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The Effect of Acu-TENS Current on Shortness of Breath and Lung Function Indicators in Patients with COPD. 急性- tens电流对慢性阻塞性肺病患者呼吸短促及肺功能指标的影响
Tanaffos Pub Date : 2025-01-01
Amir Hasan Saberi, Mohsen Abedi, Mehdi Rezaee, Mobina Khosravi, Hasan Shamsi, Azadeh Khosravi, Mohammad Mohsen Roostayi
{"title":"The Effect of Acu-TENS Current on Shortness of Breath and Lung Function Indicators in Patients with COPD.","authors":"Amir Hasan Saberi, Mohsen Abedi, Mehdi Rezaee, Mobina Khosravi, Hasan Shamsi, Azadeh Khosravi, Mohammad Mohsen Roostayi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The use of Acu-TENS is one of the physiotherapy methods to reduce shortness of breath and improve the quality of life of patients with chronic obstructive pulmonary disease (COPD). This study was conducted to evaluate the effectiveness of this method in respiratory parameters and the quality of life of patients with moderate to severe COPD.</p><p><strong>Materials and methods: </strong>The present study was a controlled clinical trial on 40 patients with COPD. Patients with moderate to severe COPD were randomly divided into two treatment groups. Exercise therapy was used in one group, and Acu-TENS (12 sessions over three weeks, Burst TENS (Frequency: 2 Hz; pulse duration: 200 ms, time: 45 minutes)) was used in the other group. Shortness of breath was evaluated using the Borg criteria, functional capacity was assessed using the six-minute walking test, quality of life was evaluated using the St. George questionnaire, and respiratory parameters were measured using a spirometer and COPD Assessment Test (CAT) questionnaire.</p><p><strong>Results: </strong>According to the results, after 12 treatment sessions, a significant difference was observed in FVC, FEV1, activity, CAT, and impact domains of St George's questionnaire. In contrast, other variables had no significant difference between the control and the intervention groups.</p><p><strong>Conclusion: </strong>Using Acu-TENS three times a week and for 12 sessions can play a significant role in the respiratory function of moderate to severe COPD patients. Also, this method is effective in reducing shortness of breath and improving the quality of life of these patients.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 1","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of MELD, PESI, PSI, and DIC Scores on Predicting Pulmonary Thromboembolism and Mortality Rate in COVID-19 Pneumonia. MELD、PESI、PSI和DIC评分对预测COVID-19肺炎肺血栓栓塞和死亡率的影响
Tanaffos Pub Date : 2025-01-01
Gülçehre Oğuztürk, Ekrem Cengiz Seyhan
{"title":"The Impact of MELD, PESI, PSI, and DIC Scores on Predicting Pulmonary Thromboembolism and Mortality Rate in COVID-19 Pneumonia.","authors":"Gülçehre Oğuztürk, Ekrem Cengiz Seyhan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Multiple studies have reported an increased incidence of thrombosis in patients with COVID-19 pneumonia, contributing to higher mortality rates. This study aimed to investigate the ability of disease severity scores, the Pneumonia Severity Index (PSI), Pulmonary Embolism Severity Index (PESI), Disseminated Intravascular Coagulation (DIC), and End-Stage Liver Disease Model (MELD), to predict embolism and embolism-related mortality in patients with COVID-19 pneumonia.</p><p><strong>Materials and methods: </strong>In this retrospective study, demographic data, comorbidities, hospitalization dates, length of stay in the intensive care unit, percentage of CT radiological involvement, presence of embolism, and biochemical and hematological test results of the patients were recorded. PSI, PESI, DIC, and MELD scores were calculated within the first 24 hours of hospitalization.</p><p><strong>Results: </strong>A total of 158 patients (82 males, 76 females) with a mean age of 53.47± 12.49 years were included. Embolism was detected in 24 cases (15%), and the mortality rate was 11% (18 cases) across all cases. The optimal threshold values for predicting mortality were 63 for PESI and 76 for PSI (AUC values of 0.802 and 0.747). The optimal threshold value for detecting pulmonary embolism was 4 for DIC (AUC: 0.740). In the univariate analysis, variables with a p-value less than 0.1 included radiological score, age, DIC, troponin levels, and D-dimer levels. The subsequent multivariate analysis indicated that both the DIC score (p = 0.047) and the radiological score (p = 0.043) were independently associated with pulmonary embolism. In another univariate analysis, the variables with a p- value less than 0.1 included age, radiological score, the presence of comorbidities, procalcitonin, CRP, troponin, PSI, and PESI score. The follow-up multivariate analysis suggested that the PESI score (p = 0.018) and PSI (p = 0.021) were independently linked to hospital mortality.