Therapeutic Advances in Chronic Disease最新文献

{"title":"Systematic and opportunistic screening for atrial fibrillation and other arrhythmias in patients with obstructive sleep apnea: a prospective, single-center, cross-sectional study.","authors":"Tachawut Tiensuntisook, Voravut Rungpradubvong, Naruepat Sangpornsuk, Mananchaya Thapanasuta, Ronpichai Chokesuwattanaskul, Somchai Prechawat, Nattapong Jaimchariyatam","doi":"10.1177/20406223251348336","DOIUrl":"10.1177/20406223251348336","url":null,"abstract":"<p><strong>Background: </strong>Patients with obstructive sleep apnea (OSA) may be at high risk for atrial fibrillation (AF), but data on the benefits of early AF screening in this population, including the prevalence of AF detected through such screening, remain limited.</p><p><strong>Objectives: </strong>This study evaluates the prevalence of AF in OSA patients using three screening methods and aims to identify the most effective approach, as well as the potential benefits of early AF detection in this population.</p><p><strong>Design: </strong>Prospective, single-center, cross-sectional study.</p><p><strong>Methods: </strong>This study assessed AF prevalence using three screening methods: opportunistic screening via pulse taking during a routine visit, systematic screening with a handheld electrocardiogram (EKG), and EKG during polysomnography. The analysis also included the proportion of patients with positive screenings who were indicated for anticoagulation and the prevalence of other non-AF arrhythmias.</p><p><strong>Results: </strong>A total of 201 OSA patients were enrolled, with a mean age of 46 years and a mean CHA₂DS₂-VASc score of 1. The prevalence of AF was 1.5%, 2.5%, and 2.0% when detected by pulse taking, handheld EKG, and EKG during polysomnography, respectively, with no statistically significant difference (<i>p</i> = 0.933). All patients with positive screenings were indicated for oral anticoagulant therapy. The prevalence of other non-AF arrhythmias was higher than in the general population, and detecting arrhythmias during sleep appeared to be more effective than detecting them while awake, particularly for atrial tachycardia.</p><p><strong>Conclusion: </strong>The prevalence of AF in OSA patients ranged from 1.5% to 2.5%, with the highest rate observed in handheld EKG systematic screening, though the difference was not statistically significant. Non-AF arrhythmias were also more common than in the general population, highlighting the need for broader arrhythmia surveillance. Further large-scale studies in higher-risk OSA populations are needed to confirm the benefits of systematic AF screening.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251348336"},"PeriodicalIF":2.8,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis and periodontal health: an emerging oral-liver axis.","authors":"Ruth Rodríguez-Montaño, Melissa Martínez-Nieto, Gustavo Eder González-Alvarez, Mario Alberto Alarcón-Sánchez, Julieta Sarai Becerra-Ruiz, Artak Heboyan, Alba Ruiz-Gaitán, Sarah Monserrat Lomelí-Martínez","doi":"10.1177/20406223251368090","DOIUrl":"10.1177/20406223251368090","url":null,"abstract":"<p><p>Periodontitis and viral liver infections, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), are chronic inflammatory conditions with a high prevalence worldwide. Recent evidence establishes a possible bidirectional relationship between the two, based on shared immunological, microbial, and inflammatory mechanisms. The objective of this study was to analyze and synthesize the scientific literature on the interactions between viral hepatitis and periodontal health. Through a structured search of the PubMed, Scopus, and Web of Science databases, studies published in the last 20 years that explored the link between viral hepatitis and periodontitis were integrated. The findings from the reviewed studies show consistent, positive associations between HBV and HCV viruses and a higher prevalence and severity of periodontitis. Some studies show increased levels of proinflammatory cytokines (such as IL-6 and TNF-α) and immune dysfunction in participants with both diseases. Additionally, viral markers (such as HBsAg and HCV RNA) have been identified in gingival crevicular fluid, suggesting the presence of oral viral reservoirs. Ultimately, scientific evidence suggests a bidirectional relationship between viral hepatitis and periodontitis, influenced by systemic inflammation, immunological alterations, and microbial dysbiosis. The collected data support the relevance of interdisciplinary management between medical and dental professionals in patients with viral liver conditions.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251368090"},"PeriodicalIF":2.