Tohoku Journal of Experimental Medicine最新文献_第2页

Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens. 前列腺癌 NLRP3 炎酶体与肿瘤-结节-转移分期的关系：前列腺针刺活检和根治性前列腺切除术标本的免疫组化研究。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-02-07 Epub Date: 2024-08-01 DOI: 10.1620/tjem.2024.J074

Toshiya Miyauchi, Shintaro Narita, Yuriko Saiki, Yukitsugu Kudo-Asabe, Akira Horii, Shinichi Fukushige, Tomonori Habuchi, Hiroshi Nanjo, Akiteru Goto

{"title":"Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens.","authors":"Toshiya Miyauchi, Shintaro Narita, Yuriko Saiki, Yukitsugu Kudo-Asabe, Akira Horii, Shinichi Fukushige, Tomonori Habuchi, Hiroshi Nanjo, Akiteru Goto","doi":"10.1620/tjem.2024.J074","DOIUrl":"10.1620/tjem.2024.J074","url":null,"abstract":"The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 radical prostatectomy specimens from PCa revealed the expression status of NLRP3, PYCARD, and caspase-1, which form NLRP3 inflammasome. Furthermore, the association between the expression of these 3 proteins and the clinical parameters at diagnosis and operation was analyzed. In biopsy specimens, the Cochran-Armitage test demonstrated that the proportion of the high expression of NLRP3 (P < 0.001) and PYCARD (P < 0.001) in cancerous tissue tended to increase as the value of the Gleason Grade Group increased, and immunohistochemistry of NLRP3 and PYCARD helped to distinguish cancerous tissue from adjacent noncancerous tissue in some cases. Furthermore, a univariable logistic regression analysis revealed the high expression of NLRP3 to be associated with clinical T3-4 (P = 0.0056) and distant metastasis at diagnosis (P = 0.011), while the high expression of PYCARD was associated with clinical T3-4 (P < 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis at diagnosis (P < 0.001). However, a multivariable logistic regression analysis showed no significant association. In prostatectomy specimens, no significant association existed between the expression of NLRP3 inflammasome and the clinical parameters at operation, partly due to the influence of neoadjuvant chemohormonal or hormone therapy. In conclusion, these results suggest that NLRP3 inflammasome may promote disease progression and metastasis in PCa, therefore immunohistochemistry of NLRP3 and PYCARD could be useful for diagnosing PCa accurately.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"203-213"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture Alleviates Cognitive Dysfunction after Ischemic Stroke by Regulating the MiR-181a-5p/TFAM Axis.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-02-06 DOI: 10.1620/tjem.2025.J013

Chi Ma, Xu Fan

引用次数: 0

Therapeutic and Diagnostic Potential of MicroRNAs in Children with Attention-Deficit Hyperactivity Disorder.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-02-06 DOI: 10.1620/tjem.2025.J012

Jinhui Wu, Ping Li, Hong Luo, You Lu

引用次数: 0

Diagnostic Value of Contrast-Enhanced Ultrasound Combined with MiR-125b-5p in Acute Cerebral Infarction and Its Correlation with Carotid Plaque Neovascularization.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-02-06 DOI: 10.1620/tjem.2025.J011

Qianqian Pei, Renyi Zhu, Yafei Yang

引用次数: 0

Effects of Liraglutide on Leptin Promoter Methylation in Ovarian Granulosa Cells of Obese Polycystic Ovary Syndrome Patients.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-30 DOI: 10.1620/tjem.2025.J009

Lina Su, Xiaoxia Hao, Wenhong Lu

引用次数: 0

LncRNA PAX8-AS1 Serves as a Diagnostic Biomarker for Acute Coronary Syndrome and Predicts the Occurrence of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-30 DOI: 10.1620/tjem.2025.J010

Bin Xu, Yan Zhang, Shuxia Ji, Yeping Chen, Qun Zhang, Lingfeng Zhu

引用次数: 0

Neuromyelitis Optica Spectrum Disorder with Interstitial Pneumonia and Marked HyperCKemia as an Initial Presentation: A Case Report and Literature Review.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-30 DOI: 10.1620/tjem.2025.J007

Tomohiro Yoshida, Keisuke Nishimura, Kei Hirose, Hiroyuki Murabe

引用次数: 0

Different Types of Nano Lipid Bubbles for Protecting Nerve Cells from Intermittent Hypoxia Damage.