</p><p><strong>Conclusion: </strong>The PESI score was found to be a significant predictor of mortality, while the DIC score was found to be a significant predictor of pulmonary embolism in patients with COVID-19 pneumonia.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 1","pages":"51-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between Levofloxacin and Azithromycin in Short-term Spirometry and Oxygen Saturation Indices in Patients with Exacerbated Bronchiectasis: A Randomized Double-blind Clinical Trial. 左氧氟沙星与阿奇霉素对加重支气管扩张患者短期肺活量测定和氧饱和度指标的比较:一项随机双盲临床试验。
Tanaffos Pub Date : 2025-01-01
Maryam Hajimirghasemi, Mahdi Behi, Hoofer Rafiei, Mohammad Bagher Sohrabi, Babak Gholamine, Mahsa Forghani
{"title":"Comparison between Levofloxacin and Azithromycin in Short-term Spirometry and Oxygen Saturation Indices in Patients with Exacerbated Bronchiectasis: A Randomized Double-blind Clinical Trial.","authors":"Maryam Hajimirghasemi, Mahdi Behi, Hoofer Rafiei, Mohammad Bagher Sohrabi, Babak Gholamine, Mahsa Forghani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Bronchiectasis is a chronic pulmonary disease characterized by abnormal and permanent dilatation of the airways in the lung. This study was conducted to compare the effect of levofloxacin with azithromycin in improving the lung function of these patients.</p><p><strong>Materials and methods: </strong>In this parallel double-blinded randomized clinical trial, 72 patients with exacerbated bronchiectasis were included and randomly divided into two intervention groups. One group was treated with levofloxacin (500 mg daily for two weeks at first and then 250 mg daily in the next four weeks), and the other group with azithromycin (500 mg daily in the first two weeks and then with a dose of 250 mg daily for the next four weeks) for 6 weeks. The pulmonary function tests were performed and analyzed at the beginning of the study, two, four, and six weeks after the intervention.</p><p><strong>Results: </strong>The mean expiratory volume in the first second (FEV1) and the percentage of oxygen saturation (O<sub>2</sub>Sat) in the levofloxacin group and the azithromycin group were not significantly different at the beginning of the study. Importantly, six weeks after the initiation, the mean FEV1 (61.02±8.54% vs. 56.88±7.13%, p=0.029) and O<sub>2</sub>Sat (91.00±1.72% vs. 85.44±1.77%, p=0.001) in the levofloxacin group were significantly higher than those in the azithromycin group.</p><p><strong>Conclusion: </strong>The present study showed that the favorable effect of six-week therapy with levofloxacin compared to azithromycin can significantly increase the pulmonary values of FEV1 and O<sub>2</sub>Sat in patients with exacerbated bronchiectasis.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 1","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19: A Systematic Review of Metabolomics Data and Predicting Potential Biomarkers Based on Pathway Analysis. COVID-19:代谢组学数据的系统回顾和基于途径分析的潜在生物标志物预测。
Tanaffos Pub Date : 2025-01-01
Nasrin Amiri-Dashatan, Mehdi Koushki, Negin Parsamanesh, Nayebali Ahmadi, Hossein Chiti, Mitra Rezaei, Zahra Razzaghi, Reza M Robati
{"title":"COVID-19: A Systematic Review of Metabolomics Data and Predicting Potential Biomarkers Based on Pathway Analysis.","authors":"Nasrin Amiri-Dashatan, Mehdi Koushki, Negin Parsamanesh, Nayebali Ahmadi, Hossein Chiti, Mitra Rezaei, Zahra Razzaghi, Reza M Robati","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The COVID-19 pandemic is a worldwide disaster in medicine, public health, and the economy. Many details of COVID-19 are currently unknown. This study aims to offer dysregulated metabolic profiles as potential biomarkers for SARS-CoV-2 infection by analyzing identified COVID-19 metabolites. We searched PubMed, Web of Science, EMBASE, and Scopus for metabolomics studies on COVID-19 patients. Studies investigating COVID-19 metabolite changes and utilizing mass spectrometry-based techniques are included. Two reviewers separately retrieved pertinent data for each selected publication. Differences of opinion among the reviewers were settled via conversation, and a final judgment was obtained. The online MetaboAnalyst 3.0 was used to conduct the pathway analysis of COVID-19. This study comprised 31 investigations with QUADOMICS quality evaluation. We isolated modified metabolites that have been found in at least three other investigations. The metabolomics data in response to SARS-CoV-2 alter at the metabolite