Toxicology and Industrial Health最新文献

Is TiO₂ carcinogenic? A toxicological alert. TiO2致癌吗？毒理学警报。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-05-21 DOI: 10.1177/07482337251343397

Nadielle Silva Bidu, Paulo Roberto de Veloso Reis, Ricardo David Couto, Bruno Jose Dumêt Fernandes

{"title":"Is TiO2 carcinogenic? A toxicological alert.","authors":"Nadielle Silva Bidu, Paulo Roberto de Veloso Reis, Ricardo David Couto, Bruno Jose Dumêt Fernandes","doi":"10.1177/07482337251343397","DOIUrl":"https://doi.org/10.1177/07482337251343397","url":null,"abstract":"Titanium dioxide (TiO2) is a white powder used in toothpaste, pharmaceuticals, sunscreen, food additives, cosmetics, paints, decontaminants, and photocatalysts. It is produced and used in the workplace in fine and ultrafine particle sizes. International organizations set occupational exposure limits for fine and ultrafine TiO2 particles. TiO2 has not been confirmed to have carcinogenicity in humans, with available assessment data being limited and inconclusive owing to nonspecific effects observed from TiO2 inhalation. The purpose of this toxicological alert is to encourage new studies to determine whether TiO2 is a human carcinogen. TiO2's classification as a possible carcinogen was based on laboratory experiments that produced TiO2 particles with 30-60 nm diameters. These studies assessed the potential risk of exposure to TiO2 nanoparticles, which have diverse and atypical characteristics compared to those found in workplace settings. To date, there are no studies with sufficient data on the duration of pulmonary exposure to TiO2 nanoparticles with significantly relevant workplace associations. Extrapolating results from rodent studies with limited parameter controls do not provide an adequate (translational) assessment of the toxicity of TiO2 nanoparticles on the human respiratory system.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251343397"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular toxicity of benzene series released from decorative materials. 装饰材料中苯系物的血管毒性。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-05-12 DOI: 10.1177/07482337251340797

Tanliu Zhang, Xiuhong Zhou, Limei Wang, Chengwang Li, Yan Xu, Zenghui Liu

引用次数: 0

Insights into the mechanism of METTL3-mediated m6A methylation in silicon dust-induced epithelial-mesenchymal transition. mettl3介导的m6A甲基化在硅尘诱导的上皮-间质转化中的机制研究

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-05-12 DOI: 10.1177/07482337251339926

Gao Yue, Duan Zhizhen, Yu Zhengmin, Shi Xinwei, Wang Ning, Wu Liting, Li Wei, Zhu Baoli, Sun Kai, Han Lei

{"title":"Insights into the mechanism of METTL3-mediated m6A methylation in silicon dust-induced epithelial-mesenchymal transition.","authors":"Gao Yue, Duan Zhizhen, Yu Zhengmin, Shi Xinwei, Wang Ning, Wu Liting, Li Wei, Zhu Baoli, Sun Kai, Han Lei","doi":"10.1177/07482337251339926","DOIUrl":"https://doi.org/10.1177/07482337251339926","url":null,"abstract":"Silicosis is an occupational lung disease caused by long-term inhalation of silica dust. Its characteristic pathological manifestation is progressive pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) plays an important role in the occurrence and development of silicosis fibrosis, and N6-methyladenosine (m6A), as an important form of RNA modification, is closely related to the expression and regulation of multiple genes in the process of fibrosis. In the present study, we demonstrated that m6A modification significantly increases during silica-induced EMT. Silencing Methyltransferase Like 3 (METTL3) to reduce m6A modification levels inhibited the EMT process, suggesting that METTL3-mediated m6A modification could be an effective strategy for intervening in pulmonary fibrosis. Subsequently, through RNA sequencing, protein-protein interaction network analysis, and Methylated RNA Immunoprecipitation-RT-qPCR, we identified c-Myc as a downstream target of METTL3. In summary, our findings illuminate the relationship between m6A modification, METTL3, and the progression of silicosis, particularly through the EMT process. These results suggest that targeting METTL3 could be a promising therapeutic approach for modulating m6A levels and intervening in the progression of silicosis.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251339926"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the effectiveness of personal protective equipment against engineered nanomaterials: A systematic review. 评估个人防护装备对工程纳米材料的有效性：系统综述。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-30 DOI: 10.1177/07482337251336897

