Tohoku Journal of Experimental Medicine最新文献

{"title":"Development of a Machine Learning-Based Tool for Predicting Operative Time in Robot-Assisted Laparoscopic Hysterectomy.","authors":"Shioka Kukimoto, Muneaki Shimada, Shinya Sonobe, Saori Ikumi, Eichi Takaya, Makoto Miyauchi, Tomoya Kobayashi, Junya Iwazaki, Shuko Miyahara, Takanori Shimizu, Junko Hasegawa-Minato, Yusuke Shibuya, Masumi Ishibashi, Shogo Shigeta, Yoshiko Oyama, Kojiro Tanabe, Hitoshi Niikura, Masatoshi Saito","doi":"10.1620/tjem.2026.J106","DOIUrl":"https://doi.org/10.1620/tjem.2026.J106","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dapagliflozin Alleviates Non-Alcoholic Fatty Liver Disease in Mice by Inhibiting Ferroptosis through Activating the SIRT1/Nrf2 Pathway.","authors":"Min Liu, BiYing Meng, Jing Dong, Lin Xiang","doi":"10.1620/tjem.2026.J037","DOIUrl":"10.1620/tjem.2026.J037","url":null,"abstract":"<p><p>Ferroptosis, an iron-dependent cell death form, has been identified to be closely related to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Dapagliflozin (DAPA), as the most representative drug of sodium-glucose cotransporter 2 (SGLT2) inhibitors, shows potential benefits for NAFLD prevention and treatment. However, it remains unknown whether and how DAPA alleviates hepatic ferroptosis in NAFLD. Here our research used high-fat diet (HFD) feeding to establish NAFLD mouse models and treated HepG2 cells with free fatty acid (FFA) mixture (oleic acid and palmitic acid) to construct fatty hepatic steatosis cellular models. We discovered that DAPA administration ameliorated global metabolic abnormalities, attenuated liver lipid deposition, and impeded disease progression in NAFLD mice. DAPA treatment markedly improved HFD-induced hepatic lipid peroxidation and ferroptosis. The inhibitory effects of DAPA on hepatocyte ferroptosis and lipid accumulation were also observed in FFA-treated HepG2 cells. Mechanistically, DAPA treatment promoted the SIRT1/Nrf2 signaling pathway. The SIRT1 inhibitor EX527 overturned the anti-lipid deposition and anti-ferroptotic effects of DAPA in FFA-treated HepG2 cells. Collectively, DAPA suppresses hepatic ferroptosis in NAFLD by activating the SIRT1/Nrf2 pathway, proving that targeting DAPA-mediated ferroptosis is a promising therapeutic method for treating NAFLD.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"561-574"},"PeriodicalIF":1.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Total Callosotomy in a Patient with Lennox-Gastaut Syndrome and Cardio-Facio-Cutaneous Syndrome.","authors":"Aritomo Kawashima, Haruhiko Nakamura, Kaori Kodama, Yukimune Okubo, Wakaba Endo, Takehiko Inui, Noriko Togashi, Saki Uneoka, Moriei Shibuya, Yoshitsugu Oikawa, Yu Katata, Yurika Numata-Uematsu, Mitsugu Uematsu, Hiroshi Kawame, Shin-Ichiro Osawa, Daiju Oba, Tetsuya Niihori, Yoko Aoki, Kazuhiro Haginoya","doi":"10.1620/tjem.2024.J146","DOIUrl":"10.1620/tjem.2024.J146","url":null,"abstract":"<p><p>This report presents a rare case of cardio-facio-cutaneous (CFC) syndrome and Lennox-Gastaut syndrome (LGS) experiencing intractable epilepsy characterized by drop attacks. This is the first known instance where total callosotomy has been successfully performed in a case with CFC who suffered from LGS. The procedure proved effective even in patients with developmental and epileptic encephalopathy caused by genetic variations, suggesting callosotomy as a viable option to improve quality of life in those with severe, uncontrolled drop attacks.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"555-559"},"PeriodicalIF":1.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Continuous Nursing Intervention on Medication Adherence, Self-Efficacy, and Blood Lipid Levels in Patients with Coronary Heart Disease after PCI Surgery.","authors":"Mingyue Pan, Chaoyu Cao, Qiaoping Chen, Yuefang Gao, Lanlan Xiao, Yan Tang, Qing Wang","doi":"10.1620/tjem.2026.J027","DOIUrl":"10.1620/tjem.2026.J027","url":null,"abstract":"<p><p>This study aimed to examine the impacts of continuous nursing interventions on medication adherence, self-efficacy, and lipid levels in coronary heart disease (CHD) patients post-percutaneous coronary intervention (PCI). A retrospective study was performed on the clinical records of 108 CHD patients who underwent PCI from June 2022 to May 2024. The patients were categorized into two groups according to the type of nursing care they received: the routine nursing group (RN, n = 54) and the continuous nursing group (CN, n = 54). The CN group received continuous nursing interventions in addition to routine nursing. The study compared medication adherence [Morisky Medication Adherence Scale (MMAS) scores], self-efficacy [General Self-Efficacy Scale (GSS) scores], lipid levels [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], and patient satisfaction between the two groups. After the intervention, MMAS scores, GSS scores, HDL-C levels, and satisfaction significantly increased in both groups, while TC, TG, and LDL-C levels significantly decreased (P < 0.05). Compared to the RN group, the CN group showed a significantly higher increase in MMAS scores, GSS scores, HDL-C levels, and satisfaction, and a significantly greater decrease in TC, TG, and LDL-C levels (P < 0.05). Continuous nursing intervention markedly enhanced medication adherence, self-efficacy, and lipid levels in CHD patients post-PCI, and increased patient satisfaction.