Toxicology and Industrial Health最新文献_第10页

Pollution effects on retinal health: A review on current methodologies and findings. 污染对视网膜健康的影响:当前研究方法和结果综述。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-06-01 DOI: 10.1177/07482337231174072

Yue Wang, Nuoya Yin, Renjun Yang, Francesco Faiola

引用次数: 0

Effects on blood parameters from hand-arm vibrations exposure. 手臂振动暴露对血液参数的影响。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-06-01 DOI: 10.1177/07482337231173733

Niclas Johansson, Oscar Ragnebro, Albin Stjernbrandt, Pål Graff, Ing-Liss Bryngelsson, Per Vihlborg

{"title":"Effects on blood parameters from hand-arm vibrations exposure.","authors":"Niclas Johansson, Oscar Ragnebro, Albin Stjernbrandt, Pål Graff, Ing-Liss Bryngelsson, Per Vihlborg","doi":"10.1177/07482337231173733","DOIUrl":"https://doi.org/10.1177/07482337231173733","url":null,"abstract":"Vibration exposure from handheld tools can affect the hands with neurological symptoms and vibration-induced Raynaud's phenomenon (VRP). The underlying pathophysiological mechanisms are not fully known, however, changes in the composition of blood parameters may contribute to VRP with an increase in blood viscosity and inflammatory response. The aim of this study was to examine the effect on blood parameters in capillary blood from fingers that had been exposed to a vibrating hand-held tool. This study involved nine healthy participants who had been exposed to vibration and an unexposed control group of six participants. Capillary blood samples were collected before and after vibration exposure for the exposed group, and repeated samples also from the control group. The exposed groups were exposed to vibration for a 15-min period or until they reached a 5.0 m/s2 vibration dose. Analysis of blood status and differential counting of leucocytes was performed on the capillary blood samples. The results of the blood samples showed an increase in mean value for erythrocyte volume fraction (EVF), hemoglobin, red blood cell count, white blood cell count and neutrophils, as well as a decrease of mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration. The increase of EVF and neutrophils was statistically significant for samples taken from the index finger but not the little finger. Even though the study was small it showed that an acute vibration exposure to the hands might increase EVF and neutrophilic granulocytes levels in the capillary blood taken from index fingers.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sampling chamber with minimal wall surface for simultaneous emission testing of diisocyanates and diamines from polyurethane products. 同时检测聚氨酯产品中二异氰酸酯和二胺的最小壁面取样室。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-06-01 DOI: 10.1177/07482337231172811

Daniel Karlsson

{"title":"Sampling chamber with minimal wall surface for simultaneous emission testing of diisocyanates and diamines from polyurethane products.","authors":"Daniel Karlsson","doi":"10.1177/07482337231172811","DOIUrl":"https://doi.org/10.1177/07482337231172811","url":null,"abstract":"A sampling chamber was developed for emission testing of diisocyanates, methylene diphenyl diisocyanate (MDI), toluene diisocyanate (TDI), and corresponding diamines, methylene diphenyl diamine (MDA), and toluene diamine (TDA) from polyurethane (PU) product surfaces. In addition, a methodology for validation of the sampling chamber was presented, based on the introduction of generated standard atmospheres of the different diisocyanates and diamines to the sampling chamber system. Sampling of diisocyanates and diamines was performed on a circular glass fiber filter (150 mm diameter) impregnated with dihexyl amine (DHA) and acetic acid (AA) positioned inside a cylindrical stainless steel sampling chamber. The diisocyanates were immediately derivatized to DHA derivatives, and the amines were derivatized in a subsequent work-up procedure with ethyl chloroformate (ECF). The design of the sampling chamber and the presented methodology allowed for simultaneous sampling and analysis of diisocyanates and diamines of emission from a large surface area with minimal interior wall interaction in the sampling chamber. Performance characteristics of the sampling chamber for different sampling times and air humidity were obtained by determining collected amounts of the diisocyanates and diamines in the different parts of the sampling chamber. The repeatability of the collected amount on the impregnated filters in the sampling chamber was 15% with an overall recovery for 8 h of sampling in the range of 61% to 96%. The performance of the sampling chamber was not affected by air humidity (5%-75% RH), and no breakthrough during sampling was observed. LC-MS/MS determinations allowed for emission testing of diisocyanates and diamines on product surfaces as low as 10-30 ng m-2 h-1.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/64/10.1177_07482337231172811.PMC10210200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Emission and time-resolved migration rates of aromatic diamines from two flexible polyurethane foams. 两种柔性聚氨酯泡沫中芳香二胺的释放和时间分辨迁移率。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-06-01 DOI: 10.1177/07482337231172816

