Tohoku Journal of Experimental Medicine最新文献

{"title":"A High Ratio of D-1 Dimer to Brain Natriuretic Peptide and Large Right-to-Left Shunt by Contrast-Enhanced Transthoracic Echocardiography as Risk Factors for Cryptogenic Stroke in Patent Foramen Ovale.","authors":"Fuwang Zhang, Wenfang Cui","doi":"10.1620/tjem.2025.J056","DOIUrl":"https://doi.org/10.1620/tjem.2025.J056","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hsa-miR-485-3p can be Involved in the Progression of Diabetic Retinopathy by Targeting IL1RN.","authors":"Sha Zheng, Mei Long, Yi Chen","doi":"10.1620/tjem.2025.J055","DOIUrl":"https://doi.org/10.1620/tjem.2025.J055","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Remote Symptom 1 Monitoring and Progressive Muscle Relaxation in Enhancing Well-Being and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy.","authors":"Yong Jiang, Jing-Ping Yang, Qin Liu","doi":"10.1620/tjem.2025.J057","DOIUrl":"https://doi.org/10.1620/tjem.2025.J057","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance and Functional Analysis of miR-487b-3p in Ovarian Cancer.","authors":"Shixi Zhang, Jing Chen, Qian Gao, Yan Li, Chao Wang","doi":"10.1620/tjem.2025.J059","DOIUrl":"https://doi.org/10.1620/tjem.2025.J059","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance and Biological Role of lncRNA linc00893 in Diabetic Retinopathy.","authors":"Jingdi Zhang, Wenhan Lu, Dan Xu","doi":"10.1620/tjem.2025.J058","DOIUrl":"https://doi.org/10.1620/tjem.2025.J058","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Clinicopathological Characteristics and Clinical Outcomes of Patients Who Developed Non-Muscle-Invasive Bladder Cancer After Radiotherapy for Prostate Cancer: A Retrospective Multicenter Study.","authors":"Takuma Sato, Takeshi Sano, Hisanobu Adachi, Yoshihiro Ikeda, Jun Takemoto, Shingo Myoen, Koji Mitsuzuka, Atsushi Kyan, Hiroshi Aoki, Satoru Tokuyama, Hideo Saito, Shinichi Yamashita, Yoichi Arai, Takashi Kobayashi, Akihiro Ito","doi":"10.1620/tjem.2024.J109","DOIUrl":"10.1620/tjem.2024.J109","url":null,"abstract":"<p><p>Radiotherapy for prostate cancer may induce the development of secondary bladder cancer. However, the clinicopathological characteristics and clinical outcomes of this entity have not been fully elucidated. Therefore, this study compared the clinicopathological characteristics and clinical outcomes of patients who developed secondary bladder cancer after radiotherapy with those of controls. The medical records of patients newly diagnosed with non-muscle-invasive bladder cancer were retrospectively analyzed. Newly diagnosed non-muscle-invasive bladder cancer that developed ≥ 5 years after radiotherapy for prostate cancer was defined as secondary non-muscle-invasive bladder cancer during this study. Patients with newly diagnosed non-muscle-invasive bladder cancer who did not meet this criterion were included in the control group. The clinicopathological characteristics and recurrence-free survival rates of patients with secondary non-muscle-invasive bladder cancer were compared with those of controls. A total of 26 (2.6%) of the 1,019 patients from the Tohoku Urological Evidence-Based Medicine Study Group and Kyoto University Hospital who were screened met this criterion for secondary non-muscle-invasive bladder cancer. Clinicopathological characteristics were similar between the secondary non-muscle-invasive bladder cancer and control groups, except for sex and age. Propensity score-matched analysis revealed that the recurrence-free survival rates of patients with secondary non-muscle-invasive bladder cancer may not be poorer than those of control patients. Tumor characteristics and recurrence-free survival rates of patients with secondary non-muscle invasive bladder cancer were comparable with those of controls. Further large-scale studies should be conducted to clarify the tumor characteristics and clinical outcomes of these patients after radiotherapy.