Systems Biology in Reproductive Medicine最新文献

Unveiling the role of miRNAs in Diminished Ovarian Reserve: an in silico network approach. 揭示 miRNA 在卵巢储备功能减退中的作用：硅网络方法。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-01-25 DOI: 10.1080/19396368.2024.2434268

Costanza Cimini, Angela Taraschi, Marina Ramal-Sanchez, Alessia Colosimo, Carlo Di Carlo, Ramses Belda-Perez, Luca Valbonetti, Giulia Capacchietti, Nicola Bernabò, Barbara Barboni

{"title":"Unveiling the role of miRNAs in Diminished Ovarian Reserve: an in silico network approach.","authors":"Costanza Cimini, Angela Taraschi, Marina Ramal-Sanchez, Alessia Colosimo, Carlo Di Carlo, Ramses Belda-Perez, Luca Valbonetti, Giulia Capacchietti, Nicola Bernabò, Barbara Barboni","doi":"10.1080/19396368.2024.2434268","DOIUrl":"10.1080/19396368.2024.2434268","url":null,"abstract":"MicroRNAs (miRNAs) have acquired an increased recognition to unravel the complex molecular mechanisms underlying Diminished Ovarian Reserve (DOR), one of the main responsible for infertility. To investigate the impact of miRNA profiles in granulosa cells and follicular fluid, crucial players in follicle development, this study employed a computational network theory approach to reconstruct potential pathways regulated by miRNAs in granulosa cells and follicular fluid of women suffering from DOR. Available data from published research were collected to create the FGC_MiRNome_MC, a representation of miRNA target genes and their interactions. 365 hubs were identified within the network, representing potential key regulators, and 210 nodes that act as both hubs and bottlenecks (H&BN nodes), suggesting that they may control the information flow within the network. GO enrichment analysis of the 210 H&BN nodes revealed their involvement in fundamental cellular processes relevant to ovarian function. In particular, the cluster analysis identified several shared pathways between cluster 1 and cluster 2 involved in the RAS/MAPK pathway, which plays a critical role in cell proliferation, differentiation and survival. These findings suggest that miRNAs play a significant role in DOR and highlight the potential of the RAS/MAPK pathway as a target for further investigation. Additionally, the genes identified as both hubs and bottlenecks revealed interesting connections to reproductive health in KO mice models. This in silico approach provides valuable insights into potential biomarkers and therapeutic targets for age-related reproductive disorders.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"2-12"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of male contraceptive efficacy of Caesalpinia pulcherrima (L.) sw. in human and rat: an ex-vivo study. 白腹剖宫产男性避孕效果评价。在人类和大鼠：离体研究。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-02-19 DOI: 10.1080/19396368.2025.2455059

Pampa Lohar, Dibya Pal, Tanusree Mondal, Shibani Das, Puja Das, Debidas Ghosh

{"title":"Evaluation of male contraceptive efficacy of Caesalpinia pulcherrima (L.) sw. in human and rat: an ex-vivo study.","authors":"Pampa Lohar, Dibya Pal, Tanusree Mondal, Shibani Das, Puja Das, Debidas Ghosh","doi":"10.1080/19396368.2025.2455059","DOIUrl":"10.1080/19396368.2025.2455059","url":null,"abstract":"The study focused on the spermicidal and anti-androgenic effects of aqueous-ethanolic (60:40) extract of Caesalpinia pulcherrima leaves (AEECPL) in human and rat samples from the viewpoint of its contraceptive efficacy through ex-vivo study. Six fertile adult males were selected randomly for semen collection. Parallelly sperm samples were collected by epididymal washing from six rats. Testes, epididymis, and liver were dissected from rats. Biological samples were divided into control, 1, 2, and 4 mg/ml of AEECPL exposed groups. Relevant spermiological, steroidogenic enzymes, oxidative stress, and metabolic toxicity sensors were evaluated. All the spermiological sensors were decreased significantly in dose and duration-dependent manners, and the number of comet positive spermatozoa were increased in dose-dependent mode in AEECPL exposed groups against the control both in human and rat. Activities of Δ5,3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD in testis, kinetics of superoxide dismutase both in testis and epididymis were significantly decreased along with the elevation in the level of thiobarbituric acid reactive substances in AEECPL exposed groups. Activities of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase, and alkaline phosphatase in above mentioned tissues showed no significant difference among the control and AEECPL exposed groups, indicating its non-toxic effects on reproductive and metabolic tissues. The results presenting the prominent contraceptive preventing potentiality of the said extract both in human and rat. The optimal effect was noted at 2 mg/ml dose. In-depth investigations are required through in-vivo studies on animal model to know the genomic mode of action for the execution of male contraceptive activity.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"43-53"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive microbiota in humans: characterization and role in infertility. 人类生殖微生物群：特征和在不孕症中的作用。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-06-10 DOI: 10.1080/19396368.2025.2511323