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"547-553"},"PeriodicalIF":1.5,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Optimal Ordered Subset Expectation Maximization Reconstruction for [I-123]FP-CIT Single-Photon Emission Computed Tomography Using a Ring-Type Semiconductor Scanner.","authors":"Nao Yamaguchi, Hayato Odagiri, Hayato Sato, Hiroyasu Kodama, Yoshitaka Tanaka, Takashi Takeuchi, Kentaro Takanami, Akihito Usui, Tomohiro Kaneta","doi":"10.1620/tjem.2026.J005","DOIUrl":"10.1620/tjem.2026.J005","url":null,"abstract":"<p><p>A recently introduced ring-type single-photon emission computed tomography (SPECT)/computed tomography (CT) scanner equipped with 12 small semiconductor detectors is expected to shorten the acquisition time and improve spatial resolution. This study evaluated the optimal ordered subset expectation maximization (OSEM) reconstruction for [I-123] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodo-phenyl) nor tropane SPECT using a striatum phantom. The phantom was filled with an I-123 solution, and the radioactivity concentration ratio in the background, right striatum, left caudate, and left putamen was 1:8:8:4. The evaluated acquisition time was 15, 20, 30, and 120 min. The acquired data were reconstructed using OSEM under various conditions. The reconstructed images were evaluated regarding coefficient of variation (Δ%CV), normalized mean squared errors (NMSE), and visual interpretation. In addition, the striatal uptake ratio (SUR) and contrast ratio of the images were compared between the ring-type and the conventional 2-detecter (Anger-type) scanner. The Δ%CV of the 120 min image was sufficiently small when the number of updates reached 100 and converged uniformly. The NMSE of the 20 and 30 min images were almost constant when the number of updates exceeded 120. Regarding visual interpretation, cut-off frequencies of 0.4 and 0.5 cycles/cm for the Butterworth filter were considered optimal. The SUR and contrast ratio of the ring-type scanner were significantly higher than those of the Anger-type. In conclusion, an acquisition time of 20 min, OSEM reconstruction with 120 updates, and a Butterworth filter of 0.4-0.5 cycles/cm were suitable for [I-123]FP-CIT SPECT using a ring-type scanner.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"479-490"},"PeriodicalIF":1.5,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Noncoding RNA ST8SIA6-AS1 Promotes the Development of Prostate Cancer by Activating the TGF-β/Smad Signaling Pathway Through Regulating the miR-18a-5p/TGFBR1 Axis.","authors":"Qingshan Liu, Jian Ke, Yu Luo","doi":"10.1620/tjem.2025.J140","DOIUrl":"10.1620/tjem.2025.J140","url":null,"abstract":"<p><p>Prostate cancer (PCa) is one of the most malignant tumors in men. ST8SIA6-AS1 is a newly identified lncRNA that has been identified as an oncogene in many human cancers. We aimed to investigate the biological effects of lncRNA ST8SIA6-AS1 on the development of PCa. We found that ST8SIA6-AS1 expression was elevated in PCa tissues and cells. ST8SIA6-AS1 knockdown inhibited cell proliferation and migration and promoted cell apoptosis in PCa cells. Furthermore, ST8SIA6-AS1 bound with miR-18a-5p in PCa. TGFBR1 was directly targeted by miR-18a-5p in PCa and mediated the biological influence of miR-18a-5p and ST8SIA6-AS1 in PCa, resulting in TGF-β/Smad signaling pathway activation. Importantly, ST8SIA6-AS1 silencing suppressed tumor growth in PCa xenograft mouse models. In summary, this paper first demonstrated that ST8SIA6-AS1 played an oncogenic role via sponging miR-18a-5p and promoting TGFBR1 level and TGF-β/Smad activation in PCa, providing novel insights for the therapeutic strategies of PCa.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"527-539"},"PeriodicalIF":1.