Sultan Qaboos University Medical Journal最新文献_第9页

Dengue Fever: Clinical features and health outcomes in patients presenting to a tertiary care hospital. 登革热：在三级保健医院就诊的患者的临床特征和健康结果。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI: 10.18295/2075-0528.2835

Khalfan Al Zeedy, Sheikha Al Shibli, Jawahar H Al Noumani, Mohammed Al Azri, Abdullah Al Alawi

{"title":"Dengue Fever: Clinical features and health outcomes in patients presenting to a tertiary care hospital.","authors":"Khalfan Al Zeedy, Sheikha Al Shibli, Jawahar H Al Noumani, Mohammed Al Azri, Abdullah Al Alawi","doi":"10.18295/2075-0528.2835","DOIUrl":"10.18295/2075-0528.2835","url":null,"abstract":"Objectives: This study aimed to assess the mortality rate and related factors in dengue fever (DF) patients. Additionally, it will outline the clinical and biochemical characteristics and treatments administered to confirmed cases.Methods: This retrospective cross-sectional study included DF patients who presented to Sultan Qaboos University Hospital between January 2022 and July 2023. Data were extracted from the hospital's electronic system into a pre-designed Excel data collection sheet and analysed.Results: The study identified 319 confirmed DF cases with male predominance. The overall mortality rate was 3.8% (n = 12). Mortality was significantly higher among those with ischaemic heart disease (41.7%; n = 5), chronic kidney disease (25%; n = 3) and those on aspirin (25%; n = 3). Patients presenting with fever, headache, arthralgia and body aches, along with multi-organ involvement, exhibited confusion, lower platelet counts, abnormalities in haematocrit and haemoglobin levels, as well as deranged liver and renal function. Backward stepwise multivariate regression analysis showed that the use of antibiotics (odds ratio [OR] = 6.644, 95% confidence interval [CI]: 1.202-36.742; P = 0.030) and elevated bilirubin levels (OR = 1.058, 95% CI: 1.013-1.105; P = 0.011) were significant independent predictors of mortality.Conclusions: This study identified a mortality rate of 3.8% among patients with DF. Elevated bilirubin levels and antibiotic use during hospitalisation are independent predictors of mortality. Therefore, it is recommended that such patients be closely monitored for potential signs, symptoms and biochemical changes to reduce the risk of mortality.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"258-265"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diaphragmatic Paralysis Following Chest Tube Insertion in an Infant: Case report and literature review. 1例婴儿胸管插入后膈肌麻痹：病例报告及文献复习。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI: 10.18295/squmj.10.2024.060

Mohammed Al Ghafri, Said Al Hanshi, Ahmad E Elkhamisy, Ahmed M Fouad

引用次数: 0

Profile of Perinatal Infections Among Abandoned Neonates Admitted in a Tertiary Hospital in Oman. 阿曼某三级医院遗弃新生儿围产期感染概况

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.18295/2075-0528.2881

Mahmood Dhahir Al-Mendalawi

引用次数: 0

Clinicopathological Spectrum of Myxoid Soft Tissue Tumours with Emphasis on Diagnostic Differentials. 黏液样软组织肿瘤的临床病理谱与诊断鉴别的重点。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.18295/2075-0528.1014

Sanjana Ahuja, Nisha Modi, Amit Varma, Shivani Kapur, Kamal Malukani, Harshita Deep Sahu