Rebecca Poole, Dallas Soffa, Kyle Hickman, Olivia Ognibene, Matthew Stuehr

引用次数: 0

An intelligent decision-making system for embryo transfer in reproductive technology: a machine learning-based approach. 生殖技术中胚胎移植的智能决策系统：基于机器学习的方法。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-01-28 DOI: 10.1080/19396368.2024.2445831

Sanaa Badr, Meryem Tahri, Mohamed Maanan, Jan Kašpar, Noura Yousfi

{"title":"An intelligent decision-making system for embryo transfer in reproductive technology: a machine learning-based approach.","authors":"Sanaa Badr, Meryem Tahri, Mohamed Maanan, Jan Kašpar, Noura Yousfi","doi":"10.1080/19396368.2024.2445831","DOIUrl":"10.1080/19396368.2024.2445831","url":null,"abstract":"Infertility has emerged as a significant public health concern, with assisted reproductive technology (ART) is a last-resort treatment option. However, ART's efficacy is limited by significant financial cost and physical discomfort. The aim of this study is to build Machine learning (ML) decision-support models to predict the optimal range of embryo numbers to transfer, using data from infertile couples identified through literature reviews. Binary classification models were developed to classify cases into two groups: those transferring two or fewer embryos and those transferring three or four. Four popular ML algorithms were used, including random forest (RF), logistic regression (LR), support vector machine (SVM), and artificial neural network (ANN), considering seven criteria: the woman's age, sperm origin, the developmental qualities of four potential embryos, infertility duration, assessment of the woman, morphological qualities of the four best embryos on the day of transfer, and number of oocytes extracted. The stratified 3-fold cross-validation results show that the SVM model obtained the highest average accuracy (95.83%) and demonstrated the best overall performance, closely followed by the ANN and LR models with an average accuracy equal to 91.67%. The RF model achieved a slightly lower average accuracy (88.89%), which demonstrated the lowest variability. Testing on a new dataset revealed all models performed well, with ANN and SVM models classified all test set instances correctly, while the RF and LR models achieved 91.68% accuracy. These results highlight the superior generalization and effectiveness of the ANN and SVM models in guiding ART decisions.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"13-28"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro maturation of oocytes (IVM): historical landmarks, current status and future perspectives. 卵母细胞体外成熟（IVM）：历史里程碑、现状和未来展望。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/19396368.2025.2469574

Katerina Chatzimeletiou, Konstantina Pappa, Nikos Petrogiannis, George Anifandis, Kalliopi Chatzovoulou, Elias Tsakos, Efstratios Kolibianakis, Grigoris Grimbizis, Antonia Sioga

