Toxicology and Industrial Health最新文献

The effect of alpha-lipoic acid on liver damage induced by extremely low-frequency electromagnetic fields in a rat model. α -硫辛酸对极低频电磁场致大鼠肝损伤的影响。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-09-29 DOI: 10.1177/07482337251383412

Nur Aydinbelge Dizdar, Aylin Akbulut, Gokhan Koca, Mikail Koray Demirel, Nihat Yumusak, Gaye Umurhan, Ayse Gulnihal Canseven Kursun, Meliha Korkmaz

{"title":"The effect of alpha-lipoic acid on liver damage induced by extremely low-frequency electromagnetic fields in a rat model.","authors":"Nur Aydinbelge Dizdar, Aylin Akbulut, Gokhan Koca, Mikail Koray Demirel, Nihat Yumusak, Gaye Umurhan, Ayse Gulnihal Canseven Kursun, Meliha Korkmaz","doi":"10.1177/07482337251383412","DOIUrl":"https://doi.org/10.1177/07482337251383412","url":null,"abstract":"This study aimed to investigate the effect of alpha-lipoic acid (ALA) on liver damage caused by extremely low-frequency magnetic fields (ELF-MFs) in rats. Thirty-two male rats were arbitrarily assigned into four groups: Group 1 (control group), Group 2 (ELF-MF exposure group), Group 3 (ELF-MF exposure + ALA administration), and Group 4 (sham group). Groups 2 and 3 were exposed to ELF-MF at 2 mT intensity emitted by two Helmholtz coils for 4 hours/day throughout 30 days. Group 3 received ALA intraperitoneally (100 mg/kg/day) 1 hour prior to each exposure for 30 days. Group 4 was placed inside the coils, but the generator was turned off. Histopathological analysis of the liver revealed statistically significant increases in hyperemia, inflammation, fibrosis, vacuolization, multiple nuclei, and biliary proliferation in Group 2 compared to all other groups. Immunohistochemical evaluation showed that Group 2 had statistically significantly higher TUNEL and caspase-3 levels than all other groups. ELF-MF-induced alterations, including hyperemia, inflammation, vacuolization, and multiple nuclei, were significantly reduced in Group 3 compared with Group 2. However, no significant difference was observed between Group 2 and Group 3 regarding bile duct proliferation or fibrosis. No pathological changes were observed in Groups 1 and 4. ALA administration effectively reduced some histopathological changes caused by ELF-MF, particularly hyperemia, inflammation, vacuolization, and multiple nuclei, but did not improve fibrosis or biliary proliferation. Additionally, it reduced TUNEL and caspase-3 expression. Our findings suggest that ALA exhibits anti-apoptotic and anti-inflammatory effects against ELF-MF-induced liver damage.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251383412"},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress and ferroptosis mediate 3,3',4,4',5-pentachlorobiphenyl-induced non-alcoholic fatty liver disease in mice. 氧化应激和铁下垂介导3,3',4,4'，5-五氯联苯诱导的小鼠非酒精性脂肪性肝病。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-09-16 DOI: 10.1177/07482337251376455

Jingjing Wang, Yichun Chen, Hanpeng Wu, Yingrong Ye, Yifei Li, Ershun Zhou

{"title":"Oxidative stress and ferroptosis mediate 3,3',4,4',5-pentachlorobiphenyl-induced non-alcoholic fatty liver disease in mice.","authors":"Jingjing Wang, Yichun Chen, Hanpeng Wu, Yingrong Ye, Yifei Li, Ershun Zhou","doi":"10.1177/07482337251376455","DOIUrl":"https://doi.org/10.1177/07482337251376455","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is an escalating global health threat that has been linked to environmental pollutants such as the highly toxic dioxin-like congener 3,3',4,4',5-pentachlorobiphenyl (PCB 126). Although PCB 126 is known to impair hepatic function, the precise mechanisms-particularly the contribution of ferroptosis, an iron-dependent, lipid-peroxidation-mediated form of cell death-remain elusive. Here, we tested the hypothesis that ferroptosis underlies PCB 126-induced NAFLD and delineated the key molecular pathways involved. Balb/c mice were intraperitoneally injected with PCB 126 (1, 5, or 10 μM/kg) for 14 days. Hepatic injury was assessed through serum biomarkers (ALT, AST, ALP), histopathology (H&E and Oil Red O staining), and mitochondrial ultrastructure via transmission electron microscopy. Ferroptosis markers (GPX4, 4-HNE, Tf receptor), lipid peroxidation (MDA, GSH, SOD), iron homeostasis, and inflammatory cytokines (IL-1β, IL-6, TNF-α) were evaluated using qPCR, Western blotting, and ELISA. Results demonstrated that PCB 126 exposure induced NAFLD, evidenced by elevated liver-to-body weight ratios, serum liver enzymes, and steatosis. Ferroptosis was implicated through reduced mitochondrial cristae, suppressed GPX4 and SLC7A11 expression, increased lipid peroxidation, and iron accumulation. Additionally, PCB 126 activated the NF-κB pathway, elevating pro-inflammatory cytokines and myeloperoxidase (MPO) activity, while oxidative stress was marked by NRF2/KEAP1/HO-1 axis disruption. In conclusion, PCB 126 promotes NAFLD in mice by triggering ferroptosis, inflammation, and oxidative stress. These findings highlight ferroptosis as a pivotal mechanistic link in PCB 126-induced NAFLD, suggesting potential therapeutic targets for mitigating pollutant-driven liver injury.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251376455"},"PeriodicalIF":1.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined toxicity of nine typical pesticides in binary mixtures on A549 cells. 九种典型农药二元混合物对A549细胞的联合毒性研究。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-09-05 DOI: 10.1177/07482337251374930