Daniel Karlsson, Mark W Spence, Patrick M Plehiers

{"title":"Emission and time-resolved migration rates of aromatic diamines from two flexible polyurethane foams.","authors":"Daniel Karlsson, Mark W Spence, Patrick M Plehiers","doi":"10.1177/07482337231172816","DOIUrl":"https://doi.org/10.1177/07482337231172816","url":null,"abstract":"Performing risk assessments (RA) on household use of flexible polyurethane (PU) foams requires access to reliable data about emission and migration of potential diamine impurities. A toluene diisocyanate (TDI) and a methylene diphenyl diisocyanate (MDI) based foam were thermally treated to enable measurements on samples with defined concentrations of the corresponding diamines, toluene diamine (TDA), and methylene dianiline (MDA). The thermally treated foams used for emission testing contained up to 15 mg.kg-1 of TDA and 27 mg.kg-1 of MDA. Those used for migration testing contained 5.1 mg.kg-1 of TDA and 14.1 mg.kg-1 of MDA. Stability of the thermally generated diamines was sufficient for testing over a 37-day period. Analytical techniques that did not decompose the polymer matrix were applied. Emission rates for TDA and MDA isomers were less than the limit of quantitation (LOQ) of 0.008-0.07 μg.m-2.h-1. Migration was studied using samples of the same thermally treated foams over a 35-day period. Quantifiable migration of MDA from the MDI-based foam was only observed on Days 1 and 2. From Day 3 onward, migration rates were less than the LOQ. Quantifiable migration of TDA from the TDI-based foam rapidly decreased with time and was only observed on Days 1 thru 3. From Day 4 onward, migration rates were less than the LOQ. Theoretically, the migration rate should be inversely proportional to the square root of time (t) as t-0.5. This relationship was confirmed by the experimental data and enables extrapolating migration values to more extended time periods to conduct RAs.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/06/10.1177_07482337231172816.PMC10210196.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9576654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exposure to bisphenol A induces neurotoxicity associated with synaptic and cytoskeletal dysfunction in neuro-2a cells. 暴露于双酚A可诱导神经2a细胞突触和细胞骨骼功能障碍相关的神经毒性。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-06-01 DOI: 10.1177/07482337231172827

Siting Wang, Hongmei Ning, Xinrui Wang, Lingli Chen, Liushuai Hua, Fei Ren, Dongfang Hu, Rongbo Li, Zhisheng Ma, Yaming Ge, Zhihong Yin

{"title":"Exposure to bisphenol A induces neurotoxicity associated with synaptic and cytoskeletal dysfunction in neuro-2a cells.","authors":"Siting Wang, Hongmei Ning, Xinrui Wang, Lingli Chen, Liushuai Hua, Fei Ren, Dongfang Hu, Rongbo Li, Zhisheng Ma, Yaming Ge, Zhihong Yin","doi":"10.1177/07482337231172827","DOIUrl":"https://doi.org/10.1177/07482337231172827","url":null,"abstract":"Bisphenol A (BPA) has been reported to injure the developing and adult brain. However, the underlying mechanism still remains elusive. This study used neuro-2a cells as a cellular model to investigate the neurotoxic effects of BPA. Microtubule-associated protein 2 (MAP2) and tau protein maintain microtubule normal function and promote the normal development of the nervous system. Synaptophysin (SYP) and drebrin (Dbn) proteins are involved in regulating synaptic plasticity. Cells were exposed to the minimum essential medium (MEM), 0.01% (v/v) DMSO, and 150 μM BPA for 12, 24, or 36 h. Morphological analysis revealed that the cells in the BPA-treated groups shrank and collapsed compared with those in the control groups. CCK-8 and lactate dehydrogenase assay (LDH) assays showed that the mortality of neuro-2a cells increased as the BPA treatment time was prolonged. Ultrastructural analysis further revealed that cells demonstrated nucleolar swelling, dissolution of nuclear and mitochondrial membranes, and partial mitochondrial condensation following exposure to BPA. BPA also decreased the relative protein expression levels of MAP2, tau, and Dbn. Interestingly, the relative protein expression levels of SYP increased. These results indicated that BPA inhibited the proliferation and disrupted cytoskeleton and synaptic integrity of neuro-2a cells.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levels of Clara cell secretory protein and surfactant protein A in municipal solid waste management workers in Ibadan, Southwest Nigeria. 尼日利亚西南部伊巴丹市城市固体废物管理工人Clara细胞分泌蛋白和表面活性剂蛋白A水平

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-05-01 DOI: 10.1177/07482337231169085

