Toxicology and Industrial Health最新文献_第4页

Manganese dioxide nanoparticles provoke inflammatory damage in BV2 microglial cells via increasing reactive oxygen species to activate the p38 MAPK pathway. 二氧化锰纳米粒子通过增加活性氧激活 p38 MAPK 通路，从而引发 BV2 小胶质细胞的炎症损伤。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-05-01 Epub Date: 2024-03-22 DOI: 10.1177/07482337241242508

Xingchang Sun, Xin Qin, Gaofeng Liang, Xuhong Chang, Huike Zhu, Jiahao Zhang, Dan Zhang, Yingbiao Sun, Sanwei Feng

{"title":"Manganese dioxide nanoparticles provoke inflammatory damage in BV2 microglial cells via increasing reactive oxygen species to activate the p38 MAPK pathway.","authors":"Xingchang Sun, Xin Qin, Gaofeng Liang, Xuhong Chang, Huike Zhu, Jiahao Zhang, Dan Zhang, Yingbiao Sun, Sanwei Feng","doi":"10.1177/07482337241242508","DOIUrl":"10.1177/07482337241242508","url":null,"abstract":"With the widespread use of manganese dioxide nanoparticles (nano MnO2), health hazards have also emerged. The inflammatory damage of brain tissues could result from nano MnO2, in which the underlying mechanism is still unclear. During this study, we aimed to investigate the role of ROS-mediated p38 MAPK pathway in nano MnO2-induced inflammatory response in BV2 microglial cells. The inflammatory injury model was established by treating BV2 cells with 2.5, 5.0, and 10.0 μg/mL nano MnO2 suspensions for 12 h. Then, the reactive oxygen species (ROS) scavenger (20 nM N-acetylcysteine, NAC) and the p38 MAPK pathway inhibitor (10 μM SB203580) were used to clarify the role of ROS and the p38 MAPK pathway in nano MnO2-induced inflammatory lesions in BV2 cells. The results indicated that nano MnO2 enhanced the expression of pro-inflammatory cytokines IL-1β and TNF-α, elevated intracellular ROS levels and activated the p38 MAPK pathway in BV2 cells. Controlling intracellular ROS levels with NAC inhibited p38 MAPK pathway activation and attenuated the inflammatory response induced by nano MnO2. Furthermore, inhibition of the p38 MAPK pathway with SB203580 led to a decrease in the production of inflammatory factors (IL-1β and TNF-α) in BV2 cells. In summary, nano MnO2 can induce inflammatory damage by increasing intracellular ROS levels and further activating the p38 MAPK pathway in BV2 microglial cells.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos. 在胎儿高血糖模型中，邻苯二甲酸二乙基己酯暴露会扩大氧化和炎症反应，导致斑马鱼胚胎出现胰岛素抵抗。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-05-01 Epub Date: 2024-03-11 DOI: 10.1177/07482337241238475

Gül Kaplan, Merih Beler, Ismail Ünal, Atakan Karagöz, Gizem Eğilmezer, Ünsal Veli Üstündağ, Derya Cansız, A Ata Alturfan, Ebru Emekli-Alturfan

