Toxicology and Industrial Health最新文献

{"title":"Exposure to Bisphenol A and Z causes DNA damage and testicular histopathology impairing male fertility.","authors":"Haseeb Ur Rehman, Asif Nadeem, Nadia Mukhtar, Muhammad Muddassir Ali, Huma Mujahid, Muhammad Zubair Shabbir, Maryam Javed","doi":"10.1177/07482337261438341","DOIUrl":"10.1177/07482337261438341","url":null,"abstract":"<p><p>Bisphenol analogues are commonly found in various consumer products such as food and beverage containers, electronic devices, toys, paper products, water pipes, and medical equipment. These compounds have been shown to disrupt endocrine function and exert harmful effects on multiple body organs. To investigate the tissue- and DNA-damaging effects of varying oral doses of Bisphenol Z (BPZ), a study was conducted on Wistar rats over a 4-week period. After 28 days, the rats were dissected, and tissue samples were collected. Tissue histology, Comet assay, and real-time PCR were performed to assess the effects of BPZ at the tissue and genomic levels. Sperm count and motility were significantly reduced in groups exposed to higher doses of BPZ (mean ± SD: 27.00 ± 7.94 and 4.33 ± 0.43, respectively). Morphologically abnormal sperm, including deformed heads and curly tails, were observed. The Comet assay on testicular tissues from rats treated with higher BPZ doses showed clear signs of DNA fragmentation. Histopathological analysis revealed narrowing of the interstitial spaces and constriction of the epididymal lumen. Additionally, down regulation of the Protamine1 gene was observed in rats receiving higher doses of BPZ, significantly associated with spermatogenesis. Our findings not only highlight the severity of BPZ's toxic effects but also emphasize that these chemicals are unsafe in any analogue form.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"198-206"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of taurine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative and histopathological damage in the heart tissue of rats.","authors":"Osman Çiftçi, Münevver Nazlıcan Kaplan, Neşe Başak Türkmen, Aslı Çetin, Bedriye Çiftçi, İdris Ayhan","doi":"10.1177/07482337261436345","DOIUrl":"10.1177/07482337261436345","url":null,"abstract":"<p><p>This study investigated the protective effects of taurine against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cardiotoxic damage in rats. Adult male Wistar rats (250-300 g) were randomly assigned to four groups (<i>n</i> = 8 per group): Control, TCDD, TAU, and TCDD + TAU. TCDD (2 μg/kg/week) and/or taurine (200 mg/kg/day) were administered via gavage for 30 days. Following the experimental period, heart tissue samples were collected for analysis. Oxidative stress parameters, including thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) activity, and glutathione (GSH) levels, were assessed using biochemical methods. Histopathological and immunohistochemical evaluations of cardiac tissue were also performed. The TCDD group showed significantly increased TBARS levels (<i>p</i> < 0.05) and decreased SOD activity and GSH levels (<i>p</i> < 0.001) compared with the Control group. In contrast, taurine co-administration significantly increased SOD activity and GSH levels while reducing TBARS levels relative to the TCDD group. Moreover, TCDD exposure induced marked histopathological alterations in heart tissue, whereas taurine co-administration attenuated these structural alterations. Immunohistochemical findings indicated that taurine attenuated TCDD-induced apoptosis by reducing caspase-3 activation. Overall, taurine effectively mitigated TCDD-induced oxidative stress, histopathological damage, and apoptotic signaling in cardiac tissue, suggesting that taurine co-administration may exert protective effects against TCDD-induced cardiotoxicity.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"167-177"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective roles of gallic acid and lycopene against 4-nonylphenol induced testicular damage in SD rats.","authors":"Ozay Gules, Sadiye Kum, Zahid Naseer, Murat Boyacioglu, Emine Ozel Armutoglu, Mustafa Yildiz, Murat Kırıkkulak, Göksel Doğan, Esra Bilici, Aybike Türkmen, Bilginer Tuna, Ulker Eren","doi":"10.1177/07482337261439550","DOIUrl":"10.1177/07482337261439550","url":null,"abstract":"<p><p>4-Nonylphenol (4-NP), an endocrine disruptor, is known to induce mutagenic, toxic, or carcinogenic effects, including testicular toxicity via inducing oxidative stress and apoptosis. The objective of this work was to determine the capacity of lycopene (LC) and gallic acid (GA) to protect testicular histological structure, biochemical responses, and semen parameters in rats exposed to 4-NP. In this 28-day dietary trial, six groups (n= 6 per group) received treatment via oral gavage: a control (corn oil, 2 mL/kg/day), LC (10 mg/kg body weight (BW)/day), GA (50 mg/kg BW/day), 4-NP (125 mg/kg BW/day), LC + 4-NP (LC followed by 4-NP), and GA + 4-NP (GA followed by 4-NP) groups. The results indicated that 4-NP administration adversely affects the final body weight, testicular histology, seminiferous epithelium heights (SEHs) (4-NP: 57.95 ± 0.49, <i>p</i>: 0.000), follicle-stimulating hormone (FSH) level, testis antioxidant capacity, testis malondialdehyde (MDA) level, and sperm viability and morphology. LC and GA supplementation significantly improved SEHs, activities of testis superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), and sperm viability compared to the 4-NP group. Moreover, LC and GA exposures decreased histopathological lesions, including germinal epithelial degeneration, vacuolization, immature germ cells in the tubular lumen, and congestion in the interstitial area. Furthermore, they lowered TUNEL-positive cell counts and tubule percentages, testicular MDA levels, and abnormal sperm percentages. To our knowledge, this study provides one of the first systematic comparisons of lycopene and gallic acid in protecting against 4-NP-induced testicular toxicity under identical experimental conditions. The findings suggest that both compounds preserve testicular structure and function through their antioxidant and anti-apoptotic properties.