Tohoku Journal of Experimental Medicine最新文献_第5页

Evaluation and Comparison of Intervertebral Disc Degeneration Models Induced by Cervical Instability in Rats. 颈椎不稳致大鼠椎间盘退变模型的评价与比较。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-19 DOI: 10.1620/tjem.2025.J077

Yutao Wang, Jiaxin Chen, Dinghao Zhang, Haoshan Lin, Xinjun Fan, Shenyi Lu, Yiqi Huang, Weizheng Guo, Jianlang Liang, Zhaoke Huang, Hailan Hu, Qi Liu

引用次数: 0

The Potential of CAR-T cells for Treating Heart Diseases: Current Status and Hurdles in Clinical Translation. CAR-T 细胞治疗心脏病的潜力：临床转化的现状与障碍。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-13 Epub Date: 2024-11-07 DOI: 10.1620/tjem.2024.J116

Ruxia Zhang, Ganggang Si, Jianjun Li, Xiangbing Li, Huahua Cui, Sancong Pan

{"title":"The Potential of CAR-T cells for Treating Heart Diseases: Current Status and Hurdles in Clinical Translation.","authors":"Ruxia Zhang, Ganggang Si, Jianjun Li, Xiangbing Li, Huahua Cui, Sancong Pan","doi":"10.1620/tjem.2024.J116","DOIUrl":"10.1620/tjem.2024.J116","url":null,"abstract":"Traditional treatments for heart disease, including pharmacotherapy and surgical interventions, are effective in managing symptoms and preventing complications but often fail to fully restore cardiac function or halt the progression of the disease. Additionally, these approaches are frequently associated with significant adverse effects. Inspired by the success of CAR-T cell therapy in oncology, this review examines the potential of CAR-T cell technology for treating heart diseases, detailing how CAR-T cells, engineered by merging antibody-derived targeting domains with T-cell signaling domains. The technology's core includes an extracellular antigen-binding domain, hinge region, transmembrane domain, and intracellular signaling domain, with the single-chain variable fragment (scFv) playing a crucial role in antigen recognition. The paper delves into the immune mechanisms in cardiovascular diseases like heart failure, hypertension, and myocardial infarction, focusing on the roles of T cells in promoting myocardial fibrosis and the therapeutic potential of regulatory T cells (Tregs) in recovery phases. Additionally, it explores the use of lipid nanoparticles (LNPs) carrying mRNA to produce transient, non-integrative CAR-T cells targeting fibroblast activation protein (FAP) to reduce myocardial fibrosis, a method showing promise in preclinical models by enhancing cardiac function and reducing ventricular fibrosis. Despite its potential, the study acknowledges challenges in clinical translation, such as limited therapeutic effects and severe inflammatory responses, highlighting the need for further optimization and research in CAR-T cell technology for cardiovascular disease treatment.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"145-152"},"PeriodicalIF":1.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Specific Trends and Health Status of Children Aged 12-19 Years with Specified Chronic Pediatric Diseases in Japan - Insights from a National Database Study. 日本患有特定慢性儿科疾病的12-19岁儿童的年龄特定趋势和健康状况——来自国家数据库研究的见解

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-12 DOI: 10.1620/tjem.2025.J073

Erika Kuwahara, Akinori Moriichi, Hitoshi Kato

引用次数: 0

Assessment of the Physical Properties, drug Loadability and Release Profile, and Biocompatibility of UniPearls® Microspheres. UniPearls®微球的物理性质、药物负荷性、释放特性和生物相容性的评价

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-12 DOI: 10.1620/tjem.2025.J071

Fei Guo, Min Xu, Baosheng Ren, Fengxuan Han

引用次数: 0

The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography. 结合计算机断层扫描位置数据的修正数据驱动运动校正方法在正电子发射断层扫描中的应用。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-12 DOI: 10.1620/tjem.2025.J072