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-30 DOI: 10.1620/tjem.2025.J008

Ying Guo, Yuyang Miao, Kailin Wang, Jin Tan, Zhen Jiao, Qiang Zhang

引用次数: 0

Plasma miR-21-5p and miRNA-93-5p Levels as Early Assessment Tools for In-Stent Restenosis Following Endovascular Stenting Treatment in Patients with Lower Extremity Atherosclerotic Disease. 血浆 MiR-21-5p 和 MiRNA-93-5p 水平作为下肢动脉粥样硬化患者血管内支架治疗后支架内再狭窄的早期评估工具。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-23 Epub Date: 2024-07-18 DOI: 10.1620/tjem.2024.J066

Zhijun Wang, Shuanlin Ma

{"title":"Plasma miR-21-5p and miRNA-93-5p Levels as Early Assessment Tools for In-Stent Restenosis Following Endovascular Stenting Treatment in Patients with Lower Extremity Atherosclerotic Disease.","authors":"Zhijun Wang, Shuanlin Ma","doi":"10.1620/tjem.2024.J066","DOIUrl":"10.1620/tjem.2024.J066","url":null,"abstract":"In-stent restenosis (ISR) still remains a leading cause of failure of interventional therapy in patients with lower extremity atherosclerotic disease (LEAD). Sensitive and reliable biomarkers to predict ISR should be identified. This study aims to investigate predictive values of two microRNAs, miR-21-5p and miR-93-5p for ISR following endovascular stenting treatment. A total of 128 LEAD patients receiving endovascular stenting treatment were included into the study and their restenotic status followed up by computed tomography angiography after 6 months to examine the incidence of ISR. The results of two-way ANOVAs showed a significant effect of ISR presence, time, and ISR × time interaction on the plasma level of miR-21-5p and miR-93-5p among LEAD patients, which reduced at the postoperative 14th day. The following multiple comparisons test showed higher plasma level of miR-21-5p and miR-93-5p at the postoperative 14th day in the ISR than the non-ISR (P < 0.0001). The plasma levels of miR-21-5p and miR-93-5p at 14 days after surgery used alone or combination as a test to predict ISR occurrence 6 months after surgery produced an AUC of 0.845, 0.839, and 0.906, respectively. Multiple logistic regression analysis revealed the plasma levels of miR-21-5p and miR-93-5p at 14 days after surgery were risk factors for LEAD patients developing ISR at 6 months after surgery (P < 0.001). Our results suggest that plasma miR-21-5p and miR-93-5p levels at 14 days after surgery may serve as potential biomarkers for developing ISR following endovascular stenting treatment among LEAD patients.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"185-192"},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiological Characteristics and Risk Factors of Chronic Obstructive Pulmonary Disease Combined with Infection. 慢性阻塞性肺病合并感染的病因特征和风险因素。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-01-23 Epub Date: 2024-07-04 DOI: 10.1620/tjem.2024.J062

Shaojun Huang, Jinghan Jiang

{"title":"Etiological Characteristics and Risk Factors of Chronic Obstructive Pulmonary Disease Combined with Infection.","authors":"Shaojun Huang, Jinghan Jiang","doi":"10.1620/tjem.2024.J062","DOIUrl":"10.1620/tjem.2024.J062","url":null,"abstract":"The distribution characteristics of pathogenic bacteria and the related health risk of pulmonary infection in patients with chronic obstructive pulmonary disease (COPD) were retrospectively analyzed to develop targeted measures to enhance patient prognosis. A retrospective analysis was conducted on the clinical data of 108 patients with COPD complicated with pulmonary infection and 108 patients without pulmonary infection. Analyze the distribution of pathogens in the lung infection group. Perform univariate analysis on the general data of two groups of patients and use multivariate logistic regression analysis to screen for independent risk factors affecting pulmonary infection in COPD patients. The results of univariate analysis showed that the ratio of patients aged ≥ 60 years, complicated with diabetes, duration of hospitalization ≥ 15 days, type of antimicrobial agents ≥ 2, and transforming growth factor-β (TGF-β) and serum tumor necrosis factor-α (TNF-α) in the pulmonary infection group were significantly greater than those in the group without pulmonary infection. Forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were significantly lower than in the group without pulmonary infection (P < 0.05). Multivariate Logistic regression analysis showed that unrelated health risks for pulmonary infection in COPD patients were age ≥ 60 years, length of hospitalization ≥ 15 days, combination of diabetes mellitus, and use of ≥ 2 types of antibacterial drugs. Age ≥ 60 years old, hospital stay ≥ 15 days, diabetes patients, and antibacterial drugs ≥ 2 are the risk factors of COPD patients with pulmonary infection.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"179-184"},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0