Toxicology Reports最新文献

{"title":"UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effect on gastritis in rats","authors":"Aya A. Wafaey ,&nbsp;Seham S. El-Hawary ,&nbsp;Osama G. Mohamed ,&nbsp;Sahar S. Abdelrahman ,&nbsp;Alaa M. Ali ,&nbsp;Ahmed A. El-Rashedy ,&nbsp;Mohamed F. Abdelhameed ,&nbsp;Farid N. Kirollos","doi":"10.1016/j.toxrep.2025.101944","DOIUrl":"10.1016/j.toxrep.2025.101944","url":null,"abstract":"<div><div>Metabolic profiling of the crude ethanolic extract of <em>Gliricidia sepium</em> (Jacq.) Kunth. ex. Walp. stem ethanolic extract (GSS) was conducted using ultra-high performance quadrupole time of flight mass spectrometry/mass spectrometry (UHPLC-QTOF-MS/MS) in negative mode, resulting in the identification of 23 compounds belonging to various classes such as flavonoids, fatty acids, triterpenoid saponins, and phenolic acids. Notably, eight flavonoids including kaempferol-3-<em>O</em>-robinoside-7-<em>O</em>-rhamnoside, isoquercitrin, kaempferol-3-<em>O</em>-rutinoside, apigenin-7-glucoside, kaempeferol-7-<em>O</em>-rhamnoside, luteolin, apigenin, and liquiritigenin, along with two phenolic acids (4-hydroxycinnamic acid and 2-hydroxyhydrocinnamic acid) and four triterpenoid saponins (soyasaponin I, soyasaponin II, soyasaponin III, and kaikasaponin III) were dereplicated. Additionally, nine fatty acid derivatives were identified, including azelaic acid and 2-isopropyl malic acid. Molecular networking analysis revealed the formation of clusters among compounds while others do not form clusters. Further analysis indicated that the GSS ethanolic extract exhibited a total phenolic content of 38.78 ± 1.609 µg of gallic acid equivalent/mg and a total flavonoid content of 5.62 ± 0.50 µg of rutin equivalent/mg. Biological evaluations showed that GSS ethanolic extract mitigated gastric tissue injury induced by pyloric ligation, with a notable reduction in oxidative stress marker reactive oxygen species levels and inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha levels. Additionally, it enhanced superoxide dismutase and inhibitor of nuclear factor kappa B alpha levels, while lowering the expression of inducible nitric oxide synthase. Histopathological examination revealed significant improvements in gastric tissue morphology in GSS-treated groups compared to the control group. Molecular docking studies indicated potential interactions between GSS ethanolic extract compounds and various target proteins involved in oxidative stress, inflammation, and gastric protection in gastritis. This study aims to investigate the potential gastroprotective activity of GSS ethanolic extract against gastritis induced via pyloric ligation.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101944"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antioxidant potential of bacoside and its derivatives in Alzheimer's disease: The molecular mechanistic paths and therapeutic prospects","authors":"Dipanjan Karati ,&nbsp;Swarupananda Mukherjee ,&nbsp;Souvik Roy","doi":"10.1016/j.toxrep.2025.101945","DOIUrl":"10.1016/j.toxrep.2025.101945","url":null,"abstract":"<div><div>Central nervous system disorders are likely to have a substantial effect on the worldwide healthcare demands of humanity in this era. Alzheimer’s disease (AD) is a senile decay of neurons. Extracellular beta-amyloid accumulation and intracellular tau hyperphosphorylation are two key characteristics of the pathogenesis of AD. Because of the multifactorial character of many disorders, new medicine-based psychoactive treatments have had limited success. As a result, there is a growing demand for innovative products that can target different receptors and improve behavioral abilities on their own or in combination with established treatments. In recent years, both industrialized and developing countries have seen a surge in herbal products based on traditional knowledge. According to recent research, bacoside and its congeners can dramatically lower the build-up of amyloid-β plaques, which are a defining feature of AD. This decrease is explained by bacoside's capacity to regulate β-secretase activity, which lowers the production of amyloid-β. Ayurveda is a medical science that focuses on the use of naturally occurring plant products to treat ailments. Many neuroprotective plants are said to be found in Ayurveda. The key physiological dysfunctions linked to tau aggregates, which contribute to dementia and behavioral inconsistencies, include the formation of reactive oxygen species, augmented neuronal swelling, and neurotoxicity. Here, we have focused on bacopa as an anti-Alzheimer medication. Bacoside A, Baccoside B, Apigenin, Betullinic acid, etc. are the pharmacologically active congeners of Brahmi belonging to several chemical families. In this review, the neuroprotective properties, pharmacological effectiveness, and molecular mechanism of bacoside scaffolds against AD have been discussed.