Tohoku Journal of Experimental Medicine最新文献_第5页

Long Intergenic Non-Protein Coding RNA 1355 Drives Hepatocellular Carcinoma Progression by Promoting Epithelial-Mesenchymal Transition and M2 Macrophage Polarization. 长基因间非蛋白编码RNA 1355通过促进上皮-间质转化和M2巨噬细胞极化驱动肝癌进展。

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-10-01 DOI: 10.1620/tjem.2026.J101

Jie Zhang, Guanbo Zhang, Zhi Yang, Lin Yang, Gang Li, Jinsong Li, Jiaxing Wang

引用次数: 0

Association of Neighborhood Built Environments with Physical Activity and Diabetes Mellitus Incidence. 社区建筑环境与体育活动和糖尿病发病率的关系。

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-30 Epub Date: 2026-04-02 DOI: 10.1620/tjem.2026.J039

Yasuyuki Kondo, Kei Hamazaki, Chiho Yamazaki, Satoshi Tsukui, Naoya Yahagi, Hiroshi Koyama

{"title":"Association of Neighborhood Built Environments with Physical Activity and Diabetes Mellitus Incidence.","authors":"Yasuyuki Kondo, Kei Hamazaki, Chiho Yamazaki, Satoshi Tsukui, Naoya Yahagi, Hiroshi Koyama","doi":"10.1620/tjem.2026.J039","DOIUrl":"10.1620/tjem.2026.J039","url":null,"abstract":"Globally, increasing evidence suggests that neighborhood built environments (NBE)-including walkability, access to green spaces, and food outlets-can shape residents' physical activity and lifestyle behaviors, with implications for chronic disease risk. Although several studies suggest that walkable and activity-supportive environments promote better health, other findings indicate that certain environmental features, including food establishments, might increase obesity and diabetes mellitus (DM). How different environmental elements affect both physical activity and DM incidence remains unclear. We investigated associations of NBE with physical activity and DM incidence. This study included 87,154 individuals (33,884 males and 53,270 females) with national health insurance in Gunma Prefecture, Japan, who underwent the Specific Health Checkup in FY2011. These individuals were followed up for 7 years (until FY2018). The odds ratio (OR) for engaging in physical activity was significantly higher in neighborhoods with convenience stores [OR: 1.07, 95% confidence interval (CI): 1.03, 1.10] or parks (OR: 1.09, 95% CI: 1.06, 1.13) but significantly lower in neighborhoods with train stations (OR: 0.96, 95% CI: 0.92, 0.99). The proportion of individuals engaging in physical activity tended to increase when the number of NBE increased. DM incidence risk was significantly lower in neighborhoods with parks [hazard ratio (HR): 0.90, 95% CI: 0.83, 0.98] and higher in neighborhoods with convenience stores (HR: 1.09, 95% CI: 1.01, 1.18). These results suggest that having parks in neighborhoods may contribute to reducing DM risk, whereas convenience stores may increase it. Future urban design policies should consider both protective and risk-enhancing neighborhood features.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"517-525"},"PeriodicalIF":1.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant Expression of lncRNA TTC28-AS1/miR-767-5p in Allergic Rhinitis and Its Potential Effect on the Disease Progression. lncRNA TTC28-AS1/miR-767-5p在变应性鼻炎中的异常表达及其对疾病进展的潜在影响

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-29 Epub Date: 2025-12-11 DOI: 10.1620/tjem.2025.J134

Dan Kan, Long Ran, Yongming Yu, Yuyong Huang, Guangming Lou, Junchun Wu, Yang Pan

