Tohoku Journal of Experimental Medicine最新文献_第2页

Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. 与自闭症谱系障碍核心症状相关的交流困难儿童的凝视模式

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-24 Epub Date: 2025-06-12 DOI: 10.1620/tjem.2025.J074

Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu Miyake, Tomohisa Suzuki, Mami Ishikuro, Masatsugu Orui, Eiichi N Kodama, Ritsuko Shimizu, Yohei Hamanaka, Yoko Izumi, Atsushi Hozawa, Nobuo Fuse, Atsuo Kikuchi, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama, Masayuki Yamamoto

{"title":"Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder.","authors":"Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu Miyake, Tomohisa Suzuki, Mami Ishikuro, Masatsugu Orui, Eiichi N Kodama, Ritsuko Shimizu, Yohei Hamanaka, Yoko Izumi, Atsushi Hozawa, Nobuo Fuse, Atsuo Kikuchi, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama, Masayuki Yamamoto","doi":"10.1620/tjem.2025.J074","DOIUrl":"10.1620/tjem.2025.J074","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions. There is an urgent need to establish objective, simple, and accurate screening and diagnostic methods for ASD in childhood. Recently, the ability to visualize and quantify eye movements has emerged, suggesting that ASD may exhibit characteristic gaze patterns. To examine the potential of gaze patterns as an early marker of ASD, we analyzed the relationship between gaze patterns at ages 4-6 and individual ASD characteristics, as determined by the Autism Spectrum Quotient Japanese version for children (AQ-J-child) at age 6, using data from 4- to 6-year-old children recruited into the BirThree Cohort Study of the Tohoku Medical Megabank Project. The median gaze rate, which represents the percentage of time the subjects spent looking at the screen during the test, was 92%, reflecting the highly versatile nature and proper execution of this test in our study. We found that children with social impairment tend to prefer looking at geometric patterns. In addition, children with communication difficulties tend to spend less time looking at the eyes in still images of human faces. Our analyses of the relationships between various gaze results and ASD characteristics defined by AQ-J-child revealed that specific gaze preferences are significantly associated with communication difficulties, social impairment, and impaired imagination. These findings indicate that the gaze measurement results show strong correlations with specific aspects of ASD. Therefore, gaze patterns demonstrate the potential to reflect one aspect of ASD.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"455-468"},"PeriodicalIF":1.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting GRIA3 in Breast Cancer: Cuproptosis-Related Genes Unveil Immune Dysregulation and Prognostic Stratification. 乳腺癌中靶向GRIA3：铜裂相关基因揭示免疫失调和预后分层。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-23 DOI: 10.1620/tjem.2026.J032

Fuming Yang, Jiwu Wei

引用次数: 0

Adenylate Kinase 4 Knockdown Reduces Thyroid Cancer Viability and Mobility by Regulating Oxidative Stress. 腺苷酸激酶4敲低通过调节氧化应激降低甲状腺癌的生存能力和流动性。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-23 DOI: 10.1620/tjem.2026.J011

Zhimin Liu, Jinnan Wan, Yang Li

引用次数: 0

Mammalian Sterile 20-Like Kinase 1 Knockdown Reduces Sevoflurane-Induced Oxidative Stress in HT22 and SH-SY5Y Cells via AKT Phosphorylation and YAP1 Transcriptional Activity. 哺乳动物不育20样激酶1敲低可通过AKT磷酸化和YAP1转录活性降低七氟醚诱导的HT22和SH-SY5Y细胞氧化应激

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-23 DOI: 10.1620/tjem.2026.J025

Zhihong Xu, Guangsheng Ci, Li Peng, Jiawei Chen

引用次数: 0

Association between P2RX7 rs7958311 Polymorphism and Labor Analgesia in Primiparas. 初产妇P2RX7 rs7958311多态性与分娩镇痛的关系

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-18 Epub Date: 2025-09-18 DOI: 10.1620/tjem.2025.J107

