Toxicology and Industrial Health最新文献

{"title":"Toxicological impact of tetrabromobisphenol-A on pregnant rats: Morphological, biochemical, and histopathological investigations.","authors":"Mevlahan Özkan, Eda Nur İnkaya, Evrim Arzu Koçkaya, Nurhayat Barlas","doi":"10.1177/07482337261438207","DOIUrl":"10.1177/07482337261438207","url":null,"abstract":"<p><p>Tetrabromobisphenol-A (TBBPA) is found in high concentrations in textiles, plastic polymers, flame retardants, and various industrial products. In this maternofetal study, we aimed to evaluate the potential effects of TBBPA on the mother, fetus, and placenta in pregnant rats. In the experimental design, three different gestational days (GD10, GD15, and GD20) were selected for evaluation in pregnant rats. For each gestational period, one control group (corn oil) and three TBBPA dose groups (20, 200, and 400 mg/kg) were established, resulting in a total of 12 experimental groups. Each group included six pregnant rats. We hypothesized that TBBPA exposure would lead to alterations in maternal and fetal hormonal and placental parameters when evaluated across different doses and gestational days. Placenta, kidney, liver, and ovary tissues were examined histopathologically. Levels of follicle-stimulating hormone (FSH), progesterone, luteinizing hormone (LH), and estrogen were analyzed. Estrogen from ovarian homogenates and testosterone from testicular homogenates of GD20 fetuses were also measured. We detected statistically significant differences in placental and fetal data. However, no severe effects were observed. Serum FSH levels were elevated in the GD20 group receiving 400 mg/kg, whereas LH levels increased in the GD15 group at both 200 and 400 mg/kg compared to controls. In GD20 female fetuses, estrogen levels decreased at 20 mg/kg but increased at 200 mg/kg relative to the control group. Histopathological examination of placental tissue revealed congestion, degeneration in the labyrinth region, cytoplasmic dissolution and pyknosis in giant cells, and degeneration in spongiotrophoblasts. No severe systemic toxicity was observed in our study. However, the mild to moderate level changes detected highlight the need for further investigation of TBBPA, especially considering the uncertainties regarding its effects during pregnancy.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"178-197"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Bisphenol A and Z causes DNA damage and testicular histopathology impairing male fertility.","authors":"Haseeb Ur Rehman, Asif Nadeem, Nadia Mukhtar, Muhammad Muddassir Ali, Huma Mujahid, Muhammad Zubair Shabbir, Maryam Javed","doi":"10.1177/07482337261438341","DOIUrl":"10.1177/07482337261438341","url":null,"abstract":"<p><p>Bisphenol analogues are commonly found in various consumer products such as food and beverage containers, electronic devices, toys, paper products, water pipes, and medical equipment. These compounds have been shown to disrupt endocrine function and exert harmful effects on multiple body organs. To investigate the tissue- and DNA-damaging effects of varying oral doses of Bisphenol Z (BPZ), a study was conducted on Wistar rats over a 4-week period. After 28 days, the rats were dissected, and tissue samples were collected. Tissue histology, Comet assay, and real-time PCR were performed to assess the effects of BPZ at the tissue and genomic levels. Sperm count and motility were significantly reduced in groups exposed to higher doses of BPZ (mean ± SD: 27.00 ± 7.94 and 4.33 ± 0.43, respectively). Morphologically abnormal sperm, including deformed heads and curly tails, were observed. The Comet assay on testicular tissues from rats treated with higher BPZ doses showed clear signs of DNA fragmentation. Histopathological analysis revealed narrowing of the interstitial spaces and constriction of the epididymal lumen. Additionally, down regulation of the Protamine1 gene was observed in rats receiving higher doses of BPZ, significantly associated with spermatogenesis. Our findings not only highlight the severity of BPZ's toxic effects but also emphasize that these chemicals are unsafe in any analogue form.