Tohoku Journal of Experimental Medicine最新文献_第7页

Long Noncoding RNA GAS5 Contributes to Mycoplasma pneumoniae Pneumonia by Regulating NF-κB via miR-29c/HMGB1 Axis. 长非编码 RNA GAS5 通过 MiR-29c/HMGB1 轴调控 NF-κB 促进肺炎支原体肺炎的发生

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-23 Epub Date: 2024-07-18 DOI: 10.1620/tjem.2024.J067

Juhua Ji, Fei Hong, Yi Liu, Xiaobin Chu, Lei Song, Meijun Zhu, Yan Lu, Chuangli Hao

{"title":"Long Noncoding RNA GAS5 Contributes to Mycoplasma pneumoniae Pneumonia by Regulating NF-κB via miR-29c/HMGB1 Axis.","authors":"Juhua Ji, Fei Hong, Yi Liu, Xiaobin Chu, Lei Song, Meijun Zhu, Yan Lu, Chuangli Hao","doi":"10.1620/tjem.2024.J067","DOIUrl":"10.1620/tjem.2024.J067","url":null,"abstract":"Mycoplasma pneumoniae pneumonia (MPP) poses a major threat to pediatric health. Our previous study suggested that GAS5 level was elevated in the peripheral blood of MPP children. However, the mechanism by which GAS5 regulates lung inflammation Mycoplasma pneumoniae (MP) infection-induced remains unknown. An MPP mouse model was constructed by MP intranasal injection to enrich for alveolar macrophage (AM). Mouse AM was stimulated using lipid-associated membrane proteins (LAMPs) to mimic an in vitro pneumonia model, and transfection was used to achieve specific knockdown or overexpression of target genes. GAS5 level was significantly increased in AM of the MPP mouse model, and significantly and positively related with the mRNA level of HMGB1, but no physical binding between GAS5 and HMGB1 proteins. miR-29c level was significantly decreased in AM of the MPP mouse model and negatively related with the HMGB1. We found the specific binding of GAS5 to miR-29c, and the specific binding of miR-29c to the HMGB1 mRNA 3'UTR. miR-29c mimic and knockdown of HMGB1 both significantly impeded LAMPs-induced apoptosis, IL-6 and TNF-α secretion, and the NF-κB activation. Ectopic expression of GAS5 counteracted the effect of miR-29c mimic, and miR-29c inhibitor counteracted the effect of HMGB1 knockdown. Furthermore, silencing of GAS5 significantly alleviated MPP-induced inflammation and pathological lung injury in the MPP mouse model. GAS5/miR-29c/HMGB1 is highly involved in inflammation and lung histopathological injury in MPP disease progression by regulating the NF-κB signaling pathway.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"193-202"},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of MiR-19-3p and MiR-124-3p for Complications and Pelvic Floor Dysfunction in Cesarean Section Women. MiR-19-3p和MiR-124-3p对剖宫产术后并发症及盆底功能障碍的预测价值

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2025.J003

Qun Mu, Meiyi Chen, Yuan Li, Li Liu, Xiating Shi

引用次数: 0

Enhancing Perioperative Recovery in Gestational Diabetes: Assessing the Effectiveness of an Enhanced Recovery after Surgery Protocol for Cesarean Section. 提高妊娠期糖尿病的围手术期恢复：评估剖宫产术后提高恢复的有效性。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2025.J001

Ye-Qing Xu, Xiao-Xu Zhang, Jun Xu, Li-Xiang Feng

引用次数: 0

The Far Negative Intercept of the Regression Formula Obtained from Repeated Measurements of BChE and Albumin Levels is Useful for Detecting Hereditary Heterozygous Butyrylcholinesterase Deficiency in Patients on Dialysis. 从反复测量BChE和白蛋白水平得到的回归公式的远负截距可用于检测透析患者的遗传性杂合丁基胆碱酯酶缺乏症。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2024.J149

Naoki Tokunaga, Hisato Shima, Takuya Okamoto, Masato Maekawa, Jun Minakuchi

引用次数: 0

Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project. 基于语言注册的韦氏记忆量表手写逻辑记忆评分系统-修订：在东北医疗大银行项目中开发和验证。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2025.J006

Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto

引用次数: 0

Protein-Losing Enteropathy Following Adrenocorticotropic Hormone Therapy in an Infant with West Syndrome. 西部综合征婴儿促肾上腺皮质激素治疗后的蛋白质丢失性肠病。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2025.J002

Akira Akutsu, Yuji Fujita, Hiroaki Hitomi, Fumitaka Takayanagi, Yusuke Ando, George Imataka, Hideaki Shiraishi, Shigemi Yoshihara

引用次数: 0

Efficacy of Cognitive Behavioral Therapy Combined with Jacobson Progressive Muscle Relaxation in Improving Sleep Quality and Overall Well-Being in Hemodialysis Patients with Insomnia: A Randomized Controlled Trial. 认知行为疗法联合雅各布森渐进式肌肉放松对改善血液透析失眠患者睡眠质量和整体幸福感的疗效：一项随机对照试验。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2025.J005

Wei-Ying Chen, Jin Li, Dan Xia

引用次数: 0

The Effect of CDT-Based Rehabilitation Nursing on Breast Cancer-Related Lymphedema. 基于cdt的康复护理对乳腺癌相关淋巴水肿的影响。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-16 DOI: 10.1620/tjem.2025.J004

Jing Zhao, Ying Zhang, Jingjing Han, Wenjuan Zhu, Shaomei Yang, Xin Wang, Jingjing Duan

