Therapie最新文献

{"title":"Prescription-free consultation: A cross-sectional study in general practice","authors":"Amélie Richard ,&nbsp;Élodie Charuel ,&nbsp;Sébastien Cambier ,&nbsp;Manon Turpin ,&nbsp;Bruno Baudin ,&nbsp;José-Philippe Moreno ,&nbsp;Hélène Vaillant-Roussel","doi":"10.1016/j.therap.2023.07.003","DOIUrl":"10.1016/j.therap.2023.07.003","url":null,"abstract":"<div><h3>Purpose</h3><p>In 2005, 10% of consultations in France ended without a prescription. In 2019, a review of the literature found 30 to 70% of prescription-free consultations in Northern Europe and 10 to 22% in Southern Europe and underlined the scarcity of quantitative data. Different factors contribute to this heterogeneity, such as product availability and status, modes of management, distribution channels, clinical practice recommendations, public policies targeting certain classes, etc. The main objective of our study was to quantify the rate of prescription-free consultations in general practice in France in 2021. The secondary objective was to characterize prescription-free consultations and analyze their determinants.</p></div><div><h3>Methods</h3><p>This was a quantitative observational study conducted using self-questionnaires among patients in medical practices in Auvergne.</p></div><div><h3>Results</h3><p>Out of 540 questionnaires, the rate of prescription-free consultations was 24% (95% CI [20.11–27.41]). Prescription-free consultations were for prevention, administrative problems, and gestures. The limiting factors are “feeling a need for a medication” (OR<!--> <!-->=<!--> <!-->0,006), “not knowing if a medication is needed” (OR<!--> <!-->=<!--> <!-->0.11) and “consultations for acute reasons” (OR<!--> <!-->=<!--> <!-->0.33).</p></div><div><h3>Conclusion</h3><p>Acute consultations limit prescription-free consultations. General practitioners (GPs) probably overestimate patients’ expectation of drug prescription. The French GP must be supported in their decision to not prescribe drugs. This is a long-term investment of time, to educate patients and avoid new consultations for acute reasons. A tool to help doctors manage non-prescription during acute consultations will be created in a future study in France.</p></div>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S004059572300104X/pdfft?md5=f2b8af16cae065d0d1d5837deedecdfb&pid=1-s2.0-S004059572300104X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database","authors":"Eve-Marie Thillard ,&nbsp;Paula Sade ,&nbsp;Joelle Michot ,&nbsp;Virginie Bres ,&nbsp;Annie-Pierre Jonville-Bera","doi":"10.1016/j.therap.2023.07.007","DOIUrl":"10.1016/j.therap.2023.07.007","url":null,"abstract":"<div><p><span><span>Phosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, </span>rhabdomyolysis<span>, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis and a case/non-case analysis using the cases of drug-induced hypophosphatemia reported to the French Pharmacovigilance Network. A total of 368 cases of hypophosphatemia were included in the study. Patients’ mean age was 52</span></span> <!-->±<!--> <!-->18 years. One hundred and ninety-one cases (52%) were serious including 131 (36%) hospitalizations. The median value of serum phosphorus level was 0.54<!--> <!-->mmol/L [0.40–0.66] (<em>n</em> <!-->=<!--> <span>309). Those 368 cases corresponded to 185 different suspected substances among which the most frequent drugs were tenofovir disoproxil (</span><em>n</em> <!-->=<!--> <span>175; 48%), ferric carboxymaltose (</span><em>n</em> <!-->=<!--> <span>29; 8%), denosumab (</span><em>n</em> <!-->=<!--> <span>16; 4%), zoledronic acid (</span><em>n</em> <!-->=<!--> <span>14; 4%) and hydrochlorothiazide (</span><em>n</em> <!-->=<!--> <span><span>10; 3%). For these five drugs, a significant disproportionality was found. Tenofovir-disoproxil related hypophosphatemia occurred more than one year after its introduction, and a renal tubulopathy<span> (Fanconi's syndrome) was reported in 44 cases (25%). Hypophosphatemia related to iron carboxymaltose occurred within a median of 20 days after injection and was mostly severe. Mechanism included the fibroblast growth factor 23 which can be measured to confirm drug origin. Concerning anti-osteoporosis treatments, hypophosphatemia could be explained by their mechanism of action (abrupt increase of </span></span>parathormone<span> induced by hypocalcemia) but the patient history (malignancy condition) was a major bias. For hydrochlorothiazide, hyphosphatemia was often moderate, associated with other electrolytic disturbances and occurred during a long-term treatment. Awareness of healthcare professionals is essential to detect as soon as possible hypophosphatemia and its complications related to these drugs.</span></span></p></div>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10081816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital","authors":"Jawhar Rebai ,&nbsp;Haifa Ben Romdhane ,&nbsp;Khadija Mansour ,&nbsp;Najah Ben Fadhel ,&nbsp;Ines Lahouel ,&nbsp;Zohra Chadly ,&nbsp;Amel Chaabane ,&nbsp;Nadia Ben Fredj ,&nbsp;Karim Aouam","doi":"10.1016/j.therap.2023.06.005","DOIUrl":"10.1016/j.therap.2023.06.005","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol infusion syndrome: Analysis of French pharmacovigilance and World Health Organization Pharmacovigilance (VigiBase®) databases from 2020 to 2023.","authors":"Lionel Tchatat Wangueu, Nathalie Fouilhe Sam-Laï, Marion Allouchery, Gwenaelle Veyrac, Marine Aroux-Pavard, Charlène Boulay, Vincent Richard, Nathalie Massy","doi":"10.1016/j.therap.