Tohoku Journal of Experimental Medicine最新文献_第2页

Protein-Losing Enteropathy Following Adrenocorticotropic Hormone Therapy in an Infant with West Syndrome. 西部综合征婴儿促肾上腺皮质激素治疗后的蛋白质丢失性肠病。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-25 Epub Date: 2025-01-16 DOI: 10.1620/tjem.2025.J002

Akira Akutsu, Yuji Fujita, Hiroaki Hitomi, Fumitaka Takayanagi, Yusuke Ando, George Imataka, Hideaki Shiraishi, Shigemi Yoshihara

{"title":"Protein-Losing Enteropathy Following Adrenocorticotropic Hormone Therapy in an Infant with West Syndrome.","authors":"Akira Akutsu, Yuji Fujita, Hiroaki Hitomi, Fumitaka Takayanagi, Yusuke Ando, George Imataka, Hideaki Shiraishi, Shigemi Yoshihara","doi":"10.1620/tjem.2025.J002","DOIUrl":"10.1620/tjem.2025.J002","url":null,"abstract":"Protein-losing enteropathy (PLE) is characterized by hypoproteinemia caused by the leakage of plasma proteins from the gastrointestinal tract wall into the lumen. We report a case of PLE occurring during low-dose adrenocorticotropic hormone (ACTH) therapy for West syndrome. A 6-month-old boy diagnosed with West syndrome was initially treated with sodium valproate and vitamin B6. Although the frequency of seizures decreased, electroencephalography findings did not improve. Consequently, low-dose ACTH therapy and a ketogenic diet were introduced. On day 5 (X + 5 days) after initiating ACTH therapy, scrotal edema and hypoalbuminemia were observed. Scintigraphy revealed leakage of radionuclides into the gastrointestinal tract, leading to a diagnosis of PLE. ACTH therapy was discontinued on X + 6 days, while valproate, vitamin B6, and the ketogenic diet were continued. Following the cessation of ACTH therapy, the patient showed improvement. We identified ACTH therapy as the likely cause of PLE in this case. This represents the first report of PLE diagnosed during ACTH therapy.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"111-113"},"PeriodicalIF":1.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Modulation Improves the Immune Function of Cervical Carcinoma Patients Receiving Radiotherapy: a Retrospective Analysis of 106 Cases. 营养调节对宫颈癌放疗患者免疫功能的改善：106例回顾性分析

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-20 Epub Date: 2025-05-15 DOI: 10.1620/tjem.2025.J052

Jianbo Li, Min Fang

{"title":"Nutritional Modulation Improves the Immune Function of Cervical Carcinoma Patients Receiving Radiotherapy: a Retrospective Analysis of 106 Cases.","authors":"Jianbo Li, Min Fang","doi":"10.1620/tjem.2025.J052","DOIUrl":"10.1620/tjem.2025.J052","url":null,"abstract":"The additional nutritional supplement will attenuate those impairments associated with radiotherapy. In the current study, we hypothesized that nutritional modulation could improve immune function of cervical cancer (CC) patients receiving radiotherapy. 106 CC who patients underwent radiotherapy were included in the current analysis. Fifty-five patients received a nutritional supplement containing omega-3 fats, arginine, dietary nucleotides, and soluble fiber during the radiotherapy treatment, with the remaining patients receiving a normal diet. The effects of the nutritional supplement were evaluated by collecting clinicopathological information. The analysis results showed that the body weight and body mass index (BMI) in the Nutritional group were both significantly higher than those in the Control group, along with improved nutritional status in Nutritional group assessed by patient-generated subjective global assessment (PG-SGA) and nutritional risk screening (NRS)-2002 scales. Moreover, all three proteins were significantly higher in the Nutritional group after the treatment when compared with the Control group, and the Nutritional group had significantly higher levels of CD4+, CD8+, CD4+/CD8+, NK cells, and B lymphocytes, suggesting that nutritional modulation improved immune function of CC patients undergoing radiotherapy. Collectively, nutritional modulation could effectively improve the health status of CC patients receiving radiotherapy by benefiting the patients' nutritional status and attenuating immune deficiency associated with radiotherapy.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"41-47"},"PeriodicalIF":1.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lncRNA PAX8-AS1 Serves as a Diagnostic Biomarker for Acute Coronary Syndrome and Predicts the Occurrence of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention. LncRNA PAX8-AS1作为急性冠状动脉综合征的诊断生物标志物，可预测经皮冠状动脉介入治疗后主要不良心血管事件的发生。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-20 Epub Date: 2025-01-30 DOI: 10.1620/tjem.2025.J010

