Substance Use & Misuse最新文献

{"title":"Development and Testing of a Self-Paced Virtual Reality-Based Naloxone Training.","authors":"Wasantha Jayawardene, Chesmi Kumbalatara, Matthew Kase, Alana Goodson, Amy Park, Joanna Willett, Scott Barrows, Rebecca Bolinski, Roy Magnuson","doi":"10.1080/10826084.2025.2560073","DOIUrl":"https://doi.org/10.1080/10826084.2025.2560073","url":null,"abstract":"<p><strong>Objectives: </strong>With increased availability of naloxone, there is an increased need for scalable naloxone training programs. Current naloxone training efforts are promising, however, developing more interactive training platforms to improve self-efficacy in reversing overdoses and reducing anxiety associated with attending victims in real-life, especially among laypersons, remain major challenges. To address this gap, we developed a self-paced \"Virtual Reality Naloxone Training (VeNT)\" and tested its usability and acceptability.</p><p><strong>Methods: </strong>Using the Apple Vision Pro spatial computing headset, a mixed reality (MR) application was developed to allow trainees to interact with virtual objects while seeing their surroundings, e.g., administering naloxone spray to a virtual patient. VeNT was field tested in diverse environments, e.g., offices, homes, and outdoor spaces, with diverse participants (<i>N</i> = 25), e.g., people who use drugs, potential bystanders, doctors, firefighters, tech experts, using pre-post surveys and qualitative interviews. It involved a self-paced simulated tutorial and interactive overdose response activities, rescue breathing, and chest compression.</p><p><strong>Results: </strong>VeNT significantly improved knowledge in recognizing an overdose and confidence in administering naloxone, rescue breathing, and chest compressions, while increasing intent to help and reducing uncertainty in responding to overdoses. Participants found VeNT more engaging than traditional training methods, noting its realism, simulated patient responses, immersive experience, and effectiveness in boosting knowledge and confidence.</p><p><strong>Conclusion: </strong>VeNT offers a cost-effective solution to an unmet need, because it can be provided in diverse settings, involving more engaging techniques, compared to traditional in-person or online trainings. It also demonstrates feasibility and scalability of MR-based naloxone training.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Alcohol and Marijuana Use Versus Alcohol Use Only on Protective Behavioral Strategies: The Moderating Influences of Coping and Enhancement Motives.","authors":"Olivia D Teasdale, Ty S Schepis","doi":"10.1080/10826084.2025.2556254","DOIUrl":"https://doi.org/10.1080/10826084.2025.2556254","url":null,"abstract":"<p><strong>Introduction: </strong>Simultaneous alcohol and marijuana (SAM) use is elevated among college students. Protective behavioral strategies (PBS) could help limit harms from SAM use among college students, but utilization of PBS with SAM use is understudied. The current study sought to investigate PBS endorsement differences between students with past-month SAM use and alcohol-only use, as well as the moderating roles of motives and past-month alcohol use quantity.</p><p><strong>Methods: </strong>Participants were 3,281 undergraduate college students recruited from several universities throughout the U.S., who reported past-month alcohol use (<i>M</i>_age = 19.43, 63.8% White, 72.6% cisgender woman). Participants completed a series of online, self-report measures.</p><p><strong>Results: </strong>Neither positive effects nor coping motives moderated the relationship between SAM use and PBS (<i>ps = 0.716</i>, 0.711). Coping motives did not moderate alcohol use and PBS (<i>p</i> = 0.108), yet there was a significant, negative interaction between enhancement movies and alcohol use on PBS (<i>B =</i> -0.07, <i>SE</i> = 0.02, <i>p =</i> 0.001, 95% CI [-0.12, -0.03]) such that more alcohol use and greater endorsement of enhancement motives indicated fewer PBS. Alcohol use quantity did not moderate either SAM use or alcohol use only on PBS (<i>ps = 0.092</i>, 0.711).</p><p><strong>Conclusion: </strong>Coping and positive effect motives did not moderate the relationship between SAM use and PBS, but enhancement motives moderated the relationship of the alcohol use only group and PBS. These findings suggest the importance of substance use motives on willingness to engage in PBS and illuminate a vulnerable group for negative alcohol use outcomes.