Tohoku Journal of Experimental Medicine最新文献

Acupuncture Ameliorates Cognitive Dysfunction by Modulating the Apoptosis of Hippocampal Neuron in Severe Hand Foot and Mouth Disease Infant Rats Through the p38 MAPK/CREB Pathway. 针刺通过p38 MAPK/CREB通路调节重度手足口病幼鼠海马神经元凋亡改善认知功能障碍

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-10-02 DOI: 10.1620/tjem.2025.J102

Zongtao Wu, Hongjiao Jin, Biqin Shuai, Xiang Zhang, San Wang, Lan Chen, Bo Huang

引用次数: 0

Expressions of VEGF, Vasohibin-1, and Vasohibin-2 in Benign Parotid Gland Tumors. VEGF、Vasohibin-1、Vasohibin-2在腮腺良性肿瘤中的表达

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-10-02 DOI: 10.1620/tjem.2025.J115

Yutaka Tateda, Takahiro Suzuki, Teruyuki Sato, Kazue Ise, Hiroki Shimada, Yasuhiro Nakamura, Nobuo Ohta

引用次数: 0

Text Mining-Based Drug Discovery and MAPK14, STAT3, VEGFA as Novel Candidate Genes in Post-Tuberculosis Tracheobronchial Stenosis. 基于文本挖掘的药物发现和MAPK14， STAT3， VEGFA作为结核后气管支气管狭窄的新候选基因。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-27 Epub Date: 2025-03-27 DOI: 10.1620/tjem.2025.J028

Wentao Li, Tshetiz Dahal, Guangnan Liu

{"title":"Text Mining-Based Drug Discovery and MAPK14, STAT3, VEGFA as Novel Candidate Genes in Post-Tuberculosis Tracheobronchial Stenosis.","authors":"Wentao Li, Tshetiz Dahal, Guangnan Liu","doi":"10.1620/tjem.2025.J028","DOIUrl":"10.1620/tjem.2025.J028","url":null,"abstract":"The purpose of this study was to use bioinformatics techniques to investigate the genetic basis and evaluate medication for individuals with Post-Tuberculosis Tracheobronchial Stenosis (PTTS). Text mining was done to find 63 gene sets that are related to tuberculosis, granulation tissue proliferation, cicatrization, and hypertrophic scars. Using the DAVID and STRING tool to study the functional classification of these genes, revealed that these genes are associated with significant ways for instance the 'MAPK' signaling cascade, 'JAK-STAT' signaling pathway, and the 'VEGF' signaling pathway. The relevance of the genes was suggested by real-time quantitative PCR, which verified that MAPK14, STAT3, and VEGFA expression was elevated in PTTS tissues. The 14 hub genes were used to search the DGI database for drugs associated with these genes and the corresponding diseases. Out of the identified compounds, 34 of them were found to be possible drug candidates that could target PTTS's underlying pathophysiology. Such drugs include those targeting protein kinase, a cytokine with anti-inflammatory properties, angiogenesis inhibitors, and those targeting fibrosis. By applying this bioinformatics workflow, it was possible to use very little time in identifying genes and drugs that are involved in the main disease processes of PTTS. Future work should then be directed to conducting more experimental validation on these genes and possible drug candidates for future therapeutic application.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"97-109"},"PeriodicalIF":1.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the Mechanisms and Targets of Compound Houttuynia Cordata Mixture in COVID-19 Prevention through Integrated Network Pharmacology and Experimental Verification. 通过整合网络药理学和实验验证，破译复方蕺菜虫草混合物预防 COVID-19 的机制和靶点

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-27 Epub Date: 2024-09-19 DOI: 10.1620/tjem.2024.J100

