Tohoku Journal of Experimental Medicine最新文献_第2页

Successful Total Callosotomy in a Patient with Lennox-Gastaut Syndrome and Cardio-Facio-Cutaneous Syndrome.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-19 DOI: 10.1620/tjem.2024.J146

Aritomo Kawashima, Haruhiko Nakamura, Kaori Kodama, Yukimune Okubo, Wakaba Endo, Takehiko Inui, Noriko Togashi, Saki Uneoka, Moriei Shibuya, Yoshitsugu Oikawa, Yu Katata, Yurika Numata-Uematsu, Mitsugu Uematsu, Hiroshi Kawame, Shin-Ichiro Osawa, Daiju Oba, Tetsuya Niihori, Yoko Aoki, Kazuhiro Haginoya

引用次数: 0

Expression of Vascular and Tissue Repair Factors in Laryngeal Granulomas. 喉肉芽肿中血管和组织修复因子的表达

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-13 Epub Date: 2024-06-27 DOI: 10.1620/tjem.2024.J056

Yutaka Tateda, Ryoukichi Ikeda, Risako Kakuta, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, Nobuo Ohta

{"title":"Expression of Vascular and Tissue Repair Factors in Laryngeal Granulomas.","authors":"Yutaka Tateda, Ryoukichi Ikeda, Risako Kakuta, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, Nobuo Ohta","doi":"10.1620/tjem.2024.J056","DOIUrl":"10.1620/tjem.2024.J056","url":null,"abstract":"Voice abuse, chronic cough, laryngeal surgery, and tracheal intubation may lead to injury and subsequent repair/remodeling in the vocal fold mucosa. Periostin is known to be involved in airway remodeling and is also associated with various otolaryngological diseases. D-β-aspartic acid is the major isomer of D-aspartic acid found in tissues of elderly individuals. In ischemic heart disease, increased CD31 expression has been observed around cardiomyocytes during remodeling, and endothelial proliferation has been reported at these sites. In this study, we investigated the expression and role of CD31, CD34, D-β-aspartic acid, and periostin in the formation of laryngeal granulation tissue. This retrospective study involved five patients who underwent surgical treatment for laryngeal granulation tissue. The expressions of CD31, CD34, D-β-aspartic acid, and periostin in surgical samples were investigated by immunohistochemistry. Histologically, the specimens showed inflammatory cell infiltration, fibrin exudation, fibrosis, and neovascularization, but no tumor cells. No stratified squamous epithelial covering was observed. The expression of periostin and D-β-aspartic acid was also observed in the specimens. CD31-positive cells (endothelial cells) and CD34-positive cells (progenitors of endothelial cells) were observed in the specimens. Our results indicate that the overexpression of CD31, CD34, D-β-aspartic acid, and periostin may play a role in the pathogenesis of laryngeal granulation tissue, and we speculate that D-β-aspartic acid and periostin could serve as novel biomarkers and therapeutic targets for laryngeal granulation tissue.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"93-99"},"PeriodicalIF":1.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Leucine-Rich Alpha-2-Glycoprotein 1 Reflects Higher Histological Grade, Worse Disease-Free Survival, and Unfavorable Overall Survival in Colorectal Cancer Patients who Receive Tumor Resection. 血浆亮氨酸-富甲型-2-糖蛋白 1 反映了接受肿瘤切除术的结直肠癌患者较高的组织学分级、较差的无病生存率和不利的总生存率。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-12 Epub Date: 2024-06-27 DOI: 10.1620/tjem.2024.J055

