On the absolute configuration of 1-cyclopropylethan-1-amine

Q2 Chemistry

Tetrahedron, asymmetry Pub Date : 2017-09-15 DOI:10.1016/j.tetasy.2017.08.005

Matthew W.D. Perry, Anders Eriksson, Marie Rydén Landergren

引用次数: 1

Abstract

We observed a discrepancy between the reported specific rotation for the enantiomers of 1-cyclopropylethan-1-amine and the values for commercial material. Analyses by VCD of the free amine, by NMR analysis of the derived (S)-O-methylmandelamides and an X-ray crystal structure of one of the mandelamides defined the specific rotation for each enantiomer.

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关于1-环丙基比1-胺的绝对构型

我们观察到1-环丙基比1-胺对映体的比旋光度与商业材料的值之间存在差异。通过VCD对游离胺进行分析，通过核磁共振对衍生的(S)- o -甲基曼德拉酰胺进行分析，并对其中一种曼德拉酰胺的x射线晶体结构进行分析，确定了每个对映体的比旋度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron, asymmetry 化学-无机化学与核化学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Cessation. Tetrahedron: Asymmetry presents experimental or theoretical research results of outstanding significance and timeliness on asymmetry in organic, inorganic, organometallic and physical chemistry, as well as its application to related disciplines, especially bio-organic chemistry. The journal publishes critical reviews, original research articles and preliminary communications dealing with all aspects of the chemical, physical and theoretical properties of non-racemic organic and inorganic materials and processes. Topics relevant to the journal include: the physico-chemical and biological properties of enantiomers; strategies and methodologies of asymmetric synthesis; resolution; chirality recognition and enhancement; analytical techniques for assessing enantiomeric purity and the unambiguous determination of absolute configuration; and molecular graphics and modelling methods for interpreting and predicting asymmetric phenomena. Papers describing the synthesis or properties of non-racemic molecules will be required to include a separate statement in the form of a Stereochemistry Abstract, for publication in the same issue, of the criteria used for the assignment of configuration and enantiomeric purity.