Toxicology Mechanisms and Methods最新文献_第4页

Leveraging new approach methodologies: ecotoxicological modelling of endocrine disrupting chemicals to Danio rerio through machine learning and toxicity studies. 利用新方法论：通过机器学习和毒性研究，建立干扰内分泌的化学品对小白鼠的生态毒理学模型。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-02-01 Epub Date: 2024-09-10 DOI: 10.1080/15376516.2024.2400324

Gopal Italiya, Sangeetha Subramanian

{"title":"Leveraging new approach methodologies: ecotoxicological modelling of endocrine disrupting chemicals to Danio rerio through machine learning and toxicity studies.","authors":"Gopal Italiya, Sangeetha Subramanian","doi":"10.1080/15376516.2024.2400324","DOIUrl":"10.1080/15376516.2024.2400324","url":null,"abstract":"New approach methodologies (NAMs) offer information tailored to the intended application while reducing the use of animals. NAMs aim to develop quantitative structure-activity relationship (QSAR) and quantitive-Read-Across structure-activity relationship (q-RASAR) models to predict and categorize the acute toxicity of known and unknown endocrine-disrupting chemicals (EDCs) against zebrafish. EDCs are a diverse group of toxic substances that disrupt the endocrine system of humans and animals. The q-RASAR model was constructed and verified using validation metrics (R2 = 0.886 and Q2 = 0.814) which found to be more reliable model compare to QSAR model. The substructure fingerprint was well-fitted for the classification model and it was validated using 10-fold average accuracy (Q = 86.88%), specificity (Sp = 88.89%), Matthew's correlation curve (MCC = 0.621) and receiver operating characteristics (ROC = 0.828). The dataset of unknown substances revealed that phenolphthalein (Php) exhibited a significant level of toxicity based on q-RASAR model. The docking and simulation study indicated that the computationally derived important features successfully bound to the target zebrafish sex hormone binding globulin (zfSHBG). The experimental LC50 value of 0.790 mg L-1 was very close to the predicted value of 0.763 mg L-1, which provides high confidence to the developed model.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"197-213"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into the impact of WIN 55, 212-2, a synthetic cannabinoid, on adhesion molecules PECAM-1 and VE-cadherin in HeLa cells: implications on cancer processes. 合成大麻素 WIN 55, 212-2 对 HeLa 细胞中粘附分子 PECAM-1 和 VE-cadherin 影响的机理认识：对癌症过程的影响。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-02-01 Epub Date: 2024-09-08 DOI: 10.1080/15376516.2024.2399132

Elizabeth Bejarano-Pérez, Rodolfo Sánchez-Zavaleta, Arnulfo Albores

{"title":"Mechanistic insights into the impact of WIN 55, 212-2, a synthetic cannabinoid, on adhesion molecules PECAM-1 and VE-cadherin in HeLa cells: implications on cancer processes.","authors":"Elizabeth Bejarano-Pérez, Rodolfo Sánchez-Zavaleta, Arnulfo Albores","doi":"10.1080/15376516.2024.2399132","DOIUrl":"10.1080/15376516.2024.2399132","url":null,"abstract":"The endocannabinoid (eCB) system comprises endogenous ligands, cannabinoid receptors (CBRs), and their regulatory proteins; its alteration leads to many diseases including cancer. Thus, becomes a therapeutic target for synthetic cannabinoids aimed to control cancer cell proliferation, migration, adhesion, and invasion. However, little is known about adhesion molecules regulation through CBRs activation. The aim of this study was to evaluate the effects of a CB1/CB2 agonist, WIN-55, 212-2 (WIN), on the regulation of adhesion molecules platelet endothelial cell adhesion molecule-1 (PECAM-1) and vascular endothelial cadherin (VE-cadherin) in HeLa cells. CBRs expression was evaluated by immunofluorescence staining in HeLa cells and cell viability (thiazolyl blue tetrazolium bromide), cell adhesion (crystal violet), adhesion molecules expression and location (Western blot and immunofluorescence staining assays) were all assessed on cells treated with different WIN concentrations. Receptors CB1, CB2, and G-protein-coupled receptor 55 were expressed in HeLa cells. Additionally, biphasic effects were observed in their metabolic activity and adhesive properties: low WIN concentrations resulted in significant increases whereas, high ones decreased them compared to controls (p < 0.0001), demonstrating that WIN elicits opposite effects depending on the concentration and exposure time. PECAM-1 was detected in HeLa cell's cytoplasm, membrane, and perinuclear region, whereas VE-cadherin had a nuclear distribution. There were no significant differences in PECAM-1 and VE-cadherin expression and location, suggesting that WIN does not modulate these proteins. These findings support the potential use of WIN due to its anticancer properties without dysregulating adhesion molecules. WIN possible contribution to inhibit cancer progression should be further investigated.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"167-180"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study. 镉诱导的大鼠胰腺毒性：比较维生素 C 和黑麦草的保护作用：组织形态计量学和超微结构研究。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-02-01 Epub Date: 2024-09-08 DOI: 10.1080/15376516.2024.2399779