expression level, leading to dysregulation of major metabolic pathways, including carbohydrates, amino acids, and lipids associated with COVID-19. The pathway analysis of metabolic reprogramming across different biological samples demonstrated a significant role in amino acid metabolism, including phenylalanine, tyrosine, and tryptophan production, in the severity of COVID-19. This review showed dysregulated metabolic profiling for identifying individuals with high severity of COVID-19. These results provide an understanding of metabolic pathways and how dysregulated metabolic profiling reflects the severity of COVID-19 in the general population. The high frequency of changed metabolites might be used as COVID-19 biomarkers for early detection, and significant metabolic routes could reveal new information about pathogenesis and lead to potential treatment targets.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 1","pages":"9-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Clinical, Histopathologic, and Radiologic Features in Extrapulmonary Tuberculosis Patients. 肺外结核患者的临床、组织病理学和放射学特征评估。
Tanaffos Pub Date : 2024-04-01
Ladan Kharraz, Aida Bagheri, Firouze Hatami, Mohammad Mahdi Rabiei, Farid Javandoust Gharehbagh, Ilad Alavi Darazam
{"title":"Assessment of Clinical, Histopathologic, and Radiologic Features in Extrapulmonary Tuberculosis Patients.","authors":"Ladan Kharraz, Aida Bagheri, Firouze Hatami, Mohammad Mahdi Rabiei, Farid Javandoust Gharehbagh, Ilad Alavi Darazam","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is clinically divided into two categories: pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB). PTB has many different manifestations, and sometimes the initial diagnosis is challenging and depends on the prevalence of infection as well as the experience and development of local medical centers. Thus, we aimed to review all EPTB patients in our referral center.</p><p><strong>Materials and methods: </strong>This retrospective study reviewed all confirmed cases of EPTB referred to a referral/general center within the last decade.</p><p><strong>Results: </strong>This study included 68 cases of EPTB. Percentages of males and females were 58.8% and 41.2%, respectively. The majority of EPTB patients were TB meningitis (44.1%), followed by musculoskeletal TB (17.6%). About 8.8% of patients had a positive culture. The acid-fast bacilli test was found to be positive in 19.1% of cases. The mortality rate in this study was 19.1% and the highest rate of mortality was observed in intestinal and mesenteric TB (33.3%).</p><p><strong>Conclusion: </strong>According to this study, the majority of hospitalized EPTB patients had TB meningitis. The mortality rate in intestinal and mesenteric TB was higher compared to other types of EPTB, probably due to delayed diagnosis. In the current study, Positive results for smears and cultures were also low.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 4","pages":"349-354"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Symptoms and Echocardiographic Markers Regarding the Severity of Embolism in Patients with Acute Pulmonary Embolism. 急性肺栓塞患者栓塞严重程度的临床症状和超声心动图指标
Tanaffos Pub Date : 2024-04-01
Shahabaddin Sorouri, Maryam Naseri, Sepideh Hejazi
{"title":"Clinical Symptoms and Echocardiographic Markers Regarding the Severity of Embolism in Patients with Acute Pulmonary Embolism.","authors":"Shahabaddin Sorouri, Maryam Naseri, Sepideh Hejazi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Echocardiography can be used for risk stratification in patients with acute pulmonary embolism (PE). While the severity of PE has been assessed through laboratory criteria in most studies, the Pulmonary Embolism Severity Index (PESI) scoring system was used in this study to evaluate the severity of echocardiographic criteria in acute PE patients.</p><p><strong>Materials and methods: </strong>All PE patients admitted to Ghaem Hospital in Mashhad between 2021-2022 were included in the study. Clinical symptoms and echocardiographic markers were checked and recorded when the patients entered the study. Data were analyzed in SPSS version 24 at a significance level of 0.05 using the Chi-square test and t-test.</p><p><strong>Results: </strong>Of 40 patients, 80% were at a high risk of PESI. The most common clinical symptoms were dyspnea (97.5%) and pleuritic chest pain (75%). Right ventricle (RV) size enlargement and its dysfunction were recorded in 57.5% of patients. The average age of patients in the high-risk group was significantly (pvalue: 0.001) higher than the low-risk group. There was a significant correlation between MID-right ventricle and pulmonary artery pressure with the severity of embolism, so that mid-right ventricle and pulmonary artery pressure in the high-risk group were significantly higher (p-value: 0.000) than in the low-risk group. Also, the severity of PE was significantly related to RV size (P = 0.026) and function (P = 0.038).</p><p><strong>Conclusion: </strong>RV size, function, and dilatation, and pulmonary artery pressure variated significantly in different severities of PE.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 4","pages":"364-370"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Chest Physiotherapy on the Clinical Outcomes of COVID-19 Patients. 胸部物理治疗对新冠肺炎患者临床结局的影响
