Tohoku Journal of Experimental Medicine最新文献_第8页

Correlation Between ENPP1 Gene rs1044498 Polymorphism with the Risk of Type 2 Diabetes Mellitus: A Meta-analysis. ENPP1基因rs1044498多态性与2型糖尿病风险的相关性：元分析。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-16 Epub Date: 2024-07-04 DOI: 10.1620/tjem.2024.J057

Chunlin Li, Li Liu

{"title":"Correlation Between ENPP1 Gene rs1044498 Polymorphism with the Risk of Type 2 Diabetes Mellitus: A Meta-analysis.","authors":"Chunlin Li, Li Liu","doi":"10.1620/tjem.2024.J057","DOIUrl":"10.1620/tjem.2024.J057","url":null,"abstract":"As a common metabolic disease, type 2 diabetes mellitus (T2DM) is regulated by the ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1). A functional polymorphism of ENPP1 (rs1044498, K121Q) has been found to contribute to T2DM susceptibility. This study aims to analyze the combined association of ENPP1 rs1044498 polymorphism with T2DM risk. We searched for publications in Embase, Medline, EBSCO, PubMed, China National Knowledge Infrastructure (CNKI), and Wanfang databases from January 2010 to December 2023. Pooled association strength was analyzed using either a random-effects or fixed-effects model, and expressed as combined odds ratios (ORs) with 95% confidence intervals (CIs). Data analysis was performed by STAT 12.0. Due to high heterogeneity, a random-effects model was used for the calculation. In the total population, ENPP1 rs1044498 was evidently related to an increased susceptibility to T2DM under the following models: Q vs. K (OR = 1.405, 95% CI = 1.059-1.863), KQ + QQ vs. KK (OR = 1.475, 95% CI = 1.075-2.023), QQ vs. KK + KQ (OR = 2.355, 95% CI = 1.302-4.262), QQ vs. KK (OR = 3.096, 95% CI = 1.393-6.882) and KQ vs. KK (OR = 1.399, 95% CI = 1.038-1.885). In ethnic subgroups, rs1044498 was associated with T2DM risk in Asians under the following models: Q vs. K (OR = 1.480, 95% CI = 1.017-2.154), KQ + QQ vs. KK (OR = 1.578, 95% CI = 1.047-2.379), QQ vs. KK+ KQ (OR = 3.709, 95% CI = 1.727-7.967), QQ vs. KK (OR = 5.049, 95% CI = 1.784-16.397) and KQ vs. KK (OR = 1.478, 95% CI = 1.008-2.167). The distinct association between rs1044498 and T2DM risk was discovered in the diagnostic criteria not shown subgroup and plasma subgroup. This study demonstrated high sensitivity with minimal publication bias. The ENPP1 121Q allele is a risk factor for T2DM, particularly in the Asian population.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"19-28"},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Value and Molecular Mechanism of MiR-411-5p in Coronary Atherosclerosis. MiR-411-5p在冠状动脉粥样硬化中的临床价值及分子机制

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-15 DOI: 10.1620/tjem.2025.J053

Chang Liu, Yingying Wang, Menghao Sun, Tingqi Shi

引用次数: 0

Nutritional Modulation Improves the Immune Function of Cervical Carcinoma Patients Receiving Radiotherapy: A Retrospective Analysis of 106 Cases. 营养调节对宫颈癌放疗患者免疫功能的改善：106例回顾性分析

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-15 DOI: 10.1620/tjem.2025.J052

Jianbo Li, Min Fang

引用次数: 0

Development and Performance Evaluation of a Novel Mobile X-ray System for Use in Disaster Situations. 一种用于灾害情况的新型移动x射线系统的开发和性能评估。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-15 DOI: 10.1620/tjem.2025.J054

Masaki Fujisawa, Yohei Inaba, Toshiki Kato, Masatoshi Suzuki, Koichi Chida

引用次数: 0

Predictive Value of MiR-192-5p for Complications after Caesarean Section with Scarred Uterus. miR-192-5p 对瘢痕子宫剖腹产后并发症的预测价值