{"title":"In vitro maturation of oocytes (IVM): historical landmarks, current status and future perspectives.","authors":"Katerina Chatzimeletiou, Konstantina Pappa, Nikos Petrogiannis, George Anifandis, Kalliopi Chatzovoulou, Elias Tsakos, Efstratios Kolibianakis, Grigoris Grimbizis, Antonia Sioga","doi":"10.1080/19396368.2025.2469574","DOIUrl":"10.1080/19396368.2025.2469574","url":null,"abstract":"One of the major advancements in in vitro fertilization (IVF) has been the development of culture media that enhance gamete maturation in vitro and sustain embryo development up to the blastocyst stage. The deep understanding of the mechanisms involved in gametogenesis and the complex sequence of events surrounding nuclear and cytoplasmic maturation has also enabled the development of efficient in vitro maturation (IVM) protocols. This review outlines the major landmarks in the history of in vitro maturation of oocytes, the advantages and importance of its clinical application in human, especially in patients with Polycystic Ovary Syndrome (PCOS), Resistant Ovary Syndrome, high antral follicle count or oncology patients, as well as the safety and efficacy of the technique. IVM has not been shown yet to be as effective as controlled ovarian stimulation in terms of maturation rates, fertilization rates, and clinical outcome, possibly owing to a dysfunctional or asynchronous nuclear/cytoplasmic maturation process. A confusing set of IVM clinical protocols may also have contributed to the slow incorporation of the technology into routine IVF practice. However, recent improvements have led to comparable live birth rates between IVM and IVF, in women with high antral follicle count. The current status of IVM in the Assisted Reproductive Technology (ART) laboratory and its future perspectives, aiming to provide maximum fertility care to patients will be discussed.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"102-115"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genetic basis of male and female infertility. 男性和女性不育的遗传基础。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-04-28 DOI: 10.1080/19396368.2025.2493621

Dimitrios Ioannou, Helen G Tempest

{"title":"The genetic basis of male and female infertility.","authors":"Dimitrios Ioannou, Helen G Tempest","doi":"10.1080/19396368.2025.2493621","DOIUrl":"https://doi.org/10.1080/19396368.2025.2493621","url":null,"abstract":"This review provides a comprehensive overview of the genetic factors underlying male and female infertility. Infertility affects an estimated one in six couples worldwide, with both male and female factors contributing equally to its prevalence. Approximately, 50% of infertility cases are attributed to genetic causes. We explore three main categories of genetic causes: chromosomal abnormalities, monogenic disorders, and syndromic conditions. Chromosomal causes, including numerical and structural aberrations, are discussed with a focus on their impact on gametogenesis and reproductive outcomes. We review key monogenic causes of infertility, highlighting recent discoveries in genes critical for gonadal development, gametogenesis, and hormonal regulation. Syndromic conditions affecting fertility are examined, highlighting their impact on reproductive function. Throughout the review, we address the challenges in identifying genetic mechanisms of infertility, particularly focusing on the intricate processes involved in oogenesis and spermatogenesis. We also discuss how advancements in genetic testing, such as next-generation sequencing (NGS) and genome-wide association studies (GWAS), have significantly enhanced our understanding of idiopathic infertility and promise further insights in the future. We also discuss the clinical implications of genetic diagnoses, including the role of preimplantation genetic testing (PGT) and genetic counseling in reproductive medicine. This review synthesizes current knowledge on the genetic basis of infertility, providing a comprehensive overview of chromosomal, monogenic, and syndromic causes. It aims to offer readers a solid foundation for understanding the complex genetic factors underlying reproductive disorders.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"143-169"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole exome sequencing uncovers rare variants associated with PCOS susceptibility in Indian women. 全外显子组测序揭示了与印度妇女多囊卵巢综合征易感性相关的罕见变异。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-03-14 DOI: 10.1080/19396368.2025.2471418

Medini Samant, Mahalakshmi Bhat, Roshan Dadachanji, Digumarthi V S Sudhakar, Anushree Patil, Srabani Mukherjee

