Toxicology and Industrial Health最新文献

{"title":"Prenatal microplastic exposure-induced testicular developmental toxicity and its long-term hazards in male rat offspring.","authors":"Linguo Pei, Yuanyuan Zhang, Wenjuan Zhang, Wei Wang, Wenyu Jin","doi":"10.1177/07482337261500552","DOIUrl":"https://doi.org/10.1177/07482337261500552","url":null,"abstract":"<p><p>The pervasive environmental presence of microplastics (MPs) raises concerns regarding their potential impacts on reproductive health, particularly in the context of prenatal exposure. This study aimed to establish a polystyrene microplastics (PS-MPs) exposure model in pregnant rats and to investigate the subsequent effects on the growth, hormonal profiles, steroidogenic enzyme expression, and testicular histology of male offspring from birth to adulthood. Pregnant rats were administered PS-MPs at doses of 1 mg/kg/day (MPs-L) and 10 mg/kg/day (MPs-H) during gestational days 10-20. Results indicated that birth weights in the MPs-L and MPs-H groups decreased to 88.7% and 85.3% of controls, respectively, with persistent intrauterine growth restriction and no catch-up growth observed. Testicular morphology analysis revealed significant reductions in testicular area and diameter in neonatal rats, alongside adult testicular index decline and altered sperm parameters. Hormonal assessments showed concentration-dependent decreases in serum testosterone levels during neonatal and adult stages, coupled with reduced luteinizing hormone levels in adults, indicating a non-classical \"low testosterone-low luteinizing hormone\" phenotype. Molecular evaluations demonstrated selective suppression of key steroidogenic genes (Star and 3β-Hsd) in neonatal and adult testicular tissues, while Leydig cell counts were significantly diminished. In conclusion, prenatal exposure to MPs had long-lasting repercussions on Leydig cell functionality and the spermatogenic environment, leading to dual structural and endocrine impairments that may have critical implications for male reproductive health. Future studies should further explore the mechanisms underpinning these effects and potential interventions.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261500552"},"PeriodicalIF":1.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sub-acute aluminium phosphide exposure on hepatorenal biomarkers and antioxidant defense in rats.","authors":"Ibtissem Anguel, Leila Kirane-Amrani, Tahar Tata, Lazhari Tichati, Chems Berrehail, Abdelmadjid Bairi","doi":"10.1177/07482337261467527","DOIUrl":"10.1177/07482337261467527","url":null,"abstract":"<p><p>Aluminium phosphide (AlP) is a well-known toxic pesticide, but its dose-dependent toxicity and the distinction between safe and harmful exposure levels remain poorly established. Thus, the present study aimed to investigate the dose-dependent toxicity of AlP on biochemical biomarkers, antioxidant defense responses, and histological changes in rat liver and kidneys. Adult male Wistar rats were treated orally with increasing AlP doses (0.38, 0.58, and 1.15 mg/kg body weight, corresponding to LD₅₀/30, LD₅₀/20, and LD₅₀/10, respectively) for 4 weeks. Results revealed a marked increase in body weight, serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), and PAL (alkaline phosphatase), and levels of urea, creatinine, and malondialdehyde (MDA) of treated rats as compared with controls. However, glutathione content and enzymatic activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in liver and kidney tissue were significantly decreased compared with controls. These biochemical changes following AlP treatment also mirrored hepatic and renal histopathological observations, showing dose-dependent tissue alterations, with a more pronounced effect in the higher AlP dose-treated rats. Conclusively, sub-acute AlP exposure caused dose-dependent liver and kidney toxicity, high doses induced pronounced damage, and low doses showed mild or minimal effects.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"385-397"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pesticides lambda-cyhalothrin, emamectin benzoate, and thiophanate-methyl used alone and in mixtures on reproduction and oxidative stress markers in male Wistar rats.","authors":"Narimene Chelbi, Leila Mallem, Hanene Chaabane, Cherif Abdennour, Lilya Chelbi","doi":"10.1177/07482337261472599","DOIUrl":"10.1177/07482337261472599","url":null,"abstract":"<p><p>Pesticide exposure is a growing public health concern, particularly in agricultural regions where workers and communities encounter multiple chemical compounds simultaneously. Although previous studies have investigated the reproductive toxicity of individual pesticides, the combined effects of commonly co-applied insecticide-fungicide mixtures remain poorly characterized. We hypothesized that the simultaneous administration of lambda-cyhalothrin, emamectin benzoate, and thiophanate-methyl, three pesticides routinely co-applied in eastern Algerian agriculture, would