Bin Xu, Yan Zhang, Shuxia Ji, Yeping Chen, Qun Zhang, Lingfeng Zhu

{"title":"lncRNA PAX8-AS1 Serves as a Diagnostic Biomarker for Acute Coronary Syndrome and Predicts the Occurrence of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention.","authors":"Bin Xu, Yan Zhang, Shuxia Ji, Yeping Chen, Qun Zhang, Lingfeng Zhu","doi":"10.1620/tjem.2025.J010","DOIUrl":"10.1620/tjem.2025.J010","url":null,"abstract":"Acute coronary syndrome (ACS) is a critical, life-threatening condition and a major cause of cardiovascular mortality and morbidity worldwide. The aim of this study was to investigate the clinical value of PAX8 antisense RNA 1 (PAX8-AS1) in ACS patients and to explore the effects of PAX8-AS1 on proliferation, apoptosis and migration of human umbilical vein endothelial cells (HUVECs). A total of 117 patients with ACS, including 62 patients with unstable angina pectoris (UAP) and 55 patients with acute myocardial infarction (AMI) were enrolled. RT-qPCR was used to detect the level of PAX8-AS1, and the diagnostic and prognostic value of PAX8-AS1 was analyzed using receiver operating characteristic (ROC) analysis and Kaplan-Meier analysis. Cell proliferation was detected with Cell Counting Kit-8 (CCK-8), cell apoptosis rate was detected by flow cytometry, and cell migration ability was detected by transwell assay. The binding relationship between PAX8-AS1 and miR-15a-5p was verified by dual-luciferase reporter gene assay. PAX8-AS1 was upregulated in the serum of ACS patients and had diagnostic value for ACS. PAX8-AS1 could distinguish UAP and AMI patients. High levels of PAX8-AS1 predicted the occurrence of major adverse cardiovascular events (MACEs) after percutaneous coronary intervention (PCI). In addition, PAX8-AS1 affected the proliferation, apoptosis and migration of HUVECs, and regulated the expression of miR-15a-5p. Therefore, PAX8-AS1 may be a biomarker for ACS.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"49-58"},"PeriodicalIF":1.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project. 基于语言注册的韦氏记忆量表手写逻辑记忆评分系统-修订：在东北医疗大银行项目中开发和验证。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-20 Epub Date: 2025-01-16 DOI: 10.1620/tjem.2025.J006

Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto

{"title":"Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.","authors":"Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto","doi":"10.1620/tjem.2025.J006","DOIUrl":"10.1620/tjem.2025.J006","url":null,"abstract":"The logical memory (LM) of the Wechsler Memory Scale-Revised was conducted in the Tohoku Medical Megabank Project in handwritten form. Our purpose was to develop and validate the Language registration-based scoring system for the handwritten LM. Seven hundred eighty consecutive participants underwent handwritten LM by listening to the recorded audio of two Stories and immediately afterward recalling the stories in handwriting on an answer sheet. All the answer sheets were transcribed into a digital version and were classified into the training and validation cohorts. Each Story had 25 Units, and an experienced clinical psychologist decided the variant patterns that could be scored based on Units using the training cohorts. In the validation cohort, the digital version of the answer sheets was checked to determine if it contained the variant patterns allowed as correct answers based on units, and the scores and the number of characters were calculated. The correlations between the scores and the number of characters, age, education duration, and the Japanese version of the Mini-Mental State Examination (MMSE-J) were evaluated. The score was a median of 19 (range 0-42) and was significantly correlated with the number of characters (r = 0.85, p < 0.0001). The scores significantly negatively correlated with age (r = --0.41, p < 0.0001) and significantly positively correlated with education duration and MMSE-J (ρ = 0.20, p < 0.0001; ρ = 0.35, p < 0.0001).In conclusion, we proposed the Language registration-based scoring system for the handwritten immediate recall of LM, and the scores were significantly correlated with the number of characters, age, education duration, and the MMSE-J.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"59-69"},"PeriodicalIF":1.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kampo Prescriptions for Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A Secondary Analysis of Nationwide Survey by JSOG Women's Health Care Committee. 汉方治疗经前综合征和经前烦躁不安：JSOG妇女保健委员会全国调查的二次分析。

