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Tohoku Journal of Experimental Medicine最新文献

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Development a Novel Classification Based on Serum Sodium Level Integrated with Comorbid Conditions (BASIC) in Hyponatremia Patients via Data-Driven Cluster Analysis. 通过数据驱动的聚类分析，根据低钠血症患者的血清钠水平和并发症（BASIC）建立新的分类方法
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-19 DOI: 10.1620/tjem.2024.J101
Siyu Liang, Lize Sun, Yuelun Zhang, Nan Jiang, Shi Chen, Hui Pan
{"title":"Development a Novel Classification Based on Serum Sodium Level Integrated with Comorbid Conditions (BASIC) in Hyponatremia Patients via Data-Driven Cluster Analysis.","authors":"Siyu Liang, Lize Sun, Yuelun Zhang, Nan Jiang, Shi Chen, Hui Pan","doi":"10.1620/tjem.2024.J101","DOIUrl":"https://doi.org/10.1620/tjem.2024.J101","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Continuation Rates of Romosozumab and Teriparatide Administrations in a Rural Area. 罗莫司单抗和特立帕肽在农村地区持续用药率的比较
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-19 DOI: 10.1620/tjem.2024.J102
Hiroyuki Tsuchie, Hidekazu Abe, Norimitsu Masutani, Naohisa Miyakoshi
{"title":"Comparison of the Continuation Rates of Romosozumab and Teriparatide Administrations in a Rural Area.","authors":"Hiroyuki Tsuchie, Hidekazu Abe, Norimitsu Masutani, Naohisa Miyakoshi","doi":"10.1620/tjem.2024.J102","DOIUrl":"https://doi.org/10.1620/tjem.2024.J102","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the Mechanisms and Targets of Compound Houttuynia Cordata Mixture in COVID-19 Prevention through Integrated Network Pharmacology and Experimental Verification. 通过整合网络药理学和实验验证，破译复方蕺菜虫草混合物预防 COVID-19 的机制和靶点
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-19 DOI: 10.1620/tjem.2024.J100
Dongbo Yuan, Xiaoyue Chen, Guohua Zhu, Wei Wang, Jianguo Zhu
{"title":"Deciphering the Mechanisms and Targets of Compound Houttuynia Cordata Mixture in COVID-19 Prevention through Integrated Network Pharmacology and Experimental Verification.","authors":"Dongbo Yuan, Xiaoyue Chen, Guohua Zhu, Wei Wang, Jianguo Zhu","doi":"10.1620/tjem.2024.J100","DOIUrl":"https://doi.org/10.1620/tjem.2024.J100","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma. 三氧化二砷诱导视黄酸相关孤儿受体 Beta 并阻断 WNT 通路以抑制胶质母细胞瘤的干细胞生长
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-18 Epub Date: 2024-05-24 DOI: 10.1620/tjem.2024.J033
Dacheng Ding, Kaiming Gao, Xuebin Zhang, Hu Wang
{"title":"Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma.","authors":"Dacheng Ding, Kaiming Gao, Xuebin Zhang, Hu Wang","doi":"10.1620/tjem.2024.J033","DOIUrl":"10.1620/tjem.2024.J033","url":null,"abstract":"<p><p>Glioblastoma (GBM) is a malignant primary brain tumor and an essential contributor to morbidity and mortality globally. Arsenic trioxide (ATO) exerts specific roles in preventing tumor growth. This study investigated the role of ATO in GBM cell behaviors and stemness. The effects of ATO on the malignant behavior of GBM cells, tumor stemness, and epithelial-mesenchymal transition (EMT) factors in mouse tumor tissues were explored. Targets of ATO in GBM were predicted using multiple databases. Subsequently, the expression of retinoic acid-related orphan receptor beta (RORB), WNT-1, β-Catenin, and c-Myc expression were examined in GBM cells before and after ATO treatment.ATO inhibited the malignant behavior of GBM cells in vitro and slowed down the GBM growth in vivo by inhibiting the stemness. The inhibitory effect of ATO on GBM was achieved by promoting RORB levels and strengthening the antagonism to β-Catenin to inhibit Wnt signaling, thus inhibiting tumor growth. Collectively, ATO induced RORB levels in GBM cells and strengthened the antagonistic effect on β-Catenin, thus inhibiting WNT signaling and tumor growth.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Ciliary Dyskinesia with Identical Genotype but Distinct Phenotypes in Two Siblings. 两兄妹中基因型相同但表现型不同的原发性睫状肌运动障碍症
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-18 Epub Date: 2024-05-30 DOI: 10.1620/tjem.2024.J035
Megumi Sato, Yuji Fujita, George Imataka, Shigeko Kuwashima, Kazuhiko Takeuchi, Shigemi Yoshihara