Asmaa F A Dawood, Hanan M Alharbi, Faten I Ismaeel, Shahina M Khan, Hanan D Yassa, Nermeen N Welson, Fatma El-Zahraa A Abd El-Aziz

{"title":"Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study.","authors":"Asmaa F A Dawood, Hanan M Alharbi, Faten I Ismaeel, Shahina M Khan, Hanan D Yassa, Nermeen N Welson, Fatma El-Zahraa A Abd El-Aziz","doi":"10.1080/15376516.2024.2399779","DOIUrl":"10.1080/15376516.2024.2399779","url":null,"abstract":"The study aimed to assess the toxic effect of cadmium (Cd) on the exocrine and endocrine functions of pancreas, the changes in pancreatic tissue after Cd withdrawal, and the protective effects of vitamin C (VC) and Nigella sativa (NS) against Cd-induced damage. Rats were assigned to: control, Cd-treated (0.5 mg/kg/d intraperitoneal [IP] injection), VC and Cd-treated (receiving 100 mg/kg/d VC orally and Cd concomitantly), NS and Cd-treated (receiving 20 mg/kg/d NS and Cd, simultaneously), and Cd withdrawal (receiving Cd for 30 d then living free for recovery for other 30 d). Blood samples were collected and post-sacrifice pancreatic specimens were processed for light and electron microscope study. Quantitative analyses of pancreatic collagen area%, pancreatic islet parameters, β cell density, and insulin immunoexpression were done. Fasting blood glucose was significantly increased in Cd-treated and Cd-withdrawal groups, while co-treatment with VC and NS caused significant reductions (p < 0.05). Cd-induced extensive degenerative changes in pancreatic acini and islets at light and ultrastructure levels. Obvious fibrosis and congestion of blood vessels were noticed. Significant reductions in pancreatic islet number, volume, and surface area and diminished beta cell count and insulin immunoexpression were observed. After withdrawal of Cd, the whole pancreatic tissue still showed a serious impact. Concomitant treatment with VC or NS obviously reduced these degenerative changes and significantly improved pancreatic islet parameters and insulin immunoexpression. VC showed a better amendment than NS, but this difference was statistically insignificant. Therefore, VC and NS could be used as prophylactic agents that lessen Cd consequences on the pancreas.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"181-196"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous measurement of fentanyl, fentanyl analogues and other drugs of abuse by multiplex bead assay.