Adesina O Odewabi, Romoke S Ajibola, Kolawole S Oritogun, Martins Ekor

{"title":"Levels of Clara cell secretory protein and surfactant protein A in municipal solid waste management workers in Ibadan, Southwest Nigeria.","authors":"Adesina O Odewabi, Romoke S Ajibola, Kolawole S Oritogun, Martins Ekor","doi":"10.1177/07482337231169085","DOIUrl":"https://doi.org/10.1177/07482337231169085","url":null,"abstract":"Toxic pneumonitis and related respiratory symptoms are common among waste management workers (WMWs). Products of different cellular responses following exposure to toxic components of wastes can lead to the production of a variety of biomolecules. There is a growing recognition of the importance of biomarkers in risk assessment and a strong advocacy for their determination and use as indicators of health and safety. This study assessed the prevalence of respiratory symptoms and the relevance of pulmonary surfactant protein A (SP-A) and Clara cell 16 protein (CC16) as indicators of occupational inhalation exposure to toxic substances and irritants in WMW. A total of 172 subjects consisting of 112 WMWs and 60 Non-WMWs were recruited by purposive sampling. Data on socio-economic and work-related symptoms were collected using structured questionnaire. CC16 and SP-A were determined by ELISA in serum samples. Clinical history reveals a slightly higher prevalence of respiratory symptoms in WMWs relative to control subjects. Increased permeability of the lung-blood barrier, characterized by significant elevation of serum SP-A and serum CC16, was associated with respiratory symptoms in WMWs. Steady increases in SP-A and CC16, respectively, in relation to occupational duration were observed in WMWs relative to control. Receiver operating characteristic curve and multivariate analyses revealed SP-A and CC16 as important lung biomarkers for assessing sub-clinical effects of occupational exposure. Our data suggest SP-A and CC16 may be relevant indicators for assessing occupational inhalation exposure to toxic substances and irritants among WMWs.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postnatal exposure to Bisphenol S induces liver injury in mice: Possible implication of PPARγ receptor. 出生后暴露于双酚S诱导小鼠肝损伤:可能与PPARγ受体有关。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-05-01 DOI: 10.1177/07482337231166490

Bessem Mornagui, Raja Rezg, Fadoua Neffati, Mohamed Fadhel Najjar, Ahmed Rejeb

{"title":"Postnatal exposure to Bisphenol S induces liver injury in mice: Possible implication of PPARγ receptor.","authors":"Bessem Mornagui, Raja Rezg, Fadoua Neffati, Mohamed Fadhel Najjar, Ahmed Rejeb","doi":"10.1177/07482337231166490","DOIUrl":"https://doi.org/10.1177/07482337231166490","url":null,"abstract":"There is considerable evidence that Bisphenol S (BPS) induces various toxicological effects and is an industrial health issue. However, little data are available on the in vivo effects of BPS on the liver, a major target of drug toxicity. In this study, we evaluated the potential harmfulness of low levels of BPS in the liver of male mice. Also, we investigated the interaction between BPS and peroxisome proliferator-activated receptor-gamma (PPARγ) by computational docking approach. PPARγ is a member of the superfamily of nuclear hormone receptors. It acts as a transcription factor and regulates the genes involved in lipid and glucose metabolism and in inflammation and necrosis. Mice were exposed to BPS, in drinking water at 25, 50, and 100 μg/kg for 10 weeks. The protocol was started after weaning. At the time of sacrifice, blood samples were collected for a biochemical analysis, followed by liver tissue collection for histopathological study. Results showed that BPS-induced hypertriglyceridemia, increased liver injury markers, and initiated histopathological changes, including inflammatory cell infiltration, hepatocellular necrosis, and steatosis. BPS did not affect glycated hemoglobin (HbA1C). Interestingly, data showed that BPS could interact with the PPARγ ligand-binding pocket by hydrogen bonds with Asn 219, Cys 276, Ser 280, and Thr 283. We suggest that PPARγ is among the targets of BPS and could play a key role in the cascade reaction of BPS-induced liver disruption. These findings support the hypothesis that the post-weaning period is sensitive to low-dose BPS exposure that can lead to dyslipidemia signature later in life.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9750782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The effect of melatonin on benzo(a)pyrene-induced renal toxicity in mice. 褪黑素对苯并(a)芘致小鼠肾毒性的影响。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-05-01 DOI: 10.1177/07482337231166491