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Youth Appeal in Tobacco Advertising: Evolving Tactics Targeting Those Under the Legal Age of Sale.","authors":"Suzanne Frisbee, Lauren Czaplicki, Maryam Ibrahim, Ryan David Kennedy, Meghan Bridgid Moran","doi":"10.1080/10826084.2025.2558039","DOIUrl":"https://doi.org/10.1080/10826084.2025.2558039","url":null,"abstract":"<p><strong>Introduction: </strong>Youth under the legal age of sale for tobacco (18-20 years old) remain highly receptive to tobacco advertising despite existing regulations intended to prevent use. Emerging marketing tactics-such as influencer partnerships and lifestyle-oriented messaging-may increase appeal among young audiences. This study explored which advertising features are most associated with ad receptivity among this age group.</p><p><strong>Methods: </strong>In 2023, 960 U.S. participants aged 18-20 completed an online survey assessing receptivity (liking, curiosity, interest) to cigarette and e-cigarette ads. Content analysis was used to identify potentially youth-appealing features in the ads. Content coding data and participant ratings were then merged, and mixed effects logistic regression analyses were used to assess the relationship between ad features and youth receptivity.</p><p><strong>Results: </strong>Influencer and celebrity endorsements, rebellious themes, and youth restriction messaging were significantly associated with increased ad liking and curiosity, especially for e-cigarettes. Cigarette ads featuring flavors and celebrity endorsements also showed higher receptivity. Interestingly, youth restriction messages-often intended to deter-were linked to increased interest, potentially due to perceived exclusivity. Flavors wereassociated with appeal for cigarettes, potentially reflecting changing norms in product marketing.</p><p><strong>Conclusion: </strong>Contemporary tobacco ads use both traditional and emerging tactics that appeal to young people. Features like influencer marketing and youth restriction messaging contribute to youth receptivity, highlighting gaps in current advertising regulations. These findings support the need to expand definitions of \"youth appeal\" and adapt policies to address the evolving nature of tobacco marketing.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol-Specific Masculine Norms and Drinking Motives among College Men.","authors":"Patrick R Duryea, Byron L Zamboanga, Wenyue Wang, Nyanhial Pal, Kathryne Van Hedger, Amie R Newins, Lindsay S Ham, Su Yeong Kim, Dennis E McChargue","doi":"10.1080/10826084.2025.2553306","DOIUrl":"https://doi.org/10.1080/10826084.2025.2553306","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Researchers posit that adherence to traditional masculine norms can contribute to college men's disproportionate risk for alcohol use and consequences; however, historically they have measured general masculine norms (e.g., winning, risk-taking) that are distal to alcohol use behaviors. Alcohol-specific masculine norms of <i>excess</i> (e.g., \"A real man can drink a lot\") and <i>control</i> (e.g., \"A real man knows when he has had enough to drink and is able to stop\") are conceptually more proximal to alcohol use behaviors and thus allow for a more nuanced examination of how masculinity relates to drinking. One way in which masculine norms might influence alcohol use behaviors and consequences is through their associations with drinking motives, which are considered the \"final common pathway\" to alcohol use. <b><i>Method:</i></b> In the current study, we examined the relationship between masculine drinking norms of <i>excess</i> and <i>control</i> and drinking motives in a multisite sample of male college students (<i>n</i> = 1,350), while adjusting for demographic factors (age, fraternity status, athletic involvement) and conformity to traditional masculine norms. <b><i>Results:</i></b> Results indicated that the masculine drinking norm of <i>excess</i> was positively associated with all five drinking motives, while <i>control</i> was positively associated only with social drinking motives. <i><b>Discussion:</b></i> Our findings further illustrate the potential harms of the alcohol-specific masculine norm of <i>excess</i> given that it relates to drinking for all the drinking motives and higher drinking motives of any type are associated with alcohol-related behaviors. The present study helps shine a light on potential mechanisms of the relationship between masculine drinking norms and alcohol use.