Tohoku Journal of Experimental Medicine最新文献

Immunolocalization of CD28, CTLA-4 and CD80 in Non-Small Cell Lung Carcinoma: Combined CD28/CTLA-4/CD80 Status is a Potent Prognostic Factor of These Patients. CD28、CTLA-4和CD80在非小细胞肺癌中的免疫定位：CD28/CTLA-4/CD80联合状态是这些患者预后的一个重要因素。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-05-02 Epub Date: 2025-06-19 DOI: 10.1620/tjem.2025.J078

Takashi Sato, Kiyoshi Takagi, Chihiro Inoue, Mitsunori Higuchi, Nobuko Sakuma, Michie Kojimahara, Miho Sagawa, Megumi Tanaki, Hiroshi Hojo, Takashi Suzuki, Osamu Suzuki

{"title":"Immunolocalization of CD28, CTLA-4 and CD80 in Non-Small Cell Lung Carcinoma: Combined CD28/CTLA-4/CD80 Status is a Potent Prognostic Factor of These Patients.","authors":"Takashi Sato, Kiyoshi Takagi, Chihiro Inoue, Mitsunori Higuchi, Nobuko Sakuma, Michie Kojimahara, Miho Sagawa, Megumi Tanaki, Hiroshi Hojo, Takashi Suzuki, Osamu Suzuki","doi":"10.1620/tjem.2025.J078","DOIUrl":"10.1620/tjem.2025.J078","url":null,"abstract":"The cellular immune response to tumors is regulated by the competition between the CD28 and CTLA-4 molecules on T cells for CD80 on the surface of antigen-presenting cells (APCs). It has been reported that CD80 expression plays a critical role in tumor immune responses in malignant tumors, and the clinical pathological significance of CD80 and CTLA-4 expression in lung carcinoma has also been discussed. We previously demonstrated that the immunolocalization of CD80 is an adverse prognostic factor in patients with non-small cell lung carcinoma (NSCLC). However, no studies have reported the expression of CD28, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and CD80 in lung carcinoma simultaneously, and the significance of these molecules in T cells function remains unclear. Therefore, in this study, we immunolocalized CD28, CTLA-4 and CD80 in 119 NSCLC tissues and examined the significance of their cooperative interactions. The death rate of the patients who detected 2 or 3 factors among the CD28-low, CTLA-4-high, and CD80-high status groups was much higher (18-46%) than those who showed 0 and 1 factor (0% and 13%, respectively). When we classified CD28/CTLA-4/CD80 status according to their expression, it was significantly associated with stage, pT, lymph node metastasis, histological type, and programmed cell death-ligand 1 (PD-L1). Moreover, multivariate analysis demonstrated that CD28/CTLA-4/CD80 combined status was an independent, poor prognostic factor. Therefore, CD28/CTLA-4/CD80 combined status is suggested a potent prognostic factor in the NSCLC. This is possibly because their cooperative interactions potently regulate T cells function in NSCLC, leading to a worse prognosis.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"491-504"},"PeriodicalIF":1.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-30 DOI: 10.1620/tjem.2026.J036

Jie Li, Tingting Gao, Xiangyang He, Qingjun Zhang, Xu Han

引用次数: 0

Gastrodin Inhibits the Neuronal Damage Induced by Ischemia-Reperfusion Injury Through the PERK-Mediated Endoplasmic Reticulum Stress Pathway. 天麻素通过perk介导的内质网应激途径抑制缺血再灌注损伤引起的神经元损伤。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-30 DOI: 10.1620/tjem.2026.J047

Xiuyu Wu, Chuanan Yi, Dekun Chen, Minghai Hu, Hui Yang

引用次数: 0

Long Noncoding RNA LINC01426 Modulates the miR-508-5p/MUC19 Axis to Regulate the Proliferation, Migration and Invasion of Endometrial Cancer Cells. 长链非编码RNA LINC01426调控miR-508-5p/MUC19轴调控子宫内膜癌细胞的增殖、迁移和侵袭

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-30 DOI: 10.1620/tjem.2026.J049

Xingyan Hu, Wei Wei, Weiming Tan

引用次数: 0

LncRNA PCGEM1 Promotes Endoplasmic Reticulum Stress in Osteosarcoma Cells Under Hypoxia by Activating JAK/STAT3 Signaling Pathway. LncRNA PCGEM1通过激活JAK/STAT3信号通路促进缺氧条件下骨肉瘤细胞内质网应激。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-30 DOI: 10.1620/tjem.2026.J044

Jun Li, Qian Zhou, Farui Sun, Yuanjin Zhang, Xian Pan, Bo Li, Guofu Zhang

引用次数: 0

Subacute-Onset Hypothyroidism in an Elderly Patient with Polymyalgia Rheumatica: A Case Report. 老年风湿性多肌痛患者亚急性发作甲状腺功能减退1例报告。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-30 DOI: 10.1620/tjem.2026.J042