Weizhang Qi, Tingting Meng, Shujie Wang, Chang Chen, Zhiyong Cao, Ke Fang, Yuying Liu, Yanhong Shi, Jinjing Xiao

{"title":"Combined toxicity of nine typical pesticides in binary mixtures on A549 cells.","authors":"Weizhang Qi, Tingting Meng, Shujie Wang, Chang Chen, Zhiyong Cao, Ke Fang, Yuying Liu, Yanhong Shi, Jinjing Xiao","doi":"10.1177/07482337251374930","DOIUrl":"https://doi.org/10.1177/07482337251374930","url":null,"abstract":"Air pollution caused by pesticide drift poses a significant environmental health risk. The lungs are directly targeted by airborne pesticide exposure via inhalation; however, their inhalation toxicological data are poorly understood. In the present study, we evaluated the combined toxicity and interactions of lambda-cyhalothrin and its binary mixtures with eight insecticides at a concentration ratio of 1:1 in the non-small-cell lung cancer A549 line cells. Cytotoxicity tests showed that the selected pesticide binary mixtures reduced cell viability in a concentration-dependent manner. The combination index (CI) model indicated that the mixtures of lambda-cyhalothrin with acetamiprid, thiamethoxam, or clothianidin exhibited antagonistic effects, while other combinations shifted from antagonism to synergy at a toxicity level of 40%-60%. A synergistic toxicity occurred between lambda-cyhalothrin and emamectin benzoate with CI values of 0.58-0.95, and the obtained benchmark dose limits (BMDLs) value of their binary mixture was greater than 1.5 times more toxic than that of these pesticides individually. Moreover, combined exposure to the binary mixtures produced greater amounts (1.30- to 2.93-fold increase) of reactive oxygen species, malondialdehyde, and lactate dehydrogenase compared with exposure to these pesticides individually. This result suggested that the synergistic cytotoxicity of lambda-cyhalothrin and emamectin benzoate may be driven by excessive oxidative stress. Our findings serve to better understand the complex toxic pesticide interactions that humans face in the environment.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337251374930"},"PeriodicalIF":1.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiol/disulfide homeostasis and ischemia-modified albumin as oxidative stress markers in patients with embedded fragments. 硫醇/二硫稳态和缺血修饰白蛋白作为嵌入碎片患者的氧化应激标志物。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-08-01 Epub Date: 2025-09-03 DOI: 10.1177/07482337251371774

Meşide Gündüzöz, Murat Büyükşekerci, Osman Gökhan Özakıncı, Salim Neşelioğlu, Emine Yurt, Özcan Erel

