Tohoku Journal of Experimental Medicine最新文献

{"title":"Hybrid Assistive Limb Beyond Clinical Rehabilitation: A Narrative Review of Community-Based Applications, Healthy Aging and Implementation.","authors":"Tomoko Omiya, Yoshihiko Fujita, Kazushi Hotta, Shinobu Yamaguchi, Hiroki Watanabe, Eri Saito, Yukari Hara, Megumu Iwamoto, Thomas Mayers, Yoshiyuki Sankai","doi":"10.1620/tjem.2026.J097","DOIUrl":"10.1620/tjem.2026.J097","url":null,"abstract":"<p><p>Population aging has increased the need for technologies that support functional ability, independent living, and participation beyond hospital-based rehabilitation. This narrative review examined how the Hybrid Assistive Limb (HAL), a wearable robotic system developed primarily for rehabilitation, is being extended into home, community, preventive, and long-term care settings. Structured searches of PubMed and Scopus identified 268 records, of which 19 studies were included in the thematic synthesis. Three pathways were identified: Translational Pathways, describing the transition from clinical rehabilitation to home and everyday-life settings; Preventive and Community-Oriented Applications, encompassing foundational evidence, frailty prevention, health maintenance, and social participation; and Implementation and Care Support, addressing caregiver burden and use in long-term care settings. The included studies suggested that HAL use outside conventional rehabilitation may be feasible and safe and may contribute to physical function, maintenance of mobility, caregiver support, and participation in community life. However, most studies were small pilot or feasibility studies, and evidence regarding long-term outcomes, quality of life, cost-effectiveness, and implementation remains limited. HAL should therefore be evaluated not only as a device for improving physical performance, but also as a technology that may support functional ability, autonomy, social participation, and dignity. We propose the \"socialization of HAL\" as a framework for repositioning HAL from a specialized rehabilitation device to a social resource supporting Healthy Aging.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythropoietin Hydrogel Combined with Open Decompression is Effective in Treating the Rabbit Model of Osteofascial Compartment Syndrome after a Deinagkistrodon acutus Bite.","authors":"Wei Zhang, Huan He, Junsa Zhu, Feng Yang","doi":"10.1620/tjem.2025.J159","DOIUrl":"https://doi.org/10.1620/tjem.2025.J159","url":null,"abstract":"<p><p>This study aims to evaluate the efficacy of erythropoietin (EPO) hydrogel in treating severe tissue damage caused by Deinagkistrodon acutus (D. acutus) envenomation. Given its potent anti-inflammatory, anti-apoptotic, and tissue-protective properties, EPO directly counteracts key pathological effects of the venom, making it a rational and promising therapeutic strategy for enhancing tissue repair and wound healing in this condition. Twenty-four healthy male New Zealand white rabbits (n = 6) were randomly divided into open decompression (baseline) group, EPO intraperitoneal application group, EPO external application group, and no decompression group. Open decompression was performed in the first three groups. D. acutus venom was injected into the posterior side of the right lower limb. The pressure were measured at DAY (D)1, D3, D5, D7, D11, D15 and D22 after treatment of D. acutus. Both external and intraperitoneal application of EPO hydrogel significantly accelerated wound healing, reduced femoral fascial compartment pressure in the affected limb, and decreased bleeding compared to the open decompression group (p < 0.05). Notably, EPO external application demonstrated a more rapid therapeutic effect in the early phase (days 1-3) compared to intraperitoneal administration (p < 0.05). While no major safety concerns were identified, transient elevations in ALT were observed in the EPO external application group, and certain coagulation parameters (including PT and FIB) differed between EPO-treated and non-EPO-treated groups at specific time points. Overall, EPO hydrogel, when administered via either route, effectively promoted recovery after open decompression for D. acutus envenomation without causing severe adverse effects on vital organ functions.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":"269 4","pages":"613-620"},"PeriodicalIF":1.