{"title":"Primary Ciliary Dyskinesia with Identical Genotype but Distinct Phenotypes in Two Siblings.","authors":"Megumi Sato, Yuji Fujita, George Imataka, Shigeko Kuwashima, Kazuhiko Takeuchi, Shigemi Yoshihara","doi":"10.1620/tjem.2024.J035","DOIUrl":"10.1620/tjem.2024.J035","url":null,"abstract":"<p><p>In this study, we report two cases of siblings diagnosed with primary ciliary dyskinesia (PCD) sharing an identical genotype yet exhibiting distinct phenotypes. A 13-year-old girl with acute pneumonia was admitted to our hospital. Chest and sinus radiography revealed situs inversus and bilateral maxillary sinusitis. Chest computed tomography revealed bronchiectasis. Her 6-year-old brother with acute bronchitis was admitted and was diagnosed with bronchial asthma due to recurrent wheezing. Unlike his sister, he did not have situs inversus. Both patients had a chronic wet cough and were diagnosed with bronchial asthma by their family doctor. The mean PCD rule (PICADAR) scores were 9 and 7, respectively. Genetic analysis confirmed the presence of the same homozygous mutation (c.546C > A,pTyr182Ter) in DNAI2. To date, there have been four reports of the same pathogenic variants but different PCD phenotypes. Pathological variants of DNAI2 cause the loss of the outer dynein arm, the absence of which results in a lack of primary ciliary movement involved in the left-right axis formation during the embryonic period. A lack of functional cilia results in randomized visceral asymmetry; hence, the same pathogenic variant may exhibit different phenotypes. PCD is often overlooked and is sometimes managed as bronchial asthma, as in these siblings. In our case, the PICADAR score was useful in predicting the clinical diagnosis of PCD.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value of Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index on Functional Status and Mortality in Patients with Critical Acute Ischemic Stroke. 全身免疫炎症指数和全身炎症反应指数对危重急性缺血性脑卒中患者功能状态和死亡率的预后价值
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-12 DOI: 10.1620/tjem.2024.J094
Kadir Arslan, Ayca Sultan Sahin
{"title":"Prognostic Value of Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index on Functional Status and Mortality in Patients with Critical Acute Ischemic Stroke.","authors":"Kadir Arslan, Ayca Sultan Sahin","doi":"10.1620/tjem.2024.J094","DOIUrl":"https://doi.org/10.1620/tjem.2024.J094","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor. 多环芳香烃通过调节芳香烃受体调控鼻咽癌的发生和发展
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-12 DOI: 10.1620/tjem.2024.J095
Zhicong Hong, Qiaoling Guo, Xianyang Luo, Liying Liu
{"title":"Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor.","authors":"Zhicong Hong, Qiaoling Guo, Xianyang Luo, Liying Liu","doi":"10.1620/tjem.2024.J095","DOIUrl":"https://doi.org/10.1620/tjem.2024.J095","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction and Risk Factors of Lower Extremity Deep Vein Thrombosis after Total Joint Arthroplasty. 全关节成形术后下肢深静脉血栓形成的预测和风险因素。
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-12 DOI: 10.1620/tjem.2024.J099
Zhenhua Wang, Zhiwei Liu, Zhaoxing Tian
{"title":"Prediction and Risk Factors of Lower Extremity Deep Vein Thrombosis after Total Joint Arthroplasty.","authors":"Zhenhua Wang, Zhiwei Liu, Zhaoxing Tian","doi":"10.1620/tjem.2024.J099","DOIUrl":"https://doi.org/10.1620/tjem.2024.J099","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Triglyceride Glucose Index and All-Cause Mortality in the Psoriasis Patients. 银屑病患者甘油三酯血糖指数与全因死亡率之间的关系
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-12 DOI: 10.1620/tjem.2024.J089
Yanqian Su, Huijuan Shi, Jue Tang, Siqi Zhao, Xuan Li, Jing Wang, Yanling He
{"title":"Association between Triglyceride Glucose Index and All-Cause Mortality in the Psoriasis Patients.","authors":"Yanqian Su, Huijuan Shi, Jue Tang, Siqi Zhao, Xuan Li, Jing Wang, Yanling He","doi":"10.1620/tjem.2024.J089","DOIUrl":"https://doi.org/10.1620/tjem.2024.J089","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Amputation Level and Oncologic Prognosis on Activities of Daily Living in Patients with Lower Limb Amputation for Musculoskeletal Malignancies. 肌肉骨骼恶性肿瘤下肢截肢患者截肢程度和肿瘤预后对日常生活活动的影响
IF 1.7 4区 医学
Tohoku Journal of Experimental Medicine Pub Date : 2024-09-12 DOI: 10.1620/tjem.2024.J098
Hiromori Sagae, Masato Sugawara, Daiichiro Takahara, Michiaki Takagi, Yuya Takakubo
{"title":"Impact of Amputation Level and Oncologic Prognosis on Activities of Daily Living in Patients with Lower Limb Amputation for Musculoskeletal Malignancies.","authors":"Hiromori Sagae, Masato Sugawara, Daiichiro Takahara, Michiaki Takagi, Yuya Takakubo","doi":"10.1620/tjem.2024.J098","DOIUrl":"https://doi.org/10.1620/tjem.2024.J098","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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