Ying Wang, Guantong Zhou, Lijia Long, Li Wan, Yan Hou, Churong Wang

{"title":"Association between P2RX7 rs7958311 Polymorphism and Labor Analgesia in Primiparas.","authors":"Ying Wang, Guantong Zhou, Lijia Long, Li Wan, Yan Hou, Churong Wang","doi":"10.1620/tjem.2025.J107","DOIUrl":"10.1620/tjem.2025.J107","url":null,"abstract":"Labor analgesia is commonly used in parturient women and its variable effect has been proven to be related to genetic factors. The P2RX7 rs7958311 polymorphism is closely associated with the occurrence and sensitivity of pain. This study focused on the correlation between the P2RX7 rs7958311 polymorphism and labor analgesia in primiparas. Two hundred full-term hospitalized primiparas who voluntarily requested labor analgesia were recruited in this study. P2RX7 rs7958311 genotyping was performed on all participants after genomic DNA extraction from blood samples. Ropivacaine combined with sufentanil was employed for labor analgesia. Evaluation was performed on pain scores, labor duration, and maternal and infant outcomes. Potential factors affected by rs7958311 polymorphism were assessed by logistic regression analysis. Obviously, reduced visual analog scale (VAS) scores were shown within 1 h after labor analgesia and at 2 h postpartum in GA and AA groups (P < 0.05) with lower VAS scores in the AA group than in the GA group (P < 0.01) at 2 h postpartum. The total and the first two stages of labor exhibited a shortened duration in the AA group (P < 0.05). Analysis of adverse reactions in primiparas and assessment of neonates identified a statistical difference in nausea/emesis (P = 0.005) among 3 groups. Logistic regression analysis demonstrated the effect of P2RX7 rs7958311 polymorphism on the VAS score at 2 h postpartum (OR = 0.386, 95% CI: 0.192-0.777, P = 0.008) and nausea/emesis (OR = 0.232, 95% CI: 0.071-0.762, P = 0.016) in primiparas. The P2RX7 rs7958311 polymorphism remarkably influenced the effect of labor analgesia in primiparas, especially the VAS score at 2 h postpartum and nausea/emesis.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"427-434"},"PeriodicalIF":1.6,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usefulness of a Video of a Gatekeeper Training Program for Suicide Prevention among University Students on Campus: Randomized Controlled Trial. 校园内大学生自杀预防看门人训练计划录影带的有效性：随机对照试验。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-16 DOI: 10.1620/tjem.2026.J028

Atsushi Iwasawa, Kyoko Nomura, Junko Hirayama, Takumi Kimura, Akise Umakoshi, Mari Ito, Masato Kitajima, Hideaki Ando, Masahito Fushimi, Kazuo Mishima, Hisanaga Sasaki

引用次数: 0

Predictive Value of miR-19-3p and miR-124-3p for Complications and Pelvic Floor Dysfunction in Women Undergoing Cesarean Section. MiR-19-3p和MiR-124-3p对剖宫产术后并发症及盆底功能障碍的预测价值

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-16 Epub Date: 2025-01-16 DOI: 10.1620/tjem.2025.J003

Qun Mu, Meiyi Chen, Yuan Li, Li Liu, Xiating Shi

{"title":"Predictive Value of miR-19-3p and miR-124-3p for Complications and Pelvic Floor Dysfunction in Women Undergoing Cesarean Section.","authors":"Qun Mu, Meiyi Chen, Yuan Li, Li Liu, Xiating Shi","doi":"10.1620/tjem.2025.J003","DOIUrl":"10.1620/tjem.2025.J003","url":null,"abstract":"Complications and pelvic floor dysfunction (PFD) in women after cesarean section have attracted attention. The objective was to identify novel biomarkers that would facilitate more accurate prediction of postpartum complications and PFD, thereby offering new insights into clinical prevention and management strategies. The study population consisted of 120 primigravid women who underwent cesarean section at the hospital. Serum miR-19-3p and miR-124-3p expression was determined by quantitative reverse transcription-polymerase chain reaction. Receiver operating characteristic curves were employed to assess the predictive value of miR-19-3p and miR-124-3p for the occurrence of complications and PFD in women undergoing cesarean section. Multivariate logistic regression was utilized to analyze the risk factors associated with PFD. Fifteen out of 120 women who underwent cesarean section suffered from postpartum complications, and 28 suffered from PFD. miR-19-3p expression was upregulated, and miR-124-3p was downregulated in women presenting with complications and PFD. miR-19-3p and miR-124-3p had a predictive value for both postpartum complications and PFD. miR-19-3p combined with miR-124-3p predicted complications and PFD with an AUC of 0.814 and 0.843, respectively. In addition, miR-19-3p and miR-124-3p were risk factors for PFD in women undergoing cesarean section. In conclusion, the potential exists for the use of miR-19-3p and miR-124-3p as molecular markers to predict postoperative complications and PFD, which may prove beneficial in the management of cesarean section patients.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"411-418"},"PeriodicalIF":1.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D Ameliorates Hyperuricemia-Induced Kidney Injury by Attenuating Inflammation via the NF-κB/NLRP3 Signaling Pathway. 维生素D通过NF-κB/NLRP3信号通路减轻炎症，改善高尿酸血症诱导的肾损伤