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory TAFRO Syndrome Mimicking Nodal T-Follicular Helper Cell Lymphoma, Angioimmunoblastic-Type.","authors":"Satoshi Ichikawa, Shu Nakamura, Yuya Tanaka, Keita Kanba, Kensuke Fujita, Yoko Okitsu, Masahiro Kobayashi, Fumiyoshi Fujishima, Junichi Kameoka, Tomonori Ishii","doi":"10.1620/tjem.2026.J109","DOIUrl":"https://doi.org/10.1620/tjem.2026.J109","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Romosozumab on Localized Periosteal Thickening: A Precursor to Atypical Femoral Fractures.","authors":"Hiroe Sato, Naoki Kondo, Eriko Hasegawa, Ayako Wakamatsu, Yukiko Nozawa, Daisuke Kobayashi, Junichiro James Kazama, Takeshi Kuroda, Naoto Endo, Suguru Yamamoto","doi":"10.1620/tjem.2025.J160","DOIUrl":"10.1620/tjem.2025.J160","url":null,"abstract":"<p><p>Localized periosteal thickening (LPT) of the femur is a precursor to atypical femoral fractures (AFFs), with greater LPT height indicating an increased risk of AFF. While teriparatide (TPTD) has demonstrated efficacy in promoting early bone union in surgical cases, the effects of romosozumab (ROM) on LPT remain unclear. A prospective analysis was conducted on eight femurs from five patients with LPT treated with ROM. For historical control, four femurs from four patients treated with daily TPTD were included. All patients were females using prednisolone (PSL), and had previously been treated with bisphosphonates (BPs). During ROM therapy, the changes in LPT height were within ± 0.5 mm across all cases. However, 1 year after ROM therapy, LPT height increased by ≥ 0.5 mm in three femurs of patients who received BP as sequential therapy. In the TPTD group, none of the patients received BP for sequential therapy, and no worsening of LPT height was observed after TPTD treatment. While ROM therapy led to increased bone mineral density (BMD), BMD declined 1 year after ROM discontinuation irrespective of BP use. In contrast, BMD remained stable between 1 to 2 years after ROM discontinuation. Additionally, the trabecular bone score (TBS) improved in most patients treated with ROM. ROM therapy did not appear to adversely affect LPT and may improve lumbar BMD and TBS. However, sequential BP therapy following ROM may be associated with LPT exacerbation in some cases. Further studies with larger, randomized cohorts are needed to confirm these observations.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"621-628"},"PeriodicalIF":1.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TAL1 Suppresses High-Grade Serous Ovarian Cancer Progression by Transcriptionally Inhibiting TPI1-Mediated Glycolysis.","authors":"Nan Zhao, Yu Wang, Wei Gao, Chunhe Zhou","doi":"10.1620/tjem.2025.J169","DOIUrl":"10.1620/tjem.2025.J169","url":null,"abstract":"<p><p>High-grade serous ovarian cancer (HGSOC) is often accompanied by a poor prognosis, which urges the development of new therapeutic approaches. This study attempts to explore the role of T-cell acute lymphocytic leukemia Protein 1 (TAL1)-triosephosphate isomerase 1 (TPI1) mechanism in glycolysis-driven progression of HGSOC. Bioinformatics analysis identified TPI1 as upregulated in HGSOC tissues. This was confirmed by RT-qPCR and Western blotting (WB) in HGSOC cells. Functional assays, including EdU, colony formation, and Transwell, showed that TPI1 knockdown or knockout suppressed HGSOC cell proliferation, migration, invasion, and glycolysis. TAL1 was found to be downregulated in HGSOC cells, and dual-luciferase reporter and chromatin immunoprecipitation (ChIP) assays confirmed that TAL1 directly repressed TPI1 transcription by binding to its promoter. Importantly, overexpression of TAL1 suppressed HGSOC progression and glycolysis, whereas combined overexpression of TPI1 rescued these effects. Blocking glycolysis attenuates the effect of TPI1 overexpression on malignant proliferation and metastatic-like behavior in HGSOC cells. These findings demonstrate that TAL1 inhibits HGSOC progression by blocking glycolysis through transcriptional repression of TPI1, suggesting a potential therapeutic target for intervention in HGSOC.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"599-612"},"PeriodicalIF":1.5,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Moon and Dog Bite Incidents: A Brief Clinical Analysis.","authors":"Mitsunori Suzuki, Shinji Kobayashi, Tsuyoshi Nojima, Atsunori Nakao, Takahiro Igarashi","doi":"10.1620/tjem.2026.J018","DOIUrl":"10.1620/tjem.2026.J018","url":null,"abstract":"<p><p>The potential influence of lunar phases on animal behavior, including dog bites, remain controversial. This study examined the relationship between lunar illumination and the frequency of dog and cat bite incidents. We retrospectively reviewed cases of dog or cat bites treated at a single emergency hospital in Yamagata, Japan, from January 2018 through May 2025. The lunar phase on each injury date was expressed as the illuminated fraction of the moon and grouped in 10% intervals. Scatter plots were generated to visualize the relationship between illumination and bite frequency, and cubic regression models were fitted to assess trends. A total of 48 dog bite cases and 32 cat bite cases were analyzed. Dog bite incidents increased toward higher illumination levels, with 43.8% occurring during the near-full-moon period. In contrast, cat bite incidents showed no consistent relationship with illumination. The regression model indicated a moderate positive correlation between illumination and dog bite frequency (R² = 0.72). These findings suggest that dog bite incidents may be modestly influenced by lunar brightness, whereas cat bites appear unaffected. Further studies are warranted to explore behavior and environmental mechanisms underlying this association.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"589-591"},"PeriodicalIF":1.