Substance Use & Misuse最新文献

{"title":"Modeling the Associations Between Personality, Cognition, and Social Determinants in Relation to Substance Use Disorder Severity in Community Adults.","authors":"Rickie Miglin, Naomi Sadeh","doi":"10.1080/10826084.2026.2689088","DOIUrl":"10.1080/10826084.2026.2689088","url":null,"abstract":"<p><strong>Objective: </strong>To develop more effective intervention strategies for substance use disorder (SUD), it is essential to create models that evaluate the relative influence of various risk factors. This study constructed an integrated biopsychosocial model to examine the associations of different risk vulnerability domains with SUD severity.</p><p><strong>Method: </strong>251 community adults aged 18-55 (female = 48.2%; White = 64.1%, Black = 26.7%, Asian American = 8.0%, American Indian/Alaska Native = 2.0%, Native Hawaiian/Pacific Islander = 1.6%, Hispanic =7.6%), completed clinical diagnostic interviews, neuropsychological testing, behavioral tasks, and surveys to assess SUD severity and an array of risk factors. We created latent variables to represent Disordered Personality, Cognitive Ability, and Social Determinant domains expected to contribute to SUD severity. We used structural equation modeling to model the cross-sectional associations of SUD severity with the latent variables (Disordered Personality, Cognitive Ability, and Social Determinant) and Delay Discounting.</p><p><strong>Results: </strong>An integrated model showed that Social Determinants (<i>β</i> = 0.77, z-test = 6.06, <i>p</i> < 0.001; 95% CI [0.72, 0.82]), Disordered Personality (<i>β</i> = 0.17, z-test = 2.23, <i>p</i> = 0.026; 95% CI [0.05, 0.29]) and Delay Discounting (<i>β</i> = 0.16, z-test = 3.13, <i>p</i> = 0.002; 95% CI [0.04, 0.28]) explained variance in SUD severity. In contrast, Cognitive Ability was not associated with SUD severity in the integrated model (<i>β</i> = 0.18, z-test = 1.56, <i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>These cross-sectional findings support biopsychosocial models of SUD and underscore the role of social determinant risk factors in understanding SUD severity. Further research is needed to refine these models for improved assessment and treatment strategies.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Adulthood Trends in Substance Use After Youth Criminal Legal System Involvement.","authors":"Ian A Silver, Andrew J Yockey, Jessica Meckes","doi":"10.1080/10826084.2026.2727141","DOIUrl":"https://doi.org/10.1080/10826084.2026.2727141","url":null,"abstract":"<p><strong>Objectives: </strong>Adolescent involvement in the criminal legal system (CLS) may function as a significant stressor with long-term behavioral health consequences. This study examined whether CLS involvement before age 18 influences the odds and trajectories of substance use (alcohol, cigarette, marijuana, and illicit drug use) from ages 18-28, and whether these effects vary by severity of involvement.</p><p><strong>Method: </strong>Data were drawn from the 1997-2011 surveys of the National Longitudinal Survey of Youth 1997 (<i>N</i> = 8,961; approximately 50% male), a nationally representative cohort. Random intercept and growth curve models were estimated to examine the effects of CLS involvement before 18 on the odds of substance use from 18-28 (alcohol, cigarette, marijuana, and illicit drug use).</p><p><strong>Results: </strong>Being arrested, incarcerated in a juvenile facility, or incarcerated in an adult facility before 18 was associated with an increased odds illicit drug use (OR = 2.080, <i>p</i> < 0.001; OR = 2.132, <i>p</i> < 0.001; OR = 2.598, <i>p</i> < 0.001) from 18-28 (respectively). The growth curve models suggested that CLS involvement before 18 could result in more persistent substance use.</p><p><strong>Conclusions: </strong>These findings suggest that youth CLS involvement could influence substance use and more persistent patterns of substance use in adulthood. The combination of cognitive behavioral therapy and substance use treatment should be considered for reentering youth.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping with Structural Harm: Social Support and Recent Drug Use Among Indigenous Peoples in Canada.","authors":"Liqun Cao, Hui Zhu","doi":"10.1080/10826084.2026.2725882","DOIUrl":"https://doi.org/10.1080/10826084.2026.2725882","url":null,"abstract":"<p><strong>Background: </strong>We argue that drug use should not be understood as a lifestyle choice, nor should it be regarded as a characteristic of individuals, but rather as a coping mechanism in response to structural harm. Accordingly, structural theories, social support theory, and constellation perspective provide a useful framework for explaining recent drug use.