Tohoku Journal of Experimental Medicine最新文献

{"title":"An Indolent Aldosterone-Producing Adenoma in a Young Hypertensive Patient Manifested during 7-Year Follow-up.","authors":"Yuta Tezuka, Yoshikiyo Ono, Yuto Yamazaki, Satoshi Higuchi, Jun Nishikawa, Kei Omata, Sota Oguro, Hideki Ota, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Takashi Suzuki, Hironobu Sasano, Tetsuhiro Tanaka, Fumitoshi Satoh","doi":"10.1620/tjem.2025.J060","DOIUrl":"https://doi.org/10.1620/tjem.2025.J060","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Abnormally Expressed Serum MiR-204-5p in Pregnancy during Second Trimester on Subclinical Hypothyroidism.","authors":"Qian Wang, Jingsong Cheng, Wenjing He, Xiaofeng Li, Jun Ma, Xiaoyan Wang, Xing Wu, Lin Ma, Lin Guo","doi":"10.1620/tjem.2025.J063","DOIUrl":"https://doi.org/10.1620/tjem.2025.J063","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Serum MiR-106a-5p on Vascular Calcification in Dialysis Patients.","authors":"Hong Zhang, Zhihang Jiang, Lei Xu, Jihong Zhang, Yawei Yuan, Xuanlin Lu","doi":"10.1620/tjem.2025.J064","DOIUrl":"https://doi.org/10.1620/tjem.2025.J064","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin Nano-Formulations with Enhanced Bioavailability and Therapeutic Efficacy for Osteoarthritis Treatment.","authors":"Fan Zhong, Jinyi Zhang, Lin Teng, Dahai Liu, Yongchuan Xiao, Gang Zhong","doi":"10.1620/tjem.2025.J062","DOIUrl":"https://doi.org/10.1620/tjem.2025.J062","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of SCN2A Gene Polymorphism on Drug Response in Han Chinese Children with Epilepsy.","authors":"Lin Xu, Jie Fan, Yongbiao Zou","doi":"10.1620/tjem.2025.J061","DOIUrl":"https://doi.org/10.1620/tjem.2025.J061","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: The Ohasama Study.","authors":"Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo","doi":"10.1620/tjem.2024.J139","DOIUrl":"10.1620/tjem.2024.J139","url":null,"abstract":"<p><p>Although the association between the number of deliveries and cognitive impairment has been previously examined, the influence of subclinical cerebrovascular diseases (SCDs), such as silent cerebrovascular lesions and carotid atherosclerosis, on this association remains unclear. This cross-sectional study aimed to examine whether SCDs mediated the association between the number of deliveries and cognitive impairment. Among 627 Japanese women with a mean age of 73 years, the number of deliveries was collected in the 1998 survey and classified into four groups (0-1, 2, 3, ≥ 4), with two deliveries as the reference. At the annual comprehensive medical examinations, cognitive function was assessed using the Mini-Mental State Examination (MMSE), and SCDs were evaluated using brain magnetic resonance imaging and ultrasonography. Each participant's latest data on these variables and covariates between 1992 and 2018 were used. MMSE scores were divided into three ordinal categories: ≥ 28 (normal), 24-27 (mild cognitive impairment; MCI), and ≤ 23 (severe cognitive impairment). Ordinal logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive impairment. The ORs for cognitive impairment associated with the number of deliveries were 2.13 (95% CI, 1.21-3.76) in the lowest (0-1) group and 1.45 (0.95-2.23) in the highest (≥ 4) group. These association estimates remained similar after adjusting for SCDs but were weaker in the more recent birth year group. We demonstrated a U-shaped association between the number of deliveries and cognitive impairment, independent of SCDs, and the cohort effect confounded the association.