卵母细胞体外成熟(IVM):历史里程碑、现状和未来展望。

IF 2.1 4区 医学 Q3 ANDROLOGY
Katerina Chatzimeletiou, Konstantina Pappa, Nikos Petrogiannis, George Anifandis, Kalliopi Chatzovoulou, Elias Tsakos, Efstratios Kolibianakis, Grigoris Grimbizis, Antonia Sioga
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引用次数: 0

摘要

体外受精(IVF)的主要进展之一是培养基的发展,这种培养基可以促进配子在体外成熟,并将胚胎发育到囊胚阶段。对配子体发生机制的深入了解,以及围绕核和细胞质成熟的复杂事件序列,也使高效的体外成熟(IVM)方案得以发展。本文综述了卵母细胞体外成熟史上的主要里程碑,其在人类临床应用的优势和重要性,特别是在多囊卵巢综合征(PCOS)、抗性卵巢综合征、高窦卵泡计数或肿瘤患者中的应用,以及该技术的安全性和有效性。在成熟率、受精率和临床结果方面,IVM尚未显示出与受控卵巢刺激一样有效,这可能是由于核/细胞质成熟过程功能失调或不同步所致。一套令人困惑的体外受精临床方案也可能是将该技术缓慢纳入常规体外受精实践的原因。然而,最近的改进导致了IVM和IVF之间的活产率相当,在高腔卵泡计数的妇女中。本文将讨论体外受精技术在辅助生殖技术(ART)实验室中的应用现状及其未来前景,以期为患者提供最大限度的生育护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vitro maturation of oocytes (IVM): historical landmarks, current status and future perspectives.

One of the major advancements in in vitro fertilization (IVF) has been the development of culture media that enhance gamete maturation in vitro and sustain embryo development up to the blastocyst stage. The deep understanding of the mechanisms involved in gametogenesis and the complex sequence of events surrounding nuclear and cytoplasmic maturation has also enabled the development of efficient in vitro maturation (IVM) protocols. This review outlines the major landmarks in the history of in vitro maturation of oocytes, the advantages and importance of its clinical application in human, especially in patients with Polycystic Ovary Syndrome (PCOS), Resistant Ovary Syndrome, high antral follicle count or oncology patients, as well as the safety and efficacy of the technique. IVM has not been shown yet to be as effective as controlled ovarian stimulation in terms of maturation rates, fertilization rates, and clinical outcome, possibly owing to a dysfunctional or asynchronous nuclear/cytoplasmic maturation process. A confusing set of IVM clinical protocols may also have contributed to the slow incorporation of the technology into routine IVF practice. However, recent improvements have led to comparable live birth rates between IVM and IVF, in women with high antral follicle count. The current status of IVM in the Assisted Reproductive Technology (ART) laboratory and its future perspectives, aiming to provide maximum fertility care to patients will be discussed.

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来源期刊
CiteScore
4.30
自引率
4.20%
发文量
27
审稿时长
>12 weeks
期刊介绍: Systems Biology in Reproductive Medicine, SBiRM, publishes Research Articles, Communications, Applications Notes that include protocols a Clinical Corner that includes case reports, Review Articles and Hypotheses and Letters to the Editor on human and animal reproduction. The journal will highlight the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatic, molecular, and biochemical, to address fundamental questions in reproductive biology, reproductive medicine, and translational research. The journal publishes research involving human and animal gametes, stem cells, developmental biology and toxicology, and clinical care in reproductive medicine. Specific areas of interest to the journal include: male factor infertility and germ cell biology, reproductive technologies (gamete micro-manipulation and cryopreservation, in vitro fertilization/embryo transfer (IVF/ET) and contraception. Research that is directed towards developing new or enhanced technologies for clinical medicine or scientific research in reproduction is of significant interest to the journal.
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