The Journal of Phytopharmacology最新文献

{"title":"Functional properties and health benefits of finger millet (Eleusine coracana L.): A review","authors":"Pranita Patil, S. Singh, Pankti Patel","doi":"10.31254/phyto.2023.12308","DOIUrl":"https://doi.org/10.31254/phyto.2023.12308","url":null,"abstract":"In India, ragi is the colloquial name for finger millet (Eleusine coracana L.). It is sometimes recognised as poor man’s food. Ragi flour is used to baked items to create calcium and iron-fortified biscuits. Calcium deficiency may cause birth abnormalities and dental problems. Ragi is good source of iron, which is crucial for the production of haemoglobin in red blood cells. Nutritionally, finger millets are rich in calcium, potassium, dietary fibres and polyphenolic constituents. Some individuals are allergic to protein gluten causing immune reaction. Gluten intolerance leads to chronic inflammatory bowel disorder. An ongoing strict diet (GFD) is the only solution available for these illnesses. Gluten-free products have less nutritional content and to be more expensive other lactose food products. They are well known for their health benefits like antidiabetic, antioxidant and antimicrobial properties. Hence, finger millets are naturally gluten free, these can be consumed by both gluten intolerant as well as diabetic individuals.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90331303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Diverse Bioactive Compounds from Medicinal Plants: A Review","authors":"R. Dar, Mohd. Shahnawaz, Muzaffer Ahmad Ahanger, I. Majid","doi":"10.31254/phyto.2023.12307","DOIUrl":"https://doi.org/10.31254/phyto.2023.12307","url":null,"abstract":"Bioactive chemicals have been abundantly found in medicinal plants that hold immense potential for therapeutic applications. This review aims to explore the diverse range of medicinal plant bioactive substances and their pharmacological activities. The review opens by underlining the significance of medicinal plants as important sources for developing new drugs. The relevance of various extraction techniques and analytical procedures is emphasized as the methods used for the identification and extraction of bioactive components from these plants is covered in detail. The subsequent sections focus on specific categories of bioactive compounds and their associated pharmacological activities. We examine the possible uses of bioactive substances obtained from medicinal plants in the treatment of infectious disorders as well as their antibacterial characteristics. These chemicals' anti-inflammatory and antioxidant properties are also examined, emphasizing their potential for treating inflammatory diseases and oxidative stress. The review also explores the anti-cancer potential of bioactive substances from therapeutic plants, illuminating their methods of action and their potential as innovative therapeutic agents. Furthermore, the neuroprotective and neuro-pharmacological effects of these compounds are discussed, emphasizing their relevance in neurological disorders. Immunomodulatory properties and cardiovascular health benefits of bioactive compounds from medicinal plants are also examined, providing insights into their potential applications in immunotherapy and cardiovascular disease management.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89541182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a recipe based on three leafy vegetables consumed in Brazzaville on the reproductive function of the wistar rat","authors":"Bml Peneme, LR Miamb, O. A. Etou, D. Lepondo, H. Akassa, A. Abena","doi":"10.31254/phyto.2023.12306","DOIUrl":"https://doi.org/10.31254/phyto.2023.12306","url":null,"abstract":"Spinacia oleracea, Amaranthus hybridus of the Chenopodiaceae family and Brassica campestris of the Brassicaceae family are vegetables consumed in Brazzaville for their nutritional virtues. The aim of this study is to evaluate the effects of the recipe based on these three leafy vegetables on reproductive functions. The recipe at doses of 250, 500 and 1000 mg/Kg was administered to male and female rats. The aphrodisiac effects of the recipe in males were evaluated on the numbers of sexual mounts, erections, ejaculations, and latency time; and the estrogenic activities in females, based on the variation of the sexual cycle, the state of the vaginal meatus and the cervical mucus. On acute toxicity, the results show that the aqueous extract (EA) of the recipe does not alter the general condition and behaviour of mice, and no mortality was recorded. In male rats the 500 mg/Kg recipe extract significantly increased the number of sexual mounts, erections, and ejaculations; and decreased the latency time. In females, the 500 mg/kg dose of the extract caused blocking of the cycle in oestrus and pro-oestrus, with increased cervical mucus and vaginal opening. Estradiol levels were also increased. The flavonoids, saponosides and steroids observed in this extract could be responsible for the effects observed on the sexual parameters studied in male and female rats.