{"title":"Aberrant Expression of lncRNA TTC28-AS1/miR-767-5p in Allergic Rhinitis and Its Potential Effect on the Disease Progression.","authors":"Dan Kan, Long Ran, Yongming Yu, Yuyong Huang, Guangming Lou, Junchun Wu, Yang Pan","doi":"10.1620/tjem.2025.J134","DOIUrl":"10.1620/tjem.2025.J134","url":null,"abstract":"Allergic rhinitis (AR) is a prevalent chronic inflammatory disease with significant global morbidity, severely impacting patients' quality of life and potentially leading to multiple complications. Long non-coding RNAs (lncRNAs) play critical roles in immune regulation and inflammatory responses, but their specific mechanisms in AR remain unclear. This study aimed to investigate the expression profile, clinical relevance, and functional mechanism of lncRNA TTC28-AS1 in AR, focusing on its regulation of nasal epithelial inflammation via miR-767-5p. RT-qPCR was used to measure lnc TTC28-AS1, miR-767-5p, and inflammatory cytokines (GM-CSF, eotaxin-1) expression in nasal mucosa tissues from AR patients and healthy controls. Receiver operating characteristic (ROC) curve analysis evaluated the diagnostic efficacy of lnc TTC28-AS1, while Pearson correlation assessed its association with clinical symptom scores. The targeting relationship between lnc TTC28-AS1 and miR-767-5p was validated by dual-luciferase reporter assay. In an interleukin (IL)-13-induced human nasal epithelial cell (HNEC) model, the effects of the lnc TTC28-AS1/miR-767-5p axis on cell proliferation were analyzed via CCK-8 assay. Apoptosis was examined by flow cytometry analysis. Lnc TTC28-AS1 was significantly upregulated in AR patients and positively correlated with total nasal symptom score (TNSS). Its overexpression was an independent AR risk factor. Lnc TTC28-AS1 directly suppressed miR-767-5p, exacerbating inflammation and apoptosis in HNECs. Silencing lnc TTC28-AS1 reduced IL-13-induced GM-CSF/eotaxin-1 expression and apoptosis promoting proliferation, effects reversed by miR-767-5p inhibition. In conclusion, Lnc TTC28-AS1 modulates inflammatory responses and functional status of nasal epithelial cells by targeting miR-767-5p, suggesting its potential as a novel diagnostic biomarker and therapeutic target for AR.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"499-506"},"PeriodicalIF":1.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Diagnostic Value of miR-142-3p in Pediatric Acute Respiratory Distress Syndromes and Its Effects on Human Lung Epithelial Cells. miR-142-3p在小儿急性呼吸窘迫综合征中的临床诊断价值及其对人肺上皮细胞的影响

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-29 Epub Date: 2026-01-15 DOI: 10.1620/tjem.2025.J142

Wenjing Yan, Jianzhu He, Yangping Zhou, Jian Zhu

{"title":"Clinical Diagnostic Value of miR-142-3p in Pediatric Acute Respiratory Distress Syndromes and Its Effects on Human Lung Epithelial Cells.","authors":"Wenjing Yan, Jianzhu He, Yangping Zhou, Jian Zhu","doi":"10.1620/tjem.2025.J142","DOIUrl":"10.1620/tjem.2025.J142","url":null,"abstract":"Pediatric acute respiratory distress syndrome (PARDS) is a major cause of morbidity and mortality in critically ill children. microRNAs (miRNAs) were discovered to be involved in regulating the progression of numerous disorders, including PARDS. We aim to explore the diagnostic value and relevant mechanisms of miR-142-3p in PARDS. Real-time quantitative PCR (RT-qPCR) was used to detect the levels of miR-142-3p and myristoylated-alanine rich C-kinase substrate (MARCKS) in the serum of PARDS patients or in A549 cells. Receiver operating characteristic (ROC) curve analysis predicted the diagnostic value of miR-142-3p for PARDS. The proliferation, apoptosis and inflammatory factor concentrations in lipopolysaccharide (LPS)-induced A549 cells were measured using the Cell Counting Kit-8 (CCK-8) assay, flow cytometry and Enzyme-Linked Immunosorbent Assay (ELISA), respectively. We found that the content of miR-142-3p was markedly elevated in PARDS group and positively correlated with disease severity. It had good diagnostic ability for PARDS. Moreover, miR-142-3p and pro-inflammatory factors were remarkably positively correlated. In vitro, a cell model was constructed by inducing A549 cells with LPS. Cell proliferation was repressed while apoptosis and inflammation were facilitated in LPS-induced A549 cells. Up-regulated miR-142-3p enhanced apoptosis and inflammatory factor secretion while suppressed proliferation. Down-regulated miR-142-3p facilitated proliferation while repressed apoptosis and inflammatory factor secretion. Furthermore, MARCKS was a target gene of miR-142-3p and down-regulated in cell model. miR-142-3p may be a novel diagnostic marker for PARDS. In LPS-induced A549 cells, miR-142-3p repressed cell proliferation and facilitated apoptosis and inflammatory responses via modulating MARCKS.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"471-477"},"PeriodicalIF":1.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of Total Magnetic Resonance Imaging Burden with Middle Cerebral Artery Pulsatility Index in Elderly Patients with Cerebral Small Vessel Disease. 老年脑小血管疾病患者的总磁共振成像负担与大脑中动脉搏动指数的相关性

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-29 Epub Date: 2024-07-25 DOI: 10.1620/tjem.2024.J068

