Tanaffos最新文献_第5页

Comparison of Morbidity, Mortality, and Costs of VAP Patients with Non-VAP Patients in the Tertiary Referral Hospital of Kerman, Iran. 伊朗克尔曼三级转诊医院VAP患者与非VAP患者的发病率、死亡率和费用比较。

Tanaffos Pub Date : 2023-01-01

Maryam Ahmadipour, Marzieh Lashkari, Mehdi Ahmadinejad

{"title":"Comparison of Morbidity, Mortality, and Costs of VAP Patients with Non-VAP Patients in the Tertiary Referral Hospital of Kerman, Iran.","authors":"Maryam Ahmadipour, Marzieh Lashkari, Mehdi Ahmadinejad","doi":"","DOIUrl":"","url":null,"abstract":"Background: Ventilator-associated pneumonia is the most common type of nosocomial infection in ICUs. Hence, this study shall focus on the morbidity, mortality, and costs associated with this infection among ICU patients.Materials and methods: The current research is a prospective descriptive-analytical study. The study population included patients admitted to the Tertiary Referral Hospital of Kerman University of Medical Sciences who were enrolled in the study according to inclusion criteria and demographic characteristics data, length of stay in ICU and general wards, and direct and indirect medical expenses such as unemployment and rehabilitation cost, etc.Results: Nine of the 144 patients studied died. (4 in the Ventilator-Associated Pneumonia (VAP) group and 5 in the non-VAP group). Among them, the prevalence of Acinetobacter Baumannii was significantly higher than other bacteria (P-Value=0.001). The duration of hospitalization in the ICU (18±9 vs. 9.5±6 days) and recovery time (21.6±9 9.6 vs. 13.2±7 days) were higher in the VAP group (P-Value<0.05). Moreover, the duration of hospitalization in the general ward was 15.4±8 days in the VAP group and 10.6±6 days in the non-VAP group (P-Value<0.05). The cost of treatment in the VAP group ($7952.28) was significantly higher than in the non-infected group ($4400.98). The average rehabilitation cost in the VAP group was $2571.42 and in the non-affected group was $1530.88. The financial loss due to the delay in work starting was $482 in the non-VAP group which was significantly less than the VAP group ($792).Conclusion: Having VAP can significantly increase mortality, length of stay in the ICU as well as increase direct and indirect costs for patients.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F-18 FDG PET/CT as a One-Stop Shop Imaging Modality for Assessment of Neurologic and Pulmonary Manifestations of COVID-19. F-18 FDG PET/CT作为一种一次性商店成像模式，用于评估新冠肺炎的神经和肺部表现。

Tanaffos Pub Date : 2023-01-01

Abbas Yousefi-Koma, Farahnaz Aghahosseini, Hannaneh Yousefi-Koma, Alireza Roohizadeh, Mojgan Panahmoghaddam

引用次数: 0

Lupus Anticoagulant Is Associated with Critical Cases and High Mortality in COVID-19: A Literature Review. 新冠肺炎中狼疮抗凝与危重病例和高死亡率相关：文献综述。

Tanaffos Pub Date : 2023-01-01

Maral Moafi, Mohammad Javad Ebrahimi, Firouze Hatami, Farid Javandoust Gharehbagh, Arman Ahmadzadeh, Mohammad Mehdi Emam, Alireza Rajaei, Davood Mansouri, Ilad Alavi Darazam