Tanaffos Pub Date : 2024-04-01
Reza Moradi-Azhgil, Neda Sayadi, Shayesteh Haghighi, Parya Moradi
{"title":"Effect of Chest Physiotherapy on the Clinical Outcomes of COVID-19 Patients.","authors":"Reza Moradi-Azhgil, Neda Sayadi, Shayesteh Haghighi, Parya Moradi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The novel coronavirus 2019 primarily affects the respiratory system and may lead to respiratory failure and the need for intubation. This study aimed to investigate the effect of chest physiotherapy on the clinical outcomes of patients with COVID-19.</p><p><strong>Materials and methods: </strong>This randomized clinical trial was performed in 2022-2023. The research population included 58 patients with COVID-19 who were hospitalized at Izeh Shohada Hospital, Khuzestan. Patients in the control group received routine care, which included the use of supportive drugs based on the doctor's opinion, oxygen therapy, and nutritional support. The intervention group received chest physiotherapy and breathing exercises for six days. At the end of the third and sixth days, the patients of both groups were evaluated in terms of lung function, respiratory gases, and the length of hospital stay. Moreover, the need for intubation was recorded during study time. Data analysis was done using SPSS version 23 software.</p><p><strong>Results: </strong>In the intervention group, a significant improvement was observed in FVC (P<0.01), FEV<sub>1</sub>(P<0.01), FEV<sub>1</sub>/FVC ratio (P<0.01), PaO<sub>2</sub> (P<0.01), PaCO<sub>2</sub> (P<0.01), and SPO<sub>2</sub> (P<0.01) as well as the length of hospital stay (P<0.01) after the intervention. However, no significant difference was observed in the PaO2/FiO<sub>2</sub> ratio (P>0.05) and the need for intubation (P>0.05).</p><p><strong>Conclusion: </strong>The results showed that in the new crisis resulting from COVID-19, chest physiotherapy and respiratory exercises could be used as a helpful method in improving lung function, respiratory gases, and reducing the hospital stay in COVID-19 patients.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 4","pages":"392-402"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of Quality of Life in Patients with Asthma in Ahvaz, Iran. 伊朗阿瓦士哮喘患者生活质量的预测因素
Tanaffos Pub Date : 2024-04-01
Ahmad Tahmasebi Ghorrabi, Hanieh Raji, Amin Torabipour, Seydeh Maryam Mousavi, Zahara Oraman, Parisa Badiei Nasab, Mohammad Hosein Haghighizadeh
{"title":"Predictors of Quality of Life in Patients with Asthma in Ahvaz, Iran.","authors":"Ahmad Tahmasebi Ghorrabi, Hanieh Raji, Amin Torabipour, Seydeh Maryam Mousavi, Zahara Oraman, Parisa Badiei Nasab, Mohammad Hosein Haghighizadeh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Asthma impacts the quality of life (QOL) of patients and their families. The magnitude of this morbidity is influenced by several factors, including age, disease duration, and others. This study was conducted to determine the predictors of quality of life in patients with asthma in Ahvaz, Iran.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted among patients referred to the pulmonary clinics of Imam Khomeini and Golestan hospitals in Ahvaz in 2022. The quality of life was assessed using the SF-36v2 questionnaire. The effect of socio-demographic characteristics on quality-of-life scores was examined by t-test, one-way variance (ANOVA), Pearson's correlation coefficient, and regression models.</p><p><strong>Results: </strong>From a total of 204 studied asthmatic patients, the average age of patients was 43.22±15.17 years. The average QOL in patients was 57.69±22.97. Physical role and social functioning had the lowest and highest mean scores among SF-36 dimensions, respectively. A significant difference was observed between the average QOL score and the variables of age, gender, education level, employment status, illness costs, illness severity, daily exercise, and number of visits (P<0.05). Most clinical, socio-demographic, and economic variables were predictors of SF-36, PCS, MCS, and QOL dimensions (P<0.05).</p><p><strong>Conclusion: </strong>This study showed that the quality of life in asthmatic patients is affected by the severity of the disease, number of visits, age, sex, and education. By performing appropriate interventions on social and economic factors, the quality of life of asthmatic patients can be improved.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 4","pages":"376-391"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thymoquinone Targeting T Helper 2 Cytokines in Animal Models of Asthma: A Systematic Review. 百里醌靶向辅助性T 2细胞因子在哮喘动物模型中的作用:系统综述。