exert synergistic reproductive toxicity in male rats, exceeding the effects observed with each compound alone. Seventy-two adult male Wistar rats (n = 8 per group) were treated by oral gavage for 6 weeks with each pesticide at 1/20 LD₅₀ (high dose) or 1/60 LD₅₀ (low dose), or with a ternary mixture at the same dose levels; one group served as the control. Testicular and epididymal weights, plasma testosterone concentration, sperm parameters (concentration, motility, and speed), oxidative stress markers (GSH, GPx, and MDA), and tissue histopathology were evaluated. All three pesticides at the high dose significantly impaired reproductive parameters and induced oxidative stress; however, the mixture group (G8, 1/20 LD₅₀) exhibited the most pronounced alterations, including a highly significant decrease in testicular weight, severe testosterone suppression, marked sperm parameter decline, and extensive histopathological damage consistent with synergistic toxicity. These findings provide the first evidence that the combination of lambda-cyhalothrin, emamectin benzoate, and thiophanate-methyl produces synergistic reproductive toxicity in male rats, underscoring the need for mixture-based risk assessment in agricultural pesticide regulation.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"398-414"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol inhibits coal dust nanoparticle-induced acute lung epithelial cell injury and chronic pulmonary fibrosis.","authors":"Amin Li, Ge Zhou, Ruikai Wang","doi":"10.1177/07482337261486628","DOIUrl":"10.1177/07482337261486628","url":null,"abstract":"<p><p>Coal dust nanoparticles (CD-NPs) are a major risk factor for pneumoconiosis. We evaluated the protective effect of resveratrol against pulmonary fibrosis induced by CD-NPs in pneumoconiosis. Our results showed that CD-NPs exposure significantly reduced cell viability, inhibited proliferation, and induced apoptosis in type II alveolar cells, whereas resveratrol prevented these cellular changes. Lung tissue staining from a mouse model of CD-NPs-induced pneumoconiosis revealed that resveratrol decreased the inflammatory cell infiltration, fibrotic lesions, and decline in lung function caused by CD-NPs exposure. These findings provided an important experimental rationale for developing resveratrol into a novel preventive agent for pneumoconiosis.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"415-423"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological changes in formaldehyde-exposed workers: A critical review and meta-analysis.","authors":"Reza Pourbabaki, Fatemeh Rahimian, Mohammad Ebrahim Ghaffari, Amirmohammad Rezaei, Esmaeel Soleimani","doi":"10.1177/07482337261472039","DOIUrl":"10.1177/07482337261472039","url":null,"abstract":"<p><p>Formaldehyde (FA) is a widely used chemical with known carcinogenic properties, particularly for the upper respiratory tract. Concerns about probable FA-induced hematotoxicity and leukemia have sparked investigations into its health risks. This review scrutinized the quality of exposure evaluations in studies exploring the hematotoxicity of FA and assessed the association between FA exposure and blood dyscrasias. A total of 22 studies were included in the systematic review; among them, 10 provided sufficient data for meta-analysis. FA exposure was significantly associated with changes in blood parameters, including white blood cells (standardized mean difference [SMD] = -1.450 ± 0.636), T cytotoxic cells (SMD = 2.813 ± 1.013), and natural killer (NK) cells (SMD = 1.911 ± 0.775). None of the other blood parameters were significantly affected. However, because of inconsistencies and limitations in exposure assessment methods across the reviewed studies, a clear dose-response relationship could not be established. Overall, changes in some blood parameters were possibly a response to the sensory irritation of FA in the upper respiratory tract. Based on the available scientific evidence, inhaled FA is not distributed beyond portal-of-entry to distal tissues or organs. It is recommended that the exposure of workers to FA be evaluated in a more comprehensive way by following well-validated FA sampling and analysis methods in future studies to better elucidate the association between FA exposure and hematotoxicity. Also, biological monitoring is recommended to estimate overall worker exposure to formaldehyde and to assess the association between FA exposure and its probable hematotoxicity.