Ying Zhao, Liang Zhang, Pinyi Zhu, Wei Li

{"title":"Correlation of Total Magnetic Resonance Imaging Burden with Middle Cerebral Artery Pulsatility Index in Elderly Patients with Cerebral Small Vessel Disease.","authors":"Ying Zhao, Liang Zhang, Pinyi Zhu, Wei Li","doi":"10.1620/tjem.2024.J068","DOIUrl":"10.1620/tjem.2024.J068","url":null,"abstract":"Cerebral small vessel disease (CSVD) is a prevalent, chronic, and progressive vascular disease. This study aimed to assess the predictive efficacy of the middle cerebral artery (MCA) pulsatility index (PI) for high magnetic resonance imaging (MRI) burden in elderly patients with CSVD. The study included 200 individuals, and transcranial Doppler (TCD), MRI, and clinical data were collected. Patients were divided into low-burden (0-1 points) and high-burden (2-4 points) groups according to the total MRI burden score. Univariate and multivariate logistic regression analyses and Spearman rank correlation analysis were used to assess the association between MCA PI and total MRI burden. The predictive value of MCA PI for high MRI burden in elderly patients with CSVD was assessed using receiver operating characteristic (ROC) curves. Multivariate logistic regression showed that, after adjustment for other confounding factors, MCA PI remained associated with total MRI burden (P < 0.001). Spearman rank correlation analysis showed that MCA PI was strongly correlated with the total MRI burden score in elderly patients with CSVD (rs = 0.583, P < 0.001). A cut-off value of 1.11 for MCA PI was optimal for predicting high MRI burden in elderly patients with CSVD, with an area under the curve (AUC) of 0.923 (P < 0.001, 95% CI: 0.851-0.927), a sensitivity of 0.864, and a specificity of 0.78. In conclusion, total MRI burden was positively associated with MCA PI in elderly patients with CSVD. MCA PI has high predictive value for high MRI burden in elderly patients with CSVD and may be useful for early screening and monitoring.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"491-498"},"PeriodicalIF":1.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Work Conditions Leading to Job Retention among Individuals with Neurodevelopmental Disorders. 工作条件对神经发育障碍患者工作留任的影响。

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-25 Epub Date: 2025-11-20 DOI: 10.1620/tjem.2025.J127

Tomokatsu Yoshida, Hirobumi Mashiko, Tetsuya Ohira

{"title":"Work Conditions Leading to Job Retention among Individuals with Neurodevelopmental Disorders.","authors":"Tomokatsu Yoshida, Hirobumi Mashiko, Tetsuya Ohira","doi":"10.1620/tjem.2025.J127","DOIUrl":"10.1620/tjem.2025.J127","url":null,"abstract":"Many individuals with neurodevelopmental disorders encounter several difficulties in the modern workplace because of functional impairments like lack of communication skills or inattention caused by atypical brain developments. On the other hand, other individuals with these disorders lead a social life without any significant problems in their workplace. This study suggests several conditions that might allow them to continue working in their current workspace while maintaining their social life. To confirm the effects of these conditions, we conducted an internet questionnaire survey among workers aged 16-65 years in Fukushima Prefecture. We asked the workers with neurodevelopmental disorders whether they wanted to continue working in their current workspace (yes/no). Those who had answered \"yes\" were asked to rate each of the following conditions as the reason for their answer: satisfaction with the work conditions (sufficient vacation or working hours), safety in working environment, company welfare policies, good workplace atmosphere, sufficient salary, well-equipped welfare facilities, and training or counsel system enough to satisfy. We also asked whether they were regular employees (yes/no). For each condition, we used a logistic regression model to calculate the multivariable-adjusted odds ratios to assess their willingness to continue working and feelings of anxiety about job retention at their current workplace. Those who had rated their reasons as \"applicable\" for keeping their jobs were regular employees who tended to have not experienced anxiety about retaining such jobs. Therefore, these conditions might help retain the employment of individuals with neurodevelopmental disorders.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"461-469"},"PeriodicalIF":1.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSPA1B Overexpression Induces Benign Prostatic Hyperplasia through Enhancing Endoplasmic Reticulum Stress to Promote NLRP3 Inflammasomes-Mediated Pyroptosis. HSPA1B过表达通过增强内质网应激促进NLRP3炎性体介导的热凋亡诱导良性前列腺增生。

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-25 Epub Date: 2026-01-08 DOI: 10.1620/tjem.2025.J149