{"title":"Clinicopathological Spectrum of Myxoid Soft Tissue Tumours with Emphasis on Diagnostic Differentials.","authors":"Sanjana Ahuja, Nisha Modi, Amit Varma, Shivani Kapur, Kamal Malukani, Harshita Deep Sahu","doi":"10.18295/2075-0528.1014","DOIUrl":"10.18295/2075-0528.1014","url":null,"abstract":"Objectives: Myxoid soft tissue tumours (MSTTs) represent a complex group of mesenchymal neoplasms characterised by the production of an extracellular myxoid matrix, which often poses diagnostic challenges. This study aimed to identify the relative frequency, distribution and morphological spectrum of MSTT as well as to illustrate commonly encountered diagnostic difficulties.Methods: This retrospective study of the clinicopathological profiles of MSTT cases at Sri Aurobindo Medical College & Post Graduate Institute, Indore, India, was conducted from January 2020 to December 2023.Results: A total of 110 MSTT cases were included in this study. These cases accounted for 7.3% of the soft tissue tumours (STTs), with a predominance of benign MSTT (n = 67, 60.9%). The fibroblastic/myofibroblastic family of STT constituted the majority (33.6%). The upper limb (34%) was the most frequently involved anatomical site for benign MSTT, with the 20-40 age range being the most common (46.3%). Tumour sizes were predominantly below 5 cm (57%), with 84% located superficially. In malignant MSTT, the lower limb (49%) was largely affected, with the 40-60 age group being predominant (46.5%), and the most common tumour size range was 5-10 cm (46.5%). Myxoid schwannoma (13.4%) was the most prevalent benign entity, while myxofibrosarcoma (20.9%) was the most frequent malignancy. A statistically significant correlation was observed between histological grade and tumour size (P = 0.006) as well as between grade and tumour depth (P = 0.015).Conclusions: This study presented a comprehensive array of clinical and morphological features of MSTT with variable clinical significance. It highlighted potential caveats to aid in accurate diagnosis for optimal treatment selection.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"122-131"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Systemic Autoinflammatory Diseases: Diagnostic and therapeutic challenges. 伴随全身性自身炎症性疾病：诊断和治疗的挑战。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.18295/2075-0528.2864

Eman Al Masroori, Mahadev J Mal, Reem Abdwani

引用次数: 0

Successful Treatment of Recalcitrant Eosinophilic Pustular Folliculitis with Dupilumab. Dupilumab成功治疗顽固性嗜酸性脓疱性毛囊炎。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.18295/2075-0528.2873

Miguel Mansilla-Polo, Fernando Navarro-Blanco, Javier López-Davia, Rafael Botella-Estrada

引用次数: 0

Levothyroxine Requirement in a Patient with LRBA Deficiency and GVHD Induced Cholestasis. LRBA缺乏和GVHD诱导的胆汁淤积症患者的左旋甲状腺素需求。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.18295/2075-0528.2879

Yusriya Al Rawahi, Hussain AlSaffar, Amr Abdalla, Azza N Al Shidhani

{"title":"Levothyroxine Requirement in a Patient with LRBA Deficiency and GVHD Induced Cholestasis.","authors":"Yusriya Al Rawahi, Hussain AlSaffar, Amr Abdalla, Azza N Al Shidhani","doi":"10.18295/2075-0528.2879","DOIUrl":"10.18295/2075-0528.2879","url":null,"abstract":"Levothyroxine is a lipophilic hormone that is absorbed in the small intestine, mainly in the jejunum and ileum. The absorption of levothyroxine after oral administration averages 60-80%. We report a 7-year-old male patient who presented to a tertiary care hospital in Muscat, Oman, in 2020 at the age of three years with an early diagnosis of lipopolysaccharide beige-like anchor protein (LRBA) deficiency. LRBA deficiency is characterised by recurrent infections, autoimmune thyroid disease and autoimmune cytopenia. The patient was prescribed levothyroxine treatment (112.5 mcg daily) and underwent haematopoietic stem cell transplantation (HSCT) in March 2023; four months post-HSCT, he developed appendicitis followed by jaundice and elevation of liver enzymes. His physical examination revealed a distended abdomen with enlarged liver and spleen. Graft-versus-host disease (GVHD) was diagnosed and confirmed by a liver biopsy and treatment for GVHD was initiated. Despite ongoing levothyroxine therapy, he exhibited biochemically severe hypothyroidism with very low free-throxine and high thyroid-stimulating hormone, prompting a dosage increment. Investigations to determine the cause of his severe hypothyroidism were unremarkable, ultimately attributing the need for increased thyroxine to cholestasis induced by chronic GVHD. This case emphasises the complexities of managing thyroid function in patients with hepatic GVHD, highlighting the necessity for frequent monitoring and levothyroxine dosage adjustments.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"592-597"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence-Based Human Clinical Trials on Antidiabetic Herbal Remedies Commonly Used in the Middle East. 中东地区常用抗糖尿病草药的循证人体临床试验。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI: 10.18295/2075-0528.2852

Shihab Al-Makhmari, Abir Al-Aufi, Saleh Al-Kindi, Maha Alriyami, Hussein Sakr, Mohamed-Rachid Boulassel, Khalid M Abu Khadra, Rahma Al-Haddabi, Ammar Boudaka, Jumana Saleh