Rezvan Abedinloo, Rouhollah Parvari, Zahra Cheraghi, Mohammad Javad Assari

{"title":"Evaluating the effectiveness of personal protective equipment against engineered nanomaterials: A systematic review.","authors":"Rezvan Abedinloo, Rouhollah Parvari, Zahra Cheraghi, Mohammad Javad Assari","doi":"10.1177/07482337251336897","DOIUrl":"https://doi.org/10.1177/07482337251336897","url":null,"abstract":"A key issue related to the development of nanotechnology is the protection of researchers in laboratories and workers in production facilities from exposure to engineered nanoparticles (ENPs). Personal protective equipment (PPE) can only provide protection if it is selected correctly, well maintained, and used properly in all possible exposures. The objective of this review was to systematically evaluate studies that have assessed the effectiveness of PPE against ENPs. The scientific literature search included the electronic databases of Web of Science, Scopus, MEDLINE via PubMed, Cochrane Collaboration Summaries, and NIOSHTIC. According to the PRISMA flow diagram, 24 papers that met the exclusion and inclusion criteria were included in this review. The review results on gloves, masks, and protective clothing revealed that among the common gloves assessed, nitrile 100 gloves were reported as the least suitable protection method against penetration. Also, most masks have low percent penetration. N99 and P100 masks were more effective than N95 masks. The results also indicated that the physical properties of textiles such as fiber diameter, fabric thickness, porosity, air permeability, and pore size are crucial in determining fabric performance against nanomaterials. Most studies have not used a standardized methodology for evaluating the performance of PPE against nanoparticles, highlighting the need for designing and developing a new method. It is essential to develop a precise and valid application guideline based on scientific evidence to assess protection methods for occupational exposure to ENPs.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251336897"},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased activity of acetylcholine esterase as a biomarker of pesticide exposure in female tea plantation workers. 茶园女工乙酰胆碱酯酶活性降低作为农药暴露的生物标志物。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-24 DOI: 10.1177/07482337251336580

Shashi Nandar Kumar, Rakhi Kumari, Nawaid Hussain Khan, Noor Saba Khan, Arnab Nayek, Ankita Sahu, Banajit Bastia, Meenakshi Ahluwalia, Sheikh Raisuddin, Arun Kumar Jain

{"title":"Decreased activity of acetylcholine esterase as a biomarker of pesticide exposure in female tea plantation workers.","authors":"Shashi Nandar Kumar, Rakhi Kumari, Nawaid Hussain Khan, Noor Saba Khan, Arnab Nayek, Ankita Sahu, Banajit Bastia, Meenakshi Ahluwalia, Sheikh Raisuddin, Arun Kumar Jain","doi":"10.1177/07482337251336580","DOIUrl":"https://doi.org/10.1177/07482337251336580","url":null,"abstract":"Because of their beneficial effects in controlling pests, pesticides are used worldwide to reduce pests in agricultural fields and commercial gardens, thereby increasing the crop yield. Pesticides are ubiquitous in the environment and besides targeting pests they also affect non-target organisms. This study was undertaken to evaluate the activity of acetylcholine esterase (AChE) inhibition and its associated health effects in female tea plantation workers (TPW). In silico analysis was applied to identify whether pesticide exposure had an increased affinity after binding with the AChE enzyme, and the findings were validated by measuring the AChE activity in the plasma of study subjects by the biochemical analysis. The activity of AChE was found to be considerably compromised in TPW exposed to pesticides. Inhibition of AChE activity may lead to severe adverse health effects, such as cough, fatigue, and headache in TPW exposed to pesticides. Among all pesticides, λ-cyhalothrin, fipronil, and fenazaquine had the highest binding affinity with AChE (-10.098 Kcal/mol, -8.574 Kcal/mol, and -8.507 Kcal/mol, respectively) as compared to the other pesticides and their natural acetylcholine substrate (-4.398 Kcal/mol). Based on in silico results, AChE was found to have the highest binding affinity with λ-cyhalothrin, fipronil, and fenazaquine, and these pesticides could be responsible for the enzyme activity inhibition. Hence, these pesticides may cause more adverse health effects on humans compared to other pesticides. This finding on biomarker role for AChE may aid in the development of effective antidotes against pesticide exposure, thereby faciliating mitigation of negative health effects of pesticides.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251336580"},"PeriodicalIF":1.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vinyltrimethoxysilane (VTMS). Vinyltrimethoxysilane(管理)。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-22 DOI: 10.1177/07482337251315794