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"424-439"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica-induced CDK/CDKI dysregulation in alveolar macrophages and its implications in pulmonary fibrosis via altering macrophage fate: A review.","authors":"Yan-Rui Liu, Yuan-Yuan Fu, Hui-Jie Hu, Yun-Ci Yang, Shun-Li Jiang, Zhao-Qiang Zhang","doi":"10.1177/07482337261486650","DOIUrl":"https://doi.org/10.1177/07482337261486650","url":null,"abstract":"<p><p>Cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CDKIs) are a pair of antagonistic regulators of cell-cycle progression. Both exhibit aberrant expression in silica-exposed alveolar macrophages (AMs), thereby altering cellular fate. Given the central role of AMs in silicosis pathogenesis, silica-induced CDK/CDKI dysregulation likely contributes to the pathogenesis of silicosis. However, the detailed processes have never been systematically described. In this review, we first summarized the origins of AMs and their recruitment to lung tissue following silica exposure. We then introduced the molecular mechanisms by which silica particles induce CDK/CDKI dysregulation in AMs, including their molecular forms, distribution, degradation, and the signaling pathways involved. Subsequently, we reviewed how CDK/CDKI dysregulation affects pulmonary fibrosis by reprogramming macrophage fate, encompassing pyroptosis, apoptosis, ferroptosis, and polarization. Finally, we explored the therapeutic potential, current challenges, and future strategies of targeting CDK/CDKI in silicosis fibrosis. This review focused on the impact of silica-induced CDK/CDKI dysregulation on macrophage fate and function and the underlying regulatory mechanisms. We further evaluated the significance of CDK/CDKI in pulmonary fibrosis, providing a theoretical foundation for the development of novel antifibrotic therapeutic strategies.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261486650"},"PeriodicalIF":1.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of hesperidin against nano-alumina in the rat brain: Bioaccumulation, oxidative stress, and inflammatory biomarkers.","authors":"Dina M El-Gridly, Ahmed R Ezzat, Haitham S Mohammed, Gamal M Morsy","doi":"10.1177/07482337261486662","DOIUrl":"https://doi.org/10.1177/07482337261486662","url":null,"abstract":"<p><p>The protective efficiency of hesperidin (Hesp) against the bioaccumulation and neurotoxicity induced by nano-alumina (Al₂O₃NPs) in three brain regions (BR), hippocampus (Hippo), cortex (Cor), and brainstem (BS), has been investigated in rats. The study comprised a 30-day pre-treatment period followed by 7- and 14-days experimental periods (EP) of treatments (T). Rats were divided into four groups: Group I received de-ionized water (DW) daily via both intranasal and oral routes throughout the pre-treatment and T. Group II was administered intranasal DW daily during the pre-treatment period, followed by intranasal Al₂O₃NPs every other day during the T. Group III was administered oral Hesp daily during both the pre-treatment and T. Group IV received a daily oral Hesp during the pre-treatment. During the T, rats were given an intranasal Al₂O₃NPs every other day alongside a daily oral dose of Hesp. Animal sacrifice and tissue collection occurred on day 7 and day 14 of the T. The results showed a significant increase in aluminum (Al³⁺) ion accumulation in all BR of Group II as compared with the three other groups. In Group II, the levels of iron (Fe²⁺), zinc (Zn²⁺), glutathione (GSH), as well as the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly decreased. Tumor necrosis factor-alfa (TNF-α) and interleukin-6 (IL-6) were markedly elevated in this group. Significant inverse correlations were observed between Al³⁺ ion accumulation and the levels of Fe²⁺, Zn²⁺, GSH, as well as the activities of SOD and CAT. In contrast, a significant positive correlation was found between Al³⁺ accumulation and TNF-α and IL-6 levels. In conclusion, co-administration of Hesp with Al₂O₃NPs reduced the neurotoxic effects of Al₂O₃NPs. The present findings suggest that Hesp protected against Al₂O₃NPs-induced neurotoxicity by limiting Al³⁺ ion bioaccumulation, thereby alleviating oxidative stress and inflammation.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"7482337261486662"},"PeriodicalIF":1.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological implications and human health risk assessment of heavy metal contaminated green leafy vegetables and their cultivated soil.","authors":"Varun Shankarappa, Prabhurajeshwar Chidre, Ajay Kumar Oli, Navya Hulikunte Mallikarjunaiah","doi":"10.1177/07482337261471257","DOIUrl":"10.1177/07482337261471257","url":null,"abstract":"<p><p>In the present study, fourteen green leafy vegetables, including spinach, coriander, spring onion, curry, dill, fenugreek, green amaranth, and red amaranth, along with their rhizospheric soils from Chitradurga, Davangere, Tumkur, and Haveri districts of central Karnataka, India, were examined to regulate heavy metal concentrations by ICP-MS. Human health risk assessment was performed by calculating the estimated daily intake (EDI), hazard quotient (HQ), hazard index (HI), and target cancer risk (TCR) to evaluate potential non-carcinogenic and carcinogenic risks associated with vegetable consumption, while transfer factor (TF) analysis assessed soil-to-plant metal translocation into the food chain. Further, cytotoxic effects were evaluated using the MTT assay using HDF cells. Results showed