Tanaffos最新文献

{"title":"Antiviral Effects of Sinamaz®: Potentials for COVID-19 Management.","authors":"Mohsen Naseri, Babak Daneshfard, Mehrdad Ravanshad, Arezoo Nabizadeh, Farzaneh Ghaffari","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"217-219"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Survival Probability of Patients with COVID-19 Based on Information of Patients.","authors":"Mehdi Kazempour Dizaji, Mohammad Varahram, Ali Zare, Arda Kiani, Niloufar Alizadeh Kolahdozi, Atefe Abedini, Rahim Roozbahani, Payam Tabarsi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In medical science, the probability of survival is a crucial index used to assess patient outcomes. This study aims to estimate the survival probability of patients diagnosed with COVID-19.</p><p><strong>Materials and methods: </strong>In a historical cohort study, the Kaplan-Meier method was used to assess the survival probability of 4,372 COVID-19 patients treated at Dr. Masih Daneshvari Hospital in Tehran during the pandemic.</p><p><strong>Results: </strong>The study results indicated that 199 patients (4.6%) died during the treatment, while 4,173 patients (95.4%) were censored. The daily survival probability estimation for COVID-19 patients revealed that the highest and lowest survival probabilities within 100 days from disease onset were 96% and 55%, respectively. Additionally, the survival probabilities on the 20th, 50th, 70th, and 90th days from the onset of disease and treatment were 92%, 70%, 63%, and 61%, respectively<b>.</b></p><p><strong>Conclusion: </strong>Estimating the survival probability of COVID-19 patients offers clinicians valuable insights into mortality rates and the effectiveness of common therapeutic strategies in treating the disease.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"300-303"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Severity of Chronic Obstructive Pulmonary Disease and Left Ventricular Diastolic Dysfunction.","authors":"Somayeh Lookzadeh, Seyyed Reza Seyyedi, Hamidreza Jamaati, Fatemehalsadat Miraboutalebi, Mahsa Rekabi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is an inflammatory systemic disorder that affects the respiratory tract airways and breathing. Left ventricular diastolic dysfunction (LVDD), which is the inability of the ventricle to fill to a normal end-diastolic volume, may be observed in patients with severe COPD. This study aimed to evaluate LVDD in patients with COPD.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 58 patients under 65 years of age with COPD as the case group. Moreover, 58 patients with normal spirometry and without pulmonary or cardiac disease were included as the control group. They referred to the cardiologist for echocardiography. Patients were tested for C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptides (NT -pro BNP). Data were analyzed with SPSS for descriptive reports of the relationship between variables.</p><p><strong>Results: </strong>The results showed that LVDD was significantly higher in COPD patients (60%) than in the control group (12.2%). Also, there was no significant relationship between LVDD and BMI in COPD patients. Evaluation of CRP and PRO-BNP showed that the distribution of patients in different diastolic function classes is similar. It was observed that with increasing COPD severity, LVDD severity increased (p-value =0.101). There is a direct relationship between total lung capacity (TLC) and LVDD (P-value <0.0001). In COPD patients, there was a significant relationship between diastolic function and SPAP (P-value <0.0019).</p><p><strong>Conclusion: </strong>In general, it should be noted that the prevalence of LVDD in patients with COPD is significantly higher than in other people.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"294-299"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Validation of a Persian Version of the Severe Respiratory Insufficiency Questionnaire (SRI).","authors":"Shohreh Kolagari, Zahra Sabzi, Mahmoud Khandashpour, Wolfram Windisch, Leila Teymouri Yeganeh, Elyas Hosseinzadeh Younesi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Using Health-related quality of life (HRQL) in chronic patients with severe respiratory insufficiency (SRI) requires a valid instrument. Hence, this study aimed to translate and validate the Persian version of the Severe Respiratory Insufficiency Questionnaire in chronic patients with severe respiratory insufficiency.</p><p><strong>Materials and methods: </strong>In this methodological study, the original version of the HRQL questionnaire in chronic patients with SRI was translated based on the approach presented by Wild et al. Face validity, content validity such as content validity index (CVI) and content validity ratio (CVR), convergent, and discriminant validity were evaluated. Moreover, construct validity evaluation was conducted by exploratory and confirmatory factor analyses (EFA & CFA).Reliability was also evaluated by calculating Cronbach's alpha and test-retest intraclass correlation coefficient (ICC). SPSS-16 and AMOS-24 software were used for data analysis.</p><p><strong>Results: </strong>The target group approved the face validity of the questionnaire and the content validity index was 0.94. In total, 500 chronic patients with severe respiratory insufficiency participated in the construct validity. Seven factors were extracted in exploratory factor analysis as respiratory complaints, physical functioning, social relationship, anxiety, attendant symptoms and sleep, social functioning, and psychological well-being. These factors explained 73.91% of the total variance of the concept of HRQL in chronic patients with SRI. All factors confirmed in confirmatory factor analysis based on model fit indices [Comparative Fit Index (CFI)=0.94, Goodness of fit index (GFI)=0.94, Minimum Discrepancy Function by Degrees of Freedom divided (CMIN/DF) =2.99, and Root Mean Square Error of Approximation (RMSEA)=0.01]. Convergent and discriminant validity were also confirmed. Moreover, Cronbach's alpha coefficients of 0.84 and intraclass correlation coefficient of 0.82-0.96 with 15-day intervals confirmed the internal consistency of the instrument.