Dongbo Yuan, Xiaoyue Chen, Guohua Zhu, Wei Wang, Jianguo Zhu

{"title":"Deciphering the Mechanisms and Targets of Compound Houttuynia Cordata Mixture in COVID-19 Prevention through Integrated Network Pharmacology and Experimental Verification.","authors":"Dongbo Yuan, Xiaoyue Chen, Guohua Zhu, Wei Wang, Jianguo Zhu","doi":"10.1620/tjem.2024.J100","DOIUrl":"10.1620/tjem.2024.J100","url":null,"abstract":"In December 2019, a novel coronavirus, subsequently named COVID-19, emerged and rapidly propagated both within China and globally. Although the Compound Houttuynia Cordata Mixture (CHM), a traditional Chinese medicine, has shown clinical efficacy in preventing and treating COVID-19, its underlying mechanisms remain inadequately understood. This study evaluates the effectiveness and explores the potential mechanisms of CHM against COVID-19 through the application of network pharmacology, molecular docking, and pseudovirus entry assays. Theoretical analyses based on meridian tropism principles suggest that CHM primarily targets the lung meridian, with additional effects on the heart, stomach, and other organs. An initial review of the TCMSP and STITCH databases identified 103 active components and 205 putative targets, with 69 targets considered therapeutic for COVID-19. Further examination of the GSE152586 dataset, in conjunction with previously identified targets, revealed 16 hub targets potentially critical for CHM's therapeutic effects in vivo. These hub genes are mainly associated with immune responses, inflammation, and cellular responses to external stimuli. Additionally, 59 compounds were identified, including pivotal components such as quercetin, baicalin, and luteolin, which play central roles in the drugs-compounds-targets network. At the cellular level, CHM significantly inhibited the LPS-induced secretion of IL-6 and IL-1β, and curtailed pseudovirus invasion of cells. This comprehensive study elucidates the potential mechanisms and targets of CHM in the prevention of COVID-19, thereby providing a solid foundation for further clinical research.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"115-130"},"PeriodicalIF":1.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Fanshi Tongfeng Fang on Hyperuricemia-Induced Apoptosis and Inflammation. 防风通脉方对高尿酸血症诱导的细胞凋亡和炎症的影响

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-26 Epub Date: 2024-11-14 DOI: 10.1620/tjem.2024.J133

Jia Zhao, Yehao Luo, Jia Yao, Xianzhe Wang, Zhaojun Yang, Xiuming Li, Guanjie Fan

{"title":"The Effect of Fanshi Tongfeng Fang on Hyperuricemia-Induced Apoptosis and Inflammation.","authors":"Jia Zhao, Yehao Luo, Jia Yao, Xianzhe Wang, Zhaojun Yang, Xiuming Li, Guanjie Fan","doi":"10.1620/tjem.2024.J133","DOIUrl":"10.1620/tjem.2024.J133","url":null,"abstract":"Hyperuricemia (HUA) is a metabolic disorder caused by purine metabolism. Our study attempts to explore the therapeutic effect of the Fanshi Tongfeng Fang (TFF) formula against HUA and the underlying mechanism. The uric acid (UA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine (Cr) levels were investigated in clinical research and in vivo experiments. The pathologic changes in kidney and xanthine oxidase (XOD) activity were measured by HE staining and kit respectively. The underlying mechanism was predicted by network pharmacology. The mRNA and protein expressions of ABCG2, URAT1, GLUT9, caspase 3, caspase 8, caspase 9, BID, Bax, Bcl-2, JUN, NLRP3, and TNF-α were detected by RT-qPCR assays and western blotting correspondingly.TFF showed a better inhibitory effect on UA, ALT, AST, and Cr levels among HUA patients than urate-lowing therapy and a higher successful treatment ratio. The UA levels, Cr value, and XOD activity were notably down-regulated after TFF treatment in HUA rats, but no measurable difference exists in ALT and AST levels by TFF treatment. Besides, TFF also markedly improved HUA-mediated renal damage and ABCG2 expressions and decreased URAT1 and GLUT9 expressions in HUA rats. Apoptosis and NOD-like receptor signaling pathways were selected according to the network pharmacology. The expressions of caspase 3, caspase 8, caspase 9, BID, Bax, JUN, NLRP3, and TNF-α were significantly decreased by TFF treatment, while Bcl-2 expression was increased by TFF treatment. TFF can alleviate HUA-induced apoptosis and inflammation via the JUN/NLRP3 pathway, which innovatively suggests the therapeutic potential of the TFF formula for HUA treatment.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"81-95"},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of miR-199b-5p Suppresses the Tuberculosis-Induced Inflammation in Spinal Tuberculosis via Targeting Gcnt2. 抑制miR-199b-5p通过靶向Gcnt2抑制结核结核结核结核诱导的炎症。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-25 DOI: 10.1620/tjem.2025.J111

