Stroke Research and Treatment最新文献

{"title":"Predictive Value of the Alberta Stroke Program Early CT Score (ASPECTS) in the Outcome of the Acute Ischemic Stroke and Its Correlation with Stroke Subtypes, NIHSS, and Cognitive Impairment.","authors":"Ahmed Esmael, Mohammed Elsherief, Khaled Eltoukhy","doi":"10.1155/2021/5935170","DOIUrl":"10.1155/2021/5935170","url":null,"abstract":"<p><strong>Objectives: </strong>This study is aimed at correlating ASPECTS with mortality and morbidity in patients with acute middle cerebral artery territory infarction and at determining the cutoff value of ASPECTS that may predict the outcome.</p><p><strong>Methods: </strong>150 patients diagnosed with acute middle cerebral artery territory infarction were involved in this study. Risk factors, initial NIHSS, and GCS were determined. An initial or follow-up noncontrast CT brain was done and assessed by ASPECTS. Outcomes were determined by mRS during the follow-up of cases after 3 months. Correlations of ASPECTS and outcome variables were done by Spearman correlation. Logistic regression analysis and ROC curve were done to detect the cutoff value of ASPECTS that predicts unfavorable outcomes.</p><p><strong>Results: </strong>The most common subtypes of ischemic strokes were lacunar stroke in 66 patients (44%), cardioembolic stroke in 39 patients (26%), and LAA stroke in 30 cases (20%). The cardioembolic stroke had a statistically significant lower ASPECT score than other types of ischemic strokes (<i>P</i> < 0.05). Spearman correlation showed that lower ASPECTS values (worse outcome) were more in older patients and associated with lower initial GCS. ASPECTS values were inversely correlated with initial NIHSS, inpatient stay, inpatient complications, mortality, and mRS. The ASPECTS cutoff value determined for the prediction of unfavorable outcomes was equal to ≤7. The binary logistic regression analysis detected that patients with ASPECTS ≤ 7 were significantly associated with about fourfold increased risk of poor outcomes (OR 3.95, 95% CI 2.09-11.38, and <i>P</i> < 0.01).</p><p><strong>Conclusions: </strong>ASPECTS is a valuable and appropriate technique for the evaluation of the prognosis in acute ischemic stroke. Patients with high ASPECTS values are more likely to attain favorable outcomes, and the cutoff value of ASPECTS is a strong predictor for unfavorable outcomes. This trial is registered with ClinicalTrials.gov NCT04235920.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2021 ","pages":"5935170"},"PeriodicalIF":1.5,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25360007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 Pandemic on the Incidence, Prehospital Evaluation, and Presentation of Ischemic Stroke at a Nonurban Comprehensive Stroke Center.","authors":"Cesar Velasco,&nbsp;Brandon Wattai,&nbsp;Scott Buchle,&nbsp;Alicia Richardson,&nbsp;Varun Padmanaban,&nbsp;Kathy J Morrison,&nbsp;Raymond Reichwein,&nbsp;Ephraim Church,&nbsp;Scott D Simon,&nbsp;Kevin M Cockroft","doi":"10.1155/2021/6624231","DOIUrl":"https://doi.org/10.1155/2021/6624231","url":null,"abstract":"<p><strong>Introduction: </strong>Many reports have described a decrease in the numbers of patients seeking medical attention for typical emergencies during the COVID-19 pandemic. These reports primarily relate to urban areas with widespread community transmission. The impact of COVID-19 on nonurban areas with minimal community transmission is less well understood.</p><p><strong>Methods: </strong>Using a prospectively maintained prehospital quality improvement database, we reviewed our hospital EMS transports with a diagnosis of stroke from January to April 2019 (baseline) and January to April 2020 (pandemic). We compared the volume of patients, transport/presentation times, severity of presenting symptoms, and final diagnosis.</p><p><strong>Results: </strong>In January, February, March, and April 2019, 10, 11, 17, and 19 patients, respectively, were transported in comparison to 19, 14, 10, and 8 during the same months in 2020. From January through April 2019, there was a 53% increase in transports, compared to a 42% decrease during the same months in 2020, constituting significantly different trend-line slopes (3.30; 95% CI 0.48-6.12 versus -3.70; 95% CI -5.76--1.64, <i>p</i> = 0.001). Patient demographics, comorbidities, and symptom severity were mostly similar over the two time periods, and the number of patients with a final diagnosis of stroke was also similar. However, the median interval from EMS dispatch to ED arrival for patients with a final diagnosis of stroke was significantly longer in January to April 2020 (50 ± 11.7 min) compared to the same time period in 2019 (42 ± 8.2 min, <i>p</i> = 0.01). <i>Discussion/Conclusion</i>. Our data indicate a decrease in patient transport volumes and longer intervals to EMS activation for suspected stroke care. These results suggest that even in a nonurban location without widespread community transmission, patients may be delaying or avoiding care for severe illnesses such as stroke. Clinicians and public health officials should not ignore the potential impact of pandemic-like illnesses even in areas of relatively low disease prevalence.