</p><p><strong>Conclusion: </strong>According to the findings of the present study, the Persian version of the SRI questionnaire, with 7 subscales and 40 items, is a valid and reliable instrument to assess the HRQL in chronic patients with SRI.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"266-279"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Pharmacological Approach to COVID-19 in a Referral Hospital in Tehran During Two Years.","authors":"Seyed Mehran Marashian, Mohsen Sadeghi, Somayeh Lookzadeh, Azadeh Moradkhani, Akram Qanavati, Zeinab Chaghervand, Sanaz Soleimani, Farnaz Hadipour, Maryam Shahmorad, Mahboobeh Mohammadi, Shirin Esmaeili, Latifeh Javadi, Hooman Sharifi, Esmaeil Idani, Hamidreza Jamaati, Alireza Eslaminejad","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The current study attempts to look at the trend of medication prescription among inpatients with COVID-19 by comparing two groups of them who were admitted into our hospital at separate times at around two-year intervals.</p><p><strong>Materials and methods: </strong>Through a retrospective cross-sectional design, the current study enrolled hospitalized cases from two separate periods including winter 2019 and summer 2021 to compare some characteristics of COVID-19 in addition to sex and age distribution as well as the approach and management and their changes as the time passed.</p><p><strong>Results: </strong>Remdesivir was raised to be the most commonly used medication for COVID-19 after one and a half years when approved by the FDA in this regard. Tocilizumab was prescribed for just less than 6% of earlier pandemics in winter 2019 while used in more than half of hospitalizations in 2021. After two years, corticosteroids are used in 98.6% of the cases at least in our center.</p><p><strong>Conclusion: </strong>Exact medication administration to target COVID-19 and accurate vaccination in addition to \"Herd immunity\" among the global population seems to be the chief secret of the current success at least for partial control of the disease now.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"250-255"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3-Year-Old Male Patient with A History of Fever, Cough, and Abdominal Pain.","authors":"Maryam Hassanzad, Korosh Fakhimi Derakhshan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"319-321"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Body Mass Index and Exhaled Breath Nitric Oxide: A Cross-Sectional Analysis of Shahedieh Cohort Study.","authors":"Seyyed Jalil Mirmohammadi, Alireza Dehghan Dehnavi, Mahmood Vakili, Mohammad Hossein Davari, Amir Houshang Mehrparvar, Mohammad Javad Zare Sakhvidi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Fractional exhaled nitric oxide is a method of assessing inflammation in the airway and its level may affected by some factors such as age, gender, and body mass index. This study was performed to assess the relationship between \"Body Mass Index\" (BMI) and FeNO.</p><p><strong>Materials and methods: </strong>This was a cross-sectional study on 879 adult subjects participating in the Shahedieh Cohort Study. BMI and FeNO were measured for each participant. Participants were divided into five BMI groups: underweight, normal, overweight, obese, and morbid obese FeNo level was compared between groups. The data were analyzed by SPSS (ver. 20) using Kolmogorov-Smirnov, Kruskal-Wallis, Mann-Whitney U tests, Spearman's correlation, and multivariate logistic regression tests.</p><p><strong>Results: </strong>The mean FeNO in all participants was 7.87±8.28 ppb. There was a significant positive correlation between age and FeNO. FeNO was declined by increasing BMI, so the highest FeNO was observed in underweight and the lowest FeNO was observed in morbid obese individuals. However, there was not a significant difference in FeNO level between different BMI categories (P =0.28). The mean FeNO level was significantly correlated to BMI only in participants younger than 48 years.</p><p><strong>Conclusion: </strong>The results of this study showed that BMI is probably negatively correlated with FeNO level in middle-aged people younger than 48 years, but not in older people.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"287-293"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could We Predict Chronic Obstructive Pulmonary Disease Exacerbation Based on Neutrophil to Lymphocyte Count Ratio (NLR)?","authors":"Biljana Lazovic, Radmila Dmitrovic, Ivan Zivotic, Isidora Simonovic, Nevena Jovicic","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The neutrophil to lymphocyte ratio (NLR) is an inflammatory biomarker that could be used as an indicator of systemic inflammation (sepsis) and could also be used to predict the prognosis of some diseases, such as solid cancer, community pneumonia, as well as cardiovascular diseases. This study aimed to assess the potential role of NLR and eosinopenia in patients with acute exacerbation of COPD (AECOPD) compared to those in the stable phase of the disease.