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"198-206"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of taurine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative and histopathological damage in the heart tissue of rats.","authors":"Osman Çiftçi, Münevver Nazlıcan Kaplan, Neşe Başak Türkmen, Aslı Çetin, Bedriye Çiftçi, İdris Ayhan","doi":"10.1177/07482337261436345","DOIUrl":"10.1177/07482337261436345","url":null,"abstract":"<p><p>This study investigated the protective effects of taurine against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cardiotoxic damage in rats. Adult male Wistar rats (250-300 g) were randomly assigned to four groups (<i>n</i> = 8 per group): Control, TCDD, TAU, and TCDD + TAU. TCDD (2 μg/kg/week) and/or taurine (200 mg/kg/day) were administered via gavage for 30 days. Following the experimental period, heart tissue samples were collected for analysis. Oxidative stress parameters, including thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) activity, and glutathione (GSH) levels, were assessed using biochemical methods. Histopathological and immunohistochemical evaluations of cardiac tissue were also performed. The TCDD group showed significantly increased TBARS levels (<i>p</i> < 0.05) and decreased SOD activity and GSH levels (<i>p</i> < 0.001) compared with the Control group. In contrast, taurine co-administration significantly increased SOD activity and GSH levels while reducing TBARS levels relative to the TCDD group. Moreover, TCDD exposure induced marked histopathological alterations in heart tissue, whereas taurine co-administration attenuated these structural alterations. Immunohistochemical findings indicated that taurine attenuated TCDD-induced apoptosis by reducing caspase-3 activation. Overall, taurine effectively mitigated TCDD-induced oxidative stress, histopathological damage, and apoptotic signaling in cardiac tissue, suggesting that taurine co-administration may exert protective effects against TCDD-induced cardiotoxicity.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"167-177"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective roles of gallic acid and lycopene against 4-nonylphenol induced testicular damage in SD rats.","authors":"Ozay Gules, Sadiye Kum, Zahid Naseer, Murat Boyacioglu, Emine Ozel Armutoglu, Mustafa Yildiz, Murat Kırıkkulak, Göksel Doğan, Esra Bilici, Aybike Türkmen, Bilginer Tuna, Ulker Eren","doi":"10.1177/07482337261439550","DOIUrl":"10.1177/07482337261439550","url":null,"abstract":"<p><p>4-Nonylphenol (4-NP), an endocrine disruptor, is known to induce mutagenic, toxic, or carcinogenic effects, including testicular toxicity via inducing oxidative stress and apoptosis. The objective of this work was to determine the capacity of lycopene (LC) and gallic acid (GA) to protect testicular histological structure, biochemical responses, and semen parameters in rats exposed to 4-NP. In this 28-day dietary trial, six groups (n= 6 per group) received treatment via oral gavage: a control (corn oil, 2 mL/kg/day), LC (10 mg/kg body weight (BW)/day), GA (50 mg/kg BW/day), 4-NP (125 mg/kg BW/day), LC + 4-NP (LC followed by 4-NP), and GA + 4-NP (GA followed by 4-NP) groups. The results indicated that 4-NP administration adversely affects the final body weight, testicular histology, seminiferous epithelium heights (SEHs) (4-NP: 57.95 ± 0.49, <i>p</i>: 0.000), follicle-stimulating hormone (FSH) level, testis antioxidant capacity, testis malondialdehyde (MDA) level, and sperm viability and morphology. LC and GA supplementation significantly improved SEHs, activities of testis superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), and sperm viability compared to the 4-NP group. Moreover, LC and GA exposures decreased histopathological lesions, including germinal epithelial degeneration, vacuolization, immature germ cells in the tubular lumen, and congestion in the interstitial area. Furthermore, they lowered TUNEL-positive cell counts and tubule percentages, testicular MDA levels, and abnormal sperm percentages. To our knowledge, this study provides one of the first systematic comparisons of lycopene and gallic acid in protecting against 4-NP-induced testicular toxicity under identical experimental conditions. The findings suggest that both compounds preserve testicular structure and function through their antioxidant and anti-apoptotic properties.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"207-221"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.","authors":"Yaohui Shan, Xu Liu, Wei Ge, Qifu Zhang, Sai Yan","doi":"10.1177/07482337261445494","DOIUrl":"https://doi.org/10.1177/07482337261445494","url":null,"abstract":"<p><p>ObjectiveMitochondrial dysfunction is the key factor in rotenone-induced neurotoxicity in dopaminergic neurons. This study aimed to investigate the role and potential mechanism of the mitochondrial DNA encoded peptide Humanin (HN) in alleviating rotenone-induced neurotoxicity.MethodsRotenone was added to the cultured PC12 cells to induce neurotoxicity. PC12 cells were preincubated with HN, which has a protective effect. Cell counting kit-8 (CCK-8) was used to evaluate PC12 cell viability. Flow cytometry to detect the content of reactive oxygen species (ROS) in PC12 cells. Western blot analysis was used to detect the expression of superoxide dismutase 2 (SOD2), acetylated SOD (Ac-SOD), sirtuin 3 (SIRT3), nuclear