{"title":"Lupus Anticoagulant Is Associated with Critical Cases and High Mortality in COVID-19: A Literature Review.","authors":"Maral Moafi, Mohammad Javad Ebrahimi, Firouze Hatami, Farid Javandoust Gharehbagh, Arman Ahmadzadeh, Mohammad Mehdi Emam, Alireza Rajaei, Davood Mansouri, Ilad Alavi Darazam","doi":"","DOIUrl":"","url":null,"abstract":"Background: In severe COVID-19 cases, a hypercoagulable state may occur. Antiphospholipid syndrome-related auto-antibodies (APSRAs) contribute to coagulopathy, but their role in COVID- 19 remains unclear. We aimed to investigate the prevalence of positive APSRAs and their effect on clinical outcomes in confirmed COVID-19 patients.Materials and methods: In this cross-sectional study, severe hospitalized COVID-19 cases were enrolled. Demographic and clinical data were obtained from the day of admission. APSRAs including IgG and/or IgM anticardiolipin (aCL) and anti-β2-glycoprotein1 (anti-β2GP1) as well as lupus anticoagulant (LAC) were measured.Results: In this study, 54 severe COVID-19 cases with positive RT-PCR and chest CT scans were recruited. Positive APSRAs were found in 7 (12.9%) patients. Positive LAC was a more prevalent marker as compared to other tests (11.1%). The prevalence of positive aCL (IgM or IgG) and anti-ß2 GPI (IgM or IgG) was 1.8% (in an elderly woman). Lower oxygen saturation was found in the positive APSRAs group as opposed to the negative APSRAs group (70.3±9 vs. 84.8±9.7%). The mortality rate in the positive APSRAs group was significantly higher relative to the negative APSRAs group (83.3% vs. 27.1%; P-value: 0.01). Likewise, the mechanical ventilation requirement in the positive group was also higher (50% vs. 27.1%, P-value: 0.28).Conclusion: This study indicated that LAC might be associated with critical cases and high mortality of COVID-19. Nonetheless, the mortality was not related to macrothrombotic incidence.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Mean Platelet Volume (MPV) and Mean Corpuscular Volume (MCV) with the Outcome of Patients with Acute Exacerbation of COPD. 平均血小板体积（MPV）和平均肌肉体积（MCV）与COPD急性加重患者预后的关系。

Tanaffos Pub Date : 2023-01-01

Maryam Ziaei, Meysam Sabaghzade, Mehdi Galavi, Ali Abdolrazaghnejad

{"title":"Relationship of Mean Platelet Volume (MPV) and Mean Corpuscular Volume (MCV) with the Outcome of Patients with Acute Exacerbation of COPD.","authors":"Maryam Ziaei, Meysam Sabaghzade, Mehdi Galavi, Ali Abdolrazaghnejad","doi":"","DOIUrl":"","url":null,"abstract":"Background: Mean platelet volume (MPV) reflects the platelet production rate and stimulation, while mean corpuscular volume (MCV) represents the average size of red blood cells. Considering the possibility of the relationship between red cell index changes and different severities of chronic obstructive pulmonary disease (COPD) as well as the uncertainty of the available results in this regard, the present study aimed at evaluating the relationship between MPV and MCV in the outcome of patients with acute exacerbation of COPD (AECOPD).Materials and methods: In this cross-sectional analytical study, 150 patients with AECOPD that referred to the emergency department (ED) were included in the study. The severity of the disease was recorded using the GOLD classification, and the MPV and the MCV were evaluated based on the reference range of kits in the laboratory. Then, the data were analyzed using SPSS software.Results: The mean MPV and MCV were 9.7±8.3 and 85.9±11.5, respectively, and had no significant difference in different severities of COPD(P>0.05). Moreover, although MCV in survivals with a mean of 88.81±6.47 was higher than that of non-survivals with a mean of 85.77±11.73, and MPV in the non-survivals with a mean of 8.53±9.74 was higher than that of survivals with the mean of 8.86±0.92, this difference was not statistically significant (P>0.05).Conclusion: Overall, the results of this study showed that the mean MPV and MCV did not have any significant relationship with AECOPD and patient outcome.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Dependent Changes in COVID-19 Severity Based on the Information of Patients Referring to Masih Daneshvari Hospital, Tehran, Iran. 基于伊朗德黑兰Masih Daneshvari医院患者信息的新冠肺炎严重程度随时间的变化。

Tanaffos Pub Date : 2023-01-01

Mehdi Kazempour-Dizaji, Ali Zare, Mohammad Varahram, Atefeh Abedini, Arda Kiani, Rahim Roozbahani