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of choline supplementation on oxidative stress and clinical outcomes among patients with non-alcoholic fatty liver disease: a randomized controlled study.","authors":"Sylvia S Sedhom, Lamia M El Wakeel, Eman M F Barakat, Hend I Shousha, Mostafa A Shamkh, Salwa H Salama, Doaa Z Zaky, Amal A El Kholy","doi":"10.1177/20406223251358659","DOIUrl":"10.1177/20406223251358659","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition characterized by the accumulation of fat in the liver. Nutrition, particularly micronutrients, plays a crucial role in the development and progression of NAFLD.</p><p><strong>Objectives: </strong>This study aimed to assess the impact of choline supplementation on oxidative stress, inflammation, and clinical outcomes in patients with NAFLD.</p><p><strong>Design: </strong>A randomized, controlled, single-blinded study.</p><p><strong>Methods: </strong>Eligible NAFLD patients were randomized to; <i>choline group</i> (<i>n</i> = 39), received conventional management plus phosphatidylcholine (PC) 2400 mg/day for 12 weeks, or c<i>ontrol group</i> (<i>n</i> = 40), received conventional management for 12 weeks, and 10 healthy volunteers were included. Anthropometric, clinical, and laboratory evaluations were performed at baseline and after treatment.</p><p><strong>Results: </strong>After 12 weeks, choline group showed significant differences versus controls by improvement in controlled attenuation parameter (304 vs 332 dB/m, <i>p</i> < 0.001) and fibrosis score (5.3 vs 6.8 kPa, <i>p</i> < 0.001), reduction in thiobarbituric acid reactive substances levels (1.9 vs 3.8 nmol/mL, <i>p</i> < 0.001), a decline in leptin levels (1.3 vs 2.1 ng/mL, <i>p</i> < 0.001) and liver enzyme (alanine aminotransferase and aspartate aminotransferase), <i>p</i> < 0.001 and 0.004 respectively). Also, the lipid profile improved by a significant decline in triglyceride levels in choline versus controls 133 versus 158, <i>p</i> = 0.048.</p><p><strong>Conclusion: </strong>Choline supplementation in NAFLD patients demonstrated a favorable impact on hepatic steatosis, oxidative stress, inflammatory markers, liver enzyme levels, and lipid profile. These findings suggest that choline may be a promising therapeutic option for NAFLD management. Further large-scale, long-term studies are warranted to investigate the clinical benefits of choline supplementation in NAFLD patients.</p><p><strong>Trial registration: </strong>The study was registered at clinicaltrials.gov and given the ID number: NCT05200156.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251358659"},"PeriodicalIF":2.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the therapeutic efficacy of microcurrent therapy: a narrative review.","authors":"Sarahrose Jonik, Andrew J Rothka, Neyha Cherin","doi":"10.1177/20406223251361677","DOIUrl":"10.1177/20406223251361677","url":null,"abstract":"<p><p>Microcurrent (MIC) therapy is a non-invasive, low-intensive electrical modality that remains underutilized despite evidence supporting its therapeutic potential. With applications in chronic pain, wound healing, musculoskeletal injuries, deconditioning, and neuropsychological conditions, MIC offers a pain-free alternative to traditional electrotherapies. This narrative review compiles the current literature on MIC therapy, highlighting its physiological mechanisms, such as promoting cellular repair, modulating inflammation, and reducing pain, without inducing discomfort or muscle fatigue. Though more high-quality evidence is needed, this review examines the current evidence on MIC's role in managing chronic and complex conditions across diverse healthcare environments and patient populations.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251361677"},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic treatment as secondary prophylaxis ameliorates short-term mortality for acute esophagogastric variceal bleeding in older patients with cirrhotic hepatocellular carcinoma.","authors":"Qi Li, Ruifeng Liu, Shenghui Zhou, Lingna Lyu, Chunlei Fan, Huiguo Ding","doi":"10.1177/20406223251356824","DOIUrl":"10.1177/20406223251356824","url":null,"abstract":"<p><strong>Background: </strong>Acute esophagogastric variceal bleeding (AEGVB) is a common complication of liver cirrhosis and hepatocellular carcinoma (HCC). It is unclear if older patients with cirrhotic HCC benefit from endoscopic treatment as secondary prophylaxis for AEGVB in short term.</p><p><strong>Objectives: </strong>We aim to investigate if endoscopic treatment as secondary prophylaxis for AEGVB reduces short-term mortality in older patients with cirrhotic HCC.</p><p><strong>Design: </strong>We retrospectively enrolled 138 consecutive patients over 60 years old with cirrhotic HCC and AEGVB from April 1, 2021 through December 31, 2022 in Emergency Room, Beijing You'an Hospital, Capital Medical University.