{"title":"Thiol/disulfide homeostasis and ischemia-modified albumin as oxidative stress markers in patients with embedded fragments.","authors":"Meşide Gündüzöz, Murat Büyükşekerci, Osman Gökhan Özakıncı, Salim Neşelioğlu, Emine Yurt, Özcan Erel","doi":"10.1177/07482337251371774","DOIUrl":"10.1177/07482337251371774","url":null,"abstract":"The aim of this study was to investigate oxidative stress markers in patients with embedded fragments (PEF) using thiol-disulfide homeostasis and ischemia-modified albumin (IMA). The study consisted of a PEF group and a control group. Blood or urine metal concentrations were determined using inductively coupled plasma mass spectrometry (ICP-MS). Plasma thiol/disulfide homeostasis parameters and IMA levels were assessed. In PEF, the concentrations of all metals, including antimony (Sb), arsenic (As), copper (Cu), mercury (Hg), cadmium (Cd), lead (Pb), manganese (Mn), nickel serum (Ni), iron (Fe), cobalt (Co), and selenium (Se), were significantly higher than those in the control group, except chromium (Cr). 64.86% of PEF had elevated concentrations of at least one of these metals: Sb, As, Cu, Cd, Pb, Mn, Ni, and Fe, concerning reference values. It was also found that 64.86% (72/111) of PEF had elevated concentrations of metals, such as Sb, As, Cu, Cd, Pb, Mn, Ni, and Fe, in urine or blood, in accordance with the BEI values recommended by ACGIH and clinical laboratory reference values. The disulfide/native thiol, disulfide/total thiol, and total thiol/native thiol ratios were significantly higher in PEF. There was a strong positive correlation between Pb, Cd, and disulfide and a negative correlation between native thiol and Cd, Pb, and Co. Albumin levels were significantly lower, and IMA levels were significantly higher in the PEF group than in the control group. Metal abnormality was approximately 2.7 times higher in PEF who had retained fragments for longer than 20 years. The increased metal body burden resulting from the embedded fragments may pose significant systemic health effects by inducing oxidative stress. Continuous surveillance of patients with retained fragments is essential to combat chronic metal toxicity.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"429-442"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of neonicotinoid insecticides and triazole fungicides on prostate cancer progression via CYP enzymes, miRNAs, and TF-mediated disruption of steroidogenesis: An integrated in silico approach. 新烟碱类杀虫剂和三唑类杀菌剂通过CYP酶、mirna和tnf介导的类固醇生成破坏对前列腺癌进展的影响：一种集成的硅方法。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-08-01 Epub Date: 2025-09-04 DOI: 10.1177/07482337251371763

Mine Caglayan

{"title":"The effect of neonicotinoid insecticides and triazole fungicides on prostate cancer progression via CYP enzymes, miRNAs, and TF-mediated disruption of steroidogenesis: An integrated in silico approach.","authors":"Mine Caglayan","doi":"10.1177/07482337251371763","DOIUrl":"10.1177/07482337251371763","url":null,"abstract":"Neonicotinoid insecticides and triazole fungicides are widely used in agriculture, often in combination with other pesticides, leading to concerns about potential health effects. This study investigated the combined effect of these chemicals using the Comparative Toxicogenomics Database (CTD) to identify common target genes, followed by functional enrichment analysis and gene-gene and protein-protein interaction assessments. In this study, it was determined that pesticides may interfere with biological processes such as steroid hydroxylase activity, oxidoreductase activity, and steroid metabolism, and cause hormonal imbalances and endocrine system disorders. In addition, among the 10 genes identified, CYP3A5 and CYP3A7 gene expression differed significantly between prostate cancer and normal prostate tissues, and this was supported by UALCAN data. In addition, previous studies have confirmed that hsa-miR-27b, one of the prominent miRNAs in this study, and transcription factors (PROX1 and ESR2) are associated with prostate cancer. Similar to our study, previous studies have confirmed that triazole fungicides disrupt testosterone homeostasis and steroidogenesis, while neonicotinoids damage the prostate due to their effects on androgen receptors. These genes, miRNAs, and transcription factors appear to mediate the effects of these pesticides on cancer pathways and suggest a link to prostate cancer. In conclusion, this study demonstrated that concurrent exposure to neonicotinoid insecticides and triazole fungicides may damage the prostate and potentially contribute to the development of prostate neoplasia. These findings emphasise the importance of further in vitro and in vivo validation to establish a definitive causal relationship and provide insight into the toxicological effects of pesticide exposure on prostate health.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"415-428"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and opportunities in enhancing workplace safety and health for Nigeria's fertilizer manufacturing industry: A discussion on current practices and future directions. 加强尼日利亚肥料制造业工作场所安全和卫生的挑战和机遇：关于当前做法和未来方向的讨论。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-08-01 Epub Date: 2025-07-27 DOI: 10.1177/07482337251362359