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"37-46"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Cancer Worries for Gastric Cancer by Helicobacter Pylori Infection Status at Health Check-Up Setting in Japan.","authors":"Sho Fukuda, Kenta Watanabe, Shusei Fujimori, Taiga Komatsu, Tatsuki Yoshida, Taira Kuramitsu, Yosuke Shimodaira, Tamotsu Matsuhashi, Katsunori Iijima","doi":"10.1620/tjem.2024.J108","DOIUrl":"10.1620/tjem.2024.J108","url":null,"abstract":"<p><p>Helicobacter pylori (HP) infection is the major cause of gastric cancer (GC). No reports have been published on the effects of HP infection on anxiety for GC, although the majority of HP-positive subjects received eradication therapy intending to reduce their risk of GC in Japan. This study aimed to investigate the relationship between cancer worry (CW) for GC and participants' HP infection status. The original study was a quantitative, self-administered questionnaire survey to investigate CW for esophageal cancer in Barrett's esophagus. The present study used the same dataset on CW against GC. Participants were recruited between May 2021 and March 2022 from three health screening facilities in Akita Prefecture, Japan. The Cancer Worry Scale was used to quantitatively assess the fear of developing cancer. Logistic regression analyses were used to investigate factors associated with excessive CW (defined as ≥ 13). A total of 303 respondents were included. Excessive CW accounted for 63.0% (92/146) in HP-negative, 55.0% (11/20) in HP-positive, and 71.5% (98/137) in HP-eradicated patients. While the presence of upper gastrointestinal symptoms and subnormal mental health quality were significantly associated with excessive CW, the status of HP infection did not affect it. There is a significant discrepancy between CW for GC and actual GC risk, defined as their HP infection status, among those undergoing GC screening. It may be necessary to provide appropriate patient education when introducing risk-based (mainly HP-based) stratified screening for GC shortly in Japan.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"29-36"},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between ENPP1 Gene rs1044498 Polymorphism with the Risk of Type 2 Diabetes Mellitus: A Meta-analysis.","authors":"Chunlin Li, Li Liu","doi":"10.1620/tjem.2024.J057","DOIUrl":"10.1620/tjem.2024.J057","url":null,"abstract":"<p><p>As a common metabolic disease, type 2 diabetes mellitus (T2DM) is regulated by the ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1). A functional polymorphism of ENPP1 (rs1044498, K121Q) has been found to contribute to T2DM susceptibility. This study aims to analyze the combined association of ENPP1 rs1044498 polymorphism with T2DM risk. We searched for publications in Embase, Medline, EBSCO, PubMed, China National Knowledge Infrastructure (CNKI), and Wanfang databases from January 2010 to December 2023. Pooled association strength was analyzed using either a random-effects or fixed-effects model, and expressed as combined odds ratios (ORs) with 95% confidence intervals (CIs). Data analysis was performed by STAT 12.0. Due to high heterogeneity, a random-effects model was used for the calculation. In the total population, ENPP1 rs1044498 was evidently related to an increased susceptibility to T2DM under the following models: Q vs. K (OR = 1.405, 95% CI = 1.059-1.863), KQ + QQ vs. KK (OR = 1.475, 95% CI = 1.075-2.023), QQ vs. KK + KQ (OR = 2.355, 95% CI = 1.302-4.262), QQ vs. KK (OR = 3.096, 95% CI = 1.393-6.882) and KQ vs. KK (OR = 1.399, 95% CI = 1.038-1.885). In ethnic subgroups, rs1044498 was associated with T2DM risk in Asians under the following models: Q vs. K (OR = 1.480, 95% CI = 1.017-2.154), KQ + QQ vs. KK (OR = 1.578, 95% CI = 1.047-2.379), QQ vs. KK+ KQ (OR = 3.709, 95% CI = 1.727-7.967), QQ vs. KK (OR = 5.049, 95% CI = 1.784-16.397) and KQ vs. KK (OR = 1.478, 95% CI = 1.008-2.167). The distinct association between rs1044498 and T2DM risk was discovered in the diagnostic criteria not shown subgroup and plasma subgroup. This study demonstrated high sensitivity with minimal publication bias. The ENPP1 121Q allele is a risk factor for T2DM, particularly in the Asian population.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"19-28"},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Value and Molecular Mechanism of MiR-411-5p in Coronary Atherosclerosis.","authors":"Chang Liu, Yingying Wang, Menghao Sun, Tingqi Shi","doi":"10.1620/tjem.2025.J053","DOIUrl":"https://doi.org/10.1620/tjem.2025.J053","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Modulation Improves the Immune Function of Cervical Carcinoma Patients Receiving Radiotherapy: A Retrospective Analysis of 106 Cases.","authors":"Jianbo Li, Min Fang","doi":"10.1620/tjem.2025.J052","DOIUrl":"https://doi.org/10.1620/tjem.2025.J052","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}