发布求助
文献互助 智能选刊 最新文献

Tetrahedron, asymmetry最新文献

筛选
英文 中文
Benzyl isobornyl amines: a simple and practical class of NMR discriminating agents for effective chiral recognition of acids 苄基异鸟胺:一类简单实用的核磁共振鉴别剂，用于有效的手性识别酸
Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.08.007
Jayaraman Kannappan , Aditya N. Khanvilkar , Gourav M. Upadhyay , Ashutosh V. Bedekar
{"title":"Benzyl isobornyl amines: a simple and practical class of NMR discriminating agents for effective chiral recognition of acids","authors":"Jayaraman Kannappan ,&nbsp;Aditya N. Khanvilkar ,&nbsp;Gourav M. Upadhyay ,&nbsp;Ashutosh V. Bedekar","doi":"10.1016/j.tetasy.2017.08.007","DOIUrl":"10.1016/j.tetasy.2017.08.007","url":null,"abstract":"<div><p>The design and synthesis of a few simple <em>N</em>-benzyl derivatives of isobornyl amine is presented. The derivatives have been assessed as chiral solvating agents for effective discrimination of the signals of some acids in NMR analysis. The single crystal X-ray analysis of the salts of (<em>R</em>)-mandelic acid with two of the title derivatives help to understand the supramolecular interactions and assign the induced chemical shifts in <sup>1</sup><span>H NMR analysis. The title derivative is found to be suitable for quantitative determination of the enantiomeric<span> excess of unknown enantiomeric purity as well as being efficient in resolving racemic mandelic acid.</span></span></p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72782324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Dual chiral silver catalyst in the synthetic approach to the core of hepatitis C virus inhibitor GSK 625433 using enantioselective 1,3-dipolar cycloaddition of azomethine ylides and electrophilic alkenes 双手性银催化剂在丙型肝炎病毒抑制剂GSK 625433的核心合成方法中采用对映选择性1,3-偶极环加成法将偶氮亚胺酰基与亲电烯烃结合
Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.08.011
Ihssene Chabour , Luis M. Castelló , Juan Mancebo-Aracil , María Martín-Rodríguez , María de Gracia Retamosa , Carmen Nájera , José M. Sansano
{"title":"Dual chiral silver catalyst in the synthetic approach to the core of hepatitis C virus inhibitor GSK 625433 using enantioselective 1,3-dipolar cycloaddition of azomethine ylides and electrophilic alkenes","authors":"Ihssene Chabour ,&nbsp;Luis M. Castelló ,&nbsp;Juan Mancebo-Aracil ,&nbsp;María Martín-Rodríguez ,&nbsp;María de Gracia Retamosa ,&nbsp;Carmen Nájera ,&nbsp;José M. Sansano","doi":"10.1016/j.tetasy.2017.08.011","DOIUrl":"10.1016/j.tetasy.2017.08.011","url":null,"abstract":"<div><p>The asymmetric 1,3-dipolar cycloaddition of an imino ester <strong>5</strong> with <em>tert-</em><span>butyl acrylate<span> is catalyzed by a dual chiral silver(I) complex formed from a chiral phosphoramidite </span></span><strong>14</strong> and the chiral silver(I) binolphosphate (<em>R</em>)-<strong>17</strong><span>. This reaction is selected to achieve the synthesis of enantiomerically enriched key structures to access the third generation of GSK HCV inhibitors. The scope of this dual chiral catalytic system is analyzed by employing different imino esters and dipolarophiles, and also compared with the same cycloaddition reactions performed with the chiral phosphoramidite </span><strong>14</strong>·AgClO<sub>4</sub> complex.</p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78626690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
An enantiopure diselenide based on a chiral bicyclic backbone—synthesis and configuration assignment 一种基于手性双环骨架的对映纯二硒化物-合成和构型分配
Tetrahedron, asymmetry Pub Date : 2017-10-15 DOI: 10.1016/j.tetasy.2017.08.008
Karolina Kamińska , Elżbieta Wojaczyńska , Claudio Santi , Luca Sancineto , Marianna Francesca Pensa , Andrzej Kochel , Robert Wieczorek , Jacek Wojaczyński , Gauthier Slupski