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-10 Epub Date: 2024-09-12 DOI: 10.1620/tjem.2024.J090

Yang Fan, Huiling Qin, Lei Ma, Li Bian, Biao Zhao, Wei Zeng

{"title":"Predictive Value of MiR-192-5p for Complications after Caesarean Section with Scarred Uterus.","authors":"Yang Fan, Huiling Qin, Lei Ma, Li Bian, Biao Zhao, Wei Zeng","doi":"10.1620/tjem.2024.J090","DOIUrl":"10.1620/tjem.2024.J090","url":null,"abstract":"The risk of a second caesarean section with scarred uterus has attracted attention, and this study aimed to find a molecular marker to assist physicians in prenatal screening to better predict postpartum complications. Serum miR-192-5p expression was determined by qRT-PCR and 145 subjects were divided into low expression group (76) and high expression group (69) based on the miR-192-5p levels. The Receiver Operating Characteristic curve (ROC) was plotted with pelvic floor dysfunction (PFD) score, vaginal microecological environment status, and the occurrence of serious complications occurred as dependent variables. miR-192-5p expression was the test variable. Significant differences were found between the high and low MiR-192-5p expression groups in postpartum class I, class II muscle fiber strength, PFD score (p < 0.01), postpartum vaginal leukocyte esterase (p < 0.001), sialyl glycosidase (p = 0.010), acetylglucosaminidase (p = 0.024), and severe complications (p = 0.001). The ROC for predicting PFD showed an AUC of 0.861. The ROC for predicting vaginal microecological environment showed an AUC of 0.934. The ROC for predicting serious complications showed an AUC of 0.882. MiR-192-5p has the potential to be an adjunctive preoperative screening marker for cesarean section in patients with scarred uterus and has potential value in predicting the occurrence of complications after cesarean section, including PFD, vaginal microecological disorders, postoperative hemorrhage, abdominal incision infections, puerperal infections.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"11-18"},"PeriodicalIF":1.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypokalemia-Induced Rhabdomyolysis with Coexisting Hypomagnesemia A Case Report. 低钾诱导横纹肌溶解伴低镁血症1例报告。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-08 DOI: 10.1620/tjem.2025.J051

Kiyoshi Migita, Kazufumi Yamasaki, Yoshiharu Takenaka, Ryosuke Shimanine, Naofumi Sakimura, Fumi Mori, Shinpei Araki, Shuhei Yoshida, Tomoyuki Asano, Ichiro Isomoto

引用次数: 0

Calcitriol Prevents Isoproterenol-Induced Myocardial Fibrosis by Regulating the TGF-β1/SMAD Sensor via Binding to the Nuclear Vitamin D Receptor. 骨化三醇通过与核维生素D受体结合调节TGF-β1/SMAD传感器，预防异丙肾上腺素诱导的心肌纤维化。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-08 DOI: 10.1620/tjem.2025.J050

Jinhua Wang, Qingling Wang, Chunyan Huang, Bin Zhang, Qihu Wang, Tingbo Jiang

引用次数: 0

Oxymatrine Inhibits PKM2-Mediated Glycolysis and Enhances Cisplatin Sensitivity in Bladder Cancer. 氧化苦参碱抑制pkm2介导的糖酵解并增强膀胱癌顺铂敏感性。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-08 DOI: 10.1620/tjem.2025.J049

Hui Zhang, Jun Li

引用次数: 0

Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor. 多环芳香烃通过调节芳香烃受体调控鼻咽癌的发生和发展

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-03 Epub Date: 2024-09-12 DOI: 10.1620/tjem.2024.J095