{"title":"Vinyltrimethoxysilane (VTMS).","authors":"","doi":"10.1177/07482337251315794","DOIUrl":"https://doi.org/10.1177/07482337251315794","url":null,"abstract":"Vinyltrimethoxysilane (VTMS) has been used in formulations as a coupling agent for plastic and wire cable pipes, a moisture scavenger in sealants, and a co-monomer in the preparation of latex dispersions. The amount of VTMS used in industrial products is ≤2%; there are no consumer uses of VTMS. In studies in experimental animals, VTMS showed a low acute toxicity via oral, dermal, and inhalation routes of exposure. VTMS is not a dermal or eye irritant. A weight of evidence assessment of four available dermal sensitization studies in guinea pigs supports the conclusion that VTMS is not a dermal sensitizer; however, based on one additional study that gave positive results, ECHA classified VTMS as Category 1B (may cause an allergic skin reaction). VTMS is not considered to be genotoxic based on results of in vitro and in vivo studies. In various experimental animal studies, VTMS has shown neither reproductive nor developmental effects. Short-term, oral administration of VTMS for 28 days in rats produced treatment-related effects in the urinary bladder and kidney. In a 14-week inhalation study in rats, VTMS exposure was associated with histopathological changes in the kidney and urinary bladder. However, an expert panel review of the urinary bladder and kidney observations concluded they were an adaptive response to physical or chemical irritant(s) in the urine. The NOAEC of 100 ppm (605 mg/m3) from the 14-week inhalation study was used as the point of departure for the health-based WEEL derivation. After adjusting to account for duration of exposure and interindividual variability, the 8-h TWA WEEL guideline of 10 ppm (60 mg/m3) is expected to provide a significant margin of safety against any potential adverse health effects in workers following long-term inhalation exposure to VTMS.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251315794"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taurine alleviated acrylamide-induced ovarian toxicity via suppression of oxidative stress and apoptosis in mice. 牛磺酸通过抑制氧化应激和细胞凋亡减轻丙烯酰胺诱导的小鼠卵巢毒性。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-18 DOI: 10.1177/07482337251335541

Zahra Khodabandeh, Sanaz Alaee, Mohammad Samare-Najaf, Elham Hosseini, Mahintaj Dara, Saeed Shokri, Reza Shirazi

{"title":"Taurine alleviated acrylamide-induced ovarian toxicity via suppression of oxidative stress and apoptosis in mice.","authors":"Zahra Khodabandeh, Sanaz Alaee, Mohammad Samare-Najaf, Elham Hosseini, Mahintaj Dara, Saeed Shokri, Reza Shirazi","doi":"10.1177/07482337251335541","DOIUrl":"https://doi.org/10.1177/07482337251335541","url":null,"abstract":"Acrylamide (Acr) poses reproductive toxicity risks to humans due to its ability to penetrate cell membranes and disrupt cellular balance. Taurine (Tau), a sulfur-containing amino acid with cell membrane stabilization and antioxidant properties, may mitigate these effects. This study examined how Tau can protect against oxidative stress and apoptosis induced by Acr in mouse ovarian tissue. Forty adult healthy mice, aged 6-8 weeks, were randomly assigned to four groups including the controls (received normal saline orally), Acr (50 mg/kg/day Acr orally), Acr + Tau75 (Acr and 75 mg/kg/day Tau), and Acr + Tau150 (Acr and 150 mg/kg/day Tau). Treatments were administered for 35 days, followed by assessments of stress markers and apoptosis via immunofluorescence and TUNEL assays. Both doses of Tau significantly increased the gene and protein expression levels of stress response enzymes, including Gpx1, Sod1, and Cat. Moreover, Tau significantly decreased the gene expression levels of apoptotic markers Caspase3 and Bax, while upregulating the antiapoptotic gene Bcl2l2. The TUNEL assay revealed the preventive properties of Tau against Acr-induced apoptosis in the ovaries. The current findings suggest the promising properties of Tau in the prevention of Acr-induced oxidative stress and apoptosis in mouse ovarian tissue. Therefore, Tau could play a protective role against Acr-induced reproductive toxicity in females, meriting further research into its potential applications.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251335541"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Online software for a new risk assessment method in occupational health and safety: RSCAL. 一种新的职业健康安全风险评价方法——RSCAL在线软件。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-16 DOI: 10.1177/07482337251333164

