing on surgeries conducted within two days of admission. After one-to-one propensity score matching for age, sex, and comorbidity, we identified 79,649 pairs of patients who underwent surgery either within two days or after the third day of admission. Surgery delayed beyond two days was independently associated with increased pneumonia, pulmonary embolism, pressure ulcers, and mortality during hospitalization with risk ratios of 1.335 (95% CI: 1.256-1.418, p < 0.0001), 1.287 (95% CI: 1.225-1.351, p < 0.0001), 1.229 (95% CI: 1.094-1.380, p < 0.0001), and 1.063 (95% CI: 0.978-1.155, p = 0.0035), respectively. Surgery within two days of admission for transtrochanteric femur fracture effectively prevents perioperative complications and reduces mortality during hospitalization.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"211-219"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FGF21 Activates Autophagy to Ameliorate Lipid Accumulation in NAFLD. FGF21激活自噬改善NAFLD的脂质积累。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-17 DOI: 10.1620/tjem.2025.J044

Xuexin Xu, Jiayin Ren, Cuili Gong

引用次数: 0

Association Between Low Blood 25-Hydroxyvitamin D and High C-Reactive Protein Levels in Community-Dwelling Japanese People Aged 40-74 Years. 40-74 岁日本社区居民低血 25- 羟维生素 D 与高 C-反应蛋白水平之间的关系

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-11 Epub Date: 2024-09-05 DOI: 10.1620/tjem.2024.J088

Takuya Abe, Yumi Watanabe, Kaori Kitamura, Keiko Kabasawa, Toshiko Saito, Akemi Takahashi, Ribeka Takachi, Ryosaku Kobayashi, Rieko Oshiki, Shoichiro Tsugane, Kei Watanabe, Kazutoshi Nakamura

{"title":"Association Between Low Blood 25-Hydroxyvitamin D and High C-Reactive Protein Levels in Community-Dwelling Japanese People Aged 40-74 Years.","authors":"Takuya Abe, Yumi Watanabe, Kaori Kitamura, Keiko Kabasawa, Toshiko Saito, Akemi Takahashi, Ribeka Takachi, Ryosaku Kobayashi, Rieko Oshiki, Shoichiro Tsugane, Kei Watanabe, Kazutoshi Nakamura","doi":"10.1620/tjem.2024.J088","DOIUrl":"10.1620/tjem.2024.J088","url":null,"abstract":"Low blood 25-hydroxyvitamin D (25[OH]D) levels at which C-reactive protein (CRP) levels begin to rise vary. This study investigated the association between blood 25(OH)D and elevated CRP levels and determine the cut-off of low 25(OH)D for elevated CRP in middle-aged and older individuals in the Murakami cohort, Japan. This study used a cross-sectional study design with 2,863 subjects aged 40-74 years living in the community. Plasma 25(OH)D levels were determined with the Liaison® 25OH Vitamin D Total Assay, and serum high sensitivity CRP (hs-CRP) levels were determined with a latex nephelometry assay using an automatic analyzer. Multivariate logistic regression analysis was used to calculate odds ratios (ORs) for high hs-CRP (≥ 3 mg/L) with covariates including sex, age, BMI, physical activity, smoking, drinking, and disease history. Median age of subjects was 65 years, and median 25(OH)D level was 47.4 nmol/L. The proportion of subjects with high hs-CRP levels was 4.1%. The adjusted OR of 25(OH)D < 20 nmol/L was higher (OR = 3.22, 95% CI: 1.42-7.31) than that of the reference (25[OH]D 40-49 nmol/L). In subgroup analysis, the adjusted OR of 25(OH)D < 20 nmol/L was significantly higher than the reference in the BMI ≥ 22.8 (median) group (OR = 4.52) but not in the BMI < 22.8 group (OR = 1.61) (P for interaction = 0.0892), and the adjusted OR was significantly higher in the age ≥ 65 group (OR = 8.51) but not in the age < 65 group (OR = 2.22). Low blood 25(OH)D and high CRP levels were associated, with 25(OH)D 20 nmol/L being the cut-off, which was lower than previously reported values.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"193-200"},"PeriodicalIF":1.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Amputation Level and Oncologic Prognosis on Activities of Daily Living in Patients with Lower Limb Amputation for Musculoskeletal Malignancies. 肌肉骨骼恶性肿瘤下肢截肢患者截肢程度和肿瘤预后对日常生活活动的影响

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-04-11 Epub Date: 2024-09-12 DOI: 10.1620/tjem.2024.J098

Hiromori Sagae, Masato Sugawara, Daiichiro Takahara, Michiaki Takagi, Yuya Takakubo