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-16 DOI: 10.1620/tjem.2026.J035

Rui Ruan, Shaofeng Rao, Jingjing Shao, Dan Wu

引用次数: 0

MicroRNA-940 Induces Apoptosis of HTR8-S/Vneo Cells in Intrahepatic Cholestasis of Pregnancy by Regulating RhoA. MicroRNA-940通过调节RhoA诱导妊娠肝内胆汁淤积HTR8-S/Vneo细胞凋亡

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-16 Epub Date: 2025-09-18 DOI: 10.1620/tjem.2025.J104

Chunyan Yu, Chengnan Zhang, Lei Zhang, Jinyu Gu, Li Qin

{"title":"MicroRNA-940 Induces Apoptosis of HTR8-S/Vneo Cells in Intrahepatic Cholestasis of Pregnancy by Regulating RhoA.","authors":"Chunyan Yu, Chengnan Zhang, Lei Zhang, Jinyu Gu, Li Qin","doi":"10.1620/tjem.2025.J104","DOIUrl":"10.1620/tjem.2025.J104","url":null,"abstract":"The expression of microRNA is likely to be closely associated with intrahepatic cholestasis of pregnancy (ICP). This study aimed to investigate the potential mechanisms underlying miR-940/RhoA-induced apoptosis in HTR8-S/Vneo cells in ICP. In this study, 80 pregnant women diagnosed with ICP were recruited, with healthy pregnant women as controls. RT-qPCR was utilized to quantify the expression levels of miR-940 and RhoA. Cell proliferation was evaluated using the CCK-8 assay, while flow cytometry was employed to assess cell apoptosis. The dual-luciferase reporter assay confirmed the targeting relationship between miR-940 and RhoA. miR-940 expression was significantly elevated in the ICP group. ROC curve analysis demonstrated that miR-940 exhibited high diagnostic accuracy for ICP. Cell proliferation assays indicated that miR-940 negatively regulates cell proliferation. Apoptosis experiments revealed that low levels of miR-940 inhibited apoptosis. The dual-luciferase reporter assay confirmed that miR-940 targeted RhoA, establishing a negative correlation between them. The reversed experiment demonstrated that while the downregulation of miR-940 promoted cell proliferation and inhibited apoptosis, these effects were partially reversed when RhoA expression was suppressed. In conclusion, miR-940 played a crucial role in regulating cell proliferation and apoptosis, and it held potential as a therapeutic target for inhibiting the apoptosis of HTR8-S/Vneo cells in ICP.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"419-426"},"PeriodicalIF":1.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Banana Peel Flour Attenuates Chronic Stress-Induced Sexual Dysfunction by Modulating the HPA-HPG Axis and Testicular Apoptosis-Related Signaling. 香蕉皮粉通过调节HPA-HPG轴和睾丸凋亡相关信号减轻慢性应激性性功能障碍。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-04-16 DOI: 10.1620/tjem.2026.J043

Andreanyta Meliala, Dicky Moch Rizal, Azizul Berlyansah, Paramita Narwidina, Laksmindra Fitria, Sri Lestari Sulistyo Rini

引用次数: 0