{"title":"Evidence-Based Human Clinical Trials on Antidiabetic Herbal Remedies Commonly Used in the Middle East.","authors":"Shihab Al-Makhmari, Abir Al-Aufi, Saleh Al-Kindi, Maha Alriyami, Hussein Sakr, Mohamed-Rachid Boulassel, Khalid M Abu Khadra, Rahma Al-Haddabi, Ammar Boudaka, Jumana Saleh","doi":"10.18295/2075-0528.2852","DOIUrl":"10.18295/2075-0528.2852","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder with significant health and economic impacts. This review examined Middle Eastern herbs as alternative T2DM treatments in human randomised controlled trials and meta-analyses. A comprehensive PubMed search was conducted for human randomised controlled trials and meta-analyses on black seed (Nigella sativa), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), cinnamon (Cinnamomum cassia) and curcumin (Curcuma longa), with at least 6 human studies per herb. The results revealed that N. sativa and fenugreek improved glycaemic control and lipid profiles, while ginger regulated carbohydrate metabolism enzymes. Curcumin was found to control blood sugar and lipids through its antioxidant effects, although its bioavailability remains a challenge. Cinnamon enhanced glucose transport and enzyme inhibition. Notably, N. sativa demonstrated consistent positive effects across studies. These findings highlight the potential of medicinal herbs as alternative therapies in T2DM management, emphasising the need for further research in this field, considering relevant safety profiles.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"418-429"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haemothorax as an Unusual Presentation of Osteochondroma: A case report and brief literature review. 血胸是骨软骨瘤的一种不寻常的表现：1例报告和简短的文献复习。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI: 10.18295/2075-0528.2823

Jawahar H Al Noumani, Shathra S Al Rawahi, Abdullah G Alshaharli, Hatem Al Farhan, Adil H Al Kindi, Abdullah M Al Alawi

引用次数: 0

Prevalence, Factors and Impact of Migraine on Healthcare Professionals: A cross-sectional study in the United Arab Emirates. 偏头痛对医疗保健专业人员的患病率、因素和影响：阿拉伯联合酋长国的一项横断面研究。

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI: 10.18295/2075-0528.2851

Syyeda Maleha Jeelani, Shatha Al Sharbatti

{"title":"Prevalence, Factors and Impact of Migraine on Healthcare Professionals: A cross-sectional study in the United Arab Emirates.","authors":"Syyeda Maleha Jeelani, Shatha Al Sharbatti","doi":"10.18295/2075-0528.2851","DOIUrl":"10.18295/2075-0528.2851","url":null,"abstract":"Objectives: This study aimed to determine the prevalence of migraines among healthcare professionals (HCPs) in the United Arab Emirates (UAE), identify associated factors and evaluate their impact on quality of life (QoL) and work performance.Methods: This cross-sectional study was conducted from January to June 2022 and included nurses and doctors across 4 healthcare settings in the UAE. Migraine prevalence was assessed using the Migraine Screen Questionnaire, while its impact on social support and work function was evaluated through the Migraine Disability Assessment, the Oslo Social Support Scale and the Headache Impact Test. Data were analysed using Chi-square tests, binary logistic regression and multivariable logistic regression.Results: A total of 440 nurses and doctors were included. Migraine prevalence among participants was 18.2%. The likelihood of experiencing migraines was significantly higher among females (odds ratio [OR] = 2.99, 95% confidence interval [CI]: 1.1-7.9), individuals with a family history of migraines (OR = 2.17, 95% CI: 1.1-4.3), those reporting stress (OR = 5.87, 95% CI: 2.9-11.8), sleep deprivation (OR = 4.38, 95% CI: 1.9-9.8), motion sickness (OR = 5.06, 95% CI: 1.7-15.5) and specific food triggers (OR = 11.29, 95% CI: 3.1-41.2). Participants with migraines reported significantly higher rates of disability (29.1% versus 3.4%; P <0.001) and severe work function impairment (54.4% versus 17.1%; P <0.001). Additionally, migraines were associated with a greater perceived burden on general health and QoL.Conclusions: Approximately 1 in 5 HCPs in the UAE experience migraines. Several personal and modifiable factors contribute to an increased risk of migraines, which significantly impair QoL, work performance and disability levels.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"409-417"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0