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Legalization and Cannabis Use Disorder by Sex in Veterans Health Administration Patients, 2005-2019.","authors":"Caroline G Wisell, Deborah S Hasin, Melanie M Wall, Daniel Alschuler, Carol Malte, Yoanna McDowell, Mark Olfson, Katherine M Keyes, Magdalena Cerdá, Charles C Maynard, Salomeh Keyhani, Silvia S Martins, Zachary L Mannes, Ofir Livne, David S Fink, Julia M Bujno, Malki Stohl, Andrew J Saxon, Tracy L Simpson","doi":"10.1080/10826084.2025.2554866","DOIUrl":"https://doi.org/10.1080/10826084.2025.2554866","url":null,"abstract":"<p><strong>Background: </strong>Understanding sex differences in the effects of cannabis legalization and increasing risk for cannabis use disorder (CUD) is important. We hypothesized that from 2005 to 2019, increases in CUD prevalence due to state medical or recreational cannabis laws (MCL; RCL) would differ among male and female veterans treated at the U.S. Veterans Health Administration (VHA), with greater increases among females.</p><p><strong>Methods: </strong>Data obtained through the VHA Corporate Data Warehouse included veterans 18-75 years with ≥1 VHA primary care, emergency department, or mental health visit in a given year, 2005-2019. Staggered-adoption difference-in-difference analyses were used to estimate the role of MCL and RCL on trends in CUD diagnostic prevalence, fitting a linear binomial regression model with fixed effects for state and categorical year, time-varying cannabis law status, state-level sociodemographic covariates, patient-level age group (18-35, 36-64, 65-75 years), race and ethnicity.</p><p><strong>Results: </strong>CUD prevalences increased in both sexes. CUD increased more in states enacting MCL and RCL than in states that did not enact CL. However, no CUD prevalence increases attributable to the change from no-CL to MCL-only or MCL to RCL differed significantly by sex, with one exception (greater in males aged 35-64).</p><p><strong>Conclusions: </strong>Increases in CUD prevalence following MCL or RCL enactment were greater than in states with no-CL, but generally did not show differences by sex. The increases in CUD prevalence occurring for males and females throughout the study years indicate the need for cannabis use screening by medical providers and the importance of offering evidence-based treatments for CUD.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Role of Executive Functions on the Intention-Behavior Gap of Alcohol Protective Behavioral Strategy Use.","authors":"Becky K Gius, Jared Davis, Robert Schlauch","doi":"10.1080/10826084.2025.2548316","DOIUrl":"https://doi.org/10.1080/10826084.2025.2548316","url":null,"abstract":"<p><strong>Introduction: </strong>Alcohol protective behavioral strategies (PBS) are health behaviors that minimize the likelihood or severity of consequences associated with alcohol use; however, these strategies are inconsistently used. One potential explanation for this lack of consistent use is a discrepancy between the <i>intention</i> to drink safely and <i>actually</i> drinking safely, termed the intention-behavior gap. Some drinkers have the intention to drink safely but lack the ability to effectively initiate and execute the harm reduction behaviors. As such, executive functions (EF: cognitive abilities associated with goal-directed behavior) may be one individual difference factor that helps identify for whom these \"gaps\" are greater or smaller.</p><p><strong>Materials and methods: </strong>Using ecological momentary assessment, this study explored the extent to which an intention-behavior gap in PBS use exists among college student drinkers (<i>n</i> = 77) and investigated how potential individual differences in EF (i.e., working memory, set-shifting, and inhibition) moderated the intention-behavior gap. Daily monitoring assessments contained brief measures of intention to use PBS, actual strategy use, and alcohol-related behaviors, and were assessed daily for 21 days.</p><p><strong>Results: </strong>Multilevel model analyses revealed that although intention to use strategies predicted actual strategy use, measures of EF did not significantly moderate the relationship.