</p><p><strong>Methods: </strong>A 1:1 propensity score matching (PSM) analysis was performed to adjust for confounding factors such as age, gender, Child-Pugh score in our statistical findings. Logistic regression and Cox regression analyses were used to investigate whether there was a significant negative association between endoscopic treatment and short-term mortality for AEGVB in older patients with cirrhotic HCC. Kaplan-Meier methodology was employed to compare overall survival over 6 weeks between the endoscopic treatment group and non-endoscopic treatment group.</p><p><strong>Results: </strong>In older patients with cirrhotic HCC and AEGVB, in-hospital mortality and 6-week mortality were significantly lower in the endoscopic treatment group compared to the non-endoscopic treatment group before PSM (5.33% vs 26.98%, <i>p</i> = 0.001 for in-hospital mortality; 12.00% vs 44.44%; <i>p</i> < 0.001 for 6-week mortality). These results remained consistent after PSM (4.76% vs 26.98%, <i>p</i> = 0.002 for in-hospital mortality; 9.52% vs 44.44%; <i>p</i> < 0.001 for 6-week mortality). Both logistic regression and Cox regression analyses found that endoscopic treatment contributed to reduced short-term mortality for AEGVB in older patients with cirrhotic HCC. Kaplan-Meier survival curves indicated that older patients undergoing endoscopic treatment had a higher short-term survival rate than those who didn't receive endoscopic treatment in our cohort. However, there was no significant difference in short-term survival between patients receiving endoscopic variceal ligation and those treated with endoscopic injection sclerotherapy.</p><p><strong>Conclusion: </strong>Secondary prophylaxis of endoscopic treatment helps to reduce 6-week mortality for AEGVB in older patients with cirrhotic HCC. Therefore, endoscopic treatment is suggested to be employed as secondary prophylaxis in this special population in clinical practice.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251356824"},"PeriodicalIF":2.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The profound implications of mitochondrial myopathy on activities of daily living: an observational qualitative study of standardized structured and semi-structured patient interviews.","authors":"Elizabeth M McCormick, James T Peterson, Joaquim Diego D Santos, Jean Flickinger, Rui Xiao, Richard Haas, Zarazuela Zolkipli-Cunningham","doi":"10.1177/20406223251344763","DOIUrl":"10.1177/20406223251344763","url":null,"abstract":"<p><strong>Background: </strong>The impact of Mitochondrial Myopathy (MM) symptoms on functional ability across activities of daily living (ADLs) has not been fully characterized, nor is it understood how MM patients define their key symptoms. Furthermore, it is unclear what MM individuals perceive as a clinically meaningful improvement.</p><p><strong>Objective: </strong>We sought to characterize how MM patients feel about their symptoms in the key MM domains of muscle weakness, muscle fatigue, exercise intolerance, imbalance, and peripheral neuropathy; as well as their functional ability.</p><p><strong>Design: </strong>We conducted a single-center, observational, qualitative study that involved standardized structured and semi-structured patient interviews.</p><p><strong>Methods: </strong>Most interview questions were open-ended, allowing individuals to provide personalized narratives that were transcribed in real time. A total of 33 individuals with MM were interviewed either in-person or remotely. Interview transcripts underwent thematic analysis in accordance with grounded theory. Data was presented using a mixed-methods approach.</p><p><strong>Results: </strong>Subjects provided extensive narratives that demonstrated the substantial and widespread impact of MM across many aspects of MM patient lives, including the impact of each MM domain of muscle weakness, muscle fatigue, exercise intolerance, imbalance, and peripheral neuropathy on ADLs; the need to adapt to preserve independence and quality of life (QOL); impaired self-perception, participation in social activities, hobbies, and relationships; and change in circumstances over time.</p><p><strong>Conclusion: </strong>These meaningful insights highlight the critical and emergent need for approved drug treatment(s) in this profoundly burdened patient population. Our results will serve as a comprehensive resource to inform the physician, patient, industry and advocacy communities on outcome measure selection and clinical trial design; and to help inform regulatory agencies in the United States Food and Drug Administration (FDA) drug approval process for MM.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251344763"},"PeriodicalIF":2.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of ovarian endocrine function in patients with lymphoma: a systematic review.","authors":"Hebatallah Ahmed Mohamed Moustafa, Al Shaimaa Ibrahim Rabie, Ahmed Abdullah Elberry, Ahmed Hassan Shaaban, Amany Mohamed Alboghdadly, Hind Khalid Goresh, Muath Fahmi Najjar, Mabrouk Al-Rasheedi, Raghda R S Hussein","doi":"10.1177/20406223251356815","DOIUrl":"10.1177/20406223251356815","url":null,"abstract":"<p><strong>Background: </strong>Lymphomas represent various groups of cancers. Its treatment has a cytotoxic effect on all body tissues, especially female ovaries, yielding premature ovarian insufficiency.