Tohoku Journal of Experimental Medicine最新文献_第2页

Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor. 神经营养酪氨酸激酶受体 I 型 NTRK1 多态性对分娩期间使用氢吗啡酮硬膜外镇痛的影响

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-11 Epub Date: 2024-11-21 DOI: 10.1620/tjem.2024.J135

Kangli Lu, Yujiao Huang, Zhicai Chen, Kuncheng Cai

{"title":"Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor.","authors":"Kangli Lu, Yujiao Huang, Zhicai Chen, Kuncheng Cai","doi":"10.1620/tjem.2024.J135","DOIUrl":"10.1620/tjem.2024.J135","url":null,"abstract":"Epidural labor analgesia is a widely employed method of analgesia in current clinical practice. This study aimed to investigate the relationship between NTRK1 gene polymorphism and epidural labor analgesia, offering a novel perspective for labor analgesia related research. Epidural labor analgesia was administered with hydromorphone in 208 eligible pregnant women. Genomic DNA was extracted from EDTA anticoagulant blood samples. The NTRK1 single nucleotide polymorphisms (SNPs) rs1800880 (T > C) and rs6334 (G > A) were genotyped utilizing PCR-RFLP. Parameters such as the 24 h visual analogue score (VAS), modified Bromage score, 48 h patient controlled intravenous analgesia (PCIA) compression counts, dosage of anesthetic, adverse reactions were meticulously recorded. The immune functions were assessed by flow cytometry, and oxidative stress levels were measured by radioimmunoassay. The findings indicated that NTRK1 rs1800880 T > C and rs6334 G > A were similar, 24 h VAS score and anesthetic dosage were decreased. rs1800880 C allele was no significant difference in adverse reactions, but the level of oxidative stress was significantly reduced. The nausea and emesis response of rs6334 mutant AA was significantly reduced. Both rs1800880 TC + CC vs. TT and rs6334 GA + AA vs. GG showed significant effects on 24 h VAS score. Mutations in rs1800880 and rs6334 reduce postoperative pain, adverse reactions, and oxidative stress responses. The NTRK1 SNP may play an important role in labor analgesia and may be an effective predictor of individual pain perception, thereby providing patients with a more personalized approach to labor analgesia.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"257-264"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Presurgical Infant Orthopedic Treatment on the Maxillary Arch, Craniofacial Form, and Lip Morphology of Patients with Unilateral Cleft Lip and Palate, Aged up to 5 Years. 术前婴儿整形治疗对5岁以下单侧唇腭裂患者上颌弓、颅面形态和唇部形态的影响

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-10 DOI: 10.1620/tjem.2025.J090

Mika Unno, Shinobu Tsuchiya, Chieko Miura, Akimitsu Sato, Yoshimichi Imai, Kaoru Igarashi

引用次数: 0

Association between Iron Intake and Mental Health in Older Adults: The Yamagata Cohort Study. 老年人铁摄入量与心理健康之间的关系：山形队列研究

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-10 DOI: 10.1620/tjem.2025.J089

Yuuki Tanaka, Tsuneo Konta, Haruka Ono, Yoshiyuki Ueno, Kaori Sakurada

引用次数: 0

Long Non-coding RNA RASSF8-AS1 Promotes M1 Macrophage Polarization in Osteoarthritis via Moderating miR-27a-3p. 长非编码 RNA RASSF8-AS1 通过调节 miR-27a-3p 促进骨关节炎中 M1 型巨噬细胞的极化

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-09 Epub Date: 2024-09-12 DOI: 10.1620/tjem.2024.J092