Tanaffos Pub Date : 2024-04-01
Hanieh Tahermohammadi, Ali Abdolahinia, Mohammad Ali Tahermohammadi, Mohammad Ali Hojjati Kermani, Babak Daneshfard, Ali Akbar Velayati
{"title":"Thymoquinone Targeting T Helper 2 Cytokines in Animal Models of Asthma: A Systematic Review.","authors":"Hanieh Tahermohammadi, Ali Abdolahinia, Mohammad Ali Tahermohammadi, Mohammad Ali Hojjati Kermani, Babak Daneshfard, Ali Akbar Velayati","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Thymoquinone (TQ) is one of the active components of <i>Nigella sativa</i> L. It has therapeutic properties in allergic diseases, such as the antihistamine effect on the airways of patients with asthma and inhibition of inflammatory changes. This systematic review was conducted to investigate the effect of TQ on T helper 2 (Th2) cytokines, including IL-4, IL-5, and IL-13, in the treatment of animal models of asthma.</p><p><strong>Materials and methods: </strong>A comprehensive article search was conducted using Web of Science, Scopus, and PubMed to find articles published until 2022 regarding the efficacy of TQ in treating animal models of asthma. We found 399 articles in Scopus, 927 in Web of Science, and 790 in PubMed, from a total number of 2116 articles. After deleting duplicate articles, we read the remaining 1126 titles and abstracts. Finally, 37 articles were selected for full reading. After excluding papers without full text, duplicates, letters, case studies, and those whose topic did not meet the criteria of this study, 8 articles remained. In the manual search, we did not find any deviating articles from the systematic search.</p><p><strong>Results: </strong>Our results showed that TQ had a significant effect on the reduction of Th2 cytokines, including IL-4, IL-5, and IL-13, in animal models of asthma.</p><p><strong>Conclusion: </strong>Current evidence shows the anti-inflammatory effects of TQ on Th2 cytokines, but its association with the reduction of Th2 cytokines in animal models of asthma needs further studies.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 4","pages":"334-340"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The History of Anesthesia and Anesthesiologists in Iran. 伊朗的麻醉史和麻醉师。
Tanaffos Pub Date : 2024-04-01
Alireza Salimi, Makan Sadr, Babak Daneshfard
{"title":"The History of Anesthesia and Anesthesiologists in Iran.","authors":"Alireza Salimi, Makan Sadr, Babak Daneshfard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The evolution of anesthesia and anesthesiology represents a pivotal chapter in the history of medical science, significantly enhancing patient care and surgical outcomes. General anesthesia, defined as the deliberate induction of a temporary state of pain relief, muscle paralysis, memory impairment, and unconsciousness, has revolutionized medical procedures by inhibiting the normal functioning of the central nervous system. In Iran, the journey of anesthesiology began with early contributions from ancient scholars and practitioners, whose innovative techniques laid the groundwork for future advancements. The field witnessed significant progress in the mid-20th century, aligning with global developments in medical science. Initially focused on intraoperative care, anesthesiology in Iran expanded to encompass preoperative evaluations, postoperative assessments, and comprehensive patient monitoring, addressing complications related to surgery and anesthesia. In addition to analyzing the evolution of anesthesiology from solely surgical intervention to a broader field encompassing preoperative evaluation, postoperative care, and critical care management, this paper addresses the challenges and opportunities facing anesthesia and anesthesiology in Iran, including the need for wider access to safe and reliable services and the integration of advanced technologies.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 4","pages":"324-333"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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