Synapse最新文献_第9页

Issue Information 问题信息

IF 2.3 4区医学

Synapse Pub Date : 2021-12-01 DOI: 10.1002/syn.22173

引用次数: 0

Sensitivity of subcellular components of neuromuscular junctions to decreased neuromuscular activity. 神经肌肉连接的亚细胞成分对神经肌肉活动减少的敏感性。

IF 2.3 4区医学

Synapse Pub Date : 2021-11-01 Epub Date: 2021-08-06 DOI: 10.1002/syn.22220

Michael R Deschenes, Audrey M Trebelhorn, Madeline C High, Hannah L Tufts, Jeongeun Oh

{"title":"Sensitivity of subcellular components of neuromuscular junctions to decreased neuromuscular activity.","authors":"Michael R Deschenes, Audrey M Trebelhorn, Madeline C High, Hannah L Tufts, Jeongeun Oh","doi":"10.1002/syn.22220","DOIUrl":"https://doi.org/10.1002/syn.22220","url":null,"abstract":"<p><p>Muscle unloading imparts subtotal disuse on the neuromuscular system resulting in reduced performance capacity. This loss of function, at least in part, can be attributed to disruptions at the neuromuscular junction (NMJ). However, research has failed to document morphological remodeling of the NMJ with short term muscle unloading. Here, rather than quantifying cellular components of the NMJ, we examined subcellular active zone responses to 2 weeks of unloading in male Wistar rats. It was revealed that in the plantaris, but not the soleus muscles, unloading elicited significant (P ≤ 0.05) decrements in active zone staining as measured by Bassoon, and calcium channel expression. It was also discovered that unloading decreased the area of calcium channels staining relative to active zone areas of staining suggesting potential interference in the ability of calcium influx to trigger the release of vesicles docked at the active zone. Post-synaptic adaptations of the motor endplate were not evident. This presynaptic subcellular size reduction was not associated with atrophy of the underlying plantaris muscle fibers, although atrophy of the weight-bearing soleus fibers, where no subcellular remodeling was evident, was noted. These results suggest that the active zone is highly sensitive to alterations in neuromuscular activity, and that morphological adaptation of excitatory and contractile components of the NMJ can occur independently of each other.</p>","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"75 11","pages":"e22220"},"PeriodicalIF":2.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/syn.22220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39230207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Issue Information 问题信息

IF 2.3 4区医学

Synapse Pub Date : 2021-11-01 DOI: 10.1002/syn.22172

引用次数: 0

Sterbehilfe – vom Tod her gedacht 死神要互相帮助

IF 2.3 4区医学

Synapse Pub Date : 2021-10-14 DOI: 10.4414/SYN.2021.01411

P. Rothen

引用次数: 0

Entscheidung am Lebensende – Entscheidung für ein Lebensende? 生命终结决定——生命终结决定？

IF 2.3 4区医学