Tohoku Journal of Experimental Medicine最新文献_第9页

Sulforaphane Inhibits LPS-Induced Macrophage PANoptosis via TLR4/NFκB Pathway: A Potential Therapeutic Strategy for Acute Lung Injury. 红豆杉通过 TLR4/NFκB 通路抑制 LPS 诱导的巨噬细胞全凋亡：急性肺损伤的潜在治疗策略。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-10-03 DOI: 10.1620/tjem.2024.J105

Yanwei Wang, Huifan Liu, Yali Feng, Shujuan Wu, Jingxuan He, Lei Cao

引用次数: 0

Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans. 长非编码 RNA MAGOH-DT 的上调介导了 TNF-α 和高血糖诱导的动脉硬化闭塞症内皮-间充质转化。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-27 Epub Date: 2024-05-30 DOI: 10.1620/tjem.2024.J031

Kang-Jie Wang, Yi-Xin Zhang, Zhi-Wei Mo, Zi-Lun Li, Mian Wang, Rui Wang, Zhe-Cun Wang, Guang-Qi Chang, Wei-Bin Wu

{"title":"Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans.","authors":"Kang-Jie Wang, Yi-Xin Zhang, Zhi-Wei Mo, Zi-Lun Li, Mian Wang, Rui Wang, Zhe-Cun Wang, Guang-Qi Chang, Wei-Bin Wu","doi":"10.1620/tjem.2024.J031","DOIUrl":"10.1620/tjem.2024.J031","url":null,"abstract":"Arteriosclerosis obliterans (ASO) is characterized by arterial narrowing and blockage due to atherosclerosis, influenced by endothelial dysfunction and inflammation. This research focuses on exploring the role of MAGOH-DT, a long noncoding RNA, in mediating endothelial cell dysfunction through endothelial-mesenchymal transition (EndMT) under inflammatory and hyperglycemic stimuli, aiming to uncover potential therapeutic targets for ASO. Differential expression of lncRNAs, including MAGOH-DT, was initially identified in arterial tissues from ASO patients compared to healthy controls through lncRNA microarray analysis. Validation of MAGOH-DT expression in response to tumor necrosis factor-alpha (TNF-α) and high glucose (HG) was performed in human umbilical vein endothelial cells (HUVECs) using RT-qPCR. The effects of MAGOH-DT and HNRPC knockdown on EndMT were assessed by evaluating EndMT markers and TGF-β2 protein expression with Western blot analysis. RNA-immunoprecipitation assays were used to explore the interaction between MAGOH-DT and HNRPC, focusing on their role in regulating TGF-β2 translation. In the results, MAGOH-DT expression is found to be upregulated in ASO and further induced in HUVECs under TNF-α/HG conditions, contributing to the facilitation of EndMT. Silencing MAGOH-DT or HNRPC is shown to inhibit the TNF-α/HG-induced increase in TGF-β2 protein expression, effectively attenuating EndMT processes without altering TGF-β2 mRNA levels. In conclusion, MAGOH-DT is identified as a key mediator in the process of TNF-α/HG-induced EndMT in ASO, offering a promising therapeutic target. Inhibition of MAGOH-DT presents a novel therapeutic strategy for ASO management, especially in cases complicated by diabetes mellitus. Further exploration into the therapeutic implications of MAGOH-DT modulation in ASO treatment is warranted.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"227-238"},"PeriodicalIF":1.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shaoyao Gancao Decoction Mitigates Helicobacter Pylori-Induced Chronic Atrophic Gastritis by Suppressing MAOB. 芍药甘草煎剂通过抑制MAOB缓解幽门螺杆菌诱发的慢性萎缩性胃炎

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-26 Epub Date: 2024-06-06 DOI: 10.1620/tjem.2024.J038

Zhaoyang Li, Xueming He, Chuming Liu

{"title":"Shaoyao Gancao Decoction Mitigates Helicobacter Pylori-Induced Chronic Atrophic Gastritis by Suppressing MAOB.","authors":"Zhaoyang Li, Xueming He, Chuming Liu","doi":"10.1620/tjem.2024.J038","DOIUrl":"10.1620/tjem.2024.J038","url":null,"abstract":"Helicobacter pylori (H. pylori) plays an important role in chronic atrophic gastritis (CAG). Interestingly, Shaoyao Gancao decoction (SGD), a traditional Chinese analgesic prescription, has the efficacy of relaxing spasms and relieving pain. Here, we aimed to identify whether SGD alleviates CAG and the underlying mechanism. A CAG mouse model was developed using H. pylori colonization and a high-salt diet. Histological staining was used to study the histopathological damage changes, and RT-qPCR assays the production of inflammatory responses in the gastric mucosa of mice. H. pylori and a high-salt diet induced gastric mucosal damage and apoptosis of gastric mucosal epithelial cells in mice, eliciting a significant inflammatory response. Treatment with SGD alleviated CAG-induced gastric mucosal damage, reduced apoptosis of gastric mucosal epithelial cells, and inhibited the inflammatory response. Bioinformatics was then used to construct the pharmacological network of SGD to explore its potential targets. SGD inhibited inflammatory response in mice with CAG by suppressing the expression of MAOB. Overexpression of MAOB impaired the therapeutic effect of SGD on inflammation in mice with CAG. Collectively, our findings indicated that SGD has the potential to alleviate CAG via downregulating MAOB.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"217-226"},"PeriodicalIF":1.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of the AMPK-mTOR Pathway by Astaxanthin against Cold Ischemia-Reperfusion in Rat Liver. 虾青素对大鼠肝脏冷缺血再灌注的 AMPK-mTOR 通路激活作用