</p><p><strong>Methods: </strong>Using data from the Aboriginal Peoples Survey, we conducted multivariate logistic regression analyses to examine the correlates of drug use. Variables derived from social support theory and from the constellation model were used to explain variation in drug use among Indigenous Peoples.</p><p><strong>Results: </strong>The results indicate that Inuit respondents are significantly more likely to use drugs, whereas Métis respondents are less likely to do so, compared to First Nations respondents. In addition, persons who use drugs and who don't use drugs constitute distinct groups. Variables of social support and constellation models explain drug use more effectively than nonuse.</p><p><strong>Conclusion: </strong>The lived experiences of Indigenous Peoples are highly consequential for understanding drug use. This study underscores the importance of addressing structural inequalities, especially contumacious health care inequities between Indigenous and non-Indigenous populations, in the design of effective drug use policies and interventions.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Stress Exposure as a Predictor of Drug Use Variety: Examining Peer Drug Use and Peer Drug Dealing as Mediators.","authors":"Thomas Wojciechowski","doi":"10.1080/10826084.2026.2724153","DOIUrl":"https://doi.org/10.1080/10826084.2026.2724153","url":null,"abstract":"<p><strong>Background: </strong>Traumatic stress exposure is a risk factor for greater drug use variety, but there remains limited research on peer mediators of this relationship. This study sought to examine traumatic stress exposure as a predictor of drug use variety and determine whether peer drug use and/or peer drug selling/gifting significantly mediate this relationship.</p><p><strong>Methods: </strong>The Adolescent Brain Cognitive Development dataset was analyzed. The first four waves were used. Generalized structural equation modeling was used to estimate direct and indirect relationships of interest.</p><p><strong>Results: </strong>Past year traumatic stress exposure prior to Wave 2 was associated with greater drug use variety at Wave 4. Greater peer drug selling/gifting and peer drug use scores at Wave 3 also predicted significantly greater drug use variety at Wave 4. However, only peer drug use significantly mediated the relationship between traumatic stress exposure and drug use variety.</p><p><strong>Conclusion: </strong>Traumatic stress exposure early in life may be associated with greater risk for greater drug use variety. Peer drug use behaviors among those who have experienced trauma should be targeted for intervention as a means of mitigating this risk.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion Dysregulation Modulates the Association Between Cigarette Use and HPA-Axis Functioning Among Women Currently Experiencing Intimate Partner Violence.","authors":"Reagan E Fitzke, Alexa M Raudales, Jewelia J Ferguson, Alana Egan, Colin T Mahoney, Ceren Günsoy, Nicole H Weiss","doi":"10.1080/10826084.2026.2727142","DOIUrl":"10.1080/10826084.2026.2727142","url":null,"abstract":"<p><strong>Background: </strong>Cigarette use is a salient public health concern, particularly among women experiencing intimate partner violence (IPV). While smoking cigarettes may attenuate acute stress levels, it also exacerbates long-term stress reactivity by disrupting hypothalamic-pituitary-adrenal (HPA)-axis functioning. However, little is known about how emotion dysregulation may influence the impact of cigarette use on stress reactivity among women experiencing ongoing IPV.</p><p><strong>Method: </strong>This study examined whether emotion dysregulation moderates the association between cigarette use and HPA-axis functioning, measured by hair cortisol concentration, among 94 women currently experiencing IPV. Participants completed a baseline interview that included assessment of emotion dysregulation, followed by 30 days of thrice daily surveys that assessed cigarette use, and finally a follow-up interview where a hair sample was collected for cortisol analysis.</p><p><strong>Results: </strong>Analyses revealed a significant moderating effect of emotion dysregulation on the association between cigarette use and HPA-axis functioning. Specifically, among women with low to moderate (but not high) emotion dysregulation, greater average cigarettes per day were associated with lower hair cortisol concentration during the 30-day sampling period.</p><p><strong>Conclusion: </strong>Findings suggest a potential stress-modulating function of cigarette use among women with low to moderate levels of emotion dysregulation, while elevated dysregulation may attenuate the stress-relieving effects of cigarette use. While the foremost priority is implementing safety-focused interventions and comprehensive domestic violence services to reduce ongoing relationship violence, our results also highlight the potential utility of tailoring smoking cessation interventions for women experiencing IPV to address emotion dysregulation and promote alternative stress-coping strategies.