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Mechanism of Hippo/YAP Axis Mediating High Glucose-Induced Ferroptosis in HK-2 Cells. Hippo/YAP轴介导高糖诱导HK-2细胞铁下垂的机制。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-28 Epub Date: 2024-12-26 DOI: 10.1620/tjem.2024.J148
Yifan Zhang, Zhaoyu Lin, Zhoutao Xie, Yingxue He
{"title":"Mechanism of Hippo/YAP Axis Mediating High Glucose-Induced Ferroptosis in HK-2 Cells.","authors":"Yifan Zhang, Zhaoyu Lin, Zhoutao Xie, Yingxue He","doi":"10.1620/tjem.2024.J148","DOIUrl":"10.1620/tjem.2024.J148","url":null,"abstract":"<p><p>The current study focused on the molecular mechanisms behind high glucose (HG)-induced ferroptosis in HK-2 cells. HG-induced epithelial-to-mesenchymal transition (EMT) HK-2 cell model displayed elevated Vimentin, α-SMA, Fe<sup>2+</sup> and MDA expression, suppressed cell viability and proliferation capabilities, decreased E-cadherin, GPX4 and GSH levels, and increased cell death. Additionally, knockdown of Vimentin or α-SMA caused the opposite outcomes. Restaint of ferroptosis partially reversed the promotion role of knockdown of Vimentin or α-SMA in HK-2 cell proliferation. Further inhibition of the Hippo/YAP pathway could partly regulate the effects of Vimentin or α-SMA on HG-induced ferroptosis and proliferation in HK-2 cells. Conclusively, HG could increase the expression levels of Vimentin and α-SMA in HK-2 cells, and induce EMT, thereby inhibiting the activation of the Hippo/YAP signaling axis and cell proliferation, and promoting cell ferroptosis of HK-2 cells.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"209-217"},"PeriodicalIF":1.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of Perinatal Outcomes in Type 1 and Type 2 Diabetes Pregnancies: A Retrospective Study. 1型和2型糖尿病妊娠围产儿结局的回顾性比较分析
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-26 DOI: 10.1620/tjem.2025.J080
Mai Sue-Nagumo, Akihito Morita, Daisuke Higeta, Maki Inoue, Aya Osaki, Satoshi Yoshino, Shunichi Matsumoto, Kazuhiko Horiguchi, Shuichi Okada, Akira Iwase, Eijiro Yamada
{"title":"Comparative Analysis of Perinatal Outcomes in Type 1 and Type 2 Diabetes Pregnancies: A Retrospective Study.","authors":"Mai Sue-Nagumo, Akihito Morita, Daisuke Higeta, Maki Inoue, Aya Osaki, Satoshi Yoshino, Shunichi Matsumoto, Kazuhiko Horiguchi, Shuichi Okada, Akira Iwase, Eijiro Yamada","doi":"10.1620/tjem.2025.J080","DOIUrl":"10.1620/tjem.2025.J080","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-324-3p Drives Malignant Behaviors of Tumor Cells by Promoting M2 Macrophage Polarization in Laryngeal Squamous Cell Carcinoma. MiR-324-3p在喉癌中通过促进M2巨噬细胞极化驱动肿瘤细胞的恶性行为
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-26 DOI: 10.1620/tjem.2025.J083
Jinqiao Huang, Xiufen Chen, Xian Chen
{"title":"MiR-324-3p Drives Malignant Behaviors of Tumor Cells by Promoting M2 Macrophage Polarization in Laryngeal Squamous Cell Carcinoma.","authors":"Jinqiao Huang, Xiufen Chen, Xian Chen","doi":"10.1620/tjem.2025.J083","DOIUrl":"https://doi.org/10.1620/tjem.2025.J083","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ligustilide Promotes Gastric Cancer Cell Apoptosis via Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction and Autophagy. 藁本内酯通过内质网应激诱导的线粒体功能障碍和自噬促进胃癌细胞凋亡。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-26 DOI: 10.1620/tjem.2025.J082
Hanqing Liu, Qiong Xiang, Shasha Mei, Jingyi Yang, Dan Ma, Bowen Wang, Enfeng Song, Hong Zhu
{"title":"Ligustilide Promotes Gastric Cancer Cell Apoptosis via Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction and Autophagy.","authors":"Hanqing Liu, Qiong Xiang, Shasha Mei, Jingyi Yang, Dan Ma, Bowen Wang, Enfeng Song, Hong Zhu","doi":"10.1620/tjem.2025.J082","DOIUrl":"https://doi.org/10.1620/tjem.2025.J082","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model. 马尾草总黄酮通过PGRMC2调节卵巢储备功能减退大鼠模型中Th17/Treg平衡