Haijun Shi, Meizhi Liu, Wenhan Ma, Zhigang Chen, Yongyun Shi

{"title":"Long Non-coding RNA RASSF8-AS1 Promotes M1 Macrophage Polarization in Osteoarthritis via Moderating miR-27a-3p.","authors":"Haijun Shi, Meizhi Liu, Wenhan Ma, Zhigang Chen, Yongyun Shi","doi":"10.1620/tjem.2024.J092","DOIUrl":"10.1620/tjem.2024.J092","url":null,"abstract":"Long non-coding RNAs are major regulators in the pathophysiology of osteoarthritis (OA), which involves the dysfunction of cartilage and synovium. The aim of this study was, therefore, to discover the role of RASSF8-AS1 in cartilage degradation and M1 macrophage polarization during OA. Healthy and OA cartilage and synovium were collected. After measuring RASSF8-AS1 levels in tissues and lipopolysaccharide (LPS)- or IL-1β-induced cells, the role of RASSF8-AS1 in the expression of cartilage degradation markers and M1 macrophage molecules was assessed in vitro. The apoptotic rate of IL-1β-stimulated chondrocytes, with or without RASSF8-AS1 overexpression, was quantified using flow cytometry. RASSF8-AS1 was signiﬁcantly upregulated not only in cartilage and synovium from OA patients, but also in IL-1β- or LPS-induced cells, compared to normal controls. A decrease in RASSF8-AS1 level increased the expression of chondrogenic markers, but reduced the expression of genes encoding matrix-degrading proteases, thereby reducing cell apoptosis. Downregulation of RASSF8-AS1 reduced the M1 macrophage markers in RAW264.7 cells and bone marrow-derived macrophages. RASSF8-AS1 may be a ceRNA for miR-27a-3p. These ﬁndings support the role of RASSF8-AS1 as a promoting factor of cartilage degradation and M1 macrophage polarization in OA.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"219-227"},"PeriodicalIF":1.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the lncRNA HOTAIR Gene rs4759314 with Susceptibility to Recurrent Spontaneous Abortion in a Chinese Han Population. 中国汉族人群中 lncRNA HOTAIR 基因 rs4759314 与复发性流产易感性的关系

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-09 Epub Date: 2024-09-05 DOI: 10.1620/tjem.2024.J084

Binglai Luo, Xiaoli Liu, Jiangang Huang, Jinyong Wang

{"title":"Association of the lncRNA HOTAIR Gene rs4759314 with Susceptibility to Recurrent Spontaneous Abortion in a Chinese Han Population.","authors":"Binglai Luo, Xiaoli Liu, Jiangang Huang, Jinyong Wang","doi":"10.1620/tjem.2024.J084","DOIUrl":"10.1620/tjem.2024.J084","url":null,"abstract":"This study was to examine the association between the long noncoding RNA (lncRNA) HOTAIR polymorphism (rs4759314, rs4759314) and the risk of recurrent spontaneous abortion (RSA) in Chinese Han women. 378 women with RSA and 361 pregnant women with normal pregnancies were selected as study subjects. The expression level of lncRNA HOTAIR was detected by fluorescence quantitative PCR. PCR restriction fragment length polymorphism (PCR-RFLP) method was used to detect genotyping. Logistic regression analysis was used to assess the independent factors of HOTAIR rs4759314 affecting recurrent miscarriage. The lncRNA HOTAIR gene expression level was significantly reduced in RSA patients. Rs1899663 polymorphism and rs4759314 GG genotype do not significantly increase the risk of developing RSA (P > 0.050). Rs4759314 AG genotype and rs4759314G allele significantly increased the risk of developing RSA (P < 0.050). Logistic analysis showed a significant correlation between rs4759314 and the occurrence of RSA (OR = 0.367, 95% CI = 0.232-0.580, P < 0.050). The lncRNA HOTAIR rs4759314 locus may serve as a biomarker for RSA susceptibility in the Chinese Han population.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"229-235"},"PeriodicalIF":1.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deubiquitinating Enzyme MINDY1 Facilitates Immune Escape in Breast Cancer by Maintaining the Stability of Immune Checkpoint Protein PD-L1. 去泛素化酶 MINDY1 通过维持免疫检查点蛋白 PD-L1 的稳定性促进乳腺癌的免疫逃逸