{"title":"Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos.","authors":"Gül Kaplan, Merih Beler, Ismail Ünal, Atakan Karagöz, Gizem Eğilmezer, Ünsal Veli Üstündağ, Derya Cansız, A Ata Alturfan, Ebru Emekli-Alturfan","doi":"10.1177/07482337241238475","DOIUrl":"10.1177/07482337241238475","url":null,"abstract":"Exposure of zebrafish embryos to glucose is a suitable model for the fetal hyperglycemia seen in gestational diabetes. Diethylhexyl phthalate (DEHP), which is considered an endocrine-disrupting chemical, is one of the most common phthalate derivatives used in stretching plastic and is encountered in every area where plastic is used in daily life. In the present study, the effects of DEHP on pathways related to insulin resistance and obesity were examined in zebrafish embryos exposed to glucose as a fetal hyperglycemia model. Zebrafish embryos were exposed to DEHP, glucose, and glucose + DEHP for 72 h post-fertilization (hpf), and developmental parameters and locomotor activities were monitored. At 72 hpf ins, lepa, pparγ, atf4a, and il-6 expressions were determined by RT-PCR. Glucose, lipid peroxidation (LPO), nitric oxide (NO) levels, glutathione S-transferase (GST), superoxide dismutase (SOD), and acetylcholine esterase (AChE) activities were measured spectrophotometrically. Compared with the control group, glucose, LPO, GST activity, il6, and atf4a expressions increased in all exposure groups, while body length, locomotor, and SOD activities decreased. While AChE activity decreased in the DEHP and glucose groups, it increased in the glucose + DEHP group. Although glucose exposure increased pparγ and lepa expressions, DEHP significantly decreased the expressions of pparγ and lepa both in the DEHP and glucose + DEHP groups. Our findings showed that DEHP amplified oxidant and inflammatory responses in this fetal hyperglycemia model, predisposing insulin resistance in zebrafish embryos.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792). 三氯生是一种抗菌药物，会导致淡水鱼 Anabas testudineus（Bloch，1792 年）生殖能力受损。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-05-01 Epub Date: 2024-03-22 DOI: 10.1177/07482337241242510

Priyatha Chokki Veettil, Jeena Nikarthil Sidhick, Sajeela Kavungal Abdulkhader, Siva Prasad Ms, Chitra Kumari Chidambaran

{"title":"Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792).","authors":"Priyatha Chokki Veettil, Jeena Nikarthil Sidhick, Sajeela Kavungal Abdulkhader, Siva Prasad Ms, Chitra Kumari Chidambaran","doi":"10.1177/07482337241242510","DOIUrl":"10.1177/07482337241242510","url":null,"abstract":"Triclosan (TCS), an antimicrobial drug, is known to occupy different compartments in aquatic ecosystems. The present study focused to evaluate the reproductive toxicity of triclosan, at environmentally relevant (0.009 and 9 μg L-1) and sublethal (176.7 μg L-1) concentrations for 90 days in the pre-spawning phase of the fish, Anabas testudineus. The reproductive biomarkers, namely, gonadal steroidogenic enzymes, expression of aromatic genes, levels of serum gonadotropins, sex hormones, and histology of gonads were analyzed. The weight of the animal, brain weights along with gonadosomatic index decreased while mucus deposition increased significantly at all concentrations of triclosan as the primary defensive mechanism to prevent the entry of toxicants. Triclosan disrupted gonadal steroidogenesis as evidenced by a reduction in the activities of gonadal steroidogenic enzymes. The expressions of cyp19a1a and cyp19a1b genes were up-regulated in the brain of both sexes and testis, while down-regulated in the ovary indicating estrogenic effects of the compound. The endocrine-disrupting effects of triclosan were confirmed. The current results suggest that chronic exposure to triclosan altered reproductive endpoints thereby impairing normal reproductive functions in fish.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health risk assessment of occupational exposure to heavy metals among green space workers in Iran. 伊朗绿地工人职业接触重金属的健康风险评估。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-25 DOI: 10.1177/07482337241247088

Hossein Abbaslou, Pourya Ahmadi Jalaldehi, S. Kalantary, Kamal Azam, Elham Zanjani, S. Shahtaheri, M. Khadem