factor erythroid 2-related factor 2 (Nrf2), heme-oxygenase-1 (HO-1), and NAD(P)H:quinone oxidoreductase 1 (NQO1). The corresponding kits were used to measure the NAD+/NADH ratio and SOD content separately.ResultsHN pretreatment significantly increased PC12 cell survival, reduced ROS formation, and increased the NAD⁺/NADH ratio. It also increased the expression of SIRT3, Nrf2, HO-1, and NQO1 proteins and decreased the expression of Ac-SOD protein under rotenone exposure. At the same time, it also activated the Nrf2/HO-1 signaling pathway, which depends on HN-mediated SIRT3 activation.ConclusionThese results suggest that HN plays a protective role in rotenone-induced neurotoxicity by suppressing oxidative stress and activating the antioxidant response via the Nrf2/HO-1 pathway, which is regulated by SIRT3 in PC12 cells.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261445494"},"PeriodicalIF":1.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockout of <i>histone deacetylase</i> 6 exacerbates PM_2.5-induced pulmonary injury by affecting renin-angiotensin system balance in mice.","authors":"Yang Zhang, Lifang Jin, Caixia Fan, Guoquan Fu, Huarong Huang, Junyan Yan","doi":"10.1177/07482337261444574","DOIUrl":"https://doi.org/10.1177/07482337261444574","url":null,"abstract":"<p><p>Fine particulate matter (PM_2.5) deposition in the lungs can induce pulmonary injury. Histone deacetylase 6 (HDAC6), a critical member of the histone deacetylase family, plays a key role in regulating lung diseases. In this study, we explored the mechanism of HDAC6 in PM_2.5 (10 mg/kg)-induced pulmonary injury using an <i>HDAC6</i> knockout (KO) mouse model, employing immunohistochemical, western blot, and transcriptome analyses. Results indicated that <i>HDAC6</i> KO exacerbated PM_2.5-induced epithelial barrier dysfunction by altering the expression of zonula occludens-1 (ZO-1) and zonula occludens-2 (ZO-2). Moreover, <i>HDAC6</i> KO increased the susceptibility of lung tissue to PM_2.5 by inhibiting E-cadherin expression and promoting N-cadherin expression. Transcriptome analysis of PM_2.5-treated lungs in the <i>HDAC6</i> KO group revealed significant alterations in the renin-angiotensin system (RAS). The expression levels of RAS components, including angiotensin-converting enzyme II (ACE2), angiotensin II (Ang II), renin, and Agtrl1b, were quantified. Notably, both PM_2.5 and <i>HDAC6</i> KO disrupted RAS balance. The PM_2.5-treated <i>HDAC6</i> KO group exhibited a pronounced reduction in ACE2 and elevation in Ang II, suggesting increased susceptibility to PM_2.5. These results indicate that <i>HDAC6</i> KO exacerbates PM_2.5-induced pulmonary injury by affecting RAS balance. This study provides a theoretical foundation for understanding the role of HDAC<i>6</i> in PM_2.5-induced pulmonary injury.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261444574"},"PeriodicalIF":1.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative computational elucidation of molecular mechanisms and multi-target interactions in paraquat-induced pulmonary fibrosis.","authors":"Guiyan Du, Shengyao Tang, Tian Shi, Guosheng Liu, Xia Huang, Jian Chang","doi":"10.1177/07482337261442635","DOIUrl":"https://doi.org/10.1177/07482337261442635","url":null,"abstract":"<p><p>Paraquat (PQ), a widely used herbicide, induces severe pulmonary fibrosis through complex mechanisms that are not fully understood. This study employed an integrated computational approach combining network toxicology, molecular docking, dynamics simulations, and AlphaFold2-based protein design to systematically investigate PQ-induced pulmonary fibrotic processes. We identified 111 common targets from pulmonary fibrosis and PQ toxicity databases, among which AKT1, IL6, TP53, and CASP3 were recognized as core targets. Functional enrichment analyses revealed significant involvement of oxidative stress, inflammatory response, and apoptotic pathways. Molecular docking demonstrated strong binding affinity between PQ and key targets (docking scores < -5 kcal/mol), while molecular dynamics simulations confirmed stable interactions with favorable binding energies (< -12 kcal/mol). Furthermore, AlphaFold2 predicted three novel proteins exhibiting even higher binding affinity to PQ than natural targets. These findings reveal that PQ might promote pulmonary fibrosis by stably binding to core proteins and activating critical pathological pathways, providing valuable insights for developing targeted biomarkers and therapeutic strategies against PQ-induced lung injury.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261442635"},"PeriodicalIF":1.