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"69-79"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional Study of the Association Between Plasma Brain Natriuretic Peptide Levels and Left Ventricular Shortening Fraction in Fukuyama Congenital Muscular Dystrophy.","authors":"Takatoshi Sato, Yuki Kihara, Kumiko Ishiguro, Minobu Shichiji, Terumi Murakami, Satoru Nagata, Eriko Shimada, Kei Inai, Atsuhito Takeda, Keiko Ishigaki","doi":"10.1620/tjem.2024.J137","DOIUrl":"10.1620/tjem.2024.J137","url":null,"abstract":"<p><p>This study aimed to investigate the correlation between plasma brain natriuretic peptide levels and left ventricular shortening fraction in Fukuyama congenital muscular dystrophy. The correlation between brain natriuretic peptide levels and left ventricular shortening fraction in patients with genetically confirmed Fukuyama congenital muscular dystrophy was retrospectively investigated. The patients at Tokyo Women's Medical University were followed-up from October 2015 to October 2020. The brain natriuretic peptide level was measured using a specific immunoradiometric assay kit. Left ventricular shortening fraction was defined as a degree of left ventricular systolic function within 3 months before and after brain natriuretic peptide measurements. In addition to left ventricular shortening fraction, the ratio of early filling to early diastolic and the maximum velocity of tricuspid regurgitation, which are measures of diastolic function, were investigated. In total, 27 sets of brain natriuretic peptide levels and echocardiography results were obtained from 16 patients with Fukuyama congenital muscular dystrophy. Excellent correlations were found between the brain natriuretic peptide levels and left ventricular shortening fraction (R² = 0.8755). Patients with a left ventricular shortening fraction of > 20% had low brain natriuretic peptide levels. However, the brain natriuretic peptide values of patients with a left ventricular shortening fraction of < 20% were > 40 pg/mL. In Fukuyama congenital muscular dystrophy, the brain natriuretic peptide level was exponentially correlated with left ventricular shortening fraction. However, it did not elevate until the advanced stage of left ventricular systolic dysfunction.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"81-85"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cornuside Ameliorates Diabetic Nephropathy Possibly by Regulating Angiogenesis and MAPK Signaling.","authors":"Fang Xiang, Xin Li, Wei Hu","doi":"10.1620/tjem.2024.J112","DOIUrl":"10.1620/tjem.2024.J112","url":null,"abstract":"<p><p>Diabetic nephropathy (DN) is a prevalent diabetic complication seriously threatening patients' health and lives. Cornuside is an iridoid glycoside compound with various pharmacological properties. Nonetheless, whether cornuside has a protective effect against DN remains unillustrated. In this study, a rat model for DN was established by streptozotocin (STZ) injection. Rat podocytes were stimulated with high glucose (HG) to mimic a DN microenvironment in vitro. Several indicators linked to kidney function were evaluated. Periodic Acid-Schiff (PAS) and hematoxylin-eosin staining were implemented for renal histologic analysis. Immunofluorescence staining of CD31 was used for the detection of neovascularization. Western blotting was employed to assess levels of angiogenic factors and MAPK signaling-related proteins in the kidney or podocytes. The results showed that cornuside administration alleviated STZ-elicited renal dysfunction, as evidenced by the reduction in fasting blood glucose, proteinuria, serum creatinine, and blood urea nitrogen. Cornuside attenuated renal pathological lesions in DN rats. Cornuside repressed angiogenesis in DN rat kidney tissues and podocytes. Cornuside blocked MAPK signaling in HG-stimulated podocytes. In conclusion, cornuside alleviates renal injury in DN rats possibly by hindering angiogenesis and MAPK signaling.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"87-95"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miR-505-5p as a Diagnostic Marker for Acute Cerebral Infarction and Its Predictive Value for Clinical Outcomes After Endovascular Mechanical Thrombectomy.","authors":"Jingyi Ruan, Jian Zhou, Gaoyi Li, Tao Peng, Jingquan Zhang, Bing Wei","doi":"10.1620/tjem.2024.J085","DOIUrl":"10.1620/tjem.2024.J085","url":null,"abstract":"<p><p>This study aimed to evaluate the diagnostic significance of miR-505-5p in Acute cerebral infarction (ACI) and its prognostic utility following endovascular mechanical thrombectomy. A total of 138 patients with ACI and 120 healthy controls participated. RT-qPCR quantified miR-505-5p levels in serum and cerebrospinal fluid (CSF). The National