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101945"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress","authors":"Clécia Dias Teixeira ,&nbsp;Priscila Oliveira Barbosa ,&nbsp;Wanderson Geraldo Lima ,&nbsp;Gustavo Silveira Breguez ,&nbsp;Miliane Martins de Andrade Fagundes ,&nbsp;Daniela Caldeira Costa ,&nbsp;Cintia Lopes de Brito Magalhães ,&nbsp;Joana Ferreira Amaral ,&nbsp;Melina Oliveira de Souza","doi":"10.1016/j.toxrep.2025.101946","DOIUrl":"10.1016/j.toxrep.2025.101946","url":null,"abstract":"<div><div>Liver damage caused by high doses of paracetamol is a global public health concern. Consequently, therapeutic strategies are being explored to prevent this damage. The bioactive compounds present in fruits have shown promise in protecting against disorders associated with paracetamol-induced liver damage. This study assessed the preventive effects of guarana powder on redox status in a rat model of acute hepatotoxicity induced by a toxic dose of paracetamol. Male Wistar rats were divided into four groups: control (C), guarana (G), paracetamol (P), and guarana + paracetamol (GP). Animals in groups G and GP received 300 mg/kg guarana powder daily for seven days. Hepatotoxicity was induced in the P and GP groups by a single dose of 3 g/kg paracetamol on the last day. Paracetamol effectively induced liver damage and oxidative stress in group P animals. Preventive treatment with guarana significantly mitigated this damage and prevented the serum elevation of ALT, AST, and ALP by 44 %, 29 %, and 24 %, respectively. It also prevented a 133 % increase in the necrotic liver area in GP animals compared to the P. Guarana treatment, which prevented reductions in glutathione levels, modulated antioxidant enzyme (SOD and CAT) expression and activity, and protein carbonylation, while enhancing the total antioxidant capacity. Our results suggest that preventive treatment with guarana can attenuate oxidative damage, modulate antioxidant defense gene expression, and protect against paracetamol-induced hepatotoxicity in rats, highlighting guarana powder as a potential therapeutic agent to prevent liver damage induced by high doses of paracetamol.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101946"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Mitigation of cisplatin-induced cardiotoxicity by Isorhamnetin: Mechanistic insights into oxidative stress, inflammation, and apoptosis modulation” [Toxicol. Rep. 12 (2024) 564–573]","authors":"Rawan Abudalo ,&nbsp;Omar Gammoh ,&nbsp;Sara Altaber ,&nbsp;Yousra Bseiso ,&nbsp;Esam Qnais ,&nbsp;Mohammed Wedyan ,&nbsp;Muna Oqal ,&nbsp;Abdelrahim Alqudah","doi":"10.1016/j.toxrep.2025.101934","DOIUrl":"10.1016/j.toxrep.2025.101934","url":null,"abstract":"","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101934"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotic-induced hyperprolactinemia: Toxicologic mechanism and the increased breast cancer risk","authors":"Steven B. Bird","doi":"10.1016/j.toxrep.2025.101927","DOIUrl":"10.1016/j.toxrep.2025.101927","url":null,"abstract":"<div><div>Antipsychotic drugs are effective at improving both the positive and negative symptoms of schizophrenia as well as the manic phase of bipolar disorder. Whether an antipsychotic is termed typical or atypical is related to the xenobiotic’s propensity to cause extrapyramidal side effects. However, with a few exceptions, drugs of both classes of antipsychotics are known to cause hyperprolactinemia. As many breast cancers are responsive to prolactin concentrations, the persistent increase in prolactin of the antipsychotics has implications for public health and carcinogenesis. The objective of this study was to review the extant literature on hyperprolactinemia due to antipsychotics, and to determine the risk imposed by those drugs on human breast cancer. A summary risk of breast cancer with use of any antipsychotic was found to be 1.19 (95 % confidence interval 1.10–1.30). When limiting usage of antipsychotics to 5 or more years, the summary risk increased to 1.26 (95 % confidence interval 1.12–1.43). And when limited to those studies who evaluated only those medications with the greatest increase in prolactin, the risk increased to 1.59 (95 % confidence interval 1.37–1.85). Given this increased risk of breast cancer, stronger warnings about this increased risk are warranted, and regular monitoring of prolactin levels and breast cancer screening should be part of the management plan for these patients.