Kiysohi Migita, Fumi Mori, Kazufumi Yamasaki, Maki Fukuda, Haruki Matsumoto, Shuhei Yoshida, Tomoyuki Asano

引用次数: 0

Alteration of Brain Activity and Regional Connectivity in Patients with Tinnitus: A Resting-State Functional MRI Analysis. 耳鸣患者脑活动和区域连通性的改变：静息状态功能MRI分析。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-29 Epub Date: 2025-12-25 DOI: 10.1620/tjem.2025.J156

Yongpeng Li, Lu Peng, Ying Lan, Kejiang Du, Tao Hou, Shihua Yin

{"title":"Alteration of Brain Activity and Regional Connectivity in Patients with Tinnitus: A Resting-State Functional MRI Analysis.","authors":"Yongpeng Li, Lu Peng, Ying Lan, Kejiang Du, Tao Hou, Shihua Yin","doi":"10.1620/tjem.2025.J156","DOIUrl":"10.1620/tjem.2025.J156","url":null,"abstract":"Tinnitus is a common disorder that influences the quality of life. This study aimed to investigate its neurological underpinnings by employing resting-state functional magnetic resonance imaging (rs-fMRI). Fifty-eight patients with tinnitus and 52 healthy controls (HCs) were enrolled and underwent rs-fMRI. The fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and seed-based functional connectivity (FC) were used to detect disparities in the brains of the two groups. Comparison analyses were adjusted by family wise error (FWE) correction. Compared with HCs, patients with tinnitus showed decreased fALFF levels in left middle temporal gyrus (MTG.L) (PFWE-corrected = 0.053) and the left middle occipital gyrus (MOG.L) (PFWE-corrected = 0.073), as well as a reduced ReHo level in right fusiform gyrus (FFG.R) (Puncorrected = 0.049, PFWE-corrected = 0.735). Moreover, patients with tinnitus had lower FC in MTG.L with left thalamus (THA.L) (Puncorrected = 0.052, PFWE-corrected = 0.395) and right thalamus (THA.R) (Puncorrected = 0.012, PFWE-corrected = 0.107), reduced FC between MOG.L and left dorsolateral superior frontal gyrus (SFGdor.L) (PFWE-corrected = 0.003), and decreased FC between FFG.R and the right middle frontal gyrus (Puncorrected = 0.1). Receiver operating characteristic curve analyses showed that MTG.L (fALFF), MOG.L (fALFF), FFG.R (ReHo), FC between MTG.L and THA.L, FC between MTG.L and THA.R, and FC between MOG.L and SFGdor.L, all showed acceptable ability to discriminate patients with tinnitus and HCs, with most of the area under the curves greater than 0.7. In conclusion, patients with tinnitus show notable disturbances in neural activity in non-auditory brain areas, specifically in the prefrontal cortex.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"481-490"},"PeriodicalIF":1.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Presurgical Infant Orthopedic Treatment on the Maxillary Arch, Craniofacial Form, and Lip Morphology of Patients with Unilateral Cleft Lip and Palate, Aged up to 5 Years. 术前婴儿整形治疗对5岁以下单侧唇腭裂患者上颌弓、颅面形态和唇部形态的影响

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-28 Epub Date: 2025-07-10 DOI: 10.1620/tjem.2025.J090

Mika Unno, Shinobu Tsuchiya, Chieko Miura, Akimitsu Sato, Yoshimichi Imai, Kaoru Igarashi

{"title":"The Effects of Presurgical Infant Orthopedic Treatment on the Maxillary Arch, Craniofacial Form, and Lip Morphology of Patients with Unilateral Cleft Lip and Palate, Aged up to 5 Years.","authors":"Mika Unno, Shinobu Tsuchiya, Chieko Miura, Akimitsu Sato, Yoshimichi Imai, Kaoru Igarashi","doi":"10.1620/tjem.2025.J090","DOIUrl":"10.1620/tjem.2025.J090","url":null,"abstract":"Presurgical infant orthopedics (PSIO) has been used worldwide to improve orofacial deformations due to cleft lip and palate before primary surgeries. However, their effectiveness remains controversial. This retrospective study examined the effect of PSIO treatment on the orofacial morphology of patients with non-syndromic unilateral cleft lip and palate (UCLP) up to 5 years of age. The study included 22 patients with UCLP who were treated and followed up from birth to 5 years of age. The patients were divided into two groups. The PSIO group consisted of 11 patients, while the control group consisted of 11 patients who were not treated with PSIO. Maxillary dental casts obtained from birth to 5 years of age were analyzed three-dimensionally. Furthermore, 5-Year-Olds' Index evaluation was performed, along with cephalometric and facial morphometric analyses. The analyses were performed on dental casts, lateral cephalograms, and frontal facial photographs at 5 years of age, respectively. The PSIO group showed significantly superior alveolar cleft width, anterior palatal depth, and posterior palatal depth, as well as less lateral deviation of the incisor point before cheiloplasty than the control group. However, no significant differences were observed between the two groups in terms of occlusion, craniofacial form, or lip morphology at 5 years of age. The present results suggest that PSIO treatment may improve deformations of the maxillary alveolus and palate before cheiloplasty, thereby simplifying surgery. In contrast, PSIO had no long-term effects on the orofacial morphology of patients with UCLP, aged up to 5 years.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"469-480"},"PeriodicalIF":1.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of LINC01123 in Patients with Hypertension and Its Damage to Endothelial Cells. LINC01123在高血压患者中的表达及其对内皮细胞的损害

