Toxicology and Industrial Health最新文献_第4页

Assessing systemic absorption and estrogenic potential of methylparaben and propylparaben in consumer use. 评估消费者使用对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的全身吸收和雌激素潜能。

IF 1.6 4区医学

Toxicology and Industrial Health Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1177/07482337261419181

Kylie Jones, Megan J Kemp, Christy A Barlow

引用次数: 0

Classification of dermal sensitizers under the globally harmonized system of classification and labelling of chemicals (GHS): A critical review of the principles and current challenges. 全球统一化学品分类和标签制度（GHS）下皮肤致敏剂的分类：对其原则和当前挑战的批判性审查。

IF 1.6 4区医学

Toxicology and Industrial Health Pub Date : 2026-03-01 Epub Date: 2026-02-07 DOI: 10.1177/07482337261422823

Wells Utembe, Charlene Andraos

{"title":"Classification of dermal sensitizers under the globally harmonized system of classification and labelling of chemicals (GHS): A critical review of the principles and current challenges.","authors":"Wells Utembe, Charlene Andraos","doi":"10.1177/07482337261422823","DOIUrl":"10.1177/07482337261422823","url":null,"abstract":"The Globally Harmonized System (GHS) is a crucial framework for chemical hazard communication, especially in protecting workers from skin sensitizers. A critical assessment of the principles, issues, and challenges around classification of skin sensitization in GHS is warranted. Classification of dermal sensitizers relies on a weight of evidence (WoE) approach that incorporates human, animal, and non-test data. However, current testing methods have limitations in sensitivity, specificity, and predictive accuracy. Current test methods take into account the issue of potency and thresholds for sensitization. However, the focus on induction thresholds rather than induction and elicitation thresholds may create a gap in protecting already sensitized individuals since elicitation thresholds are in some cases lower than induction thresholds. While the sensitization process may take weeks or years, current test methods are largely acute in nature, potentially incapable of identifying all (chronic) sensitizers. Moreover, current methods used for classification of skin sensitizers only take into account the dermal route, whereas some chemicals may cause dermal sensitization through other routes, which presents a significant limitation, especially when considering non-animal testing methods. Finally, lack of UV irradiation in current methods may inadvertently miss potential photosensitizers, which may result in misclassification. Continuous refinement of testing methods and integrating novel approaches are essential to improve GHS classifications for skin sensitizers.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"100-112"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Workplace hydrogen sulphide intoxication - What an occupational physician should know. 工作场所硫化氢中毒——职业医生应该知道的事情。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1177/07482337261419191

James Latimer, Kiera McDowall

引用次数: 0

Association between individual and mixed volatile organic compounds and periodontitis. 单个和混合挥发性有机化合物与牙周炎的关系。

IF 1.6 4区医学

Toxicology and Industrial Health Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1177/07482337261418749

Lu Ye, Weichao Ma, Yuhan Ming, Fengjuan Zhou, Juan Liu

{"title":"Association between individual and mixed volatile organic compounds and periodontitis.","authors":"Lu Ye, Weichao Ma, Yuhan Ming, Fengjuan Zhou, Juan Liu","doi":"10.1177/07482337261418749","DOIUrl":"10.1177/07482337261418749","url":null,"abstract":"This study endeavored to elucidate the association between exposure to individual and combined volatile organic compounds (VOCs) and the occurrence of periodontitis in adults. Data were derived from the 2009-2012 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression and restricted cubic spline (RCS) analyses were employed to assess the relationship between blood VOC concentrations and periodontitis. Significant positive associations were observed for benzene, furan, 2,5-dimethylfuran, ethylbenzene, m-/p-xylene, and o-xylene, with adjusted odds ratios (ORs) ranging from 1.44 to 2.31. RCS analyses demonstrated linear associations for benzene, furan, 2,5-dimethylfuran, m-/p-xylene, and 1,4-dichlorobenzene, whereas ethylbenzene and o-xylene exhibited nonlinear associations. In addition, weighted quantile sum regression revealed that cumulative VOC exposure was positively associated with periodontitis, with 2,5-dimethylfuran, ethylbenzene, benzene, and furan identified as the most influential contributors. Collectively, these findings suggested that VOC exposure possibly plays a substantive role in the pathogenesis and progression of periodontitis, underscoring the need for strategies aimed at reducing environmental VOC exposure as part of comprehensive preventive and therapeutic public health measures.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"82-93"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peroxiredoxin Ⅱ silencing aggravates FA-induced myelotoxicity through triggering PI3K pathway mediated by PTEN. 过氧化物还蛋白Ⅱ沉默通过触发PTEN介导的PI3K通路加重fa诱导的髓毒性。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2026-01-01 Epub Date: 2025-12-13 DOI: 10.1177/07482337251406203