{"title":"An enantiopure diselenide based on a chiral bicyclic backbone—synthesis and configuration assignment","authors":"Karolina Kamińska ,&nbsp;Elżbieta Wojaczyńska ,&nbsp;Claudio Santi ,&nbsp;Luca Sancineto ,&nbsp;Marianna Francesca Pensa ,&nbsp;Andrzej Kochel ,&nbsp;Robert Wieczorek ,&nbsp;Jacek Wojaczyński ,&nbsp;Gauthier Slupski","doi":"10.1016/j.tetasy.2017.08.008","DOIUrl":"10.1016/j.tetasy.2017.08.008","url":null,"abstract":"<div><p><span><span>An enantiomerically pure </span>diselenide<span> containing two chiral bicyclic subunits was prepared from the respective halides<span>. The stereochemical outcome of the reaction was established via NMR spectroscopy and X-ray </span></span></span>diffraction measurements.</p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85849669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A closer look on various synthetic routes to Callystatin A: a cytotoxic marine sponge polyketide Callystatin A:一种具有细胞毒性的海绵聚酮
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/j.tetasy.2017.08.015
Aamer Saeed, Babar Hussain Shah, Rabia Qamar
{"title":"A closer look on various synthetic routes to Callystatin A: a cytotoxic marine sponge polyketide","authors":"Aamer Saeed,&nbsp;Babar Hussain Shah,&nbsp;Rabia Qamar","doi":"10.1016/j.tetasy.2017.08.015","DOIUrl":"10.1016/j.tetasy.2017.08.015","url":null,"abstract":"<div><p><span>Callystatin A<span><span>, a polyketide </span>marine natural product, has been known since 1997 after its isolation from the sponge </span></span><span><em>Callyspongia</em><em> truncata</em></span><span> by Kobayashi et al. It belongs to the leptomcyin family of natural products with a highly conjugated and stereodefined skeleton. The challenging structural topographies and remarkable anti-proliferative properties of (−)-Callystatin A stimulated many researchers to pursue the total synthesis of this marine polyketide. This review is exclusively focused on the research undertaken towards the concise, asymmetric total synthesis of Callystatin A over the last two decades. The various target oriented synthetic pathways are discussed in a chronological order to give a comprehensive overview.</span></p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89218764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymmetric synthesis of serinol-monoesters catalyzed by amine transaminases 胺转氨酶催化丝氨酸醇单酯的不对称合成
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/j.tetasy.2017.08.012
Ingrid C.R. Costa , Rodrigo Octavio M.A. de Souza , Uwe T. Bornscheuer
{"title":"Asymmetric synthesis of serinol-monoesters catalyzed by amine transaminases","authors":"Ingrid C.R. Costa ,&nbsp;Rodrigo Octavio M.A. de Souza ,&nbsp;Uwe T. Bornscheuer","doi":"10.1016/j.tetasy.2017.08.012","DOIUrl":"10.1016/j.tetasy.2017.08.012","url":null,"abstract":"<div><p><span>The asymmetric synthesis<span> of serinol-derivatives was investigated employing different amine transaminases<span><span> as biocatalysts. Under the optimized conditions conversions up to 92% and excellent </span>enantiomeric excesses up to 99% ee were obtained providing access to both, the (</span></span></span><em>R</em>)- and (<em>S</em>)-configurations of the serinol-monoester (2-amino-3-hydroxypropyl hexanoate).</p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73869078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
On the absolute configuration of 1-cyclopropylethan-1-amine 关于1-环丙基比1-胺的绝对构型
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/j.tetasy.2017.08.005
Matthew W.D. Perry, Anders Eriksson, Marie Rydén Landergren
