Tanaffos最新文献

{"title":"Diagnostic Performance and Learning Curve of EBUS-Guided TBNA in Western India: A Retrospective Analysis.","authors":"Ram Niwas Jalandra, Aneesa Shahul S, Poonam Elhence, Naveen Dutt, Nishant Kumar Chauhan, Shahir Asfahan, Kunal Deokar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive and highly effective modality for evaluating mediastinal and hilar lymphadenopathy. This study aimed to assess the diagnostic performance and analyze the learning curve of EBUS-guided TBNA during the first two years of its implementation at a tertiary care center in Western India.</p><p><strong>Materials and methods: </strong>Retrospective data of EBUS bronchoscopy procedures and their outcomes were collected from the bronchoscopy suite of a tertiary care hospital in Western India. Data were collected using a Google form for the first two years of EBUS operation. The percentage of diagnostic procedures conducted during each quarter was calculated over the two years. The difference in the distribution of determinate to indeterminate procedures between the first and the second year was assessed using the Chi-Square test. Statistical and graphical analyses were performed using Python 3.6.</p><p><strong>Results: </strong>Based on the cytology reports, out of 144 EBUS procedures conducted, 90 (62.5%) resulted in a diagnosis. Station 7 mediastinal node was the most frequently sampled. Among the determinate procedures, squamous cell carcinoma (31.1%) was the most frequently diagnosed. The average yield for the first four quarters was 57.4%, and for the next four quarters, it was 64.9%. There was a 7.5% increase in yield in the second year of EBUS operation; however, the difference was non-significant (p=0.46).</p><p><strong>Conclusion: </strong>In the first two years after acquiring EBUS equipment, EBUS-guided TBNA had a diagnostic yield of 62.5% in an academic institute. The diagnostic yield increased during the second year, likely due to a combination of improved operator skills and wise patient selection.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking Rates and Disease Severity in COVID-19 Patients at Masih Deneshvari Hospital.","authors":"Zahra Hessami, Maryam Vasheghani, Hooman Sharifi, Mahshid Aryanpur, Hakimeh Sheikhzadeh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Considering that smoking is a major risk factor for respiratory diseases and viral infections, in this study, we investigated the smoking status in patients admitted with the diagnosis of COVID-19 at Masih Daneshvari Hospital.</p><p><strong>Materials and methods: </strong>The information was obtained through the registration of patients' information in the hospital.</p><p><strong>Results: </strong>A total of 776 patients with COVID-19 who were admitted to Masih Daneshvari Hospital from April 2019 to June 2020 were examined, among whom 422 were men (54.4%), and 352 were women (45.5%). The mean age of the studied patients was 55.7 with a standard deviation of 15.9. The mean duration of hospitalization was 10.3 days with a standard deviation of 6.7 days. 178 (23.4%) patients were smokers. 45 smokers (25.3%) were hospitalized for more than 3 weeks, while 35 (6%) non-smokers were hospitalized for more than 3 weeks (p<0.05). There was no significant difference between smokers and non-smokers in terms of hospitalization in the intensive care unit and mortality.</p><p><strong>Conclusion: </strong>The significant finding is the high prevalence of smoking in the patient population, which should be taken into consideration. The higher length of hospitalization in smokers is also a notable finding that can cause problems for the health system and patients. Encouragement to quit smoking should be considered in health programs.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"194-197"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional and Short Course Treatment for Multidrug-Resistant Tuberculosis: A Comparative Study in National Referral Centers.","authors":"Parvaneh Baghaei, Jonathon R Campbell, Amirmohsen Mahdavian, Zahra Abtahian, Majid Marjani, Afshin Moniri, Mohammad Varahram, Mehdi Kazempour, Payam Tabarsi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Treatment of multidrug-resistant tuberculosis (MDR-TB) is difficult, expensive, and requires prolonged periods of time. Recent studies recommended short-course therapy (shorter regimen) for 9 months to one year. This study aimed to evaluate the response of the short-course therapy compared with traditional treatment in MDR-TB patients.</p><p><strong>Materials and methods: </strong>From all 94 referred MDR-TB cases, 48 patients were included in this study. Shorter regimen consisted of Moxifloxacin, Prothionamide, Amikacin, Clofazimine, Linezolid, Ethambutol, Pyrazinamide, and Cycloserine, and longer regimens consisted of the mentioned drugs, except Clofazimine and Linezolid, were prescribed randomly: in equal (24 in each group). The patients were monitored and evaluated for any complications and were followed for five years for relapse.