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Tobacco and Cannabis Use Motives Interact: Implications for Dependence and Quitting.","authors":"Tangui Barré, Géraldine Cazorla, Vincent Leroy, Gwenaëlle Maradan, Clotilde Couderc, Julia de Ternay, Carlotta Magnani, Patrizia Carrieri, Camelia Protopopescu","doi":"10.1080/10826084.2026.2723589","DOIUrl":"https://doi.org/10.1080/10826084.2026.2723589","url":null,"abstract":"<p><strong>Background: </strong>Tobacco and cannabis co-use is a major public health issue among young adults. Little is known about how motives for using these substances interact and affect co-use behaviors. This study explores these associations and identify distinct motivational profiles among young people who co-use.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among 357 French young adults (18-30 years; 54.9% men) reporting co-use. Participants indicated (Yes/No) their endorsement of 21 motives (10 tobacco-related, 11 cannabis-related, 7 shared). Correlations were computed between all motives. Hierarchical clustering identified distinct motivational profiles. Associations between profiles, motives, dependence, and readiness to quit were examined using regression models.</p><p><strong>Results: </strong>Most within-substance motives and all shared cross-substance motives were correlated. Three clusters emerged: (1) high tobacco/moderate cannabis motive endorsement (<i>n</i> = 188), with high nicotine dependence; (2) low overall motive endorsement (except pleasure) and low dependence levels (<i>n</i> = 39); and (3) high endorsement of both tobacco and cannabis motives, with high dependence levels (<i>n</i> = 130). The number of endorsed tobacco motives was negatively associated with readiness to quit tobacco but positively associated with readiness to quit cannabis.</p><p><strong>Conclusions: </strong>While tobacco and cannabis motives overlapped, these findings underscore the need to consider motivational patterns when designing tailored interventions to reduce co-use-related harms.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Pathways between Socioeconomic Factors and Overdose: A Systematic Realist Synthesis.","authors":"Sanjana Mitra, Mohammad Karamouzian, Mark Gilbert, Lindsey Richardson","doi":"10.1080/10826084.2026.2723585","DOIUrl":"https://doi.org/10.1080/10826084.2026.2723585","url":null,"abstract":"<p><strong>Background: </strong>Employing a realist approach, this review aims to describe how direct and indirect socioeconomic elements lead to overdose in people who use opioids.</p><p><strong>Methods: </strong>We conducted a systematic realist review to understand the underlying structures and processes connecting socioeconomic elements to overdose. Empirical studies published between 2004 and 2019 were identified through six electronic databases (MEDLINE, EMBASE, PyschINFO, CINAHL, Web of Science and Google Scholar), grey literature searches, and manual citation searches. We conducted title, abstract, and full-text screening. We thematically analyzed and synthesized extracted data and performed a quality and relevance appraisal (i.e., assessing the quality of evidence for mechanisms).</p><p><strong>Results: </strong>A total of 55 studies were included in this review. Eight overlapping dimensions with direct and indirect linkages to socioeconomic wellbeing were identified: income and poverty, employment, housing and drug use settings, social networks and norms, criminal justice involvement, gender-based dynamics, acute life events, and stigma. Socioeconomic determinants shaped overdose risk through intermediate outcomes and a range of intersecting material (e.g., deprivation), normative (e.g., fear of criminalization), and bio-psychosocial pathways (e.g., psychological distress or mental illness). A majority of evidence suggested that conditions of socioeconomic adversity trigger drug use as a means to cope with exacerbated mental health concerns or psychological distress (bio-psychosocial pathways), leading to overdose. Supportive evidence for this mechanism was found across all identified socioeconomic dimensions.</p><p><strong>Conclusions: </strong>Findings point to the need to address the socioeconomic production of overdose risk, with additional emphasis on the pathways and mechanisms linking socioeconomic elements to overdose outcomes.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-21"},"PeriodicalIF":1.