Hepatitis and periodontal health: an emerging oral-liver axis.

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Therapeutic Advances in Chronic Disease Pub Date : 2025-08-20 eCollection Date: 2025-01-01 DOI:10.1177/20406223251368090
Ruth Rodríguez-Montaño, Melissa Martínez-Nieto, Gustavo Eder González-Alvarez, Mario Alberto Alarcón-Sánchez, Julieta Sarai Becerra-Ruiz, Artak Heboyan, Alba Ruiz-Gaitán, Sarah Monserrat Lomelí-Martínez
{"title":"Hepatitis and periodontal health: an emerging oral-liver axis.","authors":"Ruth Rodríguez-Montaño, Melissa Martínez-Nieto, Gustavo Eder González-Alvarez, Mario Alberto Alarcón-Sánchez, Julieta Sarai Becerra-Ruiz, Artak Heboyan, Alba Ruiz-Gaitán, Sarah Monserrat Lomelí-Martínez","doi":"10.1177/20406223251368090","DOIUrl":null,"url":null,"abstract":"<p><p>Periodontitis and viral liver infections, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), are chronic inflammatory conditions with a high prevalence worldwide. Recent evidence establishes a possible bidirectional relationship between the two, based on shared immunological, microbial, and inflammatory mechanisms. The objective of this study was to analyze and synthesize the scientific literature on the interactions between viral hepatitis and periodontal health. Through a structured search of the PubMed, Scopus, and Web of Science databases, studies published in the last 20 years that explored the link between viral hepatitis and periodontitis were integrated. The findings from the reviewed studies show consistent, positive associations between HBV and HCV viruses and a higher prevalence and severity of periodontitis. Some studies show increased levels of proinflammatory cytokines (such as IL-6 and TNF-α) and immune dysfunction in participants with both diseases. Additionally, viral markers (such as HBsAg and HCV RNA) have been identified in gingival crevicular fluid, suggesting the presence of oral viral reservoirs. Ultimately, scientific evidence suggests a bidirectional relationship between viral hepatitis and periodontitis, influenced by systemic inflammation, immunological alterations, and microbial dysbiosis. The collected data support the relevance of interdisciplinary management between medical and dental professionals in patients with viral liver conditions.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"16 ","pages":"20406223251368090"},"PeriodicalIF":2.8000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368331/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Chronic Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/20406223251368090","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

Periodontitis and viral liver infections, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), are chronic inflammatory conditions with a high prevalence worldwide. Recent evidence establishes a possible bidirectional relationship between the two, based on shared immunological, microbial, and inflammatory mechanisms. The objective of this study was to analyze and synthesize the scientific literature on the interactions between viral hepatitis and periodontal health. Through a structured search of the PubMed, Scopus, and Web of Science databases, studies published in the last 20 years that explored the link between viral hepatitis and periodontitis were integrated. The findings from the reviewed studies show consistent, positive associations between HBV and HCV viruses and a higher prevalence and severity of periodontitis. Some studies show increased levels of proinflammatory cytokines (such as IL-6 and TNF-α) and immune dysfunction in participants with both diseases. Additionally, viral markers (such as HBsAg and HCV RNA) have been identified in gingival crevicular fluid, suggesting the presence of oral viral reservoirs. Ultimately, scientific evidence suggests a bidirectional relationship between viral hepatitis and periodontitis, influenced by systemic inflammation, immunological alterations, and microbial dysbiosis. The collected data support the relevance of interdisciplinary management between medical and dental professionals in patients with viral liver conditions.

Abstract Image

Abstract Image

Abstract Image

肝炎和牙周健康:一个新兴的口腔-肝脏轴。
牙周炎和病毒性肝脏感染,特别是乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV),是世界范围内高患病率的慢性炎症。最近的证据表明,基于共同的免疫、微生物和炎症机制,两者之间可能存在双向关系。本研究的目的是分析和综合有关病毒性肝炎与牙周健康相互作用的科学文献。通过对PubMed、Scopus和Web of Science数据库的结构化搜索,整合了过去20年来发表的关于病毒性肝炎和牙周炎之间联系的研究。回顾的研究结果显示,HBV和HCV病毒与牙周炎的较高患病率和严重程度之间存在一致的正相关。一些研究表明,这两种疾病的参与者的促炎细胞因子(如IL-6和TNF-α)水平升高,免疫功能紊乱。此外,在龈沟液中发现了病毒标记物(如HBsAg和HCV RNA),提示存在口腔病毒库。最终,科学证据表明病毒性肝炎和牙周炎之间存在双向关系,受全身炎症、免疫改变和微生物生态失调的影响。收集到的数据支持医学和牙科专业人员对病毒性肝病患者进行跨学科管理的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Therapeutic Advances in Chronic Disease
Therapeutic Advances in Chronic Disease Medicine-Medicine (miscellaneous)
CiteScore
6.20
自引率
0.00%
发文量
108
审稿时长
12 weeks
期刊介绍: Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信