Institutes of Health Stroke Scale (NIHSS) scores assessed the severity of the disease. Furthermore, the modified Rankin Scale (mRS) score evaluated the prognosis one year after endovascular mechanical thrombectomy. The Pearson coefficient analyzed the correlation between miR-505-5p and NIHSS or mRS scores. Logistic regression determined risk factors associated with poor outcomes. The receiver operating characteristic (ROC) curve assessed diagnostic and prognostic accuracy. miR-505-5p levels in serum and CSF were significantly elevated in ACI patients compared to controls ( P < 0.05). A positive correlation existed between serum miR-505-5p and NIHSS score, which increased with disease severity. miR-505-5p demonstrated 81.88% sensitivity and 85.83% specificity in identifying ACI patients, with levels correlated to mRS scores. Higher levels of miR-505-5p indicated a poor prognosis in ACI patients, suggesting its role as a potential biomarker for adverse outcomes and mortality. Both miR-505-5p and NIHSS scores emerged as risk factors for negative outcomes. Serum miR-505-5p serves as a biomarker for predicting poor prognosis and mortality in patients.In conclusion, elevated serum miR-505-5p may act as a diagnostic biomarker for ACI and correlates with unfavorable prognoses a worse prognosis in patients having endovascular mechanical thrombectomy.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"59-67"},"PeriodicalIF":1.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid-lowering effect of Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.","authors":"Youjin Zhang, Jin Yang, Qianyin Pang, Zhimin Lv, Dan Zhu, Yunhan Wang, Yongyan Song","doi":"10.1620/tjem.2024.J079","DOIUrl":"10.1620/tjem.2024.J079","url":null,"abstract":"<p><p>Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections, four traditional Chinese medicine prescriptions, have been widely explored regarding their lipid-lowering property, but the findings were inconsistent and inconclusive. This meta-analysis was to clarify the lipid-lowering effect of the four injections. PubMed, Scopus, Embase, Web of Science, Google Scholar, Cochrane Library and CNKI databases were searched, and data including age, sex, ethnicity, disease type, dose, duration, sample size and blood lipids were extracted from each eligible study. The alterations in lipids from pre- to post-treatment were calculated and compared between control and treatment groups, and standardized mean differences (SMDs) with 95% confidence intervals (CIs) were used to assess the lipid-lowering effect of the injections. Twenty-eight studies (2,624 subjects), 31 studies (3,023 subjects), 17 studies (1,507 subjects) and 54 studies (4,435 subjects) were respectively identified for Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections. All of the four injections could effectively and significantly reduce serum levels of triglycerides (p < 0.001 for all), total cholesterol (p < 0.001 for all) and low-density lipoprotein cholesterol (p < 0.001 for all), and elevate high-density lipoprotein cholesterol level (p ≤ 0.02 for all). Shuxuening injection had the strongest lipid-lowering effect with almost twice that of the other three injections. Danshen, Fufang Danshen and Shuxuening injections showed a good lipid-lowering effect on patients with heart disease, while Shuxuetong injection displayed a powerful lipid-lowering effect among diabetic patients. Unfortunately, all of these injections had a poor lipid-lowering effect in patients with renal disease. The meta-analysis demonstrates that Danshen, Fufang Danshen, Shuxuening and Shuxuetong injections all can effectively reduce blood lipids. Among them, Shuxuening injection has the strongest lipid-lowering effect with almost twice that of the other three injections. In terms of reducing blood lipid levels, Danshen, Fufang Danshen and Shuxuening injections are suitable for patients with cardiovascular disease, Shuxuetong injection is suitable for patients with diabetes, but none of them is suitable for patients with renal disease.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"47-58"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}