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Attitudes Toward Marijuana Legalization in Türkiye: An Analysis of Key Stakeholders.","authors":"Kemal Balica, Umut Kirli, Serap Annette Akgür","doi":"10.1080/10826084.2026.2726534","DOIUrl":"https://doi.org/10.1080/10826084.2026.2726534","url":null,"abstract":"<p><strong>Background: </strong>Despite global liberalization trends increasingly supporting the legalization of marijuana, attitudes in countries that maintain prohibition remain understudied. In Türkiye, following the introduction of regulations for hemp cultivation aimed at producing pharmaceutical active substances, understanding societal trends has become critical. This study examines the attitudes of four key stakeholder groups in Türkiye toward marijuana legalization using the harm perception literature, the Socio-Ecological Model, and the Theory of Planned Behavior.</p><p><strong>Methods: </strong>A descriptive, cross-sectional study was conducted with 300 participants equally distributed among substance users, their families, university students, and healthcare professionals using a structured questionnaire designed for this purpose.</p><p><strong>Results: </strong>A high level of opposition to legalization was observed across the entire sample (69.4%). Significant polarization was observed among the research groups (<i>p</i> < 0.001). This strong support among users may be interpreted within a self-interest framework. In contrast to Western literature, university students enrolled in health-related educational programs displayed the highest level of opposition. Ordinal logistic regression identified \"perceived harm\" as the strongest predictor of support (OR = 0.57, 95% CI [0.48, 0.68], <i>p</i> < 0.01), indicating that higher levels of perceived harm were associated with a lower likelihood of supporting legalization.</p><p><strong>Conclusion: </strong>Despite global liberalization, deep-seated societal resistance persists in Türkiye, driven more by high harm perception than by evidence-based harm reduction paradigms. Policy discussions may benefit from considering the observed gap between perceived harm and empirically documented harm, while acknowledging the contextual and methodological limitations of the present study.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Governance Processes and Recovery Environments in Recovery Homes: The Roles of Decision-Making and Rule Implementation.","authors":"Leonard A Jason, Elizabeth Garrity, Alexa Nieder, Alexander Sikora","doi":"10.1080/10826084.2026.2711946","DOIUrl":"https://doi.org/10.1080/10826084.2026.2711946","url":null,"abstract":"<p><strong>Background: </strong>Recovery homes vary in their governance structures, yet little is known about how these differences shape recovery-relevant social environments. This study examined democratic decision-making, rule implementation, and perceived social climate in peer-run Oxford Houses compared to staff-run recovery homes.</p><p><strong>Methods: </strong>Using data from 306 Oxford House residents and 80 traditional recovery home residents who completed the Social Setting Democracy Scale, analyses tested relationships among governance processes and outcomes.</p><p><strong>Results: </strong>Greater resident participation in decision-making was associated with more positive social environments, and this relationship was statistically linked to perceptions of fair and transparent rule implementation. Oxford House residents reported significantly higher levels of decision-making participation, implementation fairness, rule clarity, and positive social climate compared to residents of staff-run homes.</p><p><strong>Conclusion: </strong>These findings suggest that the enactment of governance processes. particularly fair implementation, may represent an important mechanism through which recovery environments influence functioning. Democratic governance is discussed as a potentially active ingredient of peer-run recovery models, with implications for recovery housing design and evaluation.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment for Opioid Use Disorder: A National Study Comparing Criminal Justice and Community Samples.","authors":"Laura Lutgen-Nieves, Wendy P Guastaferro, Brent Teasdale, Deborah Koetzle, Rachelle Wetsman","doi":"10.1080/10826084.2026.2724155","DOIUrl":"https://doi.org/10.1080/10826084.2026.2724155","url":null,"abstract":"<p><strong>Methods: </strong>This research compares characteristics related to receipt of medications for OUD (MOUD) across treatment episodes referred by the criminal justice system and those referred by other sources, utilizing 639,199 cases from the 2018 U.S. Treatment Episode Data Set-Discharges.</p><p><strong>Results: </strong>MOUD receipt was more than twice as likely in the non-criminal justice sample than the criminal justice sample (33% compared to 15%, respectively). The impact of demographics, substance use, need for and characteristics of treatment, and access to treatment on MOUD receipt vary considerably across the two samples.</p><p><strong>Conclusions: </strong>Understanding characteristics that inhibit and facilitate MOUD access can strengthen the public health approach to intervention, particularly for justice-involved individuals.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}