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-30 DOI: 10.1080/15376516.2025.2457336

J P Smith, M Alexander-Scott, C Striley, D Sammons

{"title":"Simultaneous measurement of fentanyl, fentanyl analogues and other drugs of abuse by multiplex bead assay.","authors":"J P Smith, M Alexander-Scott, C Striley, D Sammons","doi":"10.1080/15376516.2025.2457336","DOIUrl":"https://doi.org/10.1080/15376516.2025.2457336","url":null,"abstract":"Quantification of illicit drugs and controlled substances, in urine or as surface contamination, is often performed using expensive analytical techniques such as liquid chromatography with tandem mass spectrometry (LC-MS/MS). A time and cost-effective semi-quantitative surface-wipe and urine screening multiplex immunoassay for fentanyl and its analogues was developed in this investigation. We previously created a surface wipe multiplex immunoassay for methamphetamine, caffeine, cocaine, tetrahy-drocannabinol (THC) and oxycodone. This fluorescent covalent microsphere immunosorbent assay (FCMIA) is a competitive assay where drugs compete with protein-drug conjugates attached to microspheres for antibodies. It was assembled using a commercially available fentanyl antibody and protein-conjugate. Surface recovery from ceramic tiles was assessed by FCMIA, with results ranging from 26% for fentanyl to 60% for methamphetamine. Only fentanyl and its structurally similar analogues showed significant response to the fentanyl assay whereas, analogues structurally similar to carfentanil gave no response. Non-fentanyl drug assays did not appreciably detect fentanyl or its analogues. Overall, this method is a useful tool for assessing surface contamination and the effectiveness of decontamination by multiple drugs of abuse, potentially lowering workplace exposures. To broaden applicability, different antibodies or aptamers must be developed to detect structural differences found in classes of analogues such as carfentanil.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"1-11"},"PeriodicalIF":3.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study. 军事行动中军犬在环境中检测基因毒性物质中的哨兵作用：一项试点研究。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-26 DOI: 10.1080/15376516.2025.2453731

Lorenzo Tidu, Stefano Ciccarelli, Stefania De Sanctis, Florigio Lista, Rosaria Ferreri, Elisa Regalbuto, Fabio Grizzi, Gianluigi Taverna, Alessandro Poli, Marco Bruzzone, Marcello Ceppi, Paola Roggieri, Claudia Bolognesi

{"title":"Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study.","authors":"Lorenzo Tidu, Stefano Ciccarelli, Stefania De Sanctis, Florigio Lista, Rosaria Ferreri, Elisa Regalbuto, Fabio Grizzi, Gianluigi Taverna, Alessandro Poli, Marco Bruzzone, Marcello Ceppi, Paola Roggieri, Claudia Bolognesi","doi":"10.1080/15376516.2025.2453731","DOIUrl":"10.1080/15376516.2025.2453731","url":null,"abstract":"During out-of-area military operations, the presence of carcinogenic and/or genotoxic agents has been reported, posing potential health risks to deployed soldiers. Military working dogs (MWDs), trained to detect explosives in the same environments as soldiers, could also serve as sentinel animals, providing valuable information on exposure to hazardous agents. These dogs can help identify environmental and potential adverse effects on their health and that of their handlers, possibly before relevant pathologies manifest. This study aims to evaluate the effectiveness of 33 Italian Army MWDs, deployed to the Lebanese theater for six consecutive months from October 2013 to January 2015, as sentinel animals for detecting exposure to genotoxic agents. The Cytokinesis-Block MicroNucleus (CBMN) assay was used to assess DNA damage, cytostasis, and cytotoxicity in the lymphocytes of these dogs. DNA damage events were specifically scored in once-divided binucleated cells (BCs) and included: a) micronuclei (MNi), indicative of chromosome breakage and/or whole chromosome loss; b) nucleoplasmic bridges (NPBs), a marker of DNA misrepair and/or telomere end-fusions; and c) nuclear buds (NBUDs), which signal the elimination of amplified DNA and/or DNA repair complexes. Our findings revealed an increase in chromosomal damage, assessed before and after deployment, with a statistically significant rise in MNi frequency, thus supporting the use of MWDs as sentinels for human exposure to hazardous agents.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction.