that among the analyzed metals, iron (Fe) and manganese (Mn) were detected at the highest concentrations in green leafy vegetables, whereas cadmium (Cd) and arsenic (As) occurred at comparatively lower levels. Health risk assessment revealed elevated HQ/HI values. SHM3, SHM6, SHM12, and SHM14 exhibited below 1, indicating potential non-carcinogenic health concerns, while SHM2 and SHM12 exhibited comparatively higher values, indicating possible long-term carcinogenic risk associated with chronic exposure to heavy metals. TF analysis demonstrated variable soil-to-plant metal translocation, with cadmium showing the highest transfer efficiency. Furthermore, manganese chloride exposure reduced HDF cell viability to 49.36% after 72 h, with an IC₅₀ value of 487.00 μg/mL. The findings of the current study suggested that most green leafy vegetables from the central Karnataka region remained within acceptable safety limits. However, certain samples indicated potential toxicological risks, therefore requiring regular monitoring to protect public health.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"351-366"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of flurochloridone exposure during pregnancy on maternal and fetal development.","authors":"Rui Li, Su Zhou, Hongyan Zhu, Ping Liu, Jing Fang, Zhichao Zhang, Liming Tang, Zhen Feng, Zhijun Zhou","doi":"10.1177/07482337261467897","DOIUrl":"10.1177/07482337261467897","url":null,"abstract":"<p><p>Flurochloridone (FLC) was classified as \"May cause harm to the unborn child\" by the European Food Safety Authority (EFSA). Because of the potential for occupational exposure to FLC, and the lack of reported maternal and fetal data, we investigated the effects of FLC on sex hormones, toxicokinetics, and maternal well-being, as well as fetal development. Thirty-two pregnant Sprague-Dawley rats were divided into four groups: a vehicle control group and three FLC-treated groups (3, 10, and 30 mg/kg, respectively). FLC was administered to the dams via oral gavage from gestation day (GD) 0 to GD 20. Six dams in each group were used for toxicokinetic evaluations. Cesarean sections were performed on GD 21. Additionally, blood samples were collected for hormone analysis. We found that pregnancy decreased the clearance rate and increased the absorption of FLC in rats. In the 30-mg/kg group, FLC significantly reduced maternal heart weight and decreased testosterone and progesterone levels with no adverse effect on maternal fertility. FLC had no adverse effect on visceral development, but caused a significant increase in incomplete ossification of the fetal sternum in the 30-mg/kg group. In the present study, the no-observed-adverse-effect level (NOAEL) of FLC on embryo-fetal development was estimated to be 10 mg/kg/day.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"341-350"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of heavy metal-induced cancer: Insights from animal models and human implications.","authors":"Sneha Dhanasekaran, Kottila Veettil Dhaneesh","doi":"10.1177/07482337261469287","DOIUrl":"10.1177/07482337261469287","url":null,"abstract":"<p><p>Heavy metals and metalloids, including arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), lead (Pb), and mercury (Hg), are well-recognised human carcinogens, and the molecular mechanisms underlying their carcinogenicity are incompletely characterised. In this review, we critically discuss and synthesise the available evidence on how heavy metals and metalloids contribute to cancer development by inducing ROS, oxidative stress, DNA damage, mitochondrial dysfunction, endoplasmic reticulum stress, and alterations in apoptotic regulators such as p53, Bax, and Bcl-2. Metal-specific differences in genotoxic versus cytotoxic mechanisms and assessing endogenous protective responses, including metallothionein sequestration, antioxidant pathways, and chelation, are included. An extended analysis of the toxicodynamics of metal mixtures is also made, focusing on a realistic but underexplored exposure scenario. Co-occurring metal combinations, such as As-Cd-Cr-Pb, produce endpoint-specific interaction profiles that pose a greater risk for neurological and genotoxic effects than for renal endpoints and cardiovascular effects, depending on the binary combination. Cd and As co-exposure produces synergistic DNA damage 3-5 times greater than predicted from single-metal effects through concurrent p53 dysfunction and ROS overload. Evaluation of the role of gut microbiome interactions in modulating metal bioavailability and carcinogenic potential, limitations of traditional animal models for mixture risk assessment, and emerging technologies, including single-cell sequencing, CRISPR-based functional genomics, and organ-on-chip platforms that may resolve current knowledge gaps, are included.</p>","PeriodicalId":23171,"journal":{"name":"Toxicology and Industrial Health","volume":" ","pages":"367-383"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}