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90209228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueou Extract of the seeds of Pithecellobium dulce (Fabaceae) Demontrates Anti-inflammatory Effect Through Anti-oxydant Activity Enhancement in a Rodent Model of on Hemorrhoidal disease induced by Acetic Acid","authors":"A. À. K. Gisèle, Takvou Francis, Egre Finsia, Zramah Mathieu, Dpd Dzeufiet","doi":"10.31254/phyto.2023.12301","DOIUrl":"https://doi.org/10.31254/phyto.2023.12301","url":null,"abstract":"After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ˂ 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74934128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute toxicity, phytochemicals, and nutrient composition of Moringa oleifera leaves, a plant used as a food supplement in the tropical region of Nigeria","authors":"E. Odumeru, Costelia C Njoku, S. Ijioma, Agwunobi Kelechi","doi":"10.31254/phyto.2023.12304","DOIUrl":"https://doi.org/10.31254/phyto.2023.12304","url":null,"abstract":"Introduction: The moringa oleifera (MO) plant is popularly known as the “miracle tree”. The uses of MO leaf extract in controlling high blood pressure and as a food supplement with high nutritional value have been documented scientifically. Some studies have also shown that dosages appear to be safe from tested toxicity but a relative increase such as 3-4 times the recommended doses is known to cause genotoxic damage. However, there is a paucity of human evidence of the potency of MO presently, most studies use animal models such as rats and ethanol extract. Objective: The study aims to assess the acute toxicity lethal and sublethal doses (LD50) of MO using Swiss albino mice and its phytochemical constituents in our locality where consumption is very high. Methods: The ethanol extraction method was used to obtain the concentrates of 100 g, and thirty (30) adult mice (30 - 40g) were used for Acute Toxicity (LD50). Phytochemical analyses were carried out to determine the major Bio-constituents. Result: Showed that LD50 of 3900 mg/kg produced death in mice. Piloerection amongst others and weight gain were observed in sublethal doses. Carbohydrates (36.6%), Calcium, Phenol, Ascorbic acid, and Methyl Octadecenoate (30%) recorded the highest constituents. Conclusion: it is safe to consume MO to promote health in the right doses.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75720505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous extract of Zingiber officinale attenuates carbon tetrachloride induced hepatorenal injury in albino rats","authors":"T. Ogunmoyole, O. J. Agunbiade","doi":"10.31254/phyto.2023.12305","DOIUrl":"https://doi.org/10.31254/phyto.2023.12305","url":null,"abstract":"The rising burden of liver and kidney diseases is taking a global dimension and could threaten public health with devastating consequences. Most patients cannot cope with the cost of conventional treatment particularly in developing nations, hence there is a dire need for a cheaply available but potent alternative in the management of hepatorenal disorders. This study therefore investigates the therapeutic potential of ginger (Zingiber officinale) in rat model of hepatorenal toxicity. Twenty-five adult male albino rats were randomly divided equally into five groups. Groups I and II served as positive and negative control respectively and were administered with distilled water and CCl4 respectively. Group III and IV received a single intraperitoneal injection of 3 ml/kg b.w CCl4 and were post-treated with 50 mg/kg b.w. and 100 mg/kg b.w of Z. officinale extract respectively. Animals in group V were post-treated with standard drug (silymarin (100 mg/kg b.w.)) after exposure to CCl4. Activities of aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), as well as levels of urea, uric acid and bilirubin were determined. Lipid profile as well as reduced glutathione (GSH) were determined in the serum and organs’ homogenates. Level of reduced glutathione (GSH) as well as activities of superoxide dismutase (SOD) and catalase (CAT) were also assayed. Exposure to CCl4 caused a marked derangement in lipid profile, inhibition of CAT and SOD, increase in the levels of AST, ALP, ALT, bilirubin, urea and uric acid coupled with depletion in GSH level relative to control animals. Oral intervention of Z. officinale extract in CCl4-exposed animals resulted in the restoration of deranged lipid profiles, activity of antioxidant enzymes as well as liver and kidney biomarkers. The study suggests that Z. officinale has potentials that can be exploited for hepato-protection and nephroprotection.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84973563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity, cytotoxicity, and qualitative phytochemical composition of aqueous and methanolic leaf extracts of Physalis peruviana L. (Solanaceae)","authors":"S. Njoroge, J. Mbaria, G. Aboge, G. Moriasi","doi":"10.31254/phyto.2023.12302","DOIUrl":"https://doi.org/10.31254/phyto.2023.12302","url":null,"abstract":"Background: The high morbidity and mortality associated with microbial infections and the ineffectiveness of conventional antibiotics due to inappropriate use and resistance warrant alternative stratagems. Aim: We investigated the antimicrobial, cytotoxicity, and qualitative phytochemical composition of the aqueous and methanolic leaf extracts of Physalis peruviana L. (Solanaceae) based on its ethnomedicinal information. Methods: The antimicrobial activity of the extracts was investigated using the disk diffusion technique. The brine shrimp lethality assay method was used to determine the cytotoxicity of the study extracts on brine shrimp nauplii. Qualitative phytochemistry of the study extracts was performed using standard procedures. Results: The two extracts did not possess antimicrobial activity against P. aeruginosa and were either inactive or slightly inactive against the other microbes at concentrations of ≤ 50 µg/ml. Notably, the aqueous extract exhibited high to very high activities against E. coli and S. aureus and very high to remarkable activities against B. cereus. The methanolic extract showed remarkable activity at concentrations of ≥200 µg/ml against E. coli, moderate to very high against S. aureus, high to very high against B. cereus, and moderate to high against C. albicans. The aqueous extract's minimum inhibitory concentrations (MICs) were 50 μg/ml (E. coli and B. cereus), 100 μg/ml (S. aureus), and 