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-25 Epub Date: 2025-09-18 DOI: 10.1620/tjem.2025.J105

Yuanyuan Su, Runxi Xu, Shuqi Huang, Chong Yang, Yunhua Hao

{"title":"Expression of LINC01123 in Patients with Hypertension and Its Damage to Endothelial Cells.","authors":"Yuanyuan Su, Runxi Xu, Shuqi Huang, Chong Yang, Yunhua Hao","doi":"10.1620/tjem.2025.J105","DOIUrl":"10.1620/tjem.2025.J105","url":null,"abstract":"Hypertension affects nearly 1/4 of the global population. LINC01123 is closely related to cancer and vascular smooth muscle cell function. Its role in hypertension remains unknown. This study aimed to investigate the expression of LINC01123 in patients with hypertension and its damage to endothelial cells. In this study 149 healthy individuals and 149 hypertension patients participated. The expression of LINC01123 and miR-34a-5p was estimated by RT-qPCR. The relationship between LINC01123 and blood pressure, endothelial cell function and miR-34a-5p were analyzed by Pearson correlation analysis. Logistic regression analysis was employed to identify the potential risk factors of hypertension. The regulatory role of LINC01123 was explored in Human Umbilical Vein Endothelial Cells (HUVECs). In hypertension group, the significantly elevated LINC01123 was positively associated with systolic blood pressure (SBP) (r = 0.5182, P < 0.0001), diastolic blood pressure (DBP) (r = 0.5904, P < 0.0001), angiotensin II (Ang II) (r = 0.5614, P < 0.0001) and endothelin-1 (ET-1) (r = 0.6086, P < 0.0001) while a negative correlation was found with NO (r = --0.5534, P < 0.0001). LINC01123 (OR: 2.141, 95% CI: 1.339-3.424, P = 0.001) was identified as an independent risk factor of hypertension. LINC01123 knockdown contributed to improving the proliferation and migration of HUVECs while inhibiting its apoptosis. miR-34a-5p was a potential target of LINC01123. The significantly elevated LINC01123 was positively associated with blood pressure and vascular dysfunction in hypertension. LINC01123 was an independent risk factor for hypertension. LINC01123 knockdown facilitated the cell proliferation and migration while inhibiting apoptosis of HUVECs maybe via miR-34a-5p.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"445-453"},"PeriodicalIF":1.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography. 结合计算机断层扫描位置数据的修正数据驱动运动校正方法在正电子发射断层扫描中的应用。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-24 Epub Date: 2025-06-12 DOI: 10.1620/tjem.2025.J072

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirofumi Kawakami, Akie Katsuki, Yoshitaka Tanaka, Takashi Takeuchi, Hiroyasu Kodama, Akihito Usui, Kei Takase, Tomohiro Kaneta

{"title":"The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography.","authors":"Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirofumi Kawakami, Akie Katsuki, Yoshitaka Tanaka, Takashi Takeuchi, Hiroyasu Kodama, Akihito Usui, Kei Takase, Tomohiro Kaneta","doi":"10.1620/tjem.2025.J072","DOIUrl":"10.1620/tjem.2025.J072","url":null,"abstract":"In positron emission tomography/computed tomography (PET/CT), long image acquisition time often causes patient motion and misalignment between the PET and CT images. This misalignment can compromise the accuracy of attenuation correction and quantitative values, thus affecting diagnostic reliability. Recently, data-driven motion correction (DDMC) methods have been developed to detect motion using brief static PET images, and our previous study also demonstrated the effectiveness of the DDMC method. However, DDMC assumes alignment between PET reference images and CT scans used for attenuation correction. When patients move after CT scan, the PET and CT images misalign, necessitating rescanning or manual realignment. The present study introduces a modified approach, namely DDMC+CT, that integrates CT positional data into the DDMC process to address PET/CT misalignment. We evaluated the DDMC+CT approach using a phantom study and clinical images. The phantom study simulated PET/CT misalignment by moving a Hoffman phantom post-CT scan, with contrast and standardized uptake values (SUV) compared with and without DDMC+CT. The clinical images included whole-body PET/CT scans with head and neck motion, where quantitative and visual assessments were performed. The DDMC+CT method successfully corrected PET/CT misalignment in phantom and clinical images, yielding SUV and contrast values consistent with reference images, resulting in improved diagnostic accuracy. The DDMC+CT method demonstrates a potential for clinical application, where it may minimize rescans and reduce patient and operator burden by allowing automatic misalignment correction.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"435-443"},"PeriodicalIF":1.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0