Samira Barangi, Rouzchehr Asadi, Soghra Mehri, Gholamreza Karimi

{"title":"The effect of melatonin on benzo(a)pyrene-induced renal toxicity in mice.","authors":"Samira Barangi, Rouzchehr Asadi, Soghra Mehri, Gholamreza Karimi","doi":"10.1177/07482337231166491","DOIUrl":"https://doi.org/10.1177/07482337231166491","url":null,"abstract":"Benzo(a)pyrene is a ubiquitous environmental contaminant, which could induce renal injury. It is reported that melatonin has a protective effect against multiple organ injuries by regulating oxidative stress, apoptosis, and autophagy. The aim of this study was to estimate the melatonin effects on benzo(a)pyrene renal toxicity in mice and the possible molecular mechanisms involved in this model. Thirty male mice were allocated to five groups and treated with benzo(a)pyrene (75 mg/kg, oral gavage) and/or melatonin (10 and 20 mg/kg, intraperitoneally). The oxidative stress factors were evaluated in renal tissue. The levels of apoptotic (the Bax/Bcl-2 ratio and caspase-3) and autophagic (the LC3 II/I, Beclin-1, and Sirt1) proteins were examined using Western blot. Following the administration of benzo(a)pyrene, malondialdehyde, caspase-3 and the Bax/Bcl-2 ratio increased in renal tissue, while Sirt1, Beclin-1, and the LC3 II/I ratio diminished. Interestingly, the co-administration of 20 mg/kg melatonin along with benzo(a)pyrene reduced the oxidative stress markers, apoptotic and autophagic proteins. Collectively, melatonin exhibited a protective effect against benzo(a)pyrene-induced renal injury through the suppression of oxidative stress and apoptosis and the inhibition of Sirt1/autophagy pathway.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk assessment of lead exposure in radiology personnel in Menoufia hospitals, Egypt. 埃及Menoufia医院放射学人员铅暴露风险评估。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-05-01 DOI: 10.1177/07482337231171294

Ola Sweilum, Aziza El-Badry, Situhom El-Agamy

{"title":"Risk assessment of lead exposure in radiology personnel in Menoufia hospitals, Egypt.","authors":"Ola Sweilum, Aziza El-Badry, Situhom El-Agamy","doi":"10.1177/07482337231171294","DOIUrl":"https://doi.org/10.1177/07482337231171294","url":null,"abstract":"Lead shielding is used as a guard against scatter radiation. Lead aprons can emit particulate lead into the occupational environment, resulting in the accumulation of lead dust on the skin and garments of workers. This study aimed to assess the risk of lead exposure among radiologists working in the radiology departments by estimating hair and blood lead levels. A total of 40 radiology personnel (18 wearing aprons and 22 not wearing aprons) with a comparable control group (20 personnel not working in a radiology department) underwent a pre-designed questionnaire with estimation of blood and hair levels. The hair and blood lead levels in radiologists wearing aprons were significantly higher than those of the control group and that of the radiologist not wearing aprons. The lead levels in hair and blood were correlated significantly with the duration of wearing aprons in years and weekly working hours. Health care workers in radiology departments demonstrated high hair and blood levels that were higher among workers wearing aprons than those not wearing protective equipment. Hair lead levels can be detected quickly, cheaply, and non-invasively, and could be a helpful screening test for occupational exposure.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health implications of pesticides application among cocoa farmers in Idanre local government area, Southwest Nigeria. 尼日利亚西南部Idanre地方政府地区可可农农药施用对健康的影响。

IF 1.9 4区医学

Toxicology and Industrial Health Pub Date : 2023-05-01 DOI: 10.1177/07482337231169091

Chris O Adedire, Oluwayomi O Akinduro, Joseph A Adeyemi

{"title":"Health implications of pesticides application among cocoa farmers in Idanre local government area, Southwest Nigeria.","authors":"Chris O Adedire, Oluwayomi O Akinduro, Joseph A Adeyemi","doi":"10.1177/07482337231169091","DOIUrl":"https://doi.org/10.1177/07482337231169091","url":null,"abstract":"Pesticides are routinely applied by cocoa farmers to enhance cocoa production, which is threatened by pest infestations and diseases. However, the undesired health implications of pesticide applications on the farmers are yet to be fully elucidated especially among cocoa farmers in Idanre despite being the hub of cocoa production in Southwestern Nigeria. This study assessed the extent of pesticide use by cocoa farmers in the study area and determined the effects of exposure on their health using haematological and biochemical parameters as indices. A cross-sectional survey comprising 150 cocoa farmers and 50 controls (artisans) was carried out using structured questionnaire. Blood samples were obtained from participants for the determination of copper and sulphate levels, haematological (haematocrit, red blood cell counts, white blood cell counts and platelet counts) and biochemical (creatinine, cholesterol, direct bilirubin and total bilirubin) parameters. The blood levels of copper and sulphate were significantly higher in the cocoa farmers than in the controls. However, there was no significant difference between the subjects and controls for most of the haematological and biochemical parameters except for the platelet counts and total bilirubin levels. The data from the study did not suggest any serious health effects due to pesticide exposure on the cocoa farmers despite the high blood levels of copper and sulphate, probably due to exposure to copper-based fungicides. However, the high serum bilirubin level among the subjects was an indication of possible liver damage. As such, cocoa farmers should be guided against indiscriminate use of pesticides on their farms.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0