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirofumi Kawakami, Akie Katsuki, Yoshitaka Tanaka, Takashi Takeuchi, Hiroyasu Kodama, Akihito Usui, Kei Takase, Tomohiro Kaneta

引用次数: 0

Analysis of the Correlation between SLC6A4 rs1042173 Gene Polymorphisms and the Effect of Sufentanil Epidural Labor Analgesia in Pregnant Women. SLC6A4 rs1042173基因多态性与舒芬太尼硬膜外分娩镇痛效果的相关性分析

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-12 DOI: 10.1620/tjem.2025.J070

Xiaoyan Ma, Jie Tang, Yiyi Shen, Bei Wang, Jie Liu, Xingjie Wu

引用次数: 0

Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. 与自闭症谱系障碍核心症状相关的交流困难儿童的凝视模式

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-12 DOI: 10.1620/tjem.2025.J074

Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu Miyake, Tomohisa Suzuki, Mami Ishikuro, Masatsugu Orui, Eiichi N Kodama, Ritsuko Shimizu, Yohei Hamanaka, Yoko Izumi, Atsushi Hozawa, Nobuo Fuse, Atsuo Kikuchi, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama, Masayuki Yamamoto

引用次数: 0

Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion. 磷酸八钙/明胶（OCP/Gel）复合体植入对小型猪腰椎椎间融合术的疗效。

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-11 Epub Date: 2024-11-28 DOI: 10.1620/tjem.2024.J138

Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki

{"title":"Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion.","authors":"Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki","doi":"10.1620/tjem.2024.J138","DOIUrl":"10.1620/tjem.2024.J138","url":null,"abstract":"Synthetic octacalcium phosphate (OCP) has emerged as a potential precursor for bone apatite crystals, promoting faster bone formation and better biodegradability compared to hydroxyapatite and β-tricalcium phosphate materials. Combining OCP with various polymeric biomaterials enhances its ductility, making it suitable for clinical applications, including dentistry. Preclinical studies on OCP/gelatin (OCP/Gel) composites have shown excellent osteoconductive and osteoinductive properties, indicating potential for bone defect repairs. This study investigates the efficacy of OCP/Gel as a filler for lumbar interbody fusion cages. A miniature swine model underwent surgery using polyetheretherketone (PEEK) cages with different fillers: no filler, autologous rib, and OCP/Gel. Eight weeks post-surgery evaluations using computed tomography, histological assessments, and Fourier transform infrared (FT-IR) spectroscopy revealed that while PEEK cages without fillers showed no bone fusion, those with autologous rib and OCP/Gel demonstrated partial interbody fusion. Histological analysis indicated new bone growth in cages with OCP/Gel, and FT-IR spectroscopy confirmed the degradation of OCP at the vertebral interface and increased bone matrix proteins. The findings suggest that OCP/Gel could be a viable alternative to autologous bone grafts for lumbar interbody fusion surgeries, offering less invasive and more cost-effective solutions. The success of OCP/Gel in clinical applications could pave the way for broader use in orthopedic reconstructive surgeries, potentially eliminating the need for combined use of bone marrow aspirate or expensive growth factors.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"135-144"},"PeriodicalIF":1.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Z Promotes Proliferation in Vascular Endothelial Cell Mediated by Chemokine C-X-C-Motif Receptor 4. 趋化因子C-X-C-Motif受体4介导的Z蛋白促进血管内皮细胞增殖

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-11 Epub Date: 2024-12-12 DOI: 10.1620/tjem.2024.J143

