Aqueou Extract of the seeds of Pithecellobium dulce (Fabaceae) Demontrates Anti-inflammatory Effect Through Anti-oxydant Activity Enhancement in a Rodent Model of on Hemorrhoidal disease induced by Acetic Acid

Abstract

After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ˂ 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.