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101927"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising incidence of recreational ketamine use: Clinical cases and management in emergency settings","authors":"Sabrina Marongiu ,&nbsp;Maarten van Eijk ,&nbsp;Femke M.J. Gresnigt ,&nbsp;Esther A. Croes ,&nbsp;Eric J.F. Franssen","doi":"10.1016/j.toxrep.2025.101940","DOIUrl":"10.1016/j.toxrep.2025.101940","url":null,"abstract":"<div><div>The recreational use of ketamine has risen significantly in the Netherlands, particularly among young adults in nightlife settings. This trend has been accompanied by an increase in first aid incidents involving ketamine, often in combination with other substances such as alcohol or MDMA, leading to heightened toxicity. Acute intoxication with ketamine manifests through symptoms like agitation, hallucinations, nausea, tachycardia, and hypertension, while frequent use is associated with long-term complications, including ketamine-induced uropathy. Although ketamine is not currently included in standard toxicological screenings, its detection can aid in diagnosing mixed intoxications, excluding alternative causes, and facilitating referral to follow-up care. Routine inclusion of ketamine in toxicological screening could improve diagnostic precision and better address the health risks associated with its growing prevalence.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101940"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats","authors":"Omar Ammar Hashim ,&nbsp;Intesar Tarik Numan ,&nbsp;Nadia Hameed Mohammed","doi":"10.1016/j.toxrep.2025.101942","DOIUrl":"10.1016/j.toxrep.2025.101942","url":null,"abstract":"<div><div>The use of Simvastatin has been reported to induced muscle myopathy, with no effective preventive measures. The study objective is to study the protective effect of CoQ10, vitamin E, and their combination to prevent simvastatin-induced skeletal muscle myopathy in rat models and explore possible mechanisms by measuring muscle biomarkers and histopathological changes. All rats (n = 49) received 80 mg/kg/day of simvastatin to induce myopathy for 30 days, the study includes 7 groups (n = 7): negative control, CMC and cotton seed oils vehicles, simvastatin induction, CoQ10, vitamin E and combination of vitamin E and CoQ10 groups; rats in the intervention groups received either 100 mg/kg CoQ10 or 40 mg/kg vitamin E or their combination once daily orally for 30 days. At the end of the experiment, rats were euthanized by cervical dislocation, and blood and the collected tissue samples were collected to measure creatinine kinase (CKM), malondialdehyde (MDA), total antioxidant capacity (TAOC), inducible nitric oxide synthase-2 (iNOS2), and aldolase. In addition, gastrocnemius muscle histopathology was examined. Treatment with CoQ10, vitamin E, or their combination significantly reduced the levels of CKM, aldolase, iNO2, and MDA and increased TAOC compared to the simvastatin induction group. The combination group showed a superior protective effect than either drug alone. Treatment with vitamin E and CoQ10 showed mild vacuolation and cytoplasm with focal splitting and fragmentation of muscle fibers, scattered central nuclei, and eosinophilic cytoplasm. In conclusion, CoQ10 and vitamin E combined showed a superior protective effect against simvastatin-induced myopathy through antioxidant and antiapoptotic pathways.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101942"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemary methanolic extract","authors":"Arwa A. Elsheikh ,&nbsp;Noha Ali Abd-Almotaleb ,&nbsp;Mona Mostafa Ahmed ,&nbsp;Eman El-Sayed Khayal","doi":"10.1016/j.toxrep.2025.101935","DOIUrl":"10.1016/j.toxrep.2025.101935","url":null,"abstract":"<div><div>Iron oxide nanoparticles (IONPs) are widely used in various fields, particularly in medicine, where they can be directly injected for diagnostic and therapeutic purposes, although they may induce certain types of toxicity. Therefore, the present work aimed to estimate the potential protective role of the oral extract of rosemary (RO)against the toxic effects of injected IONPs on the brain tissues of adult male rats, and to explore the potential underlying mechanisms involved in reversing such toxicity. Thirty adult male albino rats were allocated into five groups: the control, the vehicle (intravenous saline injection once/week), the RO extract group (orally gavaged100mg/kg/day), IONPs (intravenously injected 30 mg/kg once/week), and the combined RO+IONPs (orally gavaged RO extract 1 hrh before intravenous injection of IONPs). IONPs induced neurotoxicity via triggering a cascade of neuro-oxidative stress, neuro-inflammation, and parthanatos-mediated neuronal cell death by increasing