SynapsePub Date : 2021-09-01Epub Date: 2021-07-06DOI: 10.1002/syn.22217
Christine J Reinhart, Dan C McIntyre, Sergio M Pellis, Bryan E Kolb
{"title":"Prefrontal neuronal morphology in kindling-prone (FAST) and kindling-resistant (SLOW) rats.","authors":"Christine J Reinhart, Dan C McIntyre, Sergio M Pellis, Bryan E Kolb","doi":"10.1002/syn.22217","DOIUrl":"https://doi.org/10.1002/syn.22217","url":null,"abstract":"<p><p>The epileptogenic-prone (FAST) and epileptogenic-resistant (SLOW) rat strains have become a valuable tool for investigating neural plasticity. The strains were generated by breeding the rats that required the fewest amygdala stimulations to elicit a stage-5 convulsive seizure (FAST) and rats requiring the most stimulations (SLOW). Previous studies have shown differences in behavior and amygdala physiology in the two strains. This study examined the dendritic morphology of pyramidal neurons in the brains of adult male and female rats of the two strains. The brains were stained with the Golgi-Cox method and the length and branching from layer III pyramidal cells were measured in parietal cortex (Zilles Par1), medial frontal cortex (Zilles Cg3), and orbitofrontal cortex (Zilles AID) in these two strains of rats. We observed significantly longer dendrites in Cg3 in the FAST group but longer dendrites in the SLOW group in AID and Par1. There was also a sex difference (M > F) in Par1 in both strains. These morphological differences can provide insights into the neurobiological basis of the behavioral differences and suggest that localized changes in the amygdala do not occur independently of changes in other brain regions, and especially prefrontal cortex.</p>","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"75 9","pages":"e22217"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/syn.22217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39008204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SynapsePub Date : 2021-08-12DOI: 10.4414/SYN.2021.01402
M. Savic
{"title":"Was ist Medizin?","authors":"M. Savic","doi":"10.4414/SYN.2021.01402","DOIUrl":"https://doi.org/10.4414/SYN.2021.01402","url":null,"abstract":"Die Medizin der Gegenwart ist durch eine Reihe von Tendenzen charakterisiert, die dazu führen, dass sich das traditionelle Verständnis der Medizin als bloßer Heilkunde nicht mehr von selbst versteht. Zu nennen sind hier etwa die oft beklagte Ökonomisierung der Medizin oder der Trend zur »wunscherfüllenden Medizin«. Angesichts dieser Veränderungen gewinnt die theoretische Frage nach dem Wesen der Medizin an praktischer Bedeutung. Der Band „Was ist Medizin?“ beantwortet die Frage aus verschiedenen Perspektiven. Beiträge aus der Geschichte der Medizin informieren über Konstanten und Wandlungen im Verständnis der Medizin. Medizin- und wissenschaftstheoretische Auseinandersetzungen beschäftigen sich mit der Frage, was für eine Art von Wissenschaft die Medizin ist. Dabei gilt ihr Augenmerk u. a. der Spannung zwischen der wissenschaftlichen Forschung und der klinischen Praxis. Außerdem werden aus der Sicht der Ethik die vieldiskutierten Fragen erörtert, ob die Medizin ein inhärentes Ethos aufweist, worin dieses bestehen könnte und ob es einen Beitrag zur Klärung medizinethischer Probleme leisten kann. Schließlich wird anhand von Anwendungsfällen nach den Grenzen der gegenwärtigen Medizin gefragt.","PeriodicalId":22131,"journal":{"name":"Synapse","volume":" ","pages":"11-11"},"PeriodicalIF":2.3,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46060617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SynapsePub Date : 2021-08-12DOI: 10.4414/SYN.2021.01403
G. Maio
{"title":"«Die Identität der Medizin besteht darin, dass sie nicht nach Rentabilität vorgeht, sondern nach Bedarf»","authors":"G. Maio","doi":"10.4414/SYN.2021.01403","DOIUrl":"https://doi.org/10.4414/SYN.2021.01403","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"21 1","pages":"12-14"},"PeriodicalIF":2.3,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46332597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SynapsePub Date : 2021-08-12DOI: 10.4414/SYN.2021.01398
C. Quinto
{"title":"Rahmenbedingungen für eine optimale Medizin sicherstellen – auch in Zukunft","authors":"C. Quinto","doi":"10.4414/SYN.2021.01398","DOIUrl":"https://doi.org/10.4414/SYN.2021.01398","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"21 1","pages":"1-3"},"PeriodicalIF":2.3,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43455655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SynapsePub Date : 2021-08-12DOI: 10.4414/SYN.2021.01401
Urs Stoffel
{"title":"TARDOC noch nicht genehmigt – Chance verpasst!","authors":"Urs Stoffel","doi":"10.4414/SYN.2021.01401","DOIUrl":"https://doi.org/10.4414/SYN.2021.01401","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":" ","pages":"9-10"},"PeriodicalIF":2.3,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42758720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SynapsePub Date : 2021-08-12DOI: 10.4414/SYN.2021.01399
Yvonne Gilli
{"title":"Kostendämpfungspolitik: Die Schweizer Gesundheitsversorgung im Fokus von Regulierung und Kostendruck","authors":"Yvonne Gilli","doi":"10.4414/SYN.2021.01399","DOIUrl":"https://doi.org/10.4414/SYN.2021.01399","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":"21 1","pages":"3-5"},"PeriodicalIF":2.3,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42163334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}