胺转氨酶催化丝氨酸醇单酯的不对称合成

Q2 Chemistry

Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI:10.1016/j.tetasy.2017.08.012

Ingrid C.R. Costa , Rodrigo Octavio M.A. de Souza , Uwe T. Bornscheuer

引用次数: 5

摘要

采用不同的胺转氨酶作为生物催化剂，研究了丝氨酸醇衍生物的不对称合成。在优化条件下，丝氨酸醇单酯(2-氨基-3-羟丙基己酸酯)的(R)-和(S)-构型均可获得高达92%的转化率和99% ee的极佳对映体过量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Asymmetric synthesis of serinol-monoesters catalyzed by amine transaminases

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Asymmetric synthesis of serinol-monoesters catalyzed by amine transaminases

The asymmetric synthesis of serinol-derivatives was investigated employing different amine transaminases as biocatalysts. Under the optimized conditions conversions up to 92% and excellent enantiomeric excesses up to 99% ee were obtained providing access to both, the (R)- and (S)-configurations of the serinol-monoester (2-amino-3-hydroxypropyl hexanoate).

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来源期刊

Tetrahedron, asymmetry 化学-无机化学与核化学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Cessation. Tetrahedron: Asymmetry presents experimental or theoretical research results of outstanding significance and timeliness on asymmetry in organic, inorganic, organometallic and physical chemistry, as well as its application to related disciplines, especially bio-organic chemistry. The journal publishes critical reviews, original research articles and preliminary communications dealing with all aspects of the chemical, physical and theoretical properties of non-racemic organic and inorganic materials and processes. Topics relevant to the journal include: the physico-chemical and biological properties of enantiomers; strategies and methodologies of asymmetric synthesis; resolution; chirality recognition and enhancement; analytical techniques for assessing enantiomeric purity and the unambiguous determination of absolute configuration; and molecular graphics and modelling methods for interpreting and predicting asymmetric phenomena. Papers describing the synthesis or properties of non-racemic molecules will be required to include a separate statement in the form of a Stereochemistry Abstract, for publication in the same issue, of the criteria used for the assignment of configuration and enantiomeric purity.