Aierpati Yusufu, Runze Du, Muradil Mardan, Xuyang Xie, Xiaoyu Cai, Tao Xu, Weibin Sheng, Mardan Mamat

引用次数: 0

Effectiveness of Information-Motivation-Behavioral Skills Model of Hypothyroidism Self-Management Integrated into Prenatal Care in Pregnant Women with Newly Diagnosed Hypothyroidism. 甲状腺功能减退自我管理信息-动机-行为技能模型融入新诊断甲状腺功能减退孕妇产前护理的效果。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-25 DOI: 10.1620/tjem.2025.J112

He Li, Dong-Fang Shao, Jing Zheng, Wen-Qian Chen, Ying Xie

引用次数: 0

Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulation and Hepatocellular Carcinoma Progression. 靶向SCP2/HSPB1轴：铁凋亡调控和肝细胞癌进展的新机制

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-25 DOI: 10.1620/tjem.2025.J116

Haitao Jiang, Weibin Hu, Lingling Yuan

引用次数: 0

The Effects of Cognitive Behavioral Stress Management on Loneliness, Spiritual Well-Being, Anxiety, and Depression in Patients with Unresectable Advanced Gastric Carcinoma: A Randomized, Controlled Study. 认知行为应激管理对不可切除晚期胃癌患者孤独感、精神健康、焦虑和抑郁的影响：一项随机对照研究

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-25 Epub Date: 2025-02-27 DOI: 10.1620/tjem.2025.J025

Shuli Xia

{"title":"The Effects of Cognitive Behavioral Stress Management on Loneliness, Spiritual Well-Being, Anxiety, and Depression in Patients with Unresectable Advanced Gastric Carcinoma: A Randomized, Controlled Study.","authors":"Shuli Xia","doi":"10.1620/tjem.2025.J025","DOIUrl":"10.1620/tjem.2025.J025","url":null,"abstract":"Cognitive behavioral stress management (CBSM) is an effective intervention for reducing psychological symptoms. This randomized, controlled study investigated the effects of CBSM on loneliness, spiritual well-being, anxiety, and depression in patients with unresectable advanced gastric carcinoma (GC). This study randomized 128 eligible patients into two groups: the CBSM group (N = 64), to receive 12-week CBSM plus normal care (NC), and the NC group (N = 64), to receive 12-week NC alone. The University of California-Los Angeles Loneliness Scale (UCLA-LS), functional assessment of chronic illness therapy-spiritual well-being scale (FACIT-Sp), and self-rating anxiety/depression scale (SAS/SDS) scores were assessed at week (W)0, W4, W8, and W12 in both groups. SAS-anxiety/SDS-depression was defined as SAS/SDS score ≥ 50. Compared to the NC group, the CBSM group showed lower UCLA-LS scores at W8 (P = 0.036) and W12 (P = 0.004), indicating an alleviation of loneliness. Compared with the NC group, the FACIT-Sp scores at W4 (P = 0.015), W8 (P = 0.023), and W12 (P < 0.001) were greater in the CBSM group, indicating a better spiritual status. Additionally, the CBSM group indicated reduced SAS score at W8 (P = 0.006) and W12 (P = 0.003), SAS-anxiety rate at W8 (P = 0.038) and W12 (P = 0.036), as well as SDS score at W12 (P = 0.015) than the NC group. Subgroup analyses revealed that CBSM had a greater beneficial effect on reducing the UCLA-LS, SAS, and SDS scores and increasing the FACIT-Sp score than NC in patients with SAS-anxiety or SDS-depression at W0. In conclusion, CBSM may ameliorate loneliness, enhance spiritual well-being, and reduce anxiety in patients with unresectable advanced GC.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"71-79"},"PeriodicalIF":1.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Predictive Value of miR-205-5p for Abdominal Adhesion and Postpartum Complications in Women with Scarred Uterus. miR-205-5p对瘢痕子宫妇女腹部粘连及产后并发症的预测价值

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-25 DOI: 10.1620/tjem.2025.J110

Jinhui Feng, Fang Li, Jinyun Meng, Jumei Xiao

引用次数: 0