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KRAS and MET Co-Mutation in One Lesion and EGFR Mutation in Another Lesion of Early-Stage Synchronous Multiple Lung Adenocarcinomas: A Case Report.","authors":"Takayasu Ito, Ken Onodera, Naoya Ishida, Sakiko Kumata, Takeo Togo, Tatsuaki Watanabe, Yui Watanabe, Takashi Hirama, Takaya Suzuki, Hirotsugu Notsuda, Hisashi Oishi, Yoshinori Okada","doi":"10.1620/tjem.2025.J157","DOIUrl":"10.1620/tjem.2025.J157","url":null,"abstract":"<p><p>Recent advances in medical technology have led to an increased number of reports of various driver mutations and cases of synchronous multiple primary lung cancer. Although multiple driver mutations in a lung cancer lesion are generally considered mutually exclusive, recent studies have reported rare cases of coexisting mutations known as co-mutations. In this case report, we describe a rare case of three synchronous lung adenocarcinomas presenting as ground-glass opacities in the left upper lung lobe of a 68-year-old man. The patient underwent a thoracoscopic left upper division segmentectomy. Pathological examination of these lesions revealed early-stage lung adenocarcinomas with varying degrees of invasiveness. Genetic testing revealed a MET exon 14 skipping mutation and a KRAS mutation in one lesion, and an EGFR L858R mutation in another. The postoperative course was uneventful, and no recurrence has been detected since 1 year and 9 months after surgery (without adjunctive treatment). This case is notable because co-mutations were present in one lesion, while a different driver mutation was present in another ground-glass nodule. To the best of our knowledge, only one case of synchronous multiple primary lung cancer harboring a co-mutation has been reported to date. The findings of this case report suggest that multiple driver mutations and even co-mutations can arise in the early stages of carcinogenesis. The accumulation of similar cases in the future is expected to help elucidate the molecular mechanisms and clinical significance of these mutations.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"541-545"},"PeriodicalIF":1.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence for Breast Carcinoma Detection in Histopathological Images Based on Single Shot MultiBox Detector in Intraoperative Rapid Diagnosis.","authors":"Mio Yamaguchi-Tanaka, Tomoaki Sasaki, Kodai Uemura, Yuichiro Tajima, Sho Kato, Takayoshi Asakura, Kiyoshi Takagi, Yuto Yamazaki, Atsushi Masamune, Toshio Miyata, Takashi Suzuki","doi":"10.1620/tjem.2025.J120","DOIUrl":"10.1620/tjem.2025.J120","url":null,"abstract":"<p><p>Intraoperative rapid diagnosis with pathological classification by pathologists plays a pivotal role in making appropriate surgical decisions. However, morphological evaluation of intraoperative frozen sections is apparently more difficult than that of formalin fixed paraffin embedded (FFPE) tissue because of their unavoidable tissue-processing artifacts, which compels pathologists, even well-trained, more challenging to make an accurate diagnosis. Therefore, assisting the pathological diagnosis with artificial intelligence is anticipated. Here, we built the data set consisting of histopathological micrographs of intraoperative frozen sections and demonstrated an automatic breast carcinoma detection model based on a Single Shot MultiBox Detector, an object detection method known for real-time, high-speed performance. The final 3-class classification model was trained on 943 intraoperative frozen section images and evaluated using 65 images, identifying benign lesions, non-invasive carcinoma, and invasive carcinoma. The 2-class (benign or malignant) and 3-class classification tasks achieved diagnostic accuracies for whole image of 92.3% and 89.2%, respectively. When we evaluated the performance of object detection in the 2-class task, the precision, recall and F1 scores for malignant detection are 70.3%, 74.4%, and 72.3%, respectively. Additionally, the model's object detection performance was assessed using FFPE images, yielding a precision of 55.1%, a sensitivity of 76.9%, and an F1 score of 64.2%, suggesting that it is particularly well-suited for intraoperative frozen sections. In conclusion, we presented the automatic breast carcinoma detection method, utilizing histopathological micrographs of intraoperative frozen sections. The present model may assist pathologists by reducing their workload and minimizing the risk of overlooking carcinoma cells in intraoperative diagnosis.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"507-516"},"PeriodicalIF":1.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corynoxine Attenuates Proliferation and Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells Through Inactivation of the JAK2/STAT3/PIM1 Signaling Cascade.","authors":"Meijuan Lan, Daoxu Huang, Mengchun Xiao, Lingmin Chi","doi":"10.1620/tjem.2026.J103","DOIUrl":"https://doi.org/10.1620/tjem.2026.J103","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Management of Aspiration Pneumonia in Older Adults with Frailty.","authors":"Satoru Ebihara","doi":"10.1620/tjem.2026.J110","DOIUrl":"https://doi.org/10.1620/tjem.2026.J110","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}