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-20 Epub Date: 2025-02-21 DOI: 10.1620/tjem.2025.J019

Takashi Takeda, Kana Yoshimi, Fumi Inoue, Tamami Odai, Nahoko Shirato, Zen Watanabe, Tempei Otsubo, Masakazu Terauchi

{"title":"Kampo Prescriptions for Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A Secondary Analysis of Nationwide Survey by JSOG Women's Health Care Committee.","authors":"Takashi Takeda, Kana Yoshimi, Fumi Inoue, Tamami Odai, Nahoko Shirato, Zen Watanabe, Tempei Otsubo, Masakazu Terauchi","doi":"10.1620/tjem.2025.J019","DOIUrl":"10.1620/tjem.2025.J019","url":null,"abstract":"Premenstrual syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) significantly impair women's quality of life. A survey of obstetricians and gynecologists showed that 19.5% of the doctors preferred Kampo medicine, including Tokishakuyakusan (TSS), Kamishoyosan (KSS), Keishibukuryogan (KBG), and Yokukansan (YKS), as the first-choice treatment for these conditions. We aimed to analyze the characteristics of each Kampo prescription. A secondary analysis was conducted on survey results from members of the Japan Society of Obstetrics and Gynecology collected from September to November 2021. Data from 1,259 respondents treating PMS/PMDD were analyzed. Our correspondence analysis plotted relationships among treatments, showing that Kampo prescriptions of TSS, KSS, KBG, and YKS were distributed similarly to oral contraceptives (OCPs), but different from selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and gonadotropin-releasing hormone analogs. Among the Kampo formulas, prescription YKS was the closest to SSRIs/SNRIs. Logistic regression analysis revealed that shorter physician experience (< 10 years, ≥ 10 and < 20 years) was associated with selecting prescriptions for TSS and KBG, whereas being a private practitioner was linked to selecting prescriptions for KSS and YKS (clinic vs. hospital OR: 1.57, 1.77; clinic vs. university OR: 1.53, 1.71). The prescription of YKS was also associated with choosing SSRIs/SNRIs (OR: 1.81), chasteberry (OR: 6.24), and other medications or supplements (OR: 2.41). Kampo prescriptions were strongly correlated with OCPs. Prescription TSS and KBG were likely chosen by less experienced practitioners, whereas prescription YKS was used by those more familiar with PMS/PMDD treatments, including SSRIs/SNRIs.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"33-39"},"PeriodicalIF":1.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between P2RX7 rs7958311 Polymorphism and Labor Analgesia in Primiparas. 初产妇P2RX7 rs7958311多态性与分娩镇痛的关系

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-18 DOI: 10.1620/tjem.2025.J107

Ying Wang, Guantong Zhou, Lijia Long, Li Wan, Yan Hou, Churong Wang

引用次数: 0

Sanqi Oral Solution Containing Serum Ameliorates C5b-9 Induced Podocyte Injury via the Endoplasmic Reticulum Stress/Unfolded Protein Response Dependent Pathway. 含血清三七口服液通过内质网应激/未折叠蛋白反应依赖途径改善C5b-9诱导的足细胞损伤

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-18 DOI: 10.1620/tjem.2025.J101

Yongdong Du, Ruitao Cai, Zhibin Lin, Zhengdong Wu

引用次数: 0

MicroRNA-940 Induces Apoptosis of HTR8-S/Vneo Cells in Intrahepatic Cholestasis of Pregnancy by Regulating RhoA. MicroRNA-940通过调节RhoA诱导妊娠肝内胆汁淤积HTR8-S/Vneo细胞凋亡

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-18 DOI: 10.1620/tjem.2025.J104

Chunyan Yu, Chengnan Zhang, Lei Zhang, Jinyu Gu, Li Qin

引用次数: 0

MiR-126-3p Inhibits the Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Targeting SLC7A5. MiR-126-3p通过靶向SLC7A5抑制多囊卵巢综合征卵巢颗粒细胞凋亡

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-18 DOI: 10.1620/tjem.2025.J113

Baoqin Liu, Qiong Peng

引用次数: 0

Expression of LINC01123 in Patients with Hypertension and Its Damage to Endothelial Cells. LINC01123在高血压患者中的表达及其对内皮细胞的损害

IF 1.6 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-09-18 DOI: 10.1620/tjem.2025.J105

Yuanyuan Su, Runxi Xu, Shuqi Huang, Chong Yang, Yunhua Hao

引用次数: 0