{"title":"Time-Dependent Changes in COVID-19 Severity Based on the Information of Patients Referring to Masih Daneshvari Hospital, Tehran, Iran.","authors":"Mehdi Kazempour-Dizaji, Ali Zare, Mohammad Varahram, Atefeh Abedini, Arda Kiani, Rahim Roozbahani","doi":"","DOIUrl":"","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) is a newly emerged disease with many unknown facets, so both the treatment and the cause of spreading this disease have remained mysterious so far.Materials and methods: Based on the information of 4372 patients with COVID-19 referring to Dr. Masih Daneshvari Hospital in Tehran, the time-dependent changes in COVID-19 severity were investigated in this study using correlation analysis.Results: According to the results of this study, on average 154.80 patients were infected with mild to moderate COVID-19, and 39.06 were infected with severe COVID-19. The results of this study also indicated a descending trend in the number of patients with mild to moderate COVID-19 (r=-0.40, P-value=0.004) and an ascending trend in the number of patients with severe COVID-19 (r=0.43, P-value=0.003) overtime on a daily basis so that almost two patients were removed from those with mild to moderate COVID-19 and one was added to the patients with severe COVID-19 on average per day.Conclusion: Based on the current study results, it is concluded that COVID-19 severity will not be constant over time, and there is a probability of COVID-19 becoming more aggressive. Therefore, by the lack of timely control of the disease over time, we will witness an increased number of patients with severe COVID-19 and an increased number of hospitalizations in the intensive care unit (ICU) ward.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine Release Syndrome (CRS) in Severe COVID-19 Patients: Two Controversial and Interesting Case Reports and Literature Review. 新冠肺炎重症患者的细胞因子释放综合征（CRS）：两例有争议和有趣的病例报告和文献综述。

Tanaffos Pub Date : 2023-01-01

Biljana Lazovic, Radmila Dmitrovic, Isidora Simonovic, Antonio M Esquinas

{"title":"Cytokine Release Syndrome (CRS) in Severe COVID-19 Patients: Two Controversial and Interesting Case Reports and Literature Review.","authors":"Biljana Lazovic, Radmila Dmitrovic, Isidora Simonovic, Antonio M Esquinas","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cytokine release syndrome (CRS) represents a potentially life-threatening and systematic inflammatory response where it is noted an increase of secretion of proinflammatory cytokines from lymphocytes, myeloid cells like macrophages, dendritic cells, and monocytes. This syndrome is characteristic of some conditions such as viral infections, administration of antibody-based therapy, auto immune disease, and immunotherapy, especially in severe COVID-19 patients.Case reports: We presented two cases of COVID-19 patients in which the clinical picture significantly deteriorated during hospitalization, where the value of CRP, ferritin, LDH, and IL-6 dramatically increased, especially values of IL-6 were recorded over 2000. We treated them with third-generation cephalosporins, carbapenems, glycopeptides, metronidazole, anti-IL-6 inhibitor, low molecular weight heparin (LMWH), glucocorticoids, immunoglobulins (IVIG), and vitamins. Both patients were successfully treated and were discharged from the hospital with a recommendation for oral anticoagulant therapy.Conclusion: CRS is a complex syndrome. In the future, it is necessary to educate doctors about this syndrome, as well as to develop drugs whose goal would be to reduce the inflammatory response in already developed diseases.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management Strategies of COPD during the COVID-19 Pandemic. 新冠肺炎大流行期间慢阻肺的管理策略。

Tanaffos Pub Date : 2023-01-01

Anuj Kumar Pandey, Ajay Kumar Verma, Arpita Singh, Surya Kant, Rakesh Kumar Dixit, Shyam Chand Chaudhary, Umesh Pratap Verma

引用次数: 0

Combination of Serologic Tests and Sputum Culture Results as the Best Diagnostic Method of Pseudomonas aeruginosa Infection in Cystic Fibrosis Patients. 血清学检测和痰培养结果相结合是囊性纤维化患者铜绿假单胞菌感染的最佳诊断方法。