Guangyan Yu, Xiangfu Song, Ran An, Qiuling Xu

{"title":"Peroxiredoxin Ⅱ silencing aggravates FA-induced myelotoxicity through triggering PI3K pathway mediated by PTEN.","authors":"Guangyan Yu, Xiangfu Song, Ran An, Qiuling Xu","doi":"10.1177/07482337251406203","DOIUrl":"10.1177/07482337251406203","url":null,"abstract":"Formaldehyde (FA) is a critical industrial compound implicated in leukemogenesis via the induction of oxidative stress. Our previous studies observed aberrant expression of peroxiredoxin II (PrxII), phosphatase and tensin homologue (PTEN), phosphoinositide 3-kinase (PI3K), and protein kinase B (Akt) in FA-exposed bone marrow cells (BMCs) under conditions of oxidative stress. We speculate that the PrxII gene may be functionally linked to the PI3K pathway in formaldehyde-induced oxidative damage. Therefore, in the current study, we first used a specific PI3K inhibitor (LY294002, 10 μM) to suppress the PI3K pathway at 100 μM FA, and co-treated mouse bone marrow cells for 24 hours to investigate their potential interactions. We then evaluated the expression levels of PrxII, PTEN, PI3K, and Akt (via qRT-PCR and Western blot analysis), as well as the BMC's viability (CCK-8 assay), ROS levels (DCFH-DA), and cell apoptosis (Annexin V/PI staining). Additionally, to explore the potential regulatory role of PrxⅡ in the PI3K pathway, we employed siRNA-mediated PrxⅡ gene silencing through a small interfering RNA and subsequently measured PTEN, PI3K, and Akt mRNA and protein levels using qRT-PCR and Western blot analysis. We observed that inhibition of the PI3K pathway with 10 μM LY294002 mitigated FA-induced oxidative damage in BMCs, as evidenced by improved cell viability, reduced ROS levels, and decreased apoptosis rates. Moreover, PrxII silencing led to downregulation of PTEN expression while concurrently activating the PI3K/Akt signaling cascade. This study provides evidence that PrxII silencing may trigger the PI3K pathway mediated by PTEN gene, thereby exacerbating FA-induced oxidative injury.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive toxicity of endosulfan: Mechanisms and impacts on female and male reproductive health. 硫丹的生殖毒性：机制及其对女性和男性生殖健康的影响。

IF 1.6 4区医学

Toxicology and Industrial Health Pub Date : 2026-01-01 Epub Date: 2026-01-18 DOI: 10.1177/07482337261417731

Elizabeth Glanet Durom, V A Aneesha, T S Shyamkumar, Ajmi Bin Azeez, C S Celus, Ayushi Vaidhya, Subhashree Parida, Madhu C Lingaraju, Thakur Uttam Singh, Dinesh Kumar