</p><p><strong>Objectives: </strong>This study aimed to compare the fertility and ovarian preserving role of gonadotropin-releasing hormone agonists (GnRH-a) when administered in conjunction with chemotherapy in women treated for lymphomas.</p><p><strong>Design: </strong>Only prospective clinical trials were included in this systematic review.</p><p><strong>Data sources and methods: </strong>We searched for pertinent studies in PubMed, Web of Science, Cochrane Library, Google Scholar, and Scopus till April 2025. Available prospective clinical trials comparing patients with Hodgkin lymphoma and non-Hodgkin lymphoma receiving concurrent chemotherapy and GnRH-a with patients receiving chemotherapy alone were included. The main outcomes were cyclic ovarian function (COF), pregnancy rate, follicle-stimulating hormone (FSH) level, luteinizing hormone level, estradiol level, and anti-Mullerian hormone (AMH) level. Cochrane's risk of bias tool for clinical trials was used for the risk of bias assessment, and all the included studies were deemed of acceptable quality.</p><p><strong>Results: </strong>Twelve prospective clinical trials involving 733 women were analyzed, with 374 patients receiving GnRH-a and 359 as controls. The mean age of the GnRH-a group was 25.86 years, compared to 27.62 years in the control group. GnRH-a administration was associated with a notably higher COF, higher pregnancy rates, lower FSH levels, and higher AMH levels compared to controls. No significant difference between the groups was observed in estradiol levels.</p><p><strong>Conclusion: </strong>Co-administration of GnRH-a during chemotherapy in women with lymphoma appears to offer a protective effect against ovarian damage and supports fertility preservation in women with lymphoma. These findings advocate for the integration of GnRH-a into fertility preservation strategies, emphasizing its potential to improve long-term reproductive health in this vulnerable patient population. However, further high-quality, large-scale studies are warranted to standardize protocols and confirm these findings for broader clinical applications.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251356815"},"PeriodicalIF":2.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis.","authors":"Wen-Kai Chu, Chih-Cheng Lai, Tai-Shuan Lai, Yen-Hung Lin, Vin-Cent Wu","doi":"10.1177/20406223251351779","DOIUrl":"10.1177/20406223251351779","url":null,"abstract":"<p><strong>Background: </strong>In the context of the COVID-19 pandemic, there is growing concern about the virus's effects on individuals with existing endocrine disorders such as primary aldosteronism (PA).</p><p><strong>Objectives: </strong>This study explores the potential relationship between PA and the risk of developing obstructive sleep apnea (OSA) after a COVID-19 infection.</p><p><strong>Design: </strong>In this retrospective cohort study, we utilized data from the TriNetX database, covering the period from January 2019 to January 2023. We identified essential hypertension (EH) patients as the control group, employing 1:1 propensity score matching.</p><p><strong>Methods: </strong>The endpoints included incident OSA and all-cause mortality.</p><p><strong>Results: </strong>Among 11,422,001 patients with PCR-positive COVID-19, we identified 3628 PA patients (mean 63.1 years, male 38.1%). After a median follow-up of 1.9 years, the rate of OSA was 28.9 per 1000 person-years in PA patients compared to EH with 16.7. We showed a significant increase in incident OSA (adjusted hazard ratio (aHR) 1.58, <i>p</i> < 0.001) and mortality (aHR 1.12, <i>p</i> = 0.04) in PA patients than EH post-COVID-19. The horizon plot revealed that patients with pre-existing PA had the highest risk of OSA at 2 months (aHR = 2.34) post-COVID-19. In subgroup analysis, PA patients with a high body mass index (⩾30 kg/m²; aHR 1.81, <i>p</i> = 0.001) or preserved kidney function (aHR 2.00, <i>p</i> < 0.001) had increased OSA incidences post-COVID-19.</p><p><strong>Conclusion: </strong>Our study underscores a notable rise in incident OSA among PA patients post-COVID-19, highlighting the imperative for diligent OSA screening, particularly among individuals with obesity or preserved kidney function.