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of occupational lead toxicity on testosterone secretion and the L-arginine nitric oxide pathway.","authors":"Lütfiye Tutkun, Servet Birgin İritaş, Murat Büyükşekerci, Vugar Ali Türksoy, Deniz Özkan Vardar, Özgür Öztan, Serdar Deniz, Zübeyir Dedeoğlu, Engin Tutkun","doi":"10.1177/07482337261441688","DOIUrl":"https://doi.org/10.1177/07482337261441688","url":null,"abstract":"<p><p>Endocrine-disrupting chemicals (EDCs), including heavy metals such as lead (Pb), interfere with hormonal homeostasis, particularly in the hypothalamic-pituitary-gonadal (HPG) axis. Occupational lead exposure is linked to male reproductive dysfunction and cardiovascular risk via oxidative stress and endothelial impairment. This study investigated the effects of chronic lead exposure on testosterone levels and the L-arginine-nitric oxide (NO) pathway, a key regulator of endothelial function. This case-control study compared 120 male workers with occupational lead exposure (in battery manufacturing and foundries) to 120 unexposed controls. Blood lead levels (BLLs) were quantified via inductively coupled plasma mass spectrometry (ICP-MS), while testosterone (total/free) and methylated arginine metabolites; asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and citrulline were analyzed using LC-MS/MS. Statistical analyses included <i>t</i>-tests and Pearson correlations to assess associations. Lead-exposed workers had significantly higher BLLs (31.76 ± 13.31 vs 1.72 ± 0.87 μg/dL), lower total testosterone (388.23 ± 71.78 vs 477.36 ± 104.21 ng/dL), and reduced arginine/ADMA ratios (432.48 ± 191.27 vs 544.33 ± 187.19), indicating endothelial dysfunction. Strong inverse correlations were observed between exposure duration, classified as 6 months to 1 year, 1 to 5 years, and >5 years, to evaluate its association with BLL, testosterone levels, and arginine metabolism markers. This study demonstrated that chronic occupational lead exposure significantly disrupted testosterone secretion and impaired the L-arginine-NO pathway, highlighting its dual threat to reproductive and cardiovascular health. The robust inverse correlations between BLL, testosterone, and arginine/ADMA ratios underscore the endocrine-disrupting and endothelial-damaging effects of lead. These findings support the routine biomonitoring of BLL, testosterone, and methylated arginine metabolites in high-risk occupations to enable early intervention and mitigate long-term health risks.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261441688"},"PeriodicalIF":1.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium and lead in occupationally exposed e-waste workers: Health implications.","authors":"Olubayo Michael Akinosun, Ayobola Abimbola Sonuga, Bukola Fasilat Ayoola, Oyebola Oluwagbemiga Sonuga","doi":"10.1177/07482337261428663","DOIUrl":"10.1177/07482337261428663","url":null,"abstract":"<p><p>E-waste contains over a thousand different substances, most of which are toxic and hazardous to human health. This study aimed to determine the blood levels of cadmium (Cd) and lead (Pb) among e-waste workers, and the possible health symptoms associated with chronic low dose occupational exposure to e-wastes. This was a cross-sectional study carried out among 80 individuals aged 25 years and above. Forty-two of the participants were e-waste workers and 38 were non-e-waste workers. Demographic characteristics and anthropometric data were obtained from each participant. Blood lead levels (BLLs) and blood cadmium levels (BCLs) were measured in all the participants using atomic absorption spectrometry (AAS). The mean BLL and BCL were significantly higher in the e-waste workers than in the non-e-waste workers. Most of the e-waste workers (76.2%) performed phone and laptop repairs. They reported chest pain (19.0%), abdominal pain (9.5%), throat irritation (2.4%), and cough (9.5%) as common symptoms experienced at work. Many of the e-waste cohort (73.8%) worked in poorly ventilated rooms and many (95.2%) were also involved in crude and unregulated e-waste recycling processes. In conclusion, the results from our study suggested that elevated BLL and BCL in the e-waste workers were from occupational exposure associated with crude e-waste recycling processes, and these elevated levels were probably associated with the adverse health effects in this group of workers. Continuous training and awareness of safe occupational practices is highly recommended among the e-waste workers.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"137-145"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome Editorial: A New Chapter for Toxicology and Industrial Health.","authors":"Lindsey St Mary","doi":"10.1177/07482337261434379","DOIUrl":"10.1177/07482337261434379","url":null,"abstract":"","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"113"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}