{"title":"Health risk assessment of occupational exposure to heavy metals among green space workers in Iran.","authors":"Hossein Abbaslou, Pourya Ahmadi Jalaldehi, S. Kalantary, Kamal Azam, Elham Zanjani, S. Shahtaheri, M. Khadem","doi":"10.1177/07482337241247088","DOIUrl":"https://doi.org/10.1177/07482337241247088","url":null,"abstract":"Exposure to heavy metals can result in various adverse health effects. Tehran is rated as one of the world's most polluted cities. Green space workers are continuously exposed to such pollutants in this city. Thus, this study aimed to estimate the health risks caused by exposure to heavy metals among green space workers. Eighty-eight workers and office personnel in two regions with different air quality levels were chosen for sampling. Air samples were collected using the NIOSH-7300 method and analyzed using an Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) instrument. The hazard quotient (HQ) and the lifetime cancer risk (LTCR) were calculated to assess carcinogenic and non-carcinogenic risk levels. The results revealed that the rank order of heavy metals was determined as Zn, Pb, Mn, Ni, Co, and Cd. Workers were subjected to higher concentrations of Ni, Pb, Zn, and Co than office personnel. Furthermore, the Cd, Co, and Zn exposure levels stood significantly higher in region 6 than in region 14. Non-carcinogenic risk levels for all participants fell within the acceptable range. Moreover, no employee had a carcinogenic risk level within the acceptable range when exposed to Cd. Also, 2.3% of individuals demonstrated Ni's acceptable carcinogenic risk level. Owing unacceptable risk levels, proper interventions are required to minimize occupational exposure to heavy metals. These interventions include optimizing shift schedules, using personal protective equipment, and conducting regular health assessments.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the mesotheliogenic potency of cleavage fragments found in talc 滑石中发现的裂解片段的间皮瘤致病力综述

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-15 DOI: 10.1177/07482337241246924

E Miller, EM Beckett, D Cheatham, CE Comerford, RC Lewis, C Krevanko, N Mandava, JS Pierce

引用次数: 0

Assessment of genotoxicity biomarkers in gasoline station attendants due to occupational exposure 评估加油站服务员因职业暴露而产生的基因毒性生物标志物

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-10 DOI: 10.1177/07482337241247089

Aylin Elkama, Kerem Şentürk, Bensu Karahalil

{"title":"Assessment of genotoxicity biomarkers in gasoline station attendants due to occupational exposure","authors":"Aylin Elkama, Kerem Şentürk, Bensu Karahalil","doi":"10.1177/07482337241247089","DOIUrl":"https://doi.org/10.1177/07482337241247089","url":null,"abstract":"Gasoline station attendants are exposed to numerous chemicals that might have genotoxic and carcinogenic potential, such as benzene in fuel vapor and particulate matter and polycyclic aromatic hydrocarbons in vehicle exhaust emission. According to IARC, benzene and diesel particulates are Group 1 human carcinogens, and gasoline has been classified as Group 2A “possibly carcinogenic to humans.” At gas stations, self-service is not implemented in Turkey; fuel-filling service is provided entirely by employees, and therefore they are exposed to those chemicals in the workplace during all working hours. Genetic monitoring of workers with occupational exposure to possible genotoxic agents allows early detection of cancer. We aimed to investigate the genotoxic damage due to exposures in gasoline station attendants in Turkey. Genotoxicity was evaluated by the Comet, chromosomal aberration, and cytokinesis-block micronucleus assays in peripheral blood lymphocytes. Gasoline station attendants ( n = 53) had higher tail length, tail intensity, and tail moment values than controls ( n = 61). In gasoline station attendants ( n = 46), the frequencies of chromatid gaps, chromosome gaps, and total aberrations were higher compared with controls ( n = 59). Increased frequencies of micronuclei and nucleoplasmic bridges were determined in gasoline station attendants ( n = 47) compared with controls ( n = 40). Factors such as age, duration of working, and smoking did not have any significant impact on genotoxic endpoints. Only exposure increased genotoxic damage in gasoline station attendants independently from demographic and clinical characteristics. Occupational exposure-related genotoxicity risk may increase in gasoline station attendants who are chronically exposed to gasoline and various chemicals in vehicle exhaust emissions.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ascorbic acid attenuates gasoline-induced testicular toxicity, sperm quality deterioration, and testosterone imbalance in rats 抗坏血酸可减轻汽油引起的大鼠睾丸毒性、精子质量下降和睾酮失衡