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251351779"},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic and lifestyle factors associated with chronic musculoskeletal disorders in Brazil: a network analysis of a population-based study involving 87,648 Brazilian adults.","authors":"Arão Belitardo de Oliveira, Yohannes Woubishet Woldeamanuel, Gabriel Taricani Kubota, Priscilla B Delgado, Yane C Pelicer, Kriscia Partamian, Larissa Karen Pereira, Madeline Welch, Roy La Touche, Álvaro Reina-Varona, Dale S Bond, Isabela M Benseñor, Alessandra C Goulart","doi":"10.1177/20406223251350884","DOIUrl":"10.1177/20406223251350884","url":null,"abstract":"<p><strong>Background: </strong>Musculoskeletal disorders (MSKDs) are the leading cause of disability worldwide. The associations between socioeconomic and lifestyle factors and MSKDs have been widely studied in Europe and North America. However, little data are available about their relationship in Latin America.</p><p><strong>Objectives: </strong>To estimate the prevalence of chronic MSKDs in Brazil and assess their relationship with socioeconomic and lifestyle factors.</p><p><strong>Design: </strong>This is a cross-sectional study, based on a subanalysis of the open-access database from the Brazilian National Health Survey 2019. This survey was a nationwide, cross-sectional, door-to-door study that included 87,648 adults and was conducted between 2019 and 2020.</p><p><strong>Methods: </strong>Prevalence estimates were based on weighted sample strata, and the relationship between MSKD and socioeconomic and lifestyle factors was examined through network analysis and weighted Poisson regression models with robust variance.</p><p><strong>Results: </strong>The weighted prevalence of chronic MSKDs was estimated at 26.1% (95% confidence interval, 25.5%-26.8%). In the network analysis, including all socioeconomic and lifestyle variables, MSKDs prevalence was notably linked to higher body mass index, drinking, smoking, and low income. In the regression models, MSKD prevalence was associated with obesity, sleep disorders, smoking, alcohol consumption, and depression, and inversely associated with physical activity, even after controlling for the sociodemographic disparities.</p><p><strong>Conclusion: </strong>This study identifies specific socioeconomic and lifestyle factors associated with MSKDs and highlights the need for immediate national health promotion programs focused on MSKDs prevention through targeted lifestyle modifications, especially in populations belonging to the lower-income strata in Brazil.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251350884"},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144544968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Italian validation of the credibility/expectancy questionnaire in spinal pain: a useful tool for clinicians and physiotherapist (CEQ-I).","authors":"Teresa Paolucci, Laura Belinda Rizzo, Giulia Patacchia, Chiara Sebastiani, Luca Furcas, Francesca Capuano, Marco Paoloni, Marta Di Nicola, Letizia Pezzi, Paola Borrelli","doi":"10.1177/20406223251324812","DOIUrl":"10.1177/20406223251324812","url":null,"abstract":"<p><strong>Background: </strong>The \"credibility\" and \"expectation\" regarding the treatment are important factors in the rehabilitation management of patients with spinal pain (SP).</p><p><strong>Objectives: </strong>The aim of this study was to translate, culturally adapt, and validate an Italian version of the credibility/expectancy questionnaire (CEQ-I) by Devilly and Borkovec (CEQ) for its application in SP in rehabilitative care.</p><p><strong>Design: </strong>Cross-sectional observational study.</p><p><strong>Methods: </strong>Ninety-nine patients (<i>N</i> = 99; mean age of 56.9 years ± 16.3 SD) with acute or chronic SP were recruited from September 2023 to September 2024. To evaluate construct validity, exploratory factor analysis (EFA) was conducted using a matrix of polychoric correlations along with promax rotation. The internal consistency and stability of the scale were evaluated using Cronbach's alpha coefficient and test-retest analysis through the intraclass correlation coefficient (ICC). Pearson's analysis between CEQ and other scales (Numeric Rating Scale, NRS; Roland and Morris-Disability Questionnaire, RMDQ; Oswestry Disability Index, ODI; Neuropathic Pain Symptom Inventory, NPSI) was employed to assess external validity.</p><p><strong>Results: </strong>Ninety-nine subjects were recruited. Test-retest reliability between two consecutive administrations of the CEQ showed an ICC of 0.90 (<i>p</i> < 0.001). The Kaiser-Meyer-Olkin (KMO) statistic was 0.81, indicating suitability for factor analysis. EFA revealed two factors-credibility and expectancy-accounting for 56.6% of the variance. Cronbach's alpha indicated high internal consistency (0.85). External validation using Pearson's correlation found no significant relationships between the CEQ subscale scores and NRS, RMDQ, ODI, and NPSI scales.</p><p><strong>Conclusion: </strong>The CEQ-I is a valid Italian translation of CEQ that demonstrates acceptable psychometric properties in SP in a rehabilitative setting. However, we recommend further analysis of the construct definition of the CEQ-I.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251324812"},"PeriodicalIF":3.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}