{"title":"Whole exome sequencing uncovers rare variants associated with PCOS susceptibility in Indian women.","authors":"Medini Samant, Mahalakshmi Bhat, Roshan Dadachanji, Digumarthi V S Sudhakar, Anushree Patil, Srabani Mukherjee","doi":"10.1080/19396368.2025.2471418","DOIUrl":"10.1080/19396368.2025.2471418","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a complex polygenic endocrinopathy affecting 5-20% of reproductive-age women. Familial studies, candidate gene studies, and GWAS have identified multiple PCOS-associated genetic loci. This study aims to identify the functional variants associated with PCOS. We applied whole exome sequencing (WES) to identify functional variants among eighty-five well-characterized women with PCOS. The annotated variants were filtered based on minor allele frequency and in-silico pathogenicity prediction. We found a significant association of 234 rare pathogenic nonsynonymous variants in 201 genes with PCOS in our study group. These genes are linked to steroid hormone biosynthesis, ovarian steroidogenesis, insulin resistance, and PI3K-Akt signaling pathway which are influential in PCOS pathophysiology. Further, several rare variants were found to be unique to women with and without insulin resistance, and enrichment analysis revealed that carbohydrate and lipid metabolism was especially deranged in insulin-resistant PCOS women. Variants of the steroidogenesis pathway were validated by Sanger sequencing including rs368902124 (CYP19A1), rs143286842 (IGF1R), and rs555458296 (BMP-6). In-silico analysis by DUET showed that these variants destabilized the folding of their corresponding protein. Women carrying these rare variants presented with altered hormonal profiles and clinical signs of hyperandrogenism and hyperinsulinemia, emphasizing their impact on PCOS pathophysiology. Several functional rare variants have been revealed to be associated with increased PCOS risk in the present study thus, expanding the genetic susceptibility landscape of Indian women to PCOS.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"76-89"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the practical challenges and ethical dilemmas of surplus cryopreserved human embryos. 超低温保存人类胚胎的实践挑战和伦理困境。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-01-28 DOI: 10.1080/19396368.2025.2449901

George Anifandis, Dimitrios Ioannou, Georgia Kokkali, Katerina Chatzimeletiou, Christina Messini, Sevastiani Antonouli, Helen G Tempest

{"title":"Navigating the practical challenges and ethical dilemmas of surplus cryopreserved human embryos.","authors":"George Anifandis, Dimitrios Ioannou, Georgia Kokkali, Katerina Chatzimeletiou, Christina Messini, Sevastiani Antonouli, Helen G Tempest","doi":"10.1080/19396368.2025.2449901","DOIUrl":"10.1080/19396368.2025.2449901","url":null,"abstract":"Cryopreservation, the use of very low temperatures to preserve structurally intact living cells and tissues, has seen exponential growth in the field of in vitro fertilization (IVF). In the last decade, cryopreservation of embryos and freeze-all protocols have become an essential aspect and a prerequisite for a successful IVF outcome. Moreover, vitrification, which is a fast and safe cryopreservation method, has proved to be an effective choice for cryopreserving gametes and embryos. The increasing number of cryopreserved embryos worldwide in cryobanks and IVF clinics is an undisputable fact that raises important physiological, ethical, and moral considerations that merit careful examination and discussion. Many couples utilizing assisted reproduction will have a surplus of cryopreserved embryos, in other words they already have completed their family without exhausting all the embryos that were created and cryopreserved during the process. Additionally, the global IVF market has also experienced significant growth due to various factors, including advancements in technology, increased awareness about infertility treatments, and changing societal norms towards delayed parenthood. Thus, for the foreseeable future the number of cryopreserved embryos, and the phenomenon of surplus embryos will likely remain unresolved. In the present review, following a description of the cryopreservation method and the physiological changes during the cryopreservation of embryos, the bioethical issues raised by the surplus cryopreserved embryos will be discussed alongside possible solutions for resolving this phenomenon.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"2449901"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of infertility. 不孕症概述。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-03-21 DOI: 10.1080/19396368.2025.2469582