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.therap.2024.04.005","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GPs' practices when prescribing buprenorphine in primary care: A survey among the Sentinelles network.","authors":"Barbara Lépine, Marion Debin, Lise Dassieu, Laetitia Gimenez, Aurore Palmaro, Camille Ponté, Morgane Swital, Maryse Lapeyre-Mestre, Thierry Blanchon, Julie Dupouy","doi":"10.1016/j.therap.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.therap.2024.04.002","url":null,"abstract":"<p><strong>Introduction: </strong>France is a leading country for opioid agonist treatment providing, with a predominance of buprenorphine. General practitioners (GPs) are the main prescribers of buprenorphine, but they seem to be less involved over the last 10 years. This work is the second part of a larger study analysing buprenorphine prescribing among French GPs working in primary care, and aims to describe GPs' practices when prescribing buprenorphine.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted in France from March to July 2021 among a sample of GPs in the Sentinelles network, a national epidemiologic surveillance system. Data about the last situations of initiation and renewal of buprenorphine were collected.</p><p><strong>Results: </strong>Among the 237 participants (34.3% response rate), 156 responded to the questionnaire about the last situation of renewal and 41 about the last situation of initiation. The last initiation occurred more than 12 months earlier for 46.3% of respondents, whereas the last renewal occurred less than 1 month ago for 68.6%. There was an over-representation of the male gender among the patients who were consulting (initiation 70.7%, renewal 68.6%). A majority of patients had an illicit opioid use disorder (initiation 78.0%, renewal 82.7%). Overall, GPs were involved in the general care of patients with opioids use disorder and in opioids harm reduction (initiation 87.8% and 82.9%, renewal 88.5% and 51.9%).</p><p><strong>Conclusion: </strong>Among buprenorphine prescribers, initiations were infrequent unlike renewals and involved mainly illicit opioid users.</p>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the satisfaction of healthcare professionals using the CRAT website, and launch of a new version].","authors":"Benoît Marin, Bénédicte Coulm, Delphine Beghin, Mathilde Latour, Pascale Beloni, Jean Toniolo, A. Dechartres, Florence Tubach, C. Vauzelle, E. Elefant","doi":"10.1016/j.therap.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.therap.2024.03.004","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of adverse drug reactions reported via the Continuum+ platform: Results from three-year regional follow-up.","authors":"Juliette Henry, Audrey Fresse, Mathilde Beurrier, M. Antoine, Pierre Gillet","doi":"10.1016/j.therap.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.therap.2024.04.001","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Palmar aquagenic keratoderma secondary to treatment of chronic osteitis with tedizolide: A case report].","authors":"Benjamin Valentin, Mikael Tchaparian, Louise Daran, C. Fievet, P. Odou, C. Loiez, Henri Migaud, Bertrand Décaudin, E. Senneville","doi":"10.1016/j.therap.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.therap.2024.03.003","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordance between pain specialists and patients on the perception of dependence on pain medication: A multi-centre cross-sectional study.","authors":"A. Roussin, Zénab Cissé, Vanessa Rousseau, Guillaume Roche, Cécile Lestrade, Alexandre Cauchie, Noémie Delage, Anne Donnet, Elise Van Obberghen, Chantal Wood, Maryse Lapeyre-Mestre, N. Cantagrel","doi":"10.1016/j.therap.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.therap.2024.01.008","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced psychiatric disorders: A pharmacovigilance update","authors":"François Montastruc ,&nbsp;Tanguy Taillefer de Laportaliere","doi":"10.1016/j.therap.2023.09.007","DOIUrl":"10.1016/j.therap.2023.09.007","url":null,"abstract":"<div><p>The psychiatric risks associated with drugs are sometimes one of the few restrictions on the use of certain drug classes, such as corticosteroids in patients with a history of severe psychotic episodes associated with this drug class. In this non-exhaustive review, we propose to deal with the most recent issues concerning psychiatric disorders induced by drugs and encountered in doctors’ clinical practice. Firstly, we look at depressive disorders and suicide risks, secondly at psychotic and manic disorders<span> and thirdly at anxiety and sleep disorders. While lot of drugs are associated with psychiatric disorders, the confounding by indication represents an important methodological gap since information on the psychiatric profile of patients is not always available. This is particularly the case for serotonin reuptake inhibitors<span><span> and esketamine<span> used as antidepressants. Recent pharmacovigilance concerns of psychiatric disorders emerged with montelukast, </span></span>orexin receptor antagonists<span> or cystic fibrosis transmembrane regulator (CFTR) modulators.</span></span></span></p></div>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}