</p><p><strong>Materials and methods: </strong>NLR was assessed and compared in patients with AECOPD (n=92) and those in the stable phase of COPD (n=240). Patients under the age of 18, those who used inhaled corticosteroids, or those with any condition affecting the neutrophil (NEU) or lymphocyte (LYM) count in peripheral blood, such as hematological illnesses, pregnancy, or a history of medication use, were excluded from the study. The NLR was determined using NEU and LYM counts from regular blood tests. We defined the cut-off value for eosinopenia as the percentage of eosinophils≤1%.</p><p><strong>Results: </strong>We included 332 inpatients with COPD diagnosed in our hospital from April to October 2021. AECOPD was discovered in 92 patients. Patients with exacerbation had considerably lower levels of BMI (24.32±4.38 vs 26±4.02), FEV1/FVC (55.38±9.14 vs 60.54±6.95), and NLR ratio, except for the first NLR quartile (39.13 %), the second was 20.65 %, the third was 18.48 %, and the fourth was 21.74 %. Eosinopenia was detected in 79 (85.87 %) of AECOPD patients.</p><p><strong>Conclusion: </strong>We found that the NLR was lower in patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), except for those in the first NLR quartile.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"280-286"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Sleep Disorders among Patients Suffering from Pulmonary Arterial Hypertension.","authors":"Batoul Khoundabi, Oldooz Aloosh, Parisa Adimi Naghan, Ahmad Soltani, Abolfazl Mojibian, Majid Malekmohamamd","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary arterial hypertension (PAH) is a progressive and fatal disease. Studies have shown a link between sleep disorders and pulmonary hypertension; however, sleep disorders generally remain undiagnosed. This study aimed to investigate the types of sleep disorders and their prevalence among patients with pulmonary hypertension.</p><p><strong>Materials and methods: </strong>A total of 68 patients with a definitive diagnosis of pulmonary hypertension were examined for the existence of sleep disorders. The STOP-BANG, ISI, ESS, RLS, and parasomnia questionnaires were used to evaluate sleep disorders, including obstructive sleep apnea, insomnia, excessive sleepiness, and movement disorders, such as restless leg syndrome and parasomnia, respectively. The data were analyzed using SPSS software.</p><p><strong>Results: </strong>The average age of the patients was 48.0 ± 14.2 years while 64.7% were women. The most prevalent (45.6%) sleep disorder among the patients was probable obstructive sleep apnea (STOP-BANG positive). Among STOP-BANG positive and negative groups, the ratios of men were 48.4% and 24.3%, respectively (P=0.046). In addition, there was a significant difference between STOP-BANG positive and negative groups regarding the variables of gender, age, having high systemic blood pressure, insomnia index, and daytime sleepiness (P values= 0.020, 0.046, 0.011, 0.023, and 0.011, respectively). The prevalence of parasomnia (P= 0.039) and daytime sleepiness (P=0.072) was significantly higher in people suffering from insomnia. The body mass index was significantly higher in people with idiopathic pulmonary hypertension than in those with thromboembolic pulmonary hypertension (P= 0.001). There was a significant association between age and the functional class of the patients (P= 0.003).</p><p><strong>Conclusion: </strong>The prevalence of sleep disorders, especially obstructive sleep apnea, is relatively high in patients with PAH, and its presence seems to worsen the prognosis of PAH necessitating identifying at-risk people and properly treating them to improve their quality of life.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"256-265"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus in Recent Years: Characteristics, Outbreaks, and Treatments.","authors":"Touba Eslaminejad, Saeedeh Shojaeepour, Seyedeh Atekeh Torabizadeh, Vida Mirzaie","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Coronaviruses cause acute respiratory syndromes, e.g., SARS, MERS, and COVID-19, whose treatment depends on several factors, specifically the age of patients, adopted treatments, time of hospitalization, and timely diagnosis. The present study was conducted to investigate the interaction between the mentioned factors and treatment.</p><p><strong>Materials and methods: </strong>Relevant full-text publications were indicated by searching in the five online databases MEDLINE, EMBASE, WOS, Science Direct, and Cochrane Library using MeSH terms during 2010-2024. Only original case reports (n=55) that worked on signs and treatments were selected and analysed according to age, gender, medical history, diagnostic methods, treatments, kind of respiratory syndrome, and transmission ways. Articles that met the inclusion criteria were evaluated by each of the reviewers independently, and non-agreements were solved by consulting with a fourth reviewer.</p><p><strong>Results: </strong>According to the results, the severe respiratory syndromes occurred more in the elderly than younger people and in males than females (58% and 42%, respectively). Medical history of diabetes and heart disease showed the maximum effect on the person to get involved with the severe respiratory syndrome. Clinical methods were used more for the diagnosis of the diseases because of easy access and less time consumption. Combination therapy was better than single therapy. The most common route of transmission was human to human and nosocomial.</p><p><strong>Conclusion: </strong>It can be concluded that these types of fatal respiratory illnesses can be controlled if the health care workers become familiar with the type of illness and apply the early and effective treatments.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"220-237"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}