{"title":"Impact of Amputation Level and Oncologic Prognosis on Activities of Daily Living in Patients with Lower Limb Amputation for Musculoskeletal Malignancies.","authors":"Hiromori Sagae, Masato Sugawara, Daiichiro Takahara, Michiaki Takagi, Yuya Takakubo","doi":"10.1620/tjem.2024.J098","DOIUrl":"10.1620/tjem.2024.J098","url":null,"abstract":"Activities of daily living (ADLs) with phantom limb pain (PLP) and prosthesis use in patients who underwent lower limb amputation for musculoskeletal malignancies has been reported just by a few researchers. This study aimed to investigate the influence of PLP and prosthesis use on ADLs after lower limb amputation for musculoskeletal malignancies. We conducted a retrospective study on 19 patients (10 males and 9 females) who underwent lower limb amputation for musculoskeletal malignancies between 2003 and 2011 and were followed up until 2021. The mean age was 60.4 (range, 10-85) years. We investigated PLP, prosthesis use, and ADLs after lower limb amputation; we used the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) to assess ADLs. PLP was present in 16 patients (84%), and 4 of 5 survivors (80%) were medication-free at the final follow-up. Prostheses were prescribed in 16 patients (84%), and 11 patients (69%) continued to use the prosthesis after discharge. In a multiple linear regression analysis of ADLs at discharge for the 15 patients with confirmed survival or death, excluding the four patients whose outcome was unknown at the last follow-up, lower-level amputation and good oncologic prognosis were positive independent factors, while age was the only negative independent factor. PLP and prosthesis use did not influence ADLs.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"185-191"},"PeriodicalIF":1.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tenascin C Enhances the Development of Papillary Thyroid Carcinoma and has Diagnostic Significance in Papillary Thyroid Microcarcinoma. Tenascin C促进甲状腺乳头状癌的发展及其在甲状腺乳头状微癌中的诊断意义。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-27 DOI: 10.1620/tjem.2025.J043

Qiwei Du, Minghe Zhang, Yuqing Huang, Ziqiang Wang, Nian Liu, Rongguo Li

引用次数: 0

MicroRNA-668-3p Mediates Macrophage M2 Polarization by Targeting NFKBIA to Affect Gastric Cancer Cell Proliferation and Migration. 微RNA-668-3p通过靶向NFKBIA介导巨噬细胞M2极化，从而影响胃癌细胞的增殖和迁移

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-27 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J115

Chenghao Chu, Bin Liu, Yongwei Zhang, Zhangxuan Xu, Bin Wang, Kai Ling Chin

{"title":"MicroRNA-668-3p Mediates Macrophage M2 Polarization by Targeting NFKBIA to Affect Gastric Cancer Cell Proliferation and Migration.","authors":"Chenghao Chu, Bin Liu, Yongwei Zhang, Zhangxuan Xu, Bin Wang, Kai Ling Chin","doi":"10.1620/tjem.2024.J115","DOIUrl":"10.1620/tjem.2024.J115","url":null,"abstract":"Macrophage polarization is implicated in the pathological mechanism of gastric cancer (GC). This study investigated how the miR-668-3p/ Nuclear factor kappa B inhibitor alpha (NFKBIA) axis drives macrophage polarization to contribute to GC progression. Inhibitors or shRNA were used to interfere with the expression of miR-668-3p or NFKBIA in the GC cell line. Subsequently, CCK-8, EdU, wound healing, and transwell assays were used to assess the biological behavior of the GC cells. Bioinformatics analysis predicted the target connection between miR-668-3p and NFKBIA, and a dual luciferase reporter gene experiment confirmed this relationship. After THP-1 macrophages were co-cultured with the supernatant of transfected GC cells, the M1 and M2 macrophage phenotypes were determined. Subsequently, these THP-1 macrophages were co-cultured with GC cells using the Transwell, and the biological behaviors of the GC cells were determiend. miR-668-3p inhibitor suppressed proliferation, invasion and migration of GC cells. The phenotype of M1 macrophage (IL-1β, TNF-α and IL-6) was boosted yet the phenotype of M2 macrophage (CD206, Fizz1 and IL-10) was declined by miR-668-3p inhibitor. NFKBIA was the target gene of miR-668-3p and it reversed the effects of miR-668-3p inhibitor on macrophage polarization and biological behaviors of the GC cells.miR-668-3p suppressed NFKBIA in GC cells to mediate M2 polarization of macrophages, thereby facilitating the tumorigenesis of GC.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"173-182"},"PeriodicalIF":1.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA ACTA2-AS1 Inhibits Tumorigenesis of Prostate Cancer by Maintaining ACTA2 Expression. LncRNA ACTA2- as1通过维持ACTA2的表达抑制前列腺癌的发生。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-03-27 DOI: 10.1620/tjem.2025.J042

Chang-Wei Peng, Pei-Li Ma, Hai-Tao Dai

引用次数: 0