内体循环和多巴胺神经传递:探索逆转录酶与帕金森病之间的联系。

IF 1.6 4区医学 Q4 NEUROSCIENCES

Synapse Pub Date : 2022-03-01 Epub Date: 2022-02-14 DOI:10.1002/syn.22224

Nathan Gock, Jordan Follett, Gordon L Rintoul, Timothy V Beischlag, Frank J S Lee

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引用次数: 0

摘要

反转录复合体是一种进化上保守的蛋白质复合体，参与各种货物蛋白的内体循环。它在所有组织中普遍表达，在无脊椎动物和哺乳动物的神经系统中都有发现，在那里它循环各种突触膜蛋白，包括多巴胺转运蛋白和多巴胺D1受体，这两种蛋白与多巴胺稳态和神经传递有关。反转录复合体与帕金森病(一种多巴胺系统的神经退行性疾病)的联系进一步强调了多巴胺神经生物学的参与。本文对目前文献中有关突触功能和多巴胺稳态的研究进展进行综述。通过探索逆转录物和其他帕金森病相关蛋白以及与突触功能和多巴胺传递的可能关系，强调了其他可能的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease.

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Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease.

The retromer complex is an evolutionarily conserved protein complex involved in the endosomal recycling of various cargo proteins. It is ubiquitously expressed in all tissue and is found in both invertebrate as well as mammalian nervous systems, where it recycles various synaptic membrane proteins including the dopamine transporter and dopamine D1 receptor, two proteins implicated in dopamine homeostasis and neurotransmission. The involvement of the retromer complex in dopamine neurobiology is further underscored by its links to Parkinson's disease, a neurodegenerative disorder of the dopamine system. In this article, the existing literature linking the retromer complex to synaptic function and dopamine homeostasis is reviewed. Additional possible links are highlighted by exploring the retromer and other Parkinson's disease-associated proteins and possible relationships to synaptic function and dopamine transmission.

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来源期刊

Synapse 医学-神经科学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： SYNAPSE publishes articles concerned with all aspects of synaptic structure and function. This includes neurotransmitters, neuropeptides, neuromodulators, receptors, gap junctions, metabolism, plasticity, circuitry, mathematical modeling, ion channels, patch recording, single unit recording, development, behavior, pathology, toxicology, etc.