引用次数: 0

Tumor Forkhead Box J2 as a Biomarker Reflecting Risks of Recurrence and Death in Non-Small Cell Lung Cancer Receiving Surgical Resection. 反映接受手术切除的非小细胞肺癌患者复发和死亡风险的生物标记物--肿瘤叉头盒 J2

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-11 Epub Date: 2024-07-04 DOI: 10.1620/tjem.2024.J059

Riya Su, Yao Li, Lan Du, Ze Xing, Rihan Wu, Qun Hu

{"title":"Tumor Forkhead Box J2 as a Biomarker Reflecting Risks of Recurrence and Death in Non-Small Cell Lung Cancer Receiving Surgical Resection.","authors":"Riya Su, Yao Li, Lan Du, Ze Xing, Rihan Wu, Qun Hu","doi":"10.1620/tjem.2024.J059","DOIUrl":"10.1620/tjem.2024.J059","url":null,"abstract":"Forkhead box J2 (FOXJ2) induces cell apoptosis and restrains epithelial-mesenchymal transition in lung cancer, but its capability to serve as a prognostic biomarker in non-small cell lung cancer (NSCLC) remains unclear. Hence, this study intended to investigate the association of FOXJ2 with clinical characteristics, disease-free survival (DFS), and overall survival (OS) in NSCLC patients who received surgical resection. Totally, 182 NSCLC patients who received surgical resection were retrospectively enrolled. Their tumor FOXJ2 expression was quantified by immunohistochemistry (IHC). FOXJ2 IHC score = s taining intensity × density, with a total score of 12. FOXJ2 IHC score was 0 in 128 (70.3%) patients and > 0 in the remaining 54 (29.7%) patients; meanwhile, it was ≤ 3 in 157 (86.3%) patients and > 3 in 25 (13.7%) patients. FOXJ2 was negatively related to node (N) stage (P = 0.013) and tumor-nodes-metastasis (TNM) stage (P = 0.034). Intriguingly, FOXJ2 IHC score was reduced in patients with adjuvant chemotherapy than in patients without adjuvant chemotherapy (P = 0.036). The median DFS and OS (95% confidence interval) were 35.0 (31.3-38.7) months and 48.8 (43.7-53.9) months, respectively. Notably, FOXJ2 IHC score > 0 (P = 0.006) and > 3 (P = 0.002) was correlated with prolonged DFS. Also, FOXJ2 IHC score > 0 (P = 0.027) and > 3 (P = 0.028) was associated with longer OS. After adjustment by backward stepwise multivariate model, FOXJ2 IHC score > 3 was independently associated with prolonged DFS (hazard ratio = 0.367, P = 0.009). In conclusion, tumor FOXJ2 negatively links with N stage and TNM stage; moreover, FOXJ2 IHC score > 3 estimates prolonged DFS and OS in NSCLC patients who received surgical resection.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"159-167"},"PeriodicalIF":1.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loneliness, Spiritual Well-Being, Anxiety, Depression, and Attitude to Death of Gastrointestinal Cancer Patients Treated with Rumor Resection. 接受肿瘤切除术治疗的消化道癌症患者的孤独感、精神健康、焦虑、抑郁以及对死亡的态度。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-11 Epub Date: 2024-07-18 DOI: 10.1620/tjem.2024.J065

Huikun Cao, Heng Zhou

{"title":"Loneliness, Spiritual Well-Being, Anxiety, Depression, and Attitude to Death of Gastrointestinal Cancer Patients Treated with Rumor Resection.","authors":"Huikun Cao, Heng Zhou","doi":"10.1620/tjem.2024.J065","DOIUrl":"10.1620/tjem.2024.J065","url":null,"abstract":"Gastrointestinal cancer (GIC) patients with tumor resection may experience surgical complications, economic burden, and weakened social connection, which could lead to adverse psychological status. Thus, this study aimed to explore multidimensional psychological status of these patients, encompassing loneliness, spiritual well-being, anxiety, depression, and attitudes to death. Totally, 210 GIC patients with tumor resection and 50 healthy controls (HCs) were enrolled to complete the University of California Los Angeles loneliness (UCLA-LS), functional assessment of chronic illness therapy-spiritual well-being (FACIT-Sp), hospital anxiety and depression scale-anxiety/depression (HADS-A/D), and death attitude profile-revised (DAP-R) scales. UCLA-LS score was increased (P < 0.001), while FACIT-Sp score was decreased (P < 0.001) in GIC patients than HCs. Additionally, HADS-A score (P < 0.001), anxiety rate (P < 0.001), moderate to severe anxiety rate (P < 0.001), HADS-D score (P < 0.001), depression rate (P < 0.001), and moderate to severe depression rate (P = 0.011) were all elevated in GIC patients versus HCs. Concerning attitude to death, DAP-R scores for fear of death (P < 0.001) and death avoidance (P < 0.001) were increased, and the scores for neutral (P < 0.001) and approach (P = 0.010) acceptance were declined in GIC patients than HCs. Notably, female sex, unmarried status, and drinking history were independently linked with increased UCLA-LS score, but gastric cancer was independently associated with decreased UCLA-LS score (all P < 0.050). Neoadjuvant therapy was independently related to anxiety (P = 0.012). Female sex was independently correlated with depression (P = 0.006). In conclusion, GIC patients with tumor resection experience loneliness, anxiety, depression, and reduced spiritual well-being. They tend to fear and avoid, rather than accept death.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"169-178"},"PeriodicalIF":1.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0