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-22 DOI: 10.1080/15376516.2025.2454760

引用次数: 0

Disruptive multiple cell death pathways of bisphenol-A. 双酚a的破坏性多细胞死亡途径。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-15 DOI: 10.1080/15376516.2024.2449423

Yukta S, Milan K L, Kannan Harithpriya, Cai Zong, S Sahabudeen, Gaku Ichihara, K M Ramkumar

{"title":"Disruptive multiple cell death pathways of bisphenol-A.","authors":"Yukta S, Milan K L, Kannan Harithpriya, Cai Zong, S Sahabudeen, Gaku Ichihara, K M Ramkumar","doi":"10.1080/15376516.2024.2449423","DOIUrl":"https://doi.org/10.1080/15376516.2024.2449423","url":null,"abstract":"Endocrine-disrupting chemicals (EDCs) significantly contribute to health issues by interfering with hormonal functions. Bisphenol A (BPA), a prominent EDC, is extensively utilized as a monomer and plasticizer in producing polycarbonate plastic and epoxy resins, making it one of the highest-demanded chemicals in commercial use. This is the major component used in plastic products, including bottles, containers, storage items, and food serving ware. Exposure of BPA happens through oral, respiratory, transdermal routes and eye contact. As an EDC, BPA disrupts hormonal binding, leading to various health problems, such as cancers, reproductive abnormalities, metabolic syndrome, immune dysfunction, neurological effects, cardiovascular problems, respiratory issues, and obesity. BPA mimics the hormone estrogen but exhibits a weak affinity for estrogen receptors. This weak binding affinity triggers multiple cell death pathways, including necroptosis, pyroptosis, apoptosis, ferroptosis, and autophagy, across different cell types. Numerous clinical, in-vitro, and in-vivo experiments have demonstrated that BPA exposure results in unfavorable health effects. This review highlights the mechanisms of cell death pathways initiated through BPA exposure and the associated negative health consequences. The extensive use of BPA and its frequent detection in environmental and biological models underscore the urgent need for further investigation into its effects and the development of safe alternatives. Addressing the health risks posed by BPA involves a comprehensive approach that includes reducing exposure and finding novel substitutes to lessen its detrimental impact on humans.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HepG2 spheroids cultured in alginate microcapsules as a model for exploring mitochondrial and glycolytic metabolism using the Seahorse XFe24 Analyzer. 海藻酸盐微胶囊中培养的HepG2球体作为模型，使用Seahorse XFe24分析仪探索线粒体和糖酵解代谢。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-06 DOI: 10.1080/15376516.2024.2447740

Raul Ghiraldelli Miranda, Ivo F Machado, Anabela Pinto Rolo, Daniel Junqueira Dorta, Carlos Manuel Marques Palmeira

{"title":"HepG2 spheroids cultured in alginate microcapsules as a model for exploring mitochondrial and glycolytic metabolism using the Seahorse XFe24 Analyzer.","authors":"Raul Ghiraldelli Miranda, Ivo F Machado, Anabela Pinto Rolo, Daniel Junqueira Dorta, Carlos Manuel Marques Palmeira","doi":"10.1080/15376516.2024.2447740","DOIUrl":"https://doi.org/10.1080/15376516.2024.2447740","url":null,"abstract":"Mitochondria are affected by chemical substances and play a critical role in drug-induced liver injury (DILI). Chemical substances can have a significant impact on various cellular processes, such as the disruption of oxidative phosphorylation, oxidative stress, and alteration of glucose metabolism. Given the consequences of these effects, it is crucial to understand the molecular pathways of chemical substances in the context of hepatotoxicity to prevent and treat DILI. In this regard, the Seahorse XFe24 Analyzer is a valuable tool for assessing mitochondrial bioenergetics and glucose metabolism. The Mito Stress Test and Glycolytic Rate Assay allow real-time assessment of the metabolic state after chemical exposure. Additionally, HepG2 spheroids have emerged as an important alternative tool for assessing hepatotoxicity, as they provide results that are more comparable to those found in humans than monolayer cultures or animal tests (such as rodent tests). By integrating these two powerful tools, it is possible to bridge the gap between animal and human tests, resulting in more reliable results in the assessment of human hepatotoxicity and DILI. However, because of the high variability in characteristics between 3D cultures (such as spheroids and organoids), XF analyzer assays are not well optimized for use with HepG2 spheroids. Here, we describe a streamlined and optimized protocol for performing the Mito Stress Test and Glycolytic Rate Assay using HepG2 spheroids cultured in alginate microcapsules in the Seahorse XFe24 Analyzer.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pymetrozine induced remarkable hemato-biochemical modifications and genotoxicity in vital organs of bighead carp (Aristichthys nobilis). 吡蚜酮对鳙鱼重要器官产生了显著的血液生化改变和遗传毒性。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-06 DOI: 10.1080/15376516.2024.2440738