Peng Zhang, Jie Li, Jingxuan Chen, Xinran Ruan

{"title":"Protein Z Promotes Proliferation in Vascular Endothelial Cell Mediated by Chemokine C-X-C-Motif Receptor 4.","authors":"Peng Zhang, Jie Li, Jingxuan Chen, Xinran Ruan","doi":"10.1620/tjem.2024.J143","DOIUrl":"10.1620/tjem.2024.J143","url":null,"abstract":"Preeclampsia (PE) is a multisystem progressive disease unique to pregnancy, seriously affecting maternal and infant health. Previous studies have shown that PE is associated with changes in vascular endothelial cells, but the specific mechanism is unclear. In this study, we assessed the effects of chemokine C-X-C-motif receptor 4 (CXCR4) on endothelial cells and explored the potential mechanisms. Human placental microvascular endothelial cells (HPVEC) were exposed to protein Z (PZ), qRT-PCR and Western blotting were used to detect the expression of proliferation related genes and proteins, such as PI3K/Akt/ERK. Meanwhile, qRT-PCR and Western blotting were used to detect the expression of anticoagulation markers PGI2 and t-PA. Then, HPVEC were transfected with CXCR4 siRNA or NC siRNA. The expression of proliferation related genes and proteins were also detected. Finally, PZ and CXCR4 were co-cultivated with different fluorescent labels, the binding sites of the two proteins were observed under confocal laser scanning microscopy (CLSM). PZ promoted the proliferation and expression of anticoagulant markers PGI2 and t-PA in HPVEC. CXCR4 silencing could inhibit the proliferation of HPVEC which stimulated by PZ. CLSM showed that the binding site of PZ and CXCR4 was located on the cell membrane. In conclusion, our results suggested that PZ promote the expression of PGI2/t-PA and affect the PI3K/Akt/ERK signaling pathway by binding with CXCR4 which improved our understanding of the molecular mechanisms involved in HPVEC.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"121-125"},"PeriodicalIF":1.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Warm Yang and Promote Diuresis Blood-Activating Methods in Chronic Heart Failure. 温阳利水活血法对慢性心力衰竭的疗效

IF 1.7 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2025-06-07 Epub Date: 2024-07-25 DOI: 10.1620/tjem.2024.J070

Xiaoyu Liu, Hailiang Fang, Yang Zhang

{"title":"Effectiveness of Warm Yang and Promote Diuresis Blood-Activating Methods in Chronic Heart Failure.","authors":"Xiaoyu Liu, Hailiang Fang, Yang Zhang","doi":"10.1620/tjem.2024.J070","DOIUrl":"10.1620/tjem.2024.J070","url":null,"abstract":"Chronic heart failure (CHF) is a prevalent condition with significant morbidity and mortality worldwide. Conventional treatments may not always be effective or may have considerable side effects. Warm yang and promote diuresis blood-activating method (WYLBAM), a traditional intervention, has been proposed as a complementary approach for CHF, but its clinical efficacy and impact on cardiac function have not been systematically evaluated. We performed a comprehensive meta-analysis to assess the clinical efficacy of WYLBAM for CHF. Following PRISMA guidelines, databases were searched for clinical trials comparing WYLBAM with standard care. Data on clinical efficacy rate, left ventricular ejection fraction (LVEF), left ventricular end-diastolic and end-systolic dimensions (LVEDD and LVESD), 6-minute walk test, and biomarkers BNP and NT-proBNP were extracted. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated with funnel plots and sensitivity analyses. Our search yielded 947 records, with 26 studies included after screening and eligibility assessment. Meta-analysis demonstrated a significant improvement in clinical efficacy rate, LVEF, LV dimensions, and 6-minute walk test distances in patients treated with WYLBAM. Biomarkers BNP and NT-proBNP also improved significantly, indicating a potential reduction in cardiac stress. The I² values suggested substantial heterogeneity, which was addressed through random-effects modeling. Publication bias was not evident in the funnel plot analyses. WYLBAM may be a beneficial adjunctive treatment for improving cardiac function and physical capacity in patients with CHF. However, the presence of heterogeneity suggests that individual patient factors should be considered when applying WYLBAM. Further well-designed large-scale RCTs are warranted to confirm these findings and to explore the underlying mechanisms of action.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"107-119"},"PeriodicalIF":1.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0