MDA, NO, TNF-α levels, PARP-1, AIF, and NF-κB mRNA expression alongside reducing GSH levels. These incidents contributed to neurodegenerative changes, reflected in increased mRNA expression of α-S, β-APP, and TDP-43. Additionally, IONPs induced structural degenerative changes and elevated iron levels in brain tissues reduced occludin expression, and disrupted the BBB. Furthermore, the concurrent oral RO extract alleviated these conditions and repaired BBB by increasing the occludin expression and ameliorating structural changes in brain tissues. Consequently, the current data provide evidence that RO supplementation during IONP administration holds promise to minimize potential health risks, which should be corroborated by translational studies.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101935"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes","authors":"Prasad Sherekar ,&nbsp;Sanvidhan G. Suke ,&nbsp;Archana Dhok ,&nbsp;Srikant Malegaonkar ,&nbsp;Shrikrishna A. Dhale","doi":"10.1016/j.toxrep.2025.101941","DOIUrl":"10.1016/j.toxrep.2025.101941","url":null,"abstract":"<div><div>Silicosis is an occupational fibrotic lung disease caused by exposure to respirable crystalline silica dust particles produced during industrial activities. Other crystalline silica-induced pulmonary disorders include a predisposition to mycobacterial infections, obstructive airway diseases, idiopathic pulmonary fibrosis, and lung cancer. This review paper discusses the burden of silicosis and associated co-morbidities in developed as well as developing countries globally using the published data of various government agencies, related organizations, and epidemiological findings. Moreover, it sheds light on diverse mechanisms of silicosis, outlining molecular events and peculiar alterations in lung parenchyma leading to this occupational lung disease. Evaluation of pathophysiological mechanisms could aid in the identification of novel target molecules and treatments; to date, there is no curative treatment for silicosis. In recent periods, a lot of attention has been focused on the development and fabrication of suitable nanocarriers for improved and sustained drug delivery in the pulmonary system. Nanoparticle-based therapeutic modality has been evaluated in <em>in-vitro</em> and <em>ex-vivo</em> silicosis models for prolongation of drug activity and improved therapeutic outcomes. The preclinical findings open the doors to clinical trials for operational and regenerative nanoformulations, which eventually create a positive change in medical practice. The following review summarizes various therapeutic approaches available and in the pipe line for silicosis and also stresses the preventive practices for effectively combating this occupational hazard.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101941"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental lead exposure and aggression in male rats: Influences of maternal care and environmental enrichment","authors":"Shamaila Zafar ,&nbsp;Courtney Williams ,&nbsp;Jaehyun Joo ,&nbsp;Blanca E. Himes ,&nbsp;Jay S. Schneider","doi":"10.1016/j.toxrep.2025.101937","DOIUrl":"10.1016/j.toxrep.2025.101937","url":null,"abstract":"<div><div>Developmental lead (Pb) exposure results in a variety of cognitive deficits and behavioral issues including increased antisocial behavior and aggression. This study investigated the effect of developmental Pb exposure on aggression and violent behavior in male rats and the potential modulatory influences of quality of maternal care and enriched/non-enriched housing conditions. Long-Evans male rats with or without Pb exposure (perinatal or early postnatal) from low or high maternal care mothers (based on amounts of licking/grooming and arched-back nursing) were randomly assigned to live in enriched or non-enriched environments at weaning. At postnatal day 120–190, offensive aggression was assessed using a resident intruder test. Clinch attack (CAK) frequency and latency, and occurrence of biting events were observed to determine violent behavior. Both perinatal and postnatal Pb-exposed rats were significantly more aggressive and showed more violent behavior, compared to non-Pb-exposed animals, regardless of level of maternal care and environmental enrichment. High maternal care significantly lowered the proportion of animals with short CAK latencies and enriched housing significantly lowered the occurrence of biting events. These results suggest that high maternal care and enriched housing may potentially modify expression of violent aggressive behavior in rats with early life Pb exposure.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101937"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}