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-10 DOI: 10.1177/07482337241245154

Ogechukwu E Ezim, Joy Nyeche, Chisom E Nebeolisa, Chuka D Belonwu, Sunny O Abarikwu

{"title":"Ascorbic acid attenuates gasoline-induced testicular toxicity, sperm quality deterioration, and testosterone imbalance in rats","authors":"Ogechukwu E Ezim, Joy Nyeche, Chisom E Nebeolisa, Chuka D Belonwu, Sunny O Abarikwu","doi":"10.1177/07482337241245154","DOIUrl":"https://doi.org/10.1177/07482337241245154","url":null,"abstract":"The present study evaluated the protective effect of ascorbic acid (ASCB) against gasoline fumes (PET) induced testicular oxidative stress, sperm toxicity, and testosterone imbalance in Wistar rats. Twenty-four (24) male albino rats (75 ± 16 g) were randomized into three experimental groups ( N = 8). The control group: received normal saline, PET group: exposed to PET 6 h daily by inhalation in an exposure chamber and PET + 200 mg ASCB/kg body weight group: exposed to PET 6 h daily by inhalation and administered ASCB per os. Treatment of ASCB and PET exposure was done thrice and five times weekly for a period of 10 weeks respectively. ASCB co-treatment prevented PET-induced increases in the oxidative stress markers (glutathione, glutathione S-transferase, superoxide dismutase, catalase, hydrogen peroxide generation, nitric oxide, and lipid peroxidation) and serum testosterone concentration ( p < .05). Sperm quality was low and those with damaged heads and tails increased alongside histological injuries in the PET-exposed rats, which were also minimized with ASCB administration. ASCB protected against PET-induced oxidative stress, sperm, and testis damage in rats.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender associations between phthalate exposure and biomarkers of oxidative stress: A prospective cohort study 邻苯二甲酸盐暴露与氧化应激生物标志物之间的性别关联：前瞻性队列研究

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-09 DOI: 10.1177/07482337241245453

Jian-Qing Wang, Zhi-Juan Li, Hui Gao, Jie Sheng, Chun-Mei Liang, Ya-Bin Hu, Xun Xia, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao, Fang-Biao Tao

{"title":"Gender associations between phthalate exposure and biomarkers of oxidative stress: A prospective cohort study","authors":"Jian-Qing Wang, Zhi-Juan Li, Hui Gao, Jie Sheng, Chun-Mei Liang, Ya-Bin Hu, Xun Xia, Kun Huang, Su-Fang Wang, Peng Zhu, Jia-Hu Hao, Fang-Biao Tao","doi":"10.1177/07482337241245453","DOIUrl":"https://doi.org/10.1177/07482337241245453","url":null,"abstract":"Previous epidemiologic research has shown that phthalate exposure in pregnant women is related to adverse birth outcomes in a sex-specific manner. However, the biological mechanism of phthalate exposure that causes these birth outcomes remains poorly defined. In this research, we investigated the association between phthalate exposure and placental oxidative stress in a large population-based cohort study, aiming to initially explore the relationship between phthalate exposure and gene expression in placental oxidative stress in a sex-specific manner. Quantitative PCR was performed to measure the expression of placental inflammatory mRNAs (HO-1, HIF1α, and GRP78) in 2469 placentae. The multiple linear regression models were used to investigate the associations between mRNA and urinary phthalate monoesters. Phthalate metabolites monomethyl phthalate (MMP) and mono-n-butyl phthalate (MBP) were positively correlated with higher HIF1α expression in placentae of male fetuses ( p < .05). Mono-benzyl phthalate (MBzP) increased the expression of HO-1, HIF1α, and GRP78 in placentae of male fetuses, and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) up-regulated the expression of HIF1α and GRP78. Additionally, mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) was negatively correlated with HO-1, HIF1α, and GRP78 in placentae of female fetuses. Maternal phthalate exposure was associated with oxidative stress variations in placental tissues. The associations were closer in the placentas of male fetuses than in that of female ones. The placenta oxidative stress is worth further investigation as a potential mediator of maternal exposure-induced disease risk in children.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of alkyl glucosides in rinse-off cosmetics marketed as hypoallergenic or for sensitive skin 在以低过敏性或敏感性皮肤为卖点的冲洗型化妆品中出现烷基葡糖苷的情况