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Cesarean Section due to Social Factors on Children's Attention Deficit Hyperactivity Disorder and Developmental Dyslexia.","authors":"Nian Yu, Yunge Hu, Kun Qiao, Chunfang Wang, Guimei Li, Lin Lin","doi":"10.1620/tjem.2026.J009","DOIUrl":"10.1620/tjem.2026.J009","url":null,"abstract":"<p><p>The global prevalence of cesarean delivery has shown a marked upward trajectory in recent decades, with non-medically indicated cesarean section (CSs) demonstrating particularly rapid growth. Current evidence indicates potential associations between delivery methods and childhood behavioral patterns, though comprehensive studies specifically examining elective cesarean section (ECS) in relation to attention-deficit/hyperactivity (ADHD) disorder symptomatology and reading competence acquisition remain notably scarce. This study aimed to systematically evaluate the relationship between ECS and neurobehavioral characteristics in children, with particular focus on two critical dimensions: attentional functioning and reading competence. This retrospective cohort study assessed neurodevelopmental outcomes in 4,986 children aged 7-15 years using standardized scales [(Swanson, Nolan, and Pelham Questionnaire, Fourth Version (SNAP-IV) for core ADHD symptoms and Dyslexia Checklist for Chinese Children (DCCC) for dyslexia screening)]. Primary caregivers retrospectively reported delivery modes (vaginal delivery (VD), medically indicated CS, or ECS). Statistical analyses included one-way ANOVA for between-group comparisons of ADHD symptom scores (GraphPad Prism 9.0) and chi-square tests for dyslexia prevalence rates (SPSS 27.0). The study revealed that children delivered via ECS exhibited significantly more pronounced symptoms of inattention and hyperactivity/impulsivity compared to both VD and medically indicated CS groups. In reading assessment, the ECS group demonstrated a substantially higher detection rate of dyslexia, while the medically indicated cesarean group showed intermediate prevalence. All between-group differences reached statistical significance. The results suggest a potential correlation between elective cesarean delivery and children's attentional functioning and reading development. These findings offer preliminary evidence regarding the possible influence of delivery modes on child development.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"593-598"},"PeriodicalIF":1.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating VE-Cadherin-Positive Extracellular Vesicles Reflect Pulmonary Endothelial Barrier Injury in a Rat Model of Ventilator-Induced Lung Injury.","authors":"Yusuke Takei, Mitsuhiro Yamada, Hidehisa Saito, Akihiro Kanaya, Kazuhiro Takahashi, Daisuke Irimada, Tomohiro Sekine, Yuna Sato, Junichi Sasaki, Jun Suzuki, Yutaka Ejima, Masanori Yamauchi","doi":"10.1620/tjem.2026.J104","DOIUrl":"https://doi.org/10.1620/tjem.2026.J104","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isovitexin Alleviates Airway Inflammation and Airway Remodeling in Ovalbumin-Induced Asthma in Mice.","authors":"Shan Zhang, Rong Zhang, Ying Chen, Haiyan Lin","doi":"10.1620/tjem.2026.J111","DOIUrl":"https://doi.org/10.1620/tjem.2026.J111","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Carbonic Anhydrase 12 to TGFβ1/Smad Pathway: A Key Mechanism for Isoorientin in Pulmonary Fibrosis Therapy.","authors":"Tianyu Xue, Fa Liang, Zijun Ding","doi":"10.1620/tjem.2025.J165","DOIUrl":"10.1620/tjem.2025.J165","url":null,"abstract":"<p><p>An active component of traditional Chinese medicine, isoorientin (IRT), has been shown to relieve liver fibrosis, which triggers the investigation regarding its impact on pulmonary fibrosis (PF) and the associated mechanism. An in vitro PF model was induced in rat type II alveolar RLE-6TN cells by treatment with transforming growth factor-β1 (TGF-β1), before which IRT (10 µM, 20 µM and 40 µM) pretreatment was performed. The effects of IRT on cell survival and apoptosis were detected. Western blot was used to analyze the expressions of fibrotic markers and TGF-β1/Smad2 pathway proteins in cells. An RLE-6TN cell line with carbonic anhydride enzyme 12 (CA12) knockdown was created to further explore the mechanism by which IRT improves PF. IRT (10, 20, and 40 µM) pretreatment did not induce cytotoxicity in RLE-6TN cells, but reversed the effects of TGF-β1 exposure on RLE-6TN cells, including apoptosis promotion, viability decreases, downregulation of CA12, upregulation of TGF-β1, α-smooth muscle actin (α-SMA) and Collagen I, and activation of the TGF-β1/Smad2 pathway. CA12 silencing enhanced the effect of TGF-β1 and attenuated the reversing effects of IRT (40 µM) pretreatment on TGF-β1. IRT (40 µM) pretreatment, in turn, offset the promoting role of CA12 silencing in TGF-β1. CA12 overexpression alleviated TGF-β1-induced damage, consistent with the therapeutic effects of IRT. In conclusion, IRT alleviates PF through CA12-induced suppression of the TGFβ1/Smad signaling pathway.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"575-587"},"PeriodicalIF":1.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}