A. À. K. Gisèle, Takvou Francis, Egre Finsia, Zramah Mathieu, Dpd Dzeufiet
{"title":"豆科青花种子水提物通过增强醋酸致痔疮鼠模型的抗氧化活性,显示出抗炎作用","authors":"A. À. K. Gisèle, Takvou Francis, Egre Finsia, Zramah Mathieu, Dpd Dzeufiet","doi":"10.31254/phyto.2023.12301","DOIUrl":null,"url":null,"abstract":"After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ˂ 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"92 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aqueou Extract of the seeds of Pithecellobium dulce (Fabaceae) Demontrates Anti-inflammatory Effect Through Anti-oxydant Activity Enhancement in a Rodent Model of on Hemorrhoidal disease induced by Acetic Acid\",\"authors\":\"A. À. K. Gisèle, Takvou Francis, Egre Finsia, Zramah Mathieu, Dpd Dzeufiet\",\"doi\":\"10.31254/phyto.2023.12301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ˂ 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.\",\"PeriodicalId\":22851,\"journal\":{\"name\":\"The Journal of Phytopharmacology\",\"volume\":\"92 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Phytopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31254/phyto.2023.12301\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Phytopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31254/phyto.2023.12301","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Aqueou Extract of the seeds of Pithecellobium dulce (Fabaceae) Demontrates Anti-inflammatory Effect Through Anti-oxydant Activity Enhancement in a Rodent Model of on Hemorrhoidal disease induced by Acetic Acid
After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ˂ 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.