Daniel Omeodisemi Omokpariola, Anu Adekunle Daramola

{"title":"Challenges and opportunities in enhancing workplace safety and health for Nigeria's fertilizer manufacturing industry: A discussion on current practices and future directions.","authors":"Daniel Omeodisemi Omokpariola, Anu Adekunle Daramola","doi":"10.1177/07482337251362359","DOIUrl":"10.1177/07482337251362359","url":null,"abstract":"The fertilizer manufacturing industry in Nigeria plays a crucial role in supporting the nation's agricultural sector and, by extension, its economy. However, the industry faces significant challenges regarding occupational safety and health, leading to high-risk factors and common workplace hazards such as chemical exposure, physical injuries, and psychosocial stressors. This paper aims to explore the current practices in workplace safety, identify existing challenges, and highlight opportunities for improvement within the sector. By examining regulatory frameworks, industry practices, and technological advancements, the study offers insights into enhancing safety protocols and fostering a culture of health and safety. Recommendations for stakeholders, including policymakers, industry leaders, and workers, emphasize the need for collaborative efforts and the adoption of global best practices to create a safer working environment. The findings underscore the importance of a comprehensive approach to workplace safety, which is essential for ensuring the well-being of employees and the sustainability of the fertilizer manufacturing industry in Nigeria.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"459-472"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The NHANES 2015-2016 aromatic diamine urinary biomonitoring data: A critical review and suggestions for improved data collection. NHANES 2015-2016芳香二胺尿液生物监测数据：关键回顾和改进数据收集的建议

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-08-01 Epub Date: 2025-07-27 DOI: 10.1177/07482337251359341

Patrick M Plehiers, Billy W Day, Mark W Spence

{"title":"The NHANES 2015-2016 aromatic diamine urinary biomonitoring data: A critical review and suggestions for improved data collection.","authors":"Patrick M Plehiers, Billy W Day, Mark W Spence","doi":"10.1177/07482337251359341","DOIUrl":"10.1177/07482337251359341","url":null,"abstract":"The 2015-2016 National Health and Nutrition Examination Survey (NHANES) included biomonitoring of aromatic diamines obtained after acid hydrolysis of urine samples for the first time. Aromatic diamines in hydrolyzed urine are biomarkers that are not unique to a single substance. Without further information, that renders association with potential exposures very difficult. This review provides an overview of potential sources of urinary aromatic diamines, the most important being aromatic diisocyanates (occupational and home-use), aromatic diamines themselves (predominantly from hair dye products), and polyurethanes (medical devices and implants). Expected urinary diamine concentrations from these and other sources as well as background levels are evaluated based on available literature data. Finally, recommendations are made to improve the value of future data collections. These include analytical enhancements, better mapping of potential sources of the biomarkers prior to conducting the survey, and documentation of product use to enable identification of exposure sources. These improvements are indispensable for investigating potential links with medical conditions should this be envisioned.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"443-458"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on the regulatory role of microRNA-30d in chrysotile-transformed MeT-5A cells. microRNA-30d在温石棉转化的MeT-5A细胞中的调控作用研究。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-07-01 Epub Date: 2025-06-04 DOI: 10.1177/07482337251342903

Junxian Li, Yiting Dai, Hefei Huang, Yichen Zhong, Lijin Zhu

{"title":"Studies on the regulatory role of microRNA-30d in chrysotile-transformed MeT-5A cells.","authors":"Junxian Li, Yiting Dai, Hefei Huang, Yichen Zhong, Lijin Zhu","doi":"10.1177/07482337251342903","DOIUrl":"10.1177/07482337251342903","url":null,"abstract":"Asbestos is classified as a class I carcinogen by the International Agency for Research on Cancer (IARC) because of its propensity to accumulate in the lungs and induce malignant tumors, including lung cancer and malignant mesothelioma. The objective of this study was to examine the inhibitory impact of miR-30d on the proliferation, migration, and invasion of chrysotile-transformed human pleural mesothelial cells (MeT-5A). The asbestos-transformed cell model was constructed using a chrysotile asbestos chronically exposed human pleural mesothelial cell line (MeT-5A). The expression level of miR-30d in the transfected cells was determined by qRT-PCR. Cell viability was assessed by CCK-8 assay. The apoptosis rate was evaluated by flow cytometry. The cell scratch assay and the Transwell assay were used to assess cell migration and invasion ability. It was observed that the expression level of miR-30d in Asb MeT-5A+miR-30d cells transfected with miR-30d mimics was markedly elevated in comparison to that in Asb MeT-5A+miR NC cells. Additionally, the cell viability in Asb MeT-5A+miR-30d cells was significantly diminished, while the level of apoptosis was markedly elevated in comparison to that in Asb MeT-5A+miR NC cells. The relative migration area was significantly lower in the Asb MeT-5A+miR-30d group than in the Asb MeT-5A+miR NC group. Furthermore, the number of migrated and invaded cells in the Asb MeT-5A+miR-30d group was significantly less than in the Asb MeT-5A+miR NC group. The findings suggest that miR-30d may suppress the proliferation, apoptosis, migration, and invasion of chrysotile-transformed pleural mesothelial cells.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"365-373"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotoxicity study of copper oxide nanoparticles and the protective role of a probiotic (Lactobacillus acidophilus) in Swiss albino mice. 氧化铜纳米颗粒的神经毒性研究和益生菌（嗜酸乳杆菌）对瑞士白化小鼠的保护作用。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-07-01 Epub Date: 2025-06-10 DOI: 10.1177/07482337251350165