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-26 DOI: 10.1620/tjem.2025.J081
Ting Zhou, Shanshan Xu, Juan Tang, Xiaomei Han, Yu Jiang, Huaying Chen
{"title":"Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model.","authors":"Ting Zhou, Shanshan Xu, Juan Tang, Xiaomei Han, Yu Jiang, Huaying Chen","doi":"10.1620/tjem.2025.J081","DOIUrl":"https://doi.org/10.1620/tjem.2025.J081","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulated Long Non-Coding RNA DANCR in Polycystic Ovary Syndrome Drives Granulosa Cell Apoptosis and Contributes to Ovarian Dysfunction via MiR-185-5p. 多囊卵巢综合征中长链非编码RNA DANCR异常通过MiR-185-5p驱动颗粒细胞凋亡并参与卵巢功能障碍
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-26 DOI: 10.1620/tjem.2025.J084
Jie An, Qin Zhou, Xueqian Liu, Jingjing Ren, Yijiao Cheng, Yanjiao Liu, Zhenzhen Cao
{"title":"Dysregulated Long Non-Coding RNA DANCR in Polycystic Ovary Syndrome Drives Granulosa Cell Apoptosis and Contributes to Ovarian Dysfunction via MiR-185-5p.","authors":"Jie An, Qin Zhou, Xueqian Liu, Jingjing Ren, Yijiao Cheng, Yanjiao Liu, Zhenzhen Cao","doi":"10.1620/tjem.2025.J084","DOIUrl":"https://doi.org/10.1620/tjem.2025.J084","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D Supplementation Reduces Functional Impairment of Hippocampus Caused by Dexamethasone. 补充维生素D可减轻地塞米松对海马功能的损害
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-25 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J122
Qiaoer Su, Minjie Pan, Qiu Wang, Weimin Yang
{"title":"Vitamin D Supplementation Reduces Functional Impairment of Hippocampus Caused by Dexamethasone.","authors":"Qiaoer Su, Minjie Pan, Qiu Wang, Weimin Yang","doi":"10.1620/tjem.2024.J122","DOIUrl":"10.1620/tjem.2024.J122","url":null,"abstract":"<p><p>The use of dexamethasone in premature infants has adverse effects on neurological function. Vitamin D is considered to be vital nutrient for neurological diseases. Pups were randomly divided into the control, model and treated groups. Treated group received vitamin D on postnatal day1 (60,000 IU/kg). Following, model and treated group received dexamethasone from postnatal day 2 to postnatal day 4 following tapering doses (0.5, 0.3, and 0.1 mg/kg.d, respectively). Pups' neurological function was assessed by wire-hanging test and Morris water maze task. And apoptotic cells in hippocampus were counted. Vitamin D effectively improved spatial learning and memory impairment induced by dexamethasone. The protective effects of vitamin D may be related to the modulation of apoptosis. Vitamin D may therefore have a role in bronchopulmonary dysplasia treatment process.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"127-134"},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of V. vulnificus Infection in Non-Coastal Area's Farmer. 非沿海地区农民感染弧菌的病例。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-25 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J121
Chun-Li Lv, Peng Xu, Qing-Liang Liu, Song Gao, An-Lin Chen, Wei-Qun Huang, Xiao-Min Wang
{"title":"A Case of V. vulnificus Infection in Non-Coastal Area's Farmer.","authors":"Chun-Li Lv, Peng Xu, Qing-Liang Liu, Song Gao, An-Lin Chen, Wei-Qun Huang, Xiao-Min Wang","doi":"10.1620/tjem.2024.J121","DOIUrl":"10.1620/tjem.2024.J121","url":null,"abstract":"<p><p>The infection of Vibrio vulnificus (V. vulnificus) can cause numerous clinical manifestations with high mortality. Aquatic products and sea water are typically the primary routes of infection. This article narrates a case of V. vulnificus infection in a farmer from an inland mountain area, who, unusually, contracted the infection through insect-borne transmission. The patient had a medical history of fatty liver disease and chronic alcohol consumption, which significantly increased