Zhicong Hong, Qiaoling Guo, Xianyang Luo, Liying Liu

{"title":"Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor.","authors":"Zhicong Hong, Qiaoling Guo, Xianyang Luo, Liying Liu","doi":"10.1620/tjem.2024.J095","DOIUrl":"10.1620/tjem.2024.J095","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) has hidden onset, low rate of early diagnosis, and most of them have metastases at the time of diagnosis. The specific pathogenesis of NPC is still unclear. Polycyclic aromatic hydrocarbons (PAHs) are a large group of contaminants produced by the incomplete combustion of organic matter and widespread in the air. Many of these compounds are mutagenic and carcinogenic. PAHs plays an important role in mutagenic and carcinogenic, while its role in NPC still needs further elucidation. In this study, CNE-2 cells were stimulated by PAHs, then the expression of aryl hydrocarbon receptor (AhR) and CYP1A2 were respectively examined using Real-Time fluorescence quantitative PCR (qRT-PCR) and Western Blot. CNE-2 cells proliferation, migration, invasion and apoptosis were examined by CCK-8, Wound-Healing Assay, Transwell, Flow Cytometry, respectively. We found that AhR expression was increased while the level of apoptosis was inhibited by PAHs. While the ability of cell invasion was weakened, proliferation and migration were not significantly different. After treated by PAHs and ITE, the effect of PAHs on promoting AhR expression was significantly inhibited and apoptosis was up-regulated. The present study found that, PAHs inhibit apoptosis of NPC cells and promote the expression of AhR. Besides, PAHs participates in NPC occurrence and development by regulating AhR expression. Collectively, these findings may provide a possible strategy for the clinical treatment of NPC.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"221-228"},"PeriodicalIF":1.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-24-3p Inhibits Migration and Proliferation of HUVECs by Downregulating CHI3L1. MiR-24-3p 通过下调 CHI3L1 抑制 HUVEC 的迁移和增殖

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-05-03 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J128

Guanjun Wu, Lei Gao, Xin Zhang, Qi Xue, Lifang Ye, Yaru Zheng, Jianlei Zheng

{"title":"MiR-24-3p Inhibits Migration and Proliferation of HUVECs by Downregulating CHI3L1.","authors":"Guanjun Wu, Lei Gao, Xin Zhang, Qi Xue, Lifang Ye, Yaru Zheng, Jianlei Zheng","doi":"10.1620/tjem.2024.J128","DOIUrl":"10.1620/tjem.2024.J128","url":null,"abstract":"Angiogenesis is regarded as a critical factor in the pathogenesis of unstable atherosclerotic plaques, and numerous proteins and microRNAs (miRNAs) were involved in this process. In our previous study, the overexpression of Chitinase 3-like 1 (CHI3L1) aggravates the neo-vessels in carotid plaques of apoE-/- mice fed with a high-fat diet. MiR-24-3p is one of target miRNAs adjusting the expression of CHI3L1. Extracellular signal-regulated kinase (ERK) signaling pathway is an important regulator related to cell proliferation and pathophysiological process of CHI3L1. This study aims to investigate whether the miR-24-3p plays a role in migration and proliferation of human umbilical vein endothelial cells (HUVECs) through influencing the expression of CHI3L1 and potential molecular mechanism. CCK8 assay, transwell and matrigel tests were used to determine the effects of miR-24-3p on proliferation, migration and tube formation of HUVECs by targeting CHI3L1. Luciferase assay was carried out to value the direct interaction between miR-24-3p and CHI3L1 3'-untranslated region (3'-UTR). Western blot was used to measure protein expression of CHI3L1, ERK and phosphorylation of ERK (p-ERK). This study demonstrated that miR-24-3p mimic inhibits the proliferation, migration and angiogenesis of HUVECs. The role of miR-24-3p affects the function of HUVECs through negative regulation of CHI3L1 expression targeting CHI3L1 3'-UTR. Furthermore, we found that p-ERK was accordant with CHI3L1 expression in HUVECs, and miR-24-3p mimics significantly diminished the CHI3L1 expression and the level of p-ERK. MiR-24-3p is one of miRNAs regulating the expression and function of CHI3L1, which may provide an efficient strategy for treatment of angiogenesis in atherosclerotic plaques.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"271-278"},"PeriodicalIF":1.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0