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-04 DOI: 10.1177/07482337241245152

Dejan Ćirin, Jovana Milutinov, Veljko Krstonošić

{"title":"Occurrence of alkyl glucosides in rinse-off cosmetics marketed as hypoallergenic or for sensitive skin","authors":"Dejan Ćirin, Jovana Milutinov, Veljko Krstonošić","doi":"10.1177/07482337241245152","DOIUrl":"https://doi.org/10.1177/07482337241245152","url":null,"abstract":"Rinse-off cosmetic products, primarily shampoos, are frequently implicated in the onset of allergic contact dermatitis (ACD) caused by alkyl glucosides (AGs). AGs are increasingly popular surfactants and known contact allergens. Glucoside-induced ACD was most frequently observed with shampoos and skin-cleansing products in both consumer and occupational settings. Thereby, studies have shown that atopic individuals are the most susceptible to ACD. Also, several investigations have indicated that individuals with sensitive skin might be more prone to skin allergies. This is why the presence of AGs was investigated in shampoos and body cleansers marketed as hypoallergenic or for sensitive skin. For this purpose, the website of Amazon.com was surveyed. Four groups of cosmetics were obtained by using the following keywords: “hypoallergenic shampoo for adults,” “sensitive skin shampoo for adults,” “hypoallergenic body cleanser for adults,” and “sensitive skin body cleanser for adults.” The first 30 best-selling cosmetics in each group were investigated for the presence of AGs, by analyzing the product information pages. The results showed that as much as 56.7% of hypoallergenic shampoos contained AGs, as ingredients, whereas the percentage was somewhat lower for other product categories. Even though decyl and lauryl glucoside were nearly ubiquitously used AGs in cosmetics over the past decade, the most commonly present AG in our analysis was coco-glucoside. The results of this study indicated a necessity to include coco-glucoside in the baseline series of patch testing allergens. Industry , regulators, and healthcare providers should be made aware of the frequent presence of AGs in rinse-off cosmetic products marketed as hypoallergenic or for sensitive skin to ensure the safety and well-being of consumers and patients.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health risk assessment and prevalence of work-related musculoskeletal disorders among the aged brick molders, in India 印度老年砖模工的健康风险评估和与工作有关的肌肉骨骼疾病流行率

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2024-04-03 DOI: 10.1177/07482337241244474

Banibrata Das

{"title":"Health risk assessment and prevalence of work-related musculoskeletal disorders among the aged brick molders, in India","authors":"Banibrata Das","doi":"10.1177/07482337241244474","DOIUrl":"https://doi.org/10.1177/07482337241244474","url":null,"abstract":"The Brickfield Industry is the major and oldest informal industry in India, where millions of brickfield workers make their livelihood. Aged brickfield workers are also involved in different activities in the brickfield, especially in brick mold activities owing to poor socioeconomic conditions. A cross-sectional study was designed to determine the prevalence of work-related musculoskeletal disorders among the aged brick molders and compare them with aged control subjects. A Nordic Questionnaire was applied to assess the discomfort felt among both groups of workers and the Rapid Upper Limb Assessment (RULA) method was used to evaluate posture during their job. The RULA posture analysis showed that the posture adopted by aged brick molders required changes immediately. The result of the ART tool also stated that the brick molding activities’ exposure level was high and required further investigation urgently. The study concluded that due to working in a forward bending posture for a prolonged period, aged brickmolders suffered from severe low back and knee pain along with upper-limb disorders due to repetitive activities.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0