</p><p><strong>Results: </strong>The median age was 39 years. The median interval for smear conversion was 30 days (20- 58 days) and was shorter in the short-course group (36 vs. 49 days). Also, the mean interval of sputum culture conversion in the shorter group and standard was 32 and 56 days, respectively, which is not related to the outcome of treatment. Eight of twelve patients who developed severe adverse effects were in shorter regimen. There was no difference between the two groups for the outcome of TB treatment. There is no relation between the outcome and other factors. None of them relapsed after three years following the end of the treatment.</p><p><strong>Conclusion: </strong>Shorter treatment can increase the cure rate and cooperation and adherence of the patients. It would be better to consider a shorter regimen in the national TB program for strengthening favorable treatment.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"114-127"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-Nutritional Assessment Test and Fat-Free-Mass Depletion in Tunisian Chronic Obstructive Pulmonary Disease Patients.","authors":"Soumaya Khaldi, Khouloud Kchaou, Asma Chaker, Rim Kammoun, Sahar Chakroun, Faten Chaieb, Masmoudi Kaouthar, Saloua Ben Khamsa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Fat-Free Mass (FFM) depletion is one of the systemic manifestations of COPD, causing functional impairment. We aimed to evaluate the relevance of the Mini-Nutritional Assessment (MNA) test in predicting FFM depletion in Tunisian COPD patients and to determine the relationship between nutritional status and disease severity.</p><p><strong>Materials and methods: </strong>This was a cross-sectional study of patients with stable COPD. Respiratory function was assessed. The MNA test and the COPD Assessment Test (CAT) questionnaire were also completed. FFM was measured by bioelectrical impedance analysis. Fat-Free Mass Index (FFMI) was calculated according to the following formula: FFM (kg)/height (m)². FFM depletion was defined as a FFMI < 16 kg/m².</p><p><strong>Results: </strong>The study population consisted of 160 patients with COPD. FFM depletion was higher in patients with more severe COPD. Patients with FFM depletion had a lower MNA score than patients without FFM depletion. The independent predictors of FFM depletion in COPD were MNA (p<0.0001; OR=0.333; CI: 0.2-0.552) and BMI (p<0.0001; OR=0.547; CI: 0.408-0.733). The MNA score was significantly correlated with FFMI, CAT score, and lung function. ROC curve analysis defined a value of 19.25 as the optimal cut-off value of the MNA score to discriminate COPD patients with FFM depletion from those without FFM depletion. By using this value, the sensitivity and specificity of the MNA test for detecting FFM depletion were 90% and 74%, respectively.</p><p><strong>Conclusion: </strong>Our results suggest that the MNA test, a simple and universally available tool, can predict FFM depletion in COPD.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational Examination of Cerebral Perfusion Changes in Patients Diagnosed with Sepsis Using Transcranial Doppler Ultrasonography.","authors":"Payam Rahimi, Remzi Işçimen, Pınar Küçükdemirci Kaya, Tutku Karaman Sağlam","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-associated Brain Dysfunction (SABD) affects over 70% of septic patients, often manifesting early and increasing the risk of neurological sequelae if undiagnosed. Transcranial Doppler (TCD) ultrasonography is a noninvasive, bedside method to assess Cerebral Blood Flow (CBF). This study evaluates temporal changes in middle cerebral artery blood flow in septic patients using Pulsatility Index (PI), Resistance Index (RI), and CBFi at 0, 6, 24, and 48 hours.</p><p><strong>Materials and methods: </strong>Forty-seven septic patients admitted to the Bursa Uludag University Intensive Care Unit were prospectively studied. Demographic data, comorbidities, Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation (APACHE) II scores, vital signs, laboratory parameters, and TCD measurements (PI, RI, CBFi) were recorded at baseline, 6, 24, and 48 hours.</p><p><strong>Results: </strong>No statistically significant changes were observed in PI, RI, or CBFi at 6, 24, or 48 hours compared to baseline (p>0.05), though slight increases in PI (2.13%) and CBFi (16.99%) were noted at 48 hours. A significant difference in PI was found at 48 hours in patients receiving vasoactive drugs (p<0.05), and in RI at 6 hours in those receiving sedoanalgesics (p<0.05). Stable systemic hemodynamics were maintained using advanced monitoring.</p><p><strong>Conclusion: </strong>In septic patients with optimized hemodynamic management, cerebrovascular resistance and perfusion indices (PI, RI, CBFi) remain largely stable within 48 hours, suggesting effective autoregulation. TCD shows potential as a tool to monitor cerebral perfusion and guide therapy in sepsis, warranting further research.