</p><p><strong>Discussion: </strong>Efforts to increase intentions to use PBS should be included in alcohol use prevention and intervention programs for all drinkers, regardless of differences in EF ability.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methadone Program Directors' Perceptions of Barriers and Supports to Engage People with Opioid Use Disorders in Methadone Services.","authors":"Erin L Kelly, Tracy Camacho-Esteves, Melissa Denish, Sarah Lawson, Megan K Reed, Lara Weinstein Carson, Robert Sterling","doi":"10.1080/10826084.2025.2551709","DOIUrl":"https://doi.org/10.1080/10826084.2025.2551709","url":null,"abstract":"<p><p><b><i>Background:</i></b> Methadone programs to treat opioid use disorder (OUD) are highly regulated, but many of their restrictions were relaxed during COVID-19, such as expanded medication take-home privileges and telehealth access. Many of these reforms have been sustained post-COVID-19, but substantial risks for overdose persist nationally. Identifying non-pandemic factors that improve service access and utilization is crucial to prevent additional mortality. <b><i>Objectives:</i></b> The goal of this study was to identify key stakeholder recommendations for improving methadone services and reducing treatment barriers. <b><i>Results:</i></b> In this study, 9 of the 10 program directors of methadone service programs in Philadelphia were surveyed in April-June 2023. The expansion of take-home privileges was perceived as beneficial for treatment access; however, additional changes to service delivery were deemed necessary to further improve outcomes. Specifically, program directors consistently identified staffing challenges (e.g., recruitment, retention, quality) as critical barriers to patient access and retention within their programs, suggesting an urgent need to invest in the substance use workforce. Program directors noted the importance of addressing other social determinants of health to improve service use, such as assistance with basic needs (e.g., housing, transportation, and benefits) and social factors (e.g., stigma). Directors perceived reduced patient demand as adversely affecting service use. Some attributed this to changes in the drug supply (e.g., fentanyl, xylazine) as well as a shift in patient preferences towards other forms of medication for opioid use disorder (MOUD). <b><i>Conclusions:</i></b> Program directors of methadone outpatient treatment programs identified important policies, workforce factors, and resources required to improve substance use services to address the rapidly evolving drug crisis.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Ecological Momentary Assessment Study of Fluctuations in Inhibitory Control and Its Predictive Validity of Alcohol Use.","authors":"Sam Burton, Andrew Jones","doi":"10.1080/10826084.2025.2553304","DOIUrl":"https://doi.org/10.1080/10826084.2025.2553304","url":null,"abstract":"<p><strong>Introduction: </strong>Inhibitory control is associated with reports of alcohol use in cross-sectional and lab-based research. In the current study we investigated inhibitory control using an ecological momentary assessment paradigm to investigate 'in-the-moment' relationships with alcohol consumption and other factors (e.g., location, craving, emotions) in the real-world. We hypothesized that fluctuations in inhibitory control throughout the day would predict alcohol consumption.</p><p><strong>Materials and methods: </strong>Heavy drinkers (<i>N</i> = 54: mean age = 24.30, 47 females) were asked to complete a battery of questions and a stop signal task four times per day, at random intervals between 10am and 10 pm for one week. Participants were asked to record their location, craving, emotions and alcohol consumption at each assessment. Inhibitory control was assessed using stop signal task with personalized alcohol- and generic neutral-related cues.</p><p><strong>Results: </strong>Multilevel modeling demonstrated that neutral Stop Signal Reaction Times (OR= 1.05: 95% CI 1.02, 1.08) and frequency of craving (OR = 1.65; 95% CI 1.48, 1.84) predicted subsequent alcohol use occasions. Intensity (B=-0.036; 95% CI -0.059, -0.013) and frequency (<i>B</i> = 0.026; 95% CI 0.002, 0.050) of craving significantly predicted variance in alcohol consumption.