Fatih Mehmet Ateş, Ömer Doğan

{"title":"Online software for a new risk assessment method in occupational health and safety: RSCAL.","authors":"Fatih Mehmet Ateş, Ömer Doğan","doi":"10.1177/07482337251333164","DOIUrl":"https://doi.org/10.1177/07482337251333164","url":null,"abstract":"Risk assessment is necessary for the safety of employees in the workplace. Risk assessment methods contain some deficiencies arising from the persons performing the analysis. In order to partially overcome this situation, a risk assessment method has been developed by the authors by utilizing the data on occupational accidents in Turkey. In the method, Occupational Health and Safety Professionals who will perform the risk assessment can calculate the risk score without giving a numerical value for any hazard and corresponding risk that they identify in the workplace. In the study, a user-friendly online software called RSCAL by the authors, with a web address of https://rscal.com.tr/, which can meet all the above-mentioned requirements and calculate risk scores for workplaces serving in all types of sectors, has been developed. Through this online application, the identified hazard, risk and exposures of the business to be analyzed can be selected; the necessary corrective and preventive actions can be written by the user and then the risk score can be calculated. After that, all hazards specific to the enterprise can be meticulously identified and the risk assessment of the enterprise can be made by calculating the risk scores. This risk assessment can also be printed out in excel file format. In the future, parameters such as the deadline for each hazard, the legal requirement or standard from which the corrective preventive action to be taken arises can be added to the RSCAL calculation tool.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251333164"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Effects of BPA, BPS, and TMBPF on male fertility in Caenorhabditis elegans". “双酚a， BPS和TMBPF对秀丽隐杆线虫雄性生殖能力的影响”的更正。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-01 Epub Date: 2025-03-29 DOI: 10.1177/07482337251332193

引用次数: 0

Do safety data sheets (SDS) and chemical labels effectively communicate safety hazards and precautions? An initial appraisal report with special reference to reproductive toxicant chemicals used in biotechnology applications. 安全数据表（SDS）和化学品标签是否有效传达了安全危害和预防措施？特别针对生物技术应用中使用的生殖毒性化学品的初步评估报告。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-04-01 Epub Date: 2025-03-13 DOI: 10.1177/07482337251320750

Ranil Kavindra Asela Kularatne

{"title":"Do safety data sheets (SDS) and chemical labels effectively communicate safety hazards and precautions? An initial appraisal report with special reference to reproductive toxicant chemicals used in biotechnology applications.","authors":"Ranil Kavindra Asela Kularatne","doi":"10.1177/07482337251320750","DOIUrl":"10.1177/07482337251320750","url":null,"abstract":"This article presents a preliminary commentary on the Safety Data Sheets (SDS) and chemical labels of reproductive toxicant chemicals frequently used in biotechnology laboratories. This included six chemicals (chloroform, acrylamide, cobalt chloride hexahydrate, dimethyl formamide, boric acid, and 6-benzylaminopurine) and the main chemical mixture (comprising 60-100% formamide by weight) used in next sequencing generation (NGS). Section 2 (hazard identification), Section 3 (composition), Section 4 (first aid measures and reported health effects), Section 8 (recommended engineering controls and personnel protective equipment/PPE), and Section 11 (toxicological information) of the SDS were evaluated. SDS exhibited some inadequacies with a few inaccuracies and unspecific information in the hazard classifications. Description of the prevention precautionary statements was poor in the SDS. Irrespective of the described health hazards, all SDS described the first aid measures to be taken for all routes of chemical exposure. SDS of the reviewed chemicals and mixtures are not providing enough information relating to occupational health and safety aspects. Recommendations to assess the ways in which SDS and chemical labels are written, monitored, regulated, and used are suggested in this paper.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"234-264"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0