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"187-193"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing Critical Genes Related to X-ray Radiation in Human Bronchial Epithelial BEAS-2B Cells.","authors":"Mitra Rezaei, Farideh Razi, Alireza Ahmadzadeh, Fatemeh Bandarian, Babak Arjmand, Mostafa Rezaei-Tavirani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>X-ray radiation application in radiology is a challenging subject for patients. Understanding the molecular events triggered by X-ray radiation can provide a suitable protocol for maintaining patient health. The primary aim of this study is to explore crucial affected genes in this regard.</p><p><strong>Materials and methods: </strong>Extraction and validation of data from the Gene Expression Omnibus (GEO) database is the first step in identifying significantly differentially expressed genes (DEGs). Analysis of gene expression profiles of human bronchial epithelial BEAS-2B cells through a directed protein-protein interaction (PPI) network was used to identify the key targeted genes affected by X-ray radiation.</p><p><strong>Results: </strong>Results of the analyzed directed PPI networks, based on expression, activation, inhibition, and reaction actions, and considering outdegree values, showed that IL1B, CCND1, RAC2, NDC80, and MIB1 are the crucial genes targeted by X-ray.</p><p><strong>Conclusion: </strong>In conclusion, upregulation of IL1B, RAC2, and CCND1, which are associated with cellular damages and downregulation of NDC80 and MIB1, which protect the treated cells, were pointed out as the major molecular events in response to X-ray radiation.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"128-135"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Biofilm Formation, Alginate Production, Pattern of Drug Resistance, and the Presence of Efflux Pump <i>MexAB-OprM, MexXY</i> (-OprA), and <i>AmpC</i> Gene in Clinical Isolates of <i>Pseudomonas aeruginosa</i>.","authors":"Saeid Besharati, Mohammad Rahbar, Neda Soleimani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>One of the most significant factors contributing to multidrug resistance in <i>Pseudomonas aeruginosa</i> infections is the formation of biofilms and the production of alginate. This study aimed to evaluate the overexpression of efflux pumps <i>MexAB-OprM, MexXY</i> (-OprA), and the <i>AmpC</i> gene and investigate biofilm and alginate in <i>P. aeruginosa</i> clinical isolates.</p><p><strong>Materials and methods: </strong>One-hundred isolates of <i>P. aeruginosa</i> were collected two government-specialized hospitals from February 2024 to June 2024 in Tehran, Iran. The disk diffusion method was used for antimicrobial susceptibility and detecting the pattern of antibiotics. We used a microtiter plate and carbazole assay to investigate biofilm formation and alginate production, respectively. We investigated the efflux pump <i>MexAB-OprM, MexXY</i> (-OprA), and the <i>AmpC</i> gene expression with real-time PCR and its correlation with biofilm, alginate, and antibiotic resistance.</p><p><strong>Results: </strong>30 multidrug-resistant (MDR) isolates were detected, and 27 antibiotic patterns were obtained. A significant relationship between biofilm formation and resistance to PRL was observed (P<0.01). All of the samples with more than 250μg/ml level of alginate production were resistant to Piperacillin-Tazobactam (PTZ), which was significant (P<0.05). Also, the relationship between alginate production and strong biofilm formation was significant. The expression of resistance-nodulation-division (RND) efflux pumps <i>MexABOprM, MexXY</i> (-OprA), and <i>AmpC</i> gene in MDR isolates of <i>P. aeruginosa</i> was significantly increased.</p><p><strong>Conclusion: </strong>High prevalence of MDR, along with high expression of efflux pump genes, was concerning. High production of biofilm formation and its relationship with alginate were observed in <i>P. aeruginosa</i> clinical isolates. To prevent the spread of antibiotic resistance, implementing monitoring methods and not overusing and abusing antibiotics is necessary.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"163-173"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchoscopy Procedures Implemented During the Pandemic Period in a University Hospital.","authors":"Fatih Uzer, Eminenur Topcu, Omer Ozbudak, Aykut Cilli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Our objective was to review the bronchoscopy procedures conducted at our hospital during the pandemic, with a focus on the potential risks of COVID-19 transmission associated with these interventions.</p><p><strong>Materials and methods: </strong>This comprehensive study included all patients who underwent bronchoscopy in the Department of Pulmonology at Akdeniz University from March 15 to December 31, 2020. A retrospective review of medical records covered demographic information, procedure indications, urgency, procedure type, diagnostic results, and the patient's COVID-19 history. Data collection also recorded the number of personnel involved in bronchoscopy during the pandemic, along with their COVID-19 history.