{"title":"Reproductive toxicity of endosulfan: Mechanisms and impacts on female and male reproductive health.","authors":"Elizabeth Glanet Durom, V A Aneesha, T S Shyamkumar, Ajmi Bin Azeez, C S Celus, Ayushi Vaidhya, Subhashree Parida, Madhu C Lingaraju, Thakur Uttam Singh, Dinesh Kumar","doi":"10.1177/07482337261417731","DOIUrl":"10.1177/07482337261417731","url":null,"abstract":"Endosulfan is a broad-spectrum organochlorine pesticide widely used in many developing countries despite its high toxicity potential. Endosulfan, listed as potent endocrine-disrupting chemical and xenoestrogen, gains importance for its potential to cause reproductive and developmental dysfunction. In females, endosulfan disrupts ovarian and uterine development, leading to infertility, miscarriage, and developmental toxicity. It acts by mimicking estrogen and interferes with estrogen and androgen pathways, impacting hormone regulation and gene expression, including estrogen receptor α (ERα) and progesterone receptors. Endosulfan triggers oxidative stress in ovaries, reduces follicle count, and impairs uterine differentiation, affecting embryo implantation. Additionally, it alters gene expression and causes epigenetic modifications, contributing to reproductive dysfunctions. In males, endosulfan affects spermatogenesis by causing oxidative stress, mitochondrial dysfunction, and lipid peroxidation. It reduces sperm quality, motility, and quantity, with effects on testicular tissues, sperm chromatin condensation, and enzymatic activity. Oxidative damage, increased reactive oxygen species (ROS), and disrupted energy metabolism are central to its toxicity. Epidemiological studies also link pesticide exposure to reduced sperm counts, higher DNA fragmentation, and infertility. Moreover, endosulfan can cross the placental barrier, leading to fetal resorption, malformations, and maternal toxicity. This review provides a comprehensive overview of the reproductive toxicity of endosulfan in males and females. We also highlight the various possible mechanisms of reproductive toxicity of endosulfan and its potential to impart deleterious effects over HPG axis, gonads, and uterine differentiation and development and implantation.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"39-56"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prophylactic effects of Aloe vera against X-ray irradiation-induced structural alterations and DNA damage in mice. 芦荟对x射线照射引起的小鼠结构改变和DNA损伤的预防作用。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1177/07482337251400982

Shashi Bala, Lalit Kumar Gupta, Ashwani Koul

{"title":"Prophylactic effects of Aloe vera against X-ray irradiation-induced structural alterations and DNA damage in mice.","authors":"Shashi Bala, Lalit Kumar Gupta, Ashwani Koul","doi":"10.1177/07482337251400982","DOIUrl":"10.1177/07482337251400982","url":null,"abstract":"Radiation exposures, whether planned or unexpected, can have harmful consequences on biological systems. To avoid these radiotoxic consequences, a variety of natural and synthetic radioprotectors are given prior to radiation exposure. The present study aimed to investigate the radioprotective potential of Aloe vera gel extract against damage induced by whole-body X-ray exposure in male balb/c mice. The animals were divided into four groups: Control, Aloe vera (50 mg/kg body weight orally on alternate days for 30 days), X-ray (cumulative dose of 2 Gy) (i.e., 0.258 Gy twice a day for four consecutive days) in the last week of the experimental protocol, and Aloe vera + X-ray. Following irradiation, Fourier transform infrared spectroscopy (FTIR) analysis showed structural changes in molecules by altering the ratios of CH3/lipid, CH2/lipid, lipid/protein, Amide I/II, and nucleic acid in liver and testes. X-ray exposure led to an increase in DNA strand breaks in the liver, spleen, kidney, and testes of mice, as indicated by comet assay. Bcl-2 levels were shown to be up-regulated in the kidney and testes following irradiation. In liver, kidney, and spleen, caspase 3 was also found to be up-regulated. Furthermore, after being exposed to X-rays, the expression of caspase 9 and bax was up-regulated in all the tissues examined. Administration of Aloe vera to the X-ray-exposed group exhibited decline in DNA strand breaks in all tissues investigated. Moreover, protein expressions of these genes were found to be down-regulated in the Aloe vera + X-ray-exposed group. These observations illustrate the potential of Aloe vera in providing radioprotection for rodents, possibly DNA protection, through its anti-apoptotic properties.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"11-28"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden harm? Trade secret designations and transparency in consumer product labeling. 隐藏的伤害?商业秘密指定和消费品标签的透明度。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2026-01-01 Epub Date: 2025-11-18 DOI: 10.1177/07482337251397791

Peter G Kreysa

引用次数: 0

Acute ethyl acetate exposure suppresses spontaneous locomotor activity and exploration behaviour and impairs reference memory performance in rats: No evidence to support a role for L-type calcium channels. 急性乙酸乙酯暴露抑制大鼠自发运动活动和探索行为，损害参考记忆表现：没有证据支持l型钙通道的作用。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-12-01 Epub Date: 2025-11-17 DOI: 10.1177/07482337251394072