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-26 DOI: 10.1620/tjem.2024.J103

Shujun Lu, Yajing Zhang, Wenli Yu

引用次数: 0

Development a Novel Classification Based on Serum Sodium Level Integrated with Comorbid Conditions (BASIC) in Hyponatremia Patients via Data-Driven Cluster Analysis. 通过数据驱动的聚类分析，根据低钠血症患者的血清钠水平和并发症（BASIC）建立新的分类方法

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-19 DOI: 10.1620/tjem.2024.J101

Siyu Liang, Lize Sun, Yuelun Zhang, Nan Jiang, Shi Chen, Hui Pan

引用次数: 0

Comparison of the Continuation Rates of Romosozumab and Teriparatide Administrations in a Rural Area. 罗莫司单抗和特立帕肽在农村地区持续用药率的比较

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-19 DOI: 10.1620/tjem.2024.J102

Hiroyuki Tsuchie, Hidekazu Abe, Norimitsu Masutani, Naohisa Miyakoshi

引用次数: 0

Deciphering the Mechanisms and Targets of Compound Houttuynia Cordata Mixture in COVID-19 Prevention through Integrated Network Pharmacology and Experimental Verification. 通过整合网络药理学和实验验证，破译复方蕺菜虫草混合物预防 COVID-19 的机制和靶点

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-19 DOI: 10.1620/tjem.2024.J100

Dongbo Yuan, Xiaoyue Chen, Guohua Zhu, Wei Wang, Jianguo Zhu

引用次数: 0

Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma. 三氧化二砷诱导视黄酸相关孤儿受体 Beta 并阻断 WNT 通路以抑制胶质母细胞瘤的干细胞生长

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-18 Epub Date: 2024-05-24 DOI: 10.1620/tjem.2024.J033

Dacheng Ding, Kaiming Gao, Xuebin Zhang, Hu Wang

{"title":"Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma.","authors":"Dacheng Ding, Kaiming Gao, Xuebin Zhang, Hu Wang","doi":"10.1620/tjem.2024.J033","DOIUrl":"10.1620/tjem.2024.J033","url":null,"abstract":"Glioblastoma (GBM) is a malignant primary brain tumor and an essential contributor to morbidity and mortality globally. Arsenic trioxide (ATO) exerts specific roles in preventing tumor growth. This study investigated the role of ATO in GBM cell behaviors and stemness. The effects of ATO on the malignant behavior of GBM cells, tumor stemness, and epithelial-mesenchymal transition (EMT) factors in mouse tumor tissues were explored. Targets of ATO in GBM were predicted using multiple databases. Subsequently, the expression of retinoic acid-related orphan receptor beta (RORB), WNT-1, β-Catenin, and c-Myc expression were examined in GBM cells before and after ATO treatment.ATO inhibited the malignant behavior of GBM cells in vitro and slowed down the GBM growth in vivo by inhibiting the stemness. The inhibitory effect of ATO on GBM was achieved by promoting RORB levels and strengthening the antagonism to β-Catenin to inhibit Wnt signaling, thus inhibiting tumor growth. Collectively, ATO induced RORB levels in GBM cells and strengthened the antagonistic effect on β-Catenin, thus inhibiting WNT signaling and tumor growth.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"199-210"},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Ciliary Dyskinesia with Identical Genotype but Distinct Phenotypes in Two Siblings. 两兄妹中基因型相同但表现型不同的原发性睫状肌运动障碍症

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-18 Epub Date: 2024-05-30 DOI: 10.1620/tjem.2024.J035

Megumi Sato, Yuji Fujita, George Imataka, Shigeko Kuwashima, Kazuhiko Takeuchi, Shigemi Yoshihara

{"title":"Primary Ciliary Dyskinesia with Identical Genotype but Distinct Phenotypes in Two Siblings.","authors":"Megumi Sato, Yuji Fujita, George Imataka, Shigeko Kuwashima, Kazuhiko Takeuchi, Shigemi Yoshihara","doi":"10.1620/tjem.2024.J035","DOIUrl":"10.1620/tjem.2024.J035","url":null,"abstract":"In this study, we report two cases of siblings diagnosed with primary ciliary dyskinesia (PCD) sharing an identical genotype yet exhibiting distinct phenotypes. A 13-year-old girl with acute pneumonia was admitted to our hospital. Chest and sinus radiography revealed situs inversus and bilateral maxillary sinusitis. Chest computed tomography revealed bronchiectasis. Her 6-year-old brother with acute bronchitis was admitted and was diagnosed with bronchial asthma due to recurrent wheezing. Unlike his sister, he did not have situs inversus. Both patients had a chronic wet cough and were diagnosed with bronchial asthma by their family doctor. The mean PCD rule (PICADAR) scores were 9 and 7, respectively. Genetic analysis confirmed the presence of the same homozygous mutation (c.546C > A,pTyr182Ter) in DNAI2. To date, there have been four reports of the same pathogenic variants but different PCD phenotypes. Pathological variants of DNAI2 cause the loss of the outer dynein arm, the absence of which results in a lack of primary ciliary movement involved in the left-right axis formation during the embryonic period. A lack of functional cilia results in randomized visceral asymmetry; hence, the same pathogenic variant may exhibit different phenotypes. PCD is often overlooked and is sometimes managed as bronchial asthma, as in these siblings. In our case, the PICADAR score was useful in predicting the clinical diagnosis of PCD.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"211-215"},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor. 多环芳香烃通过调节芳香烃受体调控鼻咽癌的发生和发展

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-09-12 DOI: 10.1620/tjem.2024.J095

Zhicong Hong, Qiaoling Guo, Xianyang Luo, Liying Liu

引用次数: 0