Zhi Tan, Weining Wang, Jin Peng, Wenling Fan, Hui Cao

{"title":"Plasma Leucine-Rich Alpha-2-Glycoprotein 1 Reflects Higher Histological Grade, Worse Disease-Free Survival, and Unfavorable Overall Survival in Colorectal Cancer Patients who Receive Tumor Resection.","authors":"Zhi Tan, Weining Wang, Jin Peng, Wenling Fan, Hui Cao","doi":"10.1620/tjem.2024.J055","DOIUrl":"10.1620/tjem.2024.J055","url":null,"abstract":"Leucine-rich alpha-2-glycoprotein 1 (LRG1) promotes colorectal cancer (CRC) growth, migration, and invasion. This study intended to investigate the association of plasma LRG1 with clinical characteristics, disease-free survival (DFS), and overall survival (OS) in CRC patients who received tumor resection. This study retrospectively included 125 CRC patients who received tumor resection. LGR1 level was detected in their preoperative plasma samples via enzyme-linked immunosorbent assay. The median level of plasma LRG1 was 53.4 μg/mL (quartile 1: 34.0 μg/mL, quartile 3: 102.5 μg/mL). Plasma LRG1 was elevated in patients with high histological grade versus those with low grade (P = 0.005). Plasma LRG1 was varied among patients with different node (P = 0.004) and tumor-node-metastasis (P = 0.001) stages. Moreover, plasma LRG1 ≥ 50 μg/mL (at around the median level) was not related to DFS (P = 0.074) or OS (P = 0.077). While plasma LRG1 ≥ 100 μg/mL (at around the quartile 3 level) was linked with shortened DFS (P = 0.018) and OS (P = 0.016). The 3-year accumulating DFS and OS rates were 60.8% and 64.4% in patients with plasma LRG1 ≥ 100 μg/mL; they were 75.7% and 82.9% in patients with plasma LRG1 < 100μg/mL, respectively. Furthermore, plasma LRG1 ≥ 100 μg/mL (hazard ratio (HR): 2.728, P = 0.036) and age ≥ 60 years (HR: 2.815, P = 0.041) were independently associated with shortened DFS. Only node stage (HR: 3.150, P = 0.004) was independently linked with shortened OS. In conclusion, LRG1 is associated with elevated histological grade and worse DFS and OS, with its level ≥ 100 μg/mL as an independent factor for shortened DFS in CRC patients who receive tumor resection.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"101-108"},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circular RNA Hsa_Circ_0007376 Promotes Malignancy of Gastric Cancer Cells by Regulating miR-556-5p/CREB5 Axis.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-12 DOI: 10.1620/tjem.2024.J145

Chao Liu, Xin Zhou, Guangsheng Wang, Chenyu Zhu, Rui Xu

引用次数: 0

Exploratory Study on the Relationship between Head and Neck Cancer and Japanese Cedar Pollinosis.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-12 DOI: 10.1620/tjem.2024.J142

Shigeyuki Murono, Sayaka Yagi-Nakanishi, Kazuhira Endo, Satoru Kondo, Hisashi Sugimoto, Tomokazu Yoshizaki

引用次数: 0

Development of a Temporary Custody Re-entry Risk Prediction Model Using Longitudinal Cohort Data in Japan.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-12 DOI: 10.1620/tjem.2024.J144

Sotaro Tanaka, Mariko Inoue, Kazue Yamaoka

引用次数: 0

Protein Z Promotes Proliferation in Vascular Endothelial Cell Mediated by Chemokine C-X-C-Motif Receptor 4.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-12 DOI: 10.1620/tjem.2024.J143

Peng Zhang, Jie Li, Jingxuan Chen, Xinran Ruan

引用次数: 0

Association between Maternal LDL Level during Pregnancy and Offspring LDL Level at Age 8. 母体孕期低密度脂蛋白水平与子代 8 岁时低密度脂蛋白水平之间的关系。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-11 Epub Date: 2024-06-27 DOI: 10.1620/tjem.2024.J052

Taku Oishi, Naomi Mitsuda, Kota Watanabe, Mariko Araki, Ryuhei Nagai, Masamitsu Eitoku, Mikiya Fujieda, Narufumi Suganuma

