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Entscheidung am Lebensende – Entscheidung für ein Lebensende? 生命终结决定——生命终结决定？
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01412
Christiane Leupold-Gross
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引用次数: 0
Wichtige Termine 2021
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01414
Universitäres Zentrum für Hausarztmedizin beider Basel
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引用次数: 0
«Ziel der Palliativmedizin ist nicht immer die Behandlung der Beschwerden, sondern diesen Beschwerden einen sicheren Raum zu geben» “姑息医学的目的并不总是治疗投诉，而是给这些投诉一个安全的空间”
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01407
B. Stricker
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引用次数: 0
«Es geht nicht darum, dem Leben mehr Tage zu geben, sondern den Tagen mehr Leben» «无关的生活提供更多的时间,而是更多的日子生活»
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01406
B. Stricker
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引用次数: 0
Ambivalente Erfahrungen geriatrischer Kliniken mit der Covid-Pandemie 新冠肺炎大流行期间老年诊所的模棱两可的经验
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01408
Tobias Meyer, Bernhard Flückiger
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引用次数: 0
Reorganisation der VHBB VHBB重组令
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01415
Vereinigung der Hausärzte und Hausärztinnen beider Basel
{"title":"Reorganisation der VHBB","authors":"Vereinigung der Hausärzte und Hausärztinnen beider Basel","doi":"10.4414/SYN.2021.01415","DOIUrl":"https://doi.org/10.4414/SYN.2021.01415","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":" ","pages":"15"},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47260503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Im Labyrinth der Patientenverfügungen – ein Blick nach vorn 在患者情绪的迷宫中——展望未来
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01409
Christiane Leupold-Gross
{"title":"Im Labyrinth der Patientenverfügungen – ein Blick nach vorn","authors":"Christiane Leupold-Gross","doi":"10.4414/SYN.2021.01409","DOIUrl":"https://doi.org/10.4414/SYN.2021.01409","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":" ","pages":"9-10"},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48783725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schlagwörter: Wie aus Pyramiden Urnen werden 关键词：金字塔如何变成urns
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01413
Karin Hirschi
{"title":"Schlagwörter: Wie aus Pyramiden Urnen werden","authors":"Karin Hirschi","doi":"10.4414/SYN.2021.01413","DOIUrl":"https://doi.org/10.4414/SYN.2021.01413","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"21 1","pages":"13-14"},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43943546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Delta 9-tetrahydrocannabinol administration differentially alters the hippocampal opioid system in adult female and male rats. 急性δ 9-四氢大麻酚管理不同地改变了成年雌性和雄性大鼠海马阿片系统。
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-01 DOI: 10.1002/syn.22218
Kyle A Windisch, Sanoara Mazid, Megan A Johnson, Elina Ashirova, Yan Zhou, Lennox Gergoire, Sydney Warwick, Bruce S McEwen, Mary Jeanne Kreek, Teresa A Milner
{"title":"Acute Delta 9-tetrahydrocannabinol administration differentially alters the hippocampal opioid system in adult female and male rats.","authors":"Kyle A Windisch,&nbsp;Sanoara Mazid,&nbsp;Megan A Johnson,&nbsp;Elina Ashirova,&nbsp;Yan Zhou,&nbsp;Lennox Gergoire,&nbsp;Sydney Warwick,&nbsp;Bruce S McEwen,&nbsp;Mary Jeanne Kreek,&nbsp;Teresa A Milner","doi":"10.1002/syn.22218","DOIUrl":"https://doi.org/10.1002/syn.22218","url":null,"abstract":"<p><p>Our prior studies demonstrated that the rat hippocampal opioid system can undergo sex-specific adaptations to external stimuli that can influence opioid-associated learning processes. This opioid system extensively overlaps with the cannabinoid system. Moreover, acute administration of Δ<sup>9</sup> Tetrahydrocannabinoid (THC), the primary psychoactive constituent of cannabis, can alter cognitive behaviors that involve the hippocampus. Here, we use light and electron microscopic immunocytochemical methods to examine the effects of acute THC (5 mg/kg, i.p., 1 h) on mossy fiber Leu-Enkephalin (LEnk) levels and the distribution and phosphorylation levels of delta and mu opioid receptors (DORs and MORs, respectively) in CA3 pyramidal cells and parvalbumin dentate hilar interneurons of adult female and male Sprague-Dawley rats. In females with elevated estrogen states (proestrus/estrus stage), acute THC altered the opioid system so that it resembled that seen in vehicle-injected females with low estrogen states (diestrus) and males: (1) mossy fiber LEnk levels in CA2/3a decreased; (2) phosphorylated-DOR levels in CA2/3a pyramidal cells increased; and (3) phosphorylated-MOR levels increased in most CA3b laminae. In males, acute THC resulted in the internalization of MORs in parvalbumin-containing interneuron dendrites which would decrease disinhibition of granule cells. In both sexes, acute THC redistributed DORs to the near plasma membrane of CA3 pyramidal cell dendrites, however, the dendritic region varied with sex. Additionally, acute THC also resulted in a sex-specific redistribution of DORs within CA3 pyramidal cell dendrites which could differentially promote synaptic plasticity and/or opioid-associated learning processes in both females and males.</p>","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"75 10","pages":"e22218"},"PeriodicalIF":2.3,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/syn.22218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Issue Information 问题信息
IF 2.3 4区 医学
Synapse Pub Date : 2021-10-01 DOI: 10.1002/syn.22171
{"title":"Issue Information","authors":"","doi":"10.1002/syn.22171","DOIUrl":"https://doi.org/10.1002/syn.22171","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43668155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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