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-08 Epub Date: 2024-10-24 DOI: 10.1620/tjem.2024.J111

Liang Ren, Li Wang, Zhewei Cao, Xuelin Yi, Yiran Chen, Yang Yang, Ya Liu

{"title":"Deubiquitinating Enzyme MINDY1 Facilitates Immune Escape in Breast Cancer by Maintaining the Stability of Immune Checkpoint Protein PD-L1.","authors":"Liang Ren, Li Wang, Zhewei Cao, Xuelin Yi, Yiran Chen, Yang Yang, Ya Liu","doi":"10.1620/tjem.2024.J111","DOIUrl":"10.1620/tjem.2024.J111","url":null,"abstract":"Featured with frequent recurrence and distant metastasis, the mortality of breast cancer (BC) increased year by year in recent decades. MINDY lysine 48 deubiquitinase 1 (MINDY1) played an oncogenic role in several tumors. The role of MINDY1 deserved further study in BC. A wide ranges of assays including qRT-PCR, Western blotting, CCK-8 flow cytometry analysis, co-immunoprecipitation assay, Pearson's coefficient tests, and tumor xenograft assay were designed and carried out to determine the role of MINDY1 in BC. Both MINDY1 and programmed death-ligand 1 (PD-L1) is upregulated in BC tissues and cells. In addition, knockdown of MINDY1 attenuated cell viability and promoted the activation of T cells. Mechanistically, MINDY1 stabilized PD-L1 protein by interacting with PD-L1 in BC cells, and MINDY1 is positively associated with PD-L1 in BC tissues. Moreover, rescue assay revealed that the effect of MINDY1 silencing on cell viability and T cell activation was reversed by PD-L1 overexpression. The in vivo study also demonstrated that the effect of MINDY1 knockdown on tumor growth induced by was counteracted by PD-L1 overexpression.In conclusion, we identified PD-L1 as a novel target of MINDY1 and established a significant association between MINDY1 and the cancer immune response. Importantly, our findings reveal that MINDY1 promoted BC progression via PD-L1-mediated immune evasion.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"237-246"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KLF16-Induced Increase of GARS Promotes Glycolysis in Hepatocellular Carcinoma by Stabilizing FOXK1. klf16诱导的GARS升高通过稳定FOXK1促进肝细胞癌的糖酵解。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-03 DOI: 10.1620/tjem.2025.J087

Jinghui Wang, Ruijuan Fan, Jun Li, Hanbo Qiu, Lizhu Lin

引用次数: 0

Blue Light-Blocking Glasses Attenuate Light-Induced Melatonin Suppression in Healthy Japanese Adults. 蓝光屏蔽眼镜可减弱日本健康成人光诱导的褪黑素抑制。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-03 DOI: 10.1620/tjem.2025.J086

Yuma Onodera, Naoko Kubota, Nagomi Miyagi, Noriko Matsuura, Shinya Muramatsu, Yuji Kato, Yujiro Yamanaka

引用次数: 0

Elevated Expression of EphA10 in Gastric Cancer Tissues: A Potential Biomarker for Tumor Metastasis and Poor Survival. EphA10在胃癌组织中的高表达：肿瘤转移和不良生存的潜在生物标志物。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-03 DOI: 10.1620/tjem.2025.J088

Dongni Leng, Kangjie Yu, Shiya Weng, Jiaxin Chai, Jiandong Wang, Wei Dai

引用次数: 0

The Association of High Mobility Group Box-1 with Sepsis Susceptibility and Mortality Risk: A Meta-Analysis. 高迁移率组Box-1与脓毒症易感性和死亡风险的关联：一项荟萃分析。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-07-03 DOI: 10.1620/tjem.2025.J085

Shuqi Yang, Xinfeng Song, Xingqian Jin, Xu Huang

引用次数: 0