Xingwei Yu, Hongao Tan, Yunqiu Gao, Shenhong Wang, Dandan Qiu, Yan Zhu

{"title":"HSPA1B Overexpression Induces Benign Prostatic Hyperplasia through Enhancing Endoplasmic Reticulum Stress to Promote NLRP3 Inflammasomes-Mediated Pyroptosis.","authors":"Xingwei Yu, Hongao Tan, Yunqiu Gao, Shenhong Wang, Dandan Qiu, Yan Zhu","doi":"10.1620/tjem.2025.J149","DOIUrl":"10.1620/tjem.2025.J149","url":null,"abstract":"The activated pyroptosis participates in the development of benign prostatic hyperplasia (BPH)-related diseases. However, pyroptosis-related mechanism in BPH has not yet been studied, which is the focus of our current study. The potential genes that were abnormally expressed in BPH were predicted by bioinformatics. Human prostate cell lines WPMY-1 and BPH-1 underwent transfection and treatment of endoplasmic reticulum (ER) stress inhibitors 4-phenylbutyric acid (4-PBA) or tauroursodeoxycholic acid (TUDCA), after which the cell viability, lactate dehydrogenase (LDH) activity (cytotoxicity) and pyroptosis were determined through cell counting kit-8 assay, specific kits, and flow cytometry, respectively. Co-immunoprecipitation was performed to detect whether there exists a direct interaction between HSPA1B and CHIP. Quantitative real-time reverse transcription polymerase chain reaction or western blot was applied to assess the involved expressions of genes/proteins. Heat shock protein family A (Hsp70) member 1B (HSPA1B) was highly expressed in BPH. HSPA1B overexpression decreased viability and CHIP expression, and increased pyroptosis, and upregulated expressions of NLR family pyrin domain containing 3 (NLRP3), Pro-caspase-1, Active caspase-1, GDSMD-N, CHOP, p-PERK, PERK and ATF4 in BPH-associated cells; however, shHSPA1B produced opposite effects. CHIP and HSPA1B directly interacted. HSPA1B overexpression enhances viability and reduces cytotoxicity in recipient cells through a paracrine mechanism. TUDCA and 4-PBA counteracted the effects of HSPA1B overexpression on ER stress, viability, LDH activity, and NLRP3 inflammasomes-mediated pyroptosis in BPH-associated cells. Collectively, HSPA1B overexpression induces BPH through enhancing ER stress to promote NLRP3 inflammasomes-mediated pyroptosis, implying that HSPA1B can be a promising target of pyroptosis in BPH therapy.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"449-459"},"PeriodicalIF":1.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cracking a New Era of Therapeutic Development in ALS. 开启ALS治疗发展的新时代。

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-19 Epub Date: 2026-07-16 DOI: 10.1620/tjem.2026.J082

Tetsuya Akiyama, Masashi Aoki

{"title":"Cracking a New Era of Therapeutic Development in ALS.","authors":"Tetsuya Akiyama, Masashi Aoki","doi":"10.1620/tjem.2026.J082","DOIUrl":"10.1620/tjem.2026.J082","url":null,"abstract":"Recent advances in genetics, RNA biology, disease modeling, biomarkers, and clinical trial methodology have fundamentally transformed therapeutic development in amyotrophic lateral sclerosis (ALS). Recent clinical successes, including edaravone, ultrahigh-dose methylcobalamin, and antisense oligonucleotide (ASO) therapies such as tofersen, have demonstrated that therapeutic success depends not only on effective drugs but also on improved therapeutic development strategies. These advances have highlighted several fundamental principles, including patient enrichment, intervention during appropriate therapeutic windows, biomarker-guided drug development, and innovative clinical trial design. At the biological level, human genetics and molecular neuropathology have revealed that genetically diverse forms of ALS converge on a limited number of shared pathogenic pathways. In particular, TDP-43 proteinopathy has emerged as the central molecular hallmark of ALS, linking protein aggregation, RNA dysregulation, and neuronal dysfunction. The discovery of TDP-43-dependent cryptic splicing has transformed RNA dysregulation into a therapeutically actionable target and accelerated the development of RNA-targeted therapeutics and mechanism-based biomarkers. In parallel, patient-derived induced pluripotent stem cell (iPSC) models, multi-omics technologies, and computational approaches have fundamentally altered therapeutic discovery and target validation. Furthermore, neurofilament biomarkers, adaptive platform trials, and digital technologies are reshaping clinical evaluation and accelerating therapeutic development. In this review, we discuss how advances in genetics, RNA biology, disease modeling, biomarkers, and clinical trial methodology are collectively redefining therapeutic development in ALS and shaping the next generation of precision medicine for neurodegenerative diseases.","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"437-447"},"PeriodicalIF":1.5,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Lifestyle Changes and Self-Rated Health Among Japanese University Students During the COVID-19 Pandemic: Early Evidence from Hokkaido, Where the First Outbreak Occurred in Japan. 2019冠状病毒病大流行期间日本大学生生活方式改变与自我评估健康之间的关系：来自日本首次爆发疫情的北海道的早期证据。

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-17 DOI: 10.1620/tjem.2026.J089

Noriko Matsuura, Yujiro Yamanaka

引用次数: 0

The TWIST1/NTSR1 Axis Drives Aerobic Glycolysis to Promote Metastasis of Lung Adenocarcinoma Cells. TWIST1/NTSR1轴驱动有氧糖酵解促进肺腺癌细胞转移

IF 1.5 4区医学

Tohoku Journal of Experimental Medicine Pub Date : 2026-09-17 DOI: 10.1620/tjem.2026.J098

Jianhong Liu, Shuang Bai, Liang Zhu, Xu Yang

引用次数: 0