</p><p><strong>Results: </strong>A total of 250 bronchoscopy procedures were performed during the study period. The majority of patients were male (74.8%), with a mean age of 58 ± 13.5 years. The most common indication for bronchoscopy was lung cancer (39.2%), followed by other causes like interstitial lung diseases and sarcoidosis. No patients with a positive pre-procedural COVID-19 PCR test were included in the procedure. All patients who underwent the procedure had a negative PCR test result. No post-procedural COVID-19 cases were observed among healthcare workers or patients following the procedures. All procedures were conducted with appropriate personal protective equipment (PPE), and SARSCoV-2 RT-PCR testing was performed on 76.8% of patients before the procedure. No complications, other than minor hemorrhages, were reported.</p><p><strong>Conclusion: </strong>Bronchoscopy performed with appropriate PPE, in a negative pressure room, and with pre-procedural SARS-CoV-2 RT-PCR testing, is a safe and effective diagnostic and therapeutic procedure during the COVID-19 pandemic. The safety protocols implemented in this study successfully minimized the risk of COVID-19 transmission to healthcare workers and patients.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"136-140"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Silica Returns-Erasmus Syndrome, a Rare Entity.","authors":"Parvathi B L, Aneesa Shahul, Shahir Asfahan, Naveen Dutt, Ramniwas Jalandra","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic sclerosis (SS) is an autoimmune disease with vascular changes and diffuse tissue fibrosis. Silica exposure is one of the strongest recognized risk factors for the development of systemic sclerosis (relative risk 3.2). The co-occurrence of systemic sclerosis in a patient with silica exposure is termed Erasmus Syndrome. Few case reports are available in the literature.</p><p><strong>Case presentation: </strong>We report here a case of Erasmus syndrome in a 54-year-old stone worker. The patient presented with diffuse skin thickening, hyperpigmentation, Raynaud's phenomenon, and arthralgia along with radiological features of silicosis. Serological markers of systemic sclerosis were strongly positive, and skin biopsy confirmed scleroderma. Hence, a diagnosis of Erasmus syndrome was made. The clinical, serological, and histopathological features of SA-SS in the patient were indistinguishable from those of idiopathic SS; however, a history of silica dust exposure and evidence of silicosis supported the diagnosis of SA-SS.</p><p><strong>Conclusion: </strong>Careful screening should be done in patients with silicosis along with systemic manifestations to rule out any associated connective tissue disorder. A detailed exposure history should be carefully obtained for all patients with systemic sclerosis.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"198-201"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-1 and Interleukin-8 are Prominent Inflammatory Markers in Patients with Cystic Fibrosis and Non-Cystic Fibrosis.","authors":"Hosein Ali Ghaffaripour, Maryam Hassanzad, Mahsa Mirzendehdel, Niloofar Esfahanian","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Bronchiectasis is characterized by pathological inflammation and infection that cause thickening and dilation of the airways. It is categorized into cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (NCFB). Given the disease's inflammatory nature, this study aimed to assess the levels of interleukin-1 (IL-1), IL-8, and tumor necrosis factor-alpha (TNF-α) in CF and NCFB patients compared to a healthy control (HC) group.</p><p><strong>Materials and methods: </strong>A total of 35 bronchiectasis patients (18 with CF and 16 with NCFB) and 18 individuals in the HC group were selected based on specific inclusion and exclusion criteria. After receiving informed consent, the levels of IL-1, IL-8, and TNF-α in serum and broncho-alveolar lavage (BAL) fluid were measured using ELISA. Additionally, spirometry results for the study participants were recorded before and after bronchoscopy.</p><p><strong>Results: </strong>Significant differences were observed in serum IL-8 (p = 0.018) and in BAL IL-1 and IL-8 levels (p = 0.018 and p < 0.0001, respectively). A notable positive correlation was found between serum IL-1 and both serum and BAL IL-8 (p < 0.0001). Similarly, serum IL-8 showed a significant positive correlation with its BAL levels (p = 0.007).</p><p><strong>Conclusion: </strong>Findings from this study suggest that elevated IL-1 in the lungs is a key factor in bronchiectasis-related inflammation, and the increase in IL-8 may occur via an IL-1-dependent pathway. The heightened levels of IL-8 in BAL and serum among bronchiectasis patients align with known neutrophilia in these cases. Spirometry results showed no significant association with these cytokine increases, indicating that relying solely on spirometry may be insufficient for monitoring inflammation in bronchiectasis patients.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"24 2","pages":"141-149"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}