the risk of V. vulnificus infection. He presented with swelling and pain in the lower left leg, along with scattered areas of skin necrosis and localized hemorrhagic bullae. His condition rapidly progressed to septic shock. Regrettably, the patient suffered a cardiac arrest during an emergency fasciotomy and passed away within 12 hours of admission. The retrospective analysis of this case aims to re-examine the way of infection of the disease, improve the understanding of clinicians in non-coastal areas of V. vulnificus infection, and achieve early diagnosis and treatment.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"193-197"},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal Expression of lncRNA SNHG7 in Dry Eye Disease and Its Effect on Human Conjunctival Epithelial Cells. 干眼症中 lncRNA SNHG7 的异常表达及其对人类结膜上皮细胞的影响
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-20 Epub Date: 2024-11-21 DOI: 10.1620/tjem.2024.J134
Shuang Liu, Guang Yang, Qingnan Li, Shaohua Tang
{"title":"Abnormal Expression of lncRNA SNHG7 in Dry Eye Disease and Its Effect on Human Conjunctival Epithelial Cells.","authors":"Shuang Liu, Guang Yang, Qingnan Li, Shaohua Tang","doi":"10.1620/tjem.2024.J134","DOIUrl":"10.1620/tjem.2024.J134","url":null,"abstract":"<p><p>Analyzing the pathogenic mechanism of dry eye disease provides a new research point for the treatment of patients. A total of 86 patients with dry eye disease and the same number of healthy individuals were recruited as the patient group and normal group. The levels of small nucleolar RNA host gene 7 (SNHG7) in tear samples and human conjunctival epithelial cells (HCECs) were determined by a quantitative real-time PCR (RT-qPCR). Meanwhile, TNF-α and IL-6 mRNA levels in HCECs were also detected by RT-qPCR. The molecular mechanism of SNHG7 was analyzed by biological prediction and luciferase activity assay. The correlation between the expression of SNHG7 and microRNA-146a-5p (miR-146a-5p) with clinical indicators in dry eye disease patients using Pearson analysis. SNHG7 expression in tears samples and HCECs from dry eye disease patients was significantly increased (P < 0.001). The levels of TNF-α mRNA and IL-6 mRNA were upregulated in the HCECs model group while silencing SNHG7 suppressed their expression (P < 0.05). SNHG7 level was negatively correlated with miR-146a-5p, break-up time (BUT) and Schirmer's test (SIT) value, while positively correlated with corneal fluorescein staining (CFS) score (P < 0.001). miR-146a-5p was positively proportional to BUT and SIT, and inversely proportional to CFS score (P < 0.001). SNHG7 expression was enhanced, while miR-146a-5p expression was decreased in dry eye disease. Down-regulation of SNHG7 reduced the level of inflammation in HCECs. SNHG7 and miR-146a-5p were closely related to the development of disease, probably as biological targets for treatment in dry eye disease.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"185-191"},"PeriodicalIF":1.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacillus Licheniformis Capsules 1 (Live) Modulates Gut Microbiota and Enhances Immune Function in Chemotherapy Patients with Non-Small Cell Lung Cancer. 地衣芽孢杆菌胶囊1（活）调节非小细胞肺癌化疗患者肠道微生物群并增强免疫功能
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J076
Jie Yu, Hongcan Shi, Xiaolin Wang, Shichun Lu, Chao Sun, Weiguo Jin, Yusheng Shu
{"title":"Bacillus Licheniformis Capsules 1 (Live) Modulates Gut Microbiota and Enhances Immune Function in Chemotherapy Patients with Non-Small Cell Lung Cancer.","authors":"Jie Yu, Hongcan Shi, Xiaolin Wang, Shichun Lu, Chao Sun, Weiguo Jin, Yusheng Shu","doi":"10.1620/tjem.2025.J076","DOIUrl":"https://doi.org/10.1620/tjem.2025.J076","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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