{"title":"On the absolute configuration of 1-cyclopropylethan-1-amine","authors":"Matthew W.D. Perry,&nbsp;Anders Eriksson,&nbsp;Marie Rydén Landergren","doi":"10.1016/j.tetasy.2017.08.005","DOIUrl":"10.1016/j.tetasy.2017.08.005","url":null,"abstract":"<div><p><span><span>We observed a discrepancy between the reported specific rotation for the enantiomers of 1-cyclopropylethan-1-amine and the values for commercial material. Analyses by </span>VCD of the free amine, by NMR analysis of the derived (</span><em>S</em><span>)-O-methylmandelamides and an X-ray crystal structure of one of the mandelamides defined the specific rotation for each enantiomer.</span></p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79176791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Tetrahedron: Asymmetry Reports 四面体:不对称报告
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/S0957-4166(17)30428-7
{"title":"Tetrahedron: Asymmetry Reports","authors":"","doi":"10.1016/S0957-4166(17)30428-7","DOIUrl":"https://doi.org/10.1016/S0957-4166(17)30428-7","url":null,"abstract":"","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0957-4166(17)30428-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137428837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A diversity oriented synthesis of d-erythro-sphingosine and siblings d-红鞘氨醇及其兄弟化合物的合成
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/j.tetasy.2017.08.006
Amrita Ghosh, Shital K. Chattopadhyay
{"title":"A diversity oriented synthesis of d-erythro-sphingosine and siblings","authors":"Amrita Ghosh,&nbsp;Shital K. Chattopadhyay","doi":"10.1016/j.tetasy.2017.08.006","DOIUrl":"10.1016/j.tetasy.2017.08.006","url":null,"abstract":"<div><p><span>An efficient building block-based synthetic protocol has been developed for the synthesis of 3-ketosphingoids with various chain lengths using cross metathesis<span> of a Garner’s aldehyde-derived α,β-unsaturated ketone as the key step. Stereoselective reduction of the biomimetic precursors thus obtained provided </span></span><span>d</span>-<em>erythro</em>-sphingosine and truncated anaogues in good overall yields.</p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72530377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Impact of variation of the acyl group on the efficiency and selectivity of the lipase-mediated resolution of 2-phenylalkanols 酰基的变化对脂肪酶介导的2-苯烷醇分离效率和选择性的影响
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/j.tetasy.2017.08.002
Aoife M. Foley , Declan P. Gavin , Ilona Joniec , Anita R. Maguire
{"title":"Impact of variation of the acyl group on the efficiency and selectivity of the lipase-mediated resolution of 2-phenylalkanols","authors":"Aoife M. Foley ,&nbsp;Declan P. Gavin ,&nbsp;Ilona Joniec ,&nbsp;Anita R. Maguire","doi":"10.1016/j.tetasy.2017.08.002","DOIUrl":"10.1016/j.tetasy.2017.08.002","url":null,"abstract":"<div><p><span>By tuning the steric properties of the acyl group to control the efficiency and selectivity of the resolution, 2-phenyl-1-propanol </span><strong>1a</strong> was prepared by lipase-catalysed hydrolysis using a short-chain acyl group, with <em>E</em>-values of up to 66 (<em>ee</em> up to 95%). 2-Phenylbutan-1-ol <strong>1b</strong> was similarly resolved (up to 86% <em>ee</em>) using the optimised conditions, while the ester of the more sterically demanding 3-methyl-2-phenylbutan-1-ol <strong>1c</strong><span> proved resistant to enzymatic hydrolysis under these conditions.</span></p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76435704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Cumulative author index 累计作者索引
Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI: 10.1016/S0957-4166(17)30429-9
{"title":"Cumulative author index","authors":"","doi":"10.1016/S0957-4166(17)30429-9","DOIUrl":"https://doi.org/10.1016/S0957-4166(17)30429-9","url":null,"abstract":"","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0957-4166(17)30429-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137428839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信