豆科青花种子水提物通过增强醋酸致痔疮鼠模型的抗氧化活性,显示出抗炎作用

A. À. K. Gisèle, Takvou Francis, Egre Finsia, Zramah Mathieu, Dpd Dzeufiet
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引用次数: 0

摘要

末次治疗后,所有动物均接受5%醋酸肛门穿刺至痔疮粘膜下层。服用醋酸可显著降低血压(p小于0.01;P < 0.001),与阴性对照相比,250和500 mg/kg剂量组的体重和直肠-肛门系数显著降低。不同剂量(125、250和500 mg/kg)预处理组大鼠血清一氧化氮(NO)、丙二醛(MDA)浓度较阴性对照组和正常对照组显著降低(p < 0.05 p < 0.01), SOD、CAT和GHS水平较阴性对照组显著升高(p < 0.05和p < 0.001)。组织学切片显示肛门黏膜细胞再生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aqueou Extract of the seeds of Pithecellobium dulce (Fabaceae) Demontrates Anti-inflammatory Effect Through Anti-oxydant Activity Enhancement in a Rodent Model of on Hemorrhoidal disease induced by Acetic Acid
After the last treatment, all animals received 5 % acetic acid anal route to the hemorrhoidal submucosa. Administration of acetic acid resulted in a significant reduction (p ˂ 0.01; p < 0.001) in body weight and recto-anal coefficient at doses of 250 and 500 mg/kg compared to the negative control. In addition, the concentration of nitric oxide (NO), MDA were significantly reduced (p < 0.05 p < 0.01) in the groups pretreated with different doses of the extract (125, 250 and 500 mg/kg) compared to negative and normal control with a significant increase (p < 0.05 and p < 0.001) in the level of SOD, CAT and GHS compared to the negative control. Histological sections showed cellular regeneration in the anal mucosa.
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