</p><p><strong>Discussion: </strong>Findings do not provide consistent evidence that fluctuations alone in inhibitory control predicts alcohol consumption. Future research should examine the interaction between inhibitory control and craving in the real-world, to better our understanding of the complex relationship.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Fuetsan Manhoben Curriculum: Effects on Risk Perceptions and Intentions Regarding Tobacco and Betel Nut Use Among Adolescents in Guam.","authors":"Francis Dalisay, Scott K Okamoto, Yoshito Kawabata, Pallav Pokhrel","doi":"10.1080/10826084.2025.2553311","DOIUrl":"https://doi.org/10.1080/10826084.2025.2553311","url":null,"abstract":"<p><p><b><i>Background</i></b>: While there are known high rates of tobacco and betel (areca) nut use in the U.S.-Affiliated Pacific Islands (USAPI), there have been limited efforts at preventing the initiation of tobacco and betel nut among those living in the region, particularly, adolescents. To meet this need, Fuetsan Manhoben (FM)-a culturally tailored, school-based tobacco and betel nut use prevention curriculum-was developed for adolescents in Guam, a USAPI in the Western Pacific. <b><i>Method</i></b>: A pilot randomized controlled trial was conducted to examine the efficacy of FM. Guam public middle school students were randomly assigned to either the FM intervention (n = 269) or a control (n = 269) condition. Data were collected at baseline, posttest (4 weeks after baseline), and 3-month follow-up. <b><i>Results</i></b>: At posttest, FM had a statistically significant positive direct effect on risk perceptions of both cigarettes and betel nut. Also, risk perceptions of both cigarettes and betel nut measured at posttest inversely predicted intent to use cigarettes and betel nut at follow-up. FM also had an indirect effect on reducing intent to use betel nut at follow-up through its immediate and prior effect on betel nut use risk perceptions at posttest. <b><i>Conclusions</i></b>: The results provide initial support for the efficacy and feasibility of FM.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemsex: Associations with Sexual, Psychosocial and Social Health in Australian Gay and Bisexual Men.","authors":"Daniel Demant, Bernard Saliba, Oscar Oviedo-Trespalacios, James D A Newton","doi":"10.1080/10826084.2025.2554865","DOIUrl":"https://doi.org/10.1080/10826084.2025.2554865","url":null,"abstract":"<p><strong>Introduction: </strong>Chemsex, the use of psychoactive substances to enhance sexual experience, is most prominent in gay, bisexual and other men who have sex with men (GBMSM). This study explores the prevalence of chemsex in Australian GBMSM (<i>N</i> = 632) and its associations with psychosexual and psychosocial health.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted. Measures included demographics, psychological distress, attitudes toward sexuality (Sex-Positivity-Negativity Scale), sexual self-esteem, LGBT Community Connectedness, and sexual behaviors. Data were analyzed using descriptive statistics, ANOVA, and chi-square tests.</p><p><strong>Results: </strong>One-third (32.3%) reported engaging in chemsex in the past year. Those engaged in chemsex were younger and more likely to identify as Indigenous Australians. They reported higher levels of psychological distress, sex negativity, sexual self-esteem and satisfaction with their sex life. Men engaged in chemsex reported a lower degree of connectedness to the LGBT community and were more likely to report adventurous sexual behaviors, including group sex and creating pornographic imagery.</p><p><strong>Discussion: </strong>The association between chemsex and health is complex. While some men report higher sexual self-esteem and satisfaction, their reported involvement in chemsex also correlates with increased psychological distress and lower community connectedness; however, the directionality of associations is unclear and may reflect complex or bidirectional dynamics.</p><p><strong>Conclusions: </strong>Engagement in chemsex is common among Australian GBMSM and is associated with a range of mental health, sexual wellbeing, and social connection outcomes. These findings highlight the importance of developing informed, community-based public health strategies that reflect the complexity of chemsex practices and diverse experiences of men engaged in chemsex.</p>","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}