{"title":"Association between Maternal LDL Level during Pregnancy and Offspring LDL Level at Age 8.","authors":"Taku Oishi, Naomi Mitsuda, Kota Watanabe, Mariko Araki, Ryuhei Nagai, Masamitsu Eitoku, Mikiya Fujieda, Narufumi Suganuma","doi":"10.1620/tjem.2024.J052","DOIUrl":"10.1620/tjem.2024.J052","url":null,"abstract":"The pathological process of atherosclerosis begins in childhood and increases the risk of myocardial infarction, other cardiac diseases, and subsequent stroke. To investigate the relationship between maternal low-density lipoprotein cholesterol (LDL-C) level during pregnancy and LDL-C level in offspring at 8 years old. The Japan Environment and Children's Study (JECS) is an ongoing birth cohort study to elucidate the effects of environmental factors on health from the fetal period to early childhood. A total of 1,226 mother-child pairs were enrolled in the present study, which was conducted as an adjunct study to the JECS at the Kochi Unit Center (Kochi, Japan). Peripheral blood samples and anthropometric measurements of the children were collected at age 8. In addition, 540 of the enrolled children's fathers whose peripheral blood samples were collected at the time of JECS enrollment were also analyzed. The exposures of interest were maternal serum LDL-C level during pregnancy and paternal LDL-C level. The outcome of interest was serum LDL-C level of offspring at 8 years old. Mean (SD) serum LDL-C levels were 107.0 (25.6) mg/dL for mothers, 116.5 (27.4) mg/dL for fathers, and 89.9 (21.4) mg/dL for offspring. LDL-C level in mothers whose offspring had above-normal LDL-C levels (≥ 110 mg/dL) was significantly higher than that in mothers whose offspring had normal LDL-C levels (< 110 mg/dL). If a mother has a high LDL-C level during pregnancy, her offspring might also have a high LDL-C at age 8.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"81-88"},"PeriodicalIF":1.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyogenic Ventriculitis Caused by Cholesteatoma. 胆脂瘤引发的化脓性脑室炎

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-11 Epub Date: 2024-07-04 DOI: 10.1620/tjem.2024.J061

Ryouhei Akanabe, Ryoukichi Ikeda, Shigeru Kuwashima, Toshihiko Abe, Shinsuke Kaneshiro, Aya Katsura, Iori Kusaka, Yuki Kishima, Kiyoto Shiga

引用次数: 0

Pediatric Intravenous Anesthesia in Japan-Where Are Anesthesiologists? 日本的小儿静脉麻醉--麻醉师在哪里？

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2024-12-06 Epub Date: 2024-06-27 DOI: 10.1620/tjem.2024.J051

Shun Toriumi, Eisuke Inage, Yuko Tanaka, Megumi Matsumoto, Akifumi Endo, Yosuke Nakabayashi, Susumu Yokoya, Itaru Iwama, Yasuyuki Suzuki, Shoichi Oyama, Yosuke Baba, Takahiro Kudo, Yoshikazu Ohtsuka, Toshiaki Shimizu

{"title":"Pediatric Intravenous Anesthesia in Japan-Where Are Anesthesiologists?","authors":"Shun Toriumi, Eisuke Inage, Yuko Tanaka, Megumi Matsumoto, Akifumi Endo, Yosuke Nakabayashi, Susumu Yokoya, Itaru Iwama, Yasuyuki Suzuki, Shoichi Oyama, Yosuke Baba, Takahiro Kudo, Yoshikazu Ohtsuka, Toshiaki Shimizu","doi":"10.1620/tjem.2024.J051","DOIUrl":"10.1620/tjem.2024.J051","url":null,"abstract":"Most pediatric intravenous anesthesia in Japan is performed outside the operating theatre by non-anesthetists. The 2020 revision increased reimbursement for long-term intravenous anesthesia (Category 3) by anesthesiologists, but its impact on practice behavior is unknown. We analyzed the annual number of calculations for each category of intravenous anesthesia and their age distribution from the national reimbursement data for the three-year period fiscal years (FY) 2018-20 to elucidate trends in the pediatric age group. Regional disparities of calculation rate of pediatric addition per capita were examined. According to FY 2019 statistics, 5,774 outpatient intravenous anesthesia and 50,686 inpatient intravenous anesthesia procedures were performed annually in patients under 15 years of age. Of these, no case was complex anesthesia (Category 3) performed by a specialist anesthesiologist in outpatient settings and 1,162(3.9%) in inpatient settings. Category 3 occupancy was slightly higher in infants and decreased with age. (P < 0.01) In FY 2020 data, 41(0.7%) new Category 3 procedure were calculated in outpatient cases. The share of Category 3 in inpatient cases decreased to 2.0%. There was no decrease in the number of overall venous anesthesia due to COVID-19 pandemic. Regional disparities in calculations were up to 20 times greater. Long-term total intravenous anesthesia by anesthesiologists is rarely performed in Japan. Improvements in reimbursement are not sufficient to enable total intravenous anesthesia by a specialized anesthesiologist. A system for safe intravenous anesthesia by non-anesthesiologists is needed.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"73-80"},"PeriodicalIF":1.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0