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"207-221"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium and lead in occupationally exposed e-waste workers: Health implications.","authors":"Olubayo Michael Akinosun, Ayobola Abimbola Sonuga, Bukola Fasilat Ayoola, Oyebola Oluwagbemiga Sonuga","doi":"10.1177/07482337261428663","DOIUrl":"10.1177/07482337261428663","url":null,"abstract":"<p><p>E-waste contains over a thousand different substances, most of which are toxic and hazardous to human health. This study aimed to determine the blood levels of cadmium (Cd) and lead (Pb) among e-waste workers, and the possible health symptoms associated with chronic low dose occupational exposure to e-wastes. This was a cross-sectional study carried out among 80 individuals aged 25 years and above. Forty-two of the participants were e-waste workers and 38 were non-e-waste workers. Demographic characteristics and anthropometric data were obtained from each participant. Blood lead levels (BLLs) and blood cadmium levels (BCLs) were measured in all the participants using atomic absorption spectrometry (AAS). The mean BLL and BCL were significantly higher in the e-waste workers than in the non-e-waste workers. Most of the e-waste workers (76.2%) performed phone and laptop repairs. They reported chest pain (19.0%), abdominal pain (9.5%), throat irritation (2.4%), and cough (9.5%) as common symptoms experienced at work. Many of the e-waste cohort (73.8%) worked in poorly ventilated rooms and many (95.2%) were also involved in crude and unregulated e-waste recycling processes. In conclusion, the results from our study suggested that elevated BLL and BCL in the e-waste workers were from occupational exposure associated with crude e-waste recycling processes, and these elevated levels were probably associated with the adverse health effects in this group of workers. Continuous training and awareness of safe occupational practices is highly recommended among the e-waste workers.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"137-145"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome Editorial: A New Chapter for Toxicology and Industrial Health.","authors":"Lindsey St Mary","doi":"10.1177/07482337261434379","DOIUrl":"10.1177/07482337261434379","url":null,"abstract":"","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"113"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high-frequency radiofrequency (6 GHz) electromagnetic radiation on oxidative stress and kidney morphology.","authors":"Mustafa Emre, Yasin Karamazi, Toygar Emre, Nazlı Ece Varan, Tuğba Toyran, Güzide Yücebilgiç","doi":"10.1177/07482337261422845","DOIUrl":"10.1177/07482337261422845","url":null,"abstract":"<p><p>This study aimed to investigate the effects of high-frequency (6 GHz) radiofrequency electromagnetic radiation (RF-EMR) exposure on oxidative stress markers and kidney morphology. Our study was designed with 3 groups, each containing 10 animals. These groups were: control, sham, and RF-EMR exposed group. No treatment was applied to the control group; the sham group was housed in the same room under the same conditions and for equal periods of time, except that the generator was turned off. The RF-EMR exposed group was exposed to 6 GHz RF-EMR emitted from the signal generator for 4 hours per day for 6 weeks. At the end of the experimental period, intracardiac blood was collected from animals and plasma oxidant (MDA), antioxidant (SOD, CAT and GSH) and cortisol markers were analyzed. After, the rats in all groups were sacrificed and kidney tissues were removed. Hematoxylin and eosin staining methods were applied histopathologically. Blood-plasma GSH, CAT, SOD and MDA levels (excluding cortisol) were lower in the RF-EMR exposed group compared to the control and sham groups (p < .001). No significant difference was observed in plasma levels GSH, CAT, SOD, MDA and cortisol activities between control and sham groups. In addition, we reported that the histological characteristics of kidney tissue were affected by RF-EMR. The results of our study indicated that 6 GHz RF-EMR can function as an environmental stress factor and can modulate oxidative stress in blood plasma and cause morphological changes in kidney tissue.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"124-136"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of hydrogen sulfide donors on inflammatory and oxidative factors in the hippocampus of lead-poisoned rats.","authors":"Keivan Lorian, Hossein Azizian, Maryam Yadegari, Nasrin Alborzi, Zeynab Hafizi, Fatemeh Zare Mehrjerdi","doi":"10.1177/07482337261422818","DOIUrl":"10.1177/07482337261422818","url":null,"abstract":"<p><p>Lead is one of the main environment pollutants, which has strong inhibitory effects on the functioning of the CNS. Exposure to high amounts of lead, even shortly, stimulates glial cells and activates inflammatory pathways in brain. Lead can also increase the amount of oxidative stress. In this study, the effect of hydrogen sulfide (H₂S) donors on lead-induced neurotoxicity was investigated. The protective effects of H₂S have been proven in various neurological diseases. Lead and H₂S were administered for 2 weeks. The animals' cognitive performance, exploratory behavior, and anxiety were evaluated using the shuttle box, open field, and elevated plus maze tests. The level of malondialdehyde (MDA), tumour necrosis factor alpha (TNFα), and interleukin 10 (IL-10); the total antioxidant capacity of the hippocampus; and blood lead levels were measured. Lead increased the level of TNFα and MDA and decreased the level of IL-10 in the hippocampus. H₂S was able to moderate the inflammatory and oxidative factors and tissue damage caused by lead in the hippocampus, which led to better cognitive and behavioral functions. The results of this study indicated that H₂S reduced the damage caused by lead through its well-known antioxidant and anti-inflammatory activity, which ultimately resulted in improved behavioral and cognitive functions in lead-poisoned animals. .