Pınar Yamantürk-Çelik, Selçuk Şen, Zeynep Güneş Özünal

{"title":"Acute ethyl acetate exposure suppresses spontaneous locomotor activity and exploration behaviour and impairs reference memory performance in rats: No evidence to support a role for L-type calcium channels.","authors":"Pınar Yamantürk-Çelik, Selçuk Şen, Zeynep Güneş Özünal","doi":"10.1177/07482337251394072","DOIUrl":"10.1177/07482337251394072","url":null,"abstract":"Occupational exposure to volatile organic solvents has been reported to lead to hazardous effects. Ethyl acetate is a volatile organic compound used commonly in industry and found in many commercial products. The present study aimed to investigate the acute behavioural effects of ethyl acetate exposure in rats. The mechanism of its effects was further investigated by focusing on the possible involvement of L-type calcium channels. For this purpose, ethyl acetate (0.3 g/kg, i.p.) alone or concurrently with nimodipine (3 and 5 mg/kg, i.p.), a dihydropyridine calcium channel antagonist selective to L-type calcium channels, was administered to male Wistar albino rats. When compared to the saline control group, ethyl acetate significantly decreased the number of square-crossing, rearing, and sniffing in the open-field and impaired the reference memory performance in the three-panel runway. However, administration of nimodipine at the given doses did not block these effects of ethyl acetate. The findings suggest that L-type calcium channels may not contribute to the mechanism(s) responsible for the acute toxicity of ethyl acetate in rats regarding their central nervous system depression and memory disturbances although it should be more thoroughly investigated in further studies.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"523-530"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of ursodeoxycholic acid in a co-exposure model of cadmium-induced kidney damage. 熊去氧胆酸对镉致肾损伤共暴露模型的保护作用。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-12-01 Epub Date: 2025-11-22 DOI: 10.1177/07482337251392671

Kemal Kavakli, Durmus Hatipoglu, Aysegul Bulut, Mehmet Burak Ates

{"title":"Protective effect of ursodeoxycholic acid in a co-exposure model of cadmium-induced kidney damage.","authors":"Kemal Kavakli, Durmus Hatipoglu, Aysegul Bulut, Mehmet Burak Ates","doi":"10.1177/07482337251392671","DOIUrl":"10.1177/07482337251392671","url":null,"abstract":"Cadmium (Cd) is a toxic environmental heavy metal with a long biological half-life and a high affinity for renal accumulation, posing serious health risks in both humans and animals. Ursodeoxycholic acid (UDCA), a bile acid primarily used for liver disorders, has gained attention for its antioxidant properties and potential protective effects in various toxicological settings. This study investigated the protective role of UDCA against cadmium-induced renal injury in rats. Twenty-eight male Wistar Albino rats (180-220 g) were divided into four groups: control (C, n = 6), cadmium (Cd, n = 8), UDCA (n = 6), and cadmium + UDCA (Cd + UDCA, n = 8). Cd was administered intraperitoneally (3 mg/kg) from days 8 to 15. UDCA was given intragastrically (60 mg/kg) from days 1 to 15. The Cd + UDCA group received both treatments concurrently. Biochemical analysis showed that Cd exposure significantly elevated serum BUN, creatinine, KIM-1, and MDA levels while decreasing GSH concentrations, indicating oxidative stress and renal injury. Conversely, the Cd + UDCA group demonstrated marked attenuation of these changes, with significantly lower BUN, creatinine, KIM-1, and MDA levels, and partially preserved GSH levels. Histopathological examination confirmed extensive renal damage in the Cd group, including cortical necrosis, tubular debris, vascular damage, glomerular alterations, and interstitial inflammation. These alterations were less severe in the Cd + UDCA group, supporting the biochemical findings. In conclusion, UDCA partially mitigated cadmium-induced oxidative stress and nephrotoxicity, reducing renal injury and supporting its potential as a protective agent against heavy metal-induced kidney damage.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"531-542"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0