Manisha Sharma, Neelu Kanwar Rajawat

{"title":"Neurotoxicity study of copper oxide nanoparticles and the protective role of a probiotic (Lactobacillus acidophilus) in Swiss albino mice.","authors":"Manisha Sharma, Neelu Kanwar Rajawat","doi":"10.1177/07482337251350165","DOIUrl":"10.1177/07482337251350165","url":null,"abstract":"Nanoparticles (NPs 1-100 nm) play a vital role in medicine, food, and agriculture owing to their unique reactivity and size-dependent optical properties. There are growing concerns about health risks from exposure to engineered NPs. Among these, copper oxide nanoparticles (CuONPs) are an area of research because of their unique electronic, optical, and chemical properties. CuONPs can interact with biological systems, causing oxidative stress, inflammation, neurobehavioral changes, and other pathophysiological effects. This study evaluated the ability of a probiotic (Lactobacillus acidophilus) to prevent CuONP-treated neurotoxicity. In the present study, 24 animals were classified into four groups: control, probiotic (Lactobacillus acidophilus 6.42 mg/kg b.wt.), CuONPs-treated (80 mg/kg b.wt.), and co-administered CuONPs (80 mg/kg b.wt.) + Probiotic (6.42 mg/kg b.wt.). Neurotoxicity was assessed through behavioral tests, including open field, exploratory behavior, pole test, and grip strength tests. Levels of key neurotransmitters viz. acetylcholinesterase, dopamine, and serotonin were measured and histopathological analyses were performed. The CuONP-treated group displayed significant behavioral deficits, decreased neurotransmitter levels, and histopathological abnormalities. In contrast, co-administration of probiotic with CuONPs reduced these effects, as observed by normal behavioral parameters and neurotransmitter levels and improved histopathological architecture. These findings suggested that CuONPs caused neurotoxicity at the tested dose, but co-administration of probiotic effectively mitigated this toxicity. Hence, a probiotic is a promising preventative strategy against CuONP-induced neurotoxic effects.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"398-408"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Landscapes, highlights and trending topics of ferroptosis research in the liver: A bibliometric analysis. 肝脏铁下垂研究的景观、亮点和趋势主题：文献计量学分析。

IF 1.7 4区医学

Toxicology and Industrial Health Pub Date : 2025-07-01 Epub Date: 2025-06-12 DOI: 10.1177/07482337251349366

Xiangning Zhou, Jingjing Yu, Tianwei Sun, Ying Wang, Zhenyu Yao, Ling Gao

{"title":"Landscapes, highlights and trending topics of ferroptosis research in the liver: A bibliometric analysis.","authors":"Xiangning Zhou, Jingjing Yu, Tianwei Sun, Ying Wang, Zhenyu Yao, Ling Gao","doi":"10.1177/07482337251349366","DOIUrl":"10.1177/07482337251349366","url":null,"abstract":"Ferroptosis, a form of programmed iron-dependent cell death, is associated with various liver pathologies. Recent studies have increasingly highlighted the crucial role of ferroptosis in liver function. This study aimed to explore the development of ferroptosis in liver diseases through bibliometric analysis. We retrieved the data from the Web of Science (WOS) Core Collection, then imported selected articles into VOSviewer, CiteSpace, and Microsoft Excel for knowledge mapping analysis. A total of 1,236 articles were included in this study, showing a steady increase in publications on ferroptosis in the liver over the past 11 years, with a significant surge in recent years. China emerged as a dominant contributor, accounting for 86% of global publications. Key institutions included Zhejiang University and Sun Yat-sen University. Zhang Feng from Nanjing Medical University was identified as the most prolific author. The journal Frontiers in Pharmacology published the most articles on this topic. High-frequency keywords included \"ferroptosis,\" \"cell death,\" \"hepatocellular carcinoma,\" \"oxidative stress,\" and \"cancer.\" Our analysis provides insight into the leading countries, institutions, authors, and journals and it highlights recent research hotspots. As an emerging research field, studies on ferroptosis in the liver focused primarily on molecular mechanisms, pathways, and treatment strategies. Hepatocellular carcinoma remains a primary focus within ferroptosis research in the liver. In the future, therapies targeting ferroptosis may offer promising avenues for liver disease treatment.","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"386-397"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0