</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"114-123"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to lithium-nickel-cobalt-manganese oxide materials in lithium battery: Health risks and mechanisms of toxicity.","authors":"Xiaoying Li, Ningning Li, Xiuzhi Zhang, Shanfa Yu","doi":"10.1177/07482337261433636","DOIUrl":"10.1177/07482337261433636","url":null,"abstract":"<p><p>Lithium-ion batteries are indispensable in modern energy storage systems-including portable electronics, electric vehicles, and grid-scale applications-because of their high energy density, long cycle life, and low self-discharge. Among cathode materials, lithium-nickel-cobalt-manganese oxide (LiNiMnCoO₂; NCM) is widely used because of its balanced electrochemical performance and strong commercial viability. With the rapid expansion of NCM production and recycling, concerns regarding occupational exposure and related health risks have increased. However, a comprehensive synthesis addressing the toxicological characteristics of NCM as a composite material-rather than its individual metal constituents-remains lacking. This review critically evaluates current evidence on the occupational health effects of NCM materials across their life cycle, with particular emphasis on inhalation exposure to NCM particulates in manufacturing and recycling settings. We integrated epidemiological data, in vivo and in vitro toxicological studies, and mechanistic research to characterize the health risks associated with NCM exposure. Following deposition in the respiratory tract, persistent particles initiate local inflammatory responses, while the gradual release of Ni, Co, and Mn ions within pulmonary and intracellular microenvironments drives sustained molecular and cellular toxicity. Major adverse outcomes include respiratory inflammation and fibrosis, neurotoxicity, hepatic and renal injury, and other systemic effects. We further summarized key toxicity mechanisms, including oxidative stress, inflammatory signaling, DNA damage, and related pathways, and discuss current occupational exposure limits and regulatory considerations for NCM-related metals. By consolidating multidisciplinary evidence, this review aimed to clarify knowledge gaps, inform future research priorities, support evidence-based regulatory decision-making, and promote safer manufacturing practices for next-generation energy storage technologies.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"146-164"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: \"The chemoprotective effects of l-carnitine against genotoxicity induced by diazinon in rat blood lymphocyte\".","authors":"","doi":"10.1177/07482337261425457","DOIUrl":"10.1177/07482337261425457","url":null,"abstract":"","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"165"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute oral toxicity of flutriafol in mice: Behavioral, biochemical, and histological alterations.","authors":"Naourez Ktari, Khadija Boukholda, Rabeb Ben Slama-Ben Salem, Intidhar Bkhairia, Riadh Ben Salah","doi":"10.1177/07482337261420596","DOIUrl":"10.1177/07482337261420596","url":null,"abstract":"<p><p>Human exposure to triazole fungicides such as flutriafol (FFL) is raising concerns regarding their potential toxic effects. FFL has been reported to induce oxidative stress and systemic toxicity, yet its subacute effects remain incompletely characterized. This study investigated the subacute oral toxicity of FFL in adult male mice, with a particular focus on behavioral, biochemical, hematological, and histological alterations. Behavioral assessment and median lethal dose (LD₅₀) determination were performed initially. Mice were then administered FFL by oral gavage at doses of 25, 50, 75, or 100 mg/kg body weight for 15 consecutive days. Hematological indices and biochemical parameters reflecting hepatic, renal, cardiac, and lipid metabolic function were evaluated. Oxidative stress markers, including catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), and thiobarbituric acid-reactive substances (TBARS), were measured in multiple organs, including the liver, intestine, brain, kidney, testis, lungs, pancreas, and heart. Histological examinations were conducted to assess tissue-level alterations. FFL exposure resulted in dose-dependent behavioral changes, hematological disturbances, and significant alterations in serum biochemical parameters. Antioxidant enzyme activities were reduced, while lipid peroxidation was increased across several organs, indicating enhanced oxidative stress. These findings were supported by histopathological changes consistent with organ injury. In conclusion, subacute oral exposure to FFL induced behavioral and multisystem toxicity in mice, largely mediated by oxidative stress mechanisms. These results highlight potential health risks associated with repeated FFL exposure and underscore the need for further toxicological evaluation.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"61-81"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}