Tanaffos Pub Date : 2023-01-01

Ghamartaj Khanbabaee, Ali Ahani Azari, Negarin Seyyedirad, Lobat Shahkar

{"title":"Combination of Serologic Tests and Sputum Culture Results as the Best Diagnostic Method of Pseudomonas aeruginosa Infection in Cystic Fibrosis Patients.","authors":"Ghamartaj Khanbabaee, Ali Ahani Azari, Negarin Seyyedirad, Lobat Shahkar","doi":"","DOIUrl":"","url":null,"abstract":"Background: One of the most common reasons for mortality in patients with cystic fibrosis (CF) is lung infections, among which Pseudomonas aeruginosa (Pa) infection has the largest share. Diagnosis of Pa can be assessed by various methods such as sputum culture results and IgG antibody level via measuring the specific anti-Pa antibodies. This study aimed to select the best predictive technique in the diagnosis of Pa in CF patients through spirometry, sputum culture, and serum IgG antibody levels.Materials and methods: In this cross-sectional study, blood and sputum or pharyngeal samples were taken from 68 patients with cystic fibrosis. Because spirometry was not possible in all patients, 34 patients could do the spirometry. The samples were studied concerning Pa infection. The data including variables such as age, sex, and spirometry results were obtained. Then, in the serologic method, 3 serum-specific antibody levels were determined by enzyme-linked immune sorbent assay (ELISA).Results: The average age of children was 7.4 ± 5.6 (ranging from 0.5 to 23) years. Generally, the percentage of Pa infection increased in CF patients with higher ages. A statistically direct significant relationship was observed between the concentration of serum IgG antibodies in patients with CF and Pa-positive sputum culture results (p<0.05).Conclusion: Serum IgG antibodies against specific Pa antigens could be a diagnostic method against Pa infection, especially in patients who cannot expectorate. However, because of the positive and negative predictive value of both serum IgG antibody levels and the results of the sputum culture, we suggested that utilizing the combination of these methods could be beneficial in earlier diagnosis of Pa.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-Derived Antioxidants for Management of COVID-19: A Comprehensive Review of Molecular Mechanisms. 用于新冠肺炎治疗的植物衍生抗氧化剂：分子机制的全面综述。

Tanaffos Pub Date : 2023-01-01

Tahmineh Mokhtari, Maryam Azizi, Fatemeh Sheikhbahaei, Hooman Sharifi, Makan Sadr

引用次数: 0

Effect of Pneumococcal Conjugate 13 Valent and Polysaccharide 23 Valent Vaccination on Anti-Pneumococcal Antibody Titer of Hemodialysis Patients: A Randomized Clinical Trial. 肺炎球菌结合物13价和多糖23价疫苗对血液透析患者抗肺炎球菌抗体滴度的影响：一项随机临床试验。

Tanaffos Pub Date : 2023-01-01

Shima Shahi, Sasan Tavana, Amirhesam Alirezaei, Leila Sayadi

{"title":"Effect of Pneumococcal Conjugate 13 Valent and Polysaccharide 23 Valent Vaccination on Anti-Pneumococcal Antibody Titer of Hemodialysis Patients: A Randomized Clinical Trial.","authors":"Shima Shahi, Sasan Tavana, Amirhesam Alirezaei, Leila Sayadi","doi":"","DOIUrl":"","url":null,"abstract":"Background: Pneumococcal infections are a life- threatening disease in hemodialysis patients and vaccination against pneumococcus is an effective prevention. The current study aims to evaluate the immune response and maintenance of the anti-pneumococcal antibody titer in hemodialysis patients to the 23 valent pneumococcal polysaccharide vaccine alone and 13 valent conjugated with 23 valent polysaccharide vaccine.Materials and methods: This study is a randomized clinical trial that was performed at Loghman Hakim Hospital in Tehran, Iran in 2017. A total of 70 patients undergoing hemodialysis were randomly assigned to intervention (22 patients) and control (23 patients). In the control group, only one dose of the PPSV23 vaccine while patients in the intervention group were injected initially with PCV13, and then after at least 8 weeks PPSV23 vaccine. The outcome of this study is first and sixth-month antibody titer after injection of the PPSV23 vaccine.Results: The obtained result showed no significant difference between the two groups in the first month and sixth months. The results indicate that both the intervention group (treated with PCV13+PPSV23) and the control group (treated with PPSV23 only) experienced a significant impact from the first to the sixth month. Additionally, there was a noticeable effect on the levels of anti pneumococcal antibodies during the first to sixth month between the intervention and control groups. In addition, the difference between the antibody titer of the first month and the sixth month was not significant in the two groups.Conclusion: The anti-pneumococcal antibody titer in hemodialysis patients does not show a clear difference after two vaccine injections and one vaccination.","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71432176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0