Awoniyi O Awonuga, Olivia G Camp, Mia M Biernat, Husam M Abu-Soud

{"title":"Overview of infertility.","authors":"Awoniyi O Awonuga, Olivia G Camp, Mia M Biernat, Husam M Abu-Soud","doi":"10.1080/19396368.2025.2469582","DOIUrl":"10.1080/19396368.2025.2469582","url":null,"abstract":"Having a child is an innate trait in animals, including humans, and is required for the continued existence of all animal species. Therefore, for most women, the inability to conceive or to do so in a timely fashion - termed infertility - to enable the continuation of the family line can be emotionally distressing. The definition of infertility is controversial because of its separation into primary and secondary. This is further complicated by the loosely used term subfertility, which relates to couples who have reduced ability because they take longer than the natural time to conceive, as opposed to those who are infertile and are entirely unable to conceive after 6 to 12 months, depending on age. Infertility evaluation requires a thorough male and female history, physical examination of both partners, and targeted investigation to determine the cause of infertility in a particular couple. Various treatments apply to infertile couples depending on the age of the female partner, the results of investigations, the reason for infertility, the presence of inheritance of abnormal genes, the pregnancy rates the couple is happy with, the resources available, how desperate the couple is to achieve a live birth, and how much they want to commit to treatment. Infertility treatment could include counseling and expectant management only, intrauterine insemination in a natural or stimulated cycle, and IVF and or ICSI. Men with azoospermia will need surgical options to retrieve sperm for IVF/ ICSI, but rarely for IUI. This review overviews infertility's etiology, diagnosis, investigations, and treatment.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"116-142"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of placenta previa and liver enzyme abnormalities with recurrent pregnancy loss in women. 前置胎盘和肝酶异常与女性复发性妊娠丢失的相关性。

IF 2.1 4区医学

Systems Biology in Reproductive Medicine Pub Date : 2025-12-01 Epub Date: 2025-05-22 DOI: 10.1080/19396368.2025.2479483

Eyman Al-Ali, Iman Mohammed Said Jallod

{"title":"Correlation of placenta previa and liver enzyme abnormalities with recurrent pregnancy loss in women.","authors":"Eyman Al-Ali, Iman Mohammed Said Jallod","doi":"10.1080/19396368.2025.2479483","DOIUrl":"https://doi.org/10.1080/19396368.2025.2479483","url":null,"abstract":"Recurrent pregnancy loss (RPL) affects 1% to 5% of women of reproductive age, Even after thoroughly evaluating recurrent pregnancy loss etiology and risk factors about 75% of cases remaining unexplained. While the roles of hormonal imbalances, infections, and anatomical anomalies have been investigated, liver enzyme dysregulation and placenta previa remain poorly understood in their potential contributions to RPL. This study investigates these associations to improve outcomes for women with RPL. This study investigates the correlation between placenta previa, liver enzyme alterations, and recurrent pregnancy loss in a cohort of women from Telafar City. In a cross-sectional, case-control study, 80 non-pregnant women with a history of RPL were compared with 60 healthy controls without a history of miscarriage. Placental status was clinically assessed, and liver function was evaluated by measuring serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT). The study found that 79% of women with RPL exhibited placenta previa, a condition not observed in the control group. Additionally, women with RPL demonstrated significantly elevated levels of AST (19.7750 ± 5.5 U/L), ALT (17.7 ± 7.7 U/L), and GGT (21.9375 ± 9.5 U/L) compared to controls, while ALP levels were notably reduced in the RPL group (95.5250±35.5U/L vs. 124.650±19.6U/L). According to these results, placenta previa and liver enzyme dysregulation may play a role in the pathophysiology of recurrent pregnancy loss. In addition to the importance of being aware of the status of the placenta and liver function to avoid another miscarriage.","PeriodicalId":22184,"journal":{"name":"Systems Biology in Reproductive Medicine","volume":"71 1","pages":"170-177"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0