Munir Ahmad, Yasir Mahmood, Abdul Ghaffar, Riaz Hussain, Shazia Anjum, Dalia Fouad, Farid Shokry Ataya, Ahrar Khan

{"title":"Pymetrozine induced remarkable hemato-biochemical modifications and genotoxicity in vital organs of bighead carp (Aristichthys nobilis).","authors":"Munir Ahmad, Yasir Mahmood, Abdul Ghaffar, Riaz Hussain, Shazia Anjum, Dalia Fouad, Farid Shokry Ataya, Ahrar Khan","doi":"10.1080/15376516.2024.2440738","DOIUrl":"10.1080/15376516.2024.2440738","url":null,"abstract":"Pymetrozine (a pyridine azomethine pesticide) is one of the most commonly and frequently used insecticides. Scanty information is available about the deleterious effects of Pymetrozine on fish especially bighead carp. Hence, the current study investigated chronic toxicological effects of pymetrozine in bighead carp. A total of 80 fish were reared and divided into four groups(A-D) each containing 20 fish. Pymetrozine was given to experimental fish of groups B, C, and D mixed in water at doses of 5, 10, and 15 mg/L respectively for 30 days. Group A remained as control group. On days 10, 20, and 30 of the experiment, blood and other visceral tissues were collected for analysis of genotoxic effects, erythrocytic morphological and nuclear changes, antioxidant enzymes, and oxidative stress profile. The results revealed significantly higher values of various nuclear abnormalities (erythrocyte with micronuclei, red blood cells with condensed and lobed nuclei) and morphological changes (pear shaped erythrocyte, spindle shaped erythrocytes and spherocyte) in erythrocytes of bighead carp. The investigations on status of antioxidant enzymes and oxidative stress indicated higher values of oxidative stress biomarkers and lower values of antioxidant enzymes in visceral organs (brain, liver, gills, and kidneys) of treated fish. The findings on genotoxic potential of pymetrozine revealed a considerably increased frequency of DNA damage in isolated cells of multiple tissues (brain, liver, gills, and kidneys) of experimental fish at higher doses. In conclusion, it may be suggested that pymetrozine induces toxic effects via disruption of physiological mechanisms of multiple visceral organs of bighead carp.","PeriodicalId":23177,"journal":{"name":"Toxicology Mechanisms and Methods","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of tetrahydroxyquinone solubility on apoptosis induction in human colorectal cells. 四羟基醌溶解度在人结肠细胞凋亡诱导中的作用。

IF 3.2 4区医学

Toxicology Mechanisms and Methods Pub Date : 2025-01-02 DOI: 10.1080/15376516.2024.2443455

Zaira López, M Eduardo Cano, Michelle Valdovinos Pérez, Rogelio Rodríguez Rodríguez, Martha Rodríguez Sahagún, Peter Knauth

引用次数: 0