200 μg/ml (C. albicans). The minimum bactericidal concentration concentrations (MBCs) of the aqueous extract were 100 μg/ml (E. coli and B. cereus), 200 μg/ml (S. aureus), while the minimum fungicidal concentration (MFC) for C. albicans was 400 μg/ml. The MICs of the methanolic extract were 25 μg/ml for E. coli, S. aureus, and B. cereus and 100 μg/ml for C. albicans, and the MBCs were 100 μg/ml for E. coli, S. aureus, and B. cereus, and the MFC for C. albicans was 200 μg/ml. The aqueous was non-toxic, while the methanolic extract was slightly toxic to brine shrimp nauplii, indicating their relative safety. Various phytochemicals were detected in the study extracts, depicting broad pharmacologic activity, including antimicrobial activity. Conclusion: The aqueous and methanolic leaf extracts of P. peruviana may serve as a source of efficacious and safe novel antimicrobial agents upon further evaluation.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81542898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Aqueous Leaf Extract of Vernonia amygdalina on High-Fat Diet-Induced Injury in the Heart and Aorta of the Adult Wistar Rat","authors":"MB EHI-Omosun, G. Eze","doi":"10.31254/phyto.2023.12205","DOIUrl":"https://doi.org/10.31254/phyto.2023.12205","url":null,"abstract":"The aim of this study was to investigate the effects of aqueous leaf extract of Vernonia amygdalina in Wistar rats fed with high-fat diet. 30 adult Wistar rats weighing between 250g and 280g were randomly assigned into 5 groups of 6 rats per group. Group A rats were placed on rat food and water only. Group B rats received 1000mg/kg body weight / day (BWT/D) of margarine. Group C rats received 300mg/kg BWT/D of V. amygdalina. Group D rats received 1000mg/kg BWT/D of margarine and 150mg/kg BWT/D of V. amygdalina. Group E rats received 1000mg/kg BWT/D of margarine and 300mg/kg BWT/D of V. amygdalina. The dosages were given for 56days via orogastric method. The biochemical outcome showed that Group B revealed decrease in high density lipoprotein (HDL) and marked elevation in the total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), and superoxide dismutase (SOD) levels when compared with the other groups. Histologcally, Group B showed moderate stenosis, perivascular fibrosis, asymmetrical vascular hypertrophy and mild intimal erosion while Group A, C, D and E revealed normal myocardium and vascular architecture. In conclusion, the aqueous leaf extract of Vernonia amygdalina have antihyperlipidemic and antioxidant properties against margarine-induced injury in the heart and aorta of Wistar rats.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78435402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on Genetic Diversity for Quantitative Characters in Quinoa (Chenopodium quinoa Willd.)","authors":"S. Pawar, TD Katore, P. Shinde, HJ Rajput","doi":"10.31254/phyto.2023.12206","DOIUrl":"https://doi.org/10.31254/phyto.2023.12206","url":null,"abstract":"The 30 genotypes of Quinoa (Chenopodium quinoa Willd.) were studied for genetic diversity for nine different quantitative traits. Genotypes were grouped into eleven clusters. Cluster I was the largest cluster with 11 genotypes followed by cluster II with 7 genotypes, cluster V, IX, XI with 2 genotypes each while, cluster III, IV, VI, VII, VIII and X were solitary. The calculated D2 values varied from 2.37 to 12.05. The maximum intra cluster distance was observed for cluster XI and inter cluster distance was maximum between cluster X and V. Highest mean values showed by cluster IX for characters inflorescence length, inflorescence per plant, plant height, branches per plant, Seed volume weight, seed yield days to flowering and maturity. Cluster III showed highest mean value for characters branches per plant, inflorescence per plant, inflorescence length, inflorescence width and Seed volume weight. The character days to maturity (28.97 %) showed maximum contribution towards the total divergence. It was followed by inflorescence width (20.00 %), no of branches per plant (14.94 %), days to 50 % flowering (14.48 %), seed volume weight/10 ml (7.13 %) and inflorescence length (5.98). Based on inter-cluster distance, intra-cluster distance and per se performance the genotypes viz., EC-896097, EC-896108, EC-896212, EC-896209 and IC-411824 can be used for future breeding programme.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"268 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91461634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico Evaluation of Indian Medicinal Plants to Find the Potential Remedy for Mycobacterium tuberculosis","authors":"C. Srinath, T. Raja, V. Umabarathi, A. Logeshwaran, P. Ravikumar","doi":"10.31254/phyto.2023.12201","DOIUrl":"https://doi.org/10.31254/phyto.2023.12201","url":null,"abstract":"Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis bacterium. The bacterium primarily affects the lungs, but they can also harm other organs. The goal of this study was to identify potential phytocompounds from Indian medicinal plants that could be used to treat Tuberculosis. IMPPAT and the PubChem database were used to determine the 3D structure of phytocompounds. SwissADME was used to test the Lipinski rule of five for all phytocompounds. The target protein's 3D structure was downloaded from the PDB library. PyRx was used to conduct the docking studies, and Discovery Studio 2021 was used to analyse the results. The phytocompounds Diosgenin, Agapanthagenin, and Liquiritic acid showed very strong binding affinity of -9.6, -9.6, and -9.2 Kcal/mol, respectively, according to the results.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"330 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85125221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}