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2021 ","pages":"6624231"},"PeriodicalIF":1.5,"publicationDate":"2021-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38874189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight on the Genetics of Atrial Fibrillation in Puerto Rican Hispanics.","authors":"Ariel F Gonzalez-Cordero,&nbsp;Jorge Duconge-Soler,&nbsp;Hilton Franqui-Rivera,&nbsp;Roberto Feliu-Maldonado,&nbsp;Abiel Roche-Lima,&nbsp;Israel Almodovar-Rivera","doi":"10.1155/2021/8819896","DOIUrl":"https://doi.org/10.1155/2021/8819896","url":null,"abstract":"<p><p>Non-Hispanic whites present with higher atrial fibrillation (AF) prevalence than other racial minorities living in the mainland USA. In two hospital-based studies, Puerto Rican Hispanics had a lower prevalence of atrial fibrillation of 2.5% than non-Hispanic Whites with 5.7%. This data is particularly controversial because Hispanics possess a higher prevalence of traditional risk factors for developing AF yet have a lower AF prevalence. This phenomenon is known as the atrial fibrillation paradox. Despite recent advancements in understanding AF, its pathogenesis remains unclear. In this study, we compared a genetic dataset of Puerto Rican Hispanics to 111 SNP known to be associated with AF in a large European cohort and determine if they are associated with AF susceptibility in our cohort. To achieve this aim, we performed a secondary analysis of existing data using the following two studies: (1) <i>The Pharmacogenetics of Warfarin in Puerto Ricans study</i> and the (2) <i>A Genomic Approach for Clopidogrel in Caribbean Hispanics</i>, and assess for the presence of European SNPs associated with AF from the genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation. We used data from 555 cardiovascular Puerto Rican Hispanic patients, consisting of 486 control and 69 cases. We found that the following SNPs showed significant association with AF in PHR: rs2834618, rs6462079, rs7508, rs2040862, and rs10458660. Some of these SNPs are proteins involved in lysosomal activities responsible for breaking ceramides to sphingosines and collagen deposition around atrial cardiomyocytes. Furthermore, we performed a machine learning analysis and determined that Native American admixture and heart failure were strongly predictive of AF in PHR. For the first time, this study provides some genetic insight into AF's mechanisms in a Puerto Rican Hispanic cohort.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2021 ","pages":"8819896"},"PeriodicalIF":1.5,"publicationDate":"2021-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38874190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcome and Its Determinants among Patients Admitted to Stroke Unit of Jimma University Medical Center, Southwest Ethiopia.","authors":"Ameha Zeleke Zewudie,&nbsp;Tolcha Regasa,&nbsp;Solomon Hambisa,&nbsp;Dejen Nureye,&nbsp;Yitagesu Mamo,&nbsp;Temesgen Aferu,&nbsp;Desalegn Feyissa,&nbsp;Tewodros Yosef","doi":"10.1155/2020/8817948","DOIUrl":"https://doi.org/10.1155/2020/8817948","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a public health problem in Ethiopia. Despite the high prevalence of stroke in Ethiopia, there is a paucity of data with regard to drug treatment, treatment outcome, and risk factors of poor treatment outcome of stroke. Hence, this study is aimed at assessing treatment outcome and its determinants among patients admitted to stroke unit of Jimma University Medical Center (JUMC).</p><p><strong>Methods: </strong>A two-year hospital-based retrospective cross-sectional study was employed to analyze the medical records of patients admitted with stroke to stroke unit of Jimma University Medical Centre from February 1^st, 2016 to March 30^th, 2018. Data was entered by Epidata manager version 4.0.2 and analyzed by SPSS version 24. Multivariable logistic regression analysis with the backward stepwise approach was done to identify independent predictors of poor treatment outcome of stroke. Variables with <i>P</i> value less than 0.05 were considered as statically significant determinants of poor treatment outcome.</p><p><strong>Results: </strong>Of 220 patients with stroke admitted to the Jimma University, 67.30% were male. Nearly two thirds (63.18%) of them had poor treatment outcomes. Dyslipidimics were administered to 60% of the patients, and the most popular antiplatelet used was aspirin, which was prescribed to 67.3% the patients. Age ≥ 65 adjusted odd ratio ((AOR): 2.56; 95% CI: 1.95-9.86, <i>P</i> = 0.001), presence of comorbidity (AOR: 5.25; 95% CI: 1.08-17.69, <i>P</i> < 0.001), admission with hemorrhagic stroke (AOR: 18.99; 95% CI: 7.05-42.07, <i>P</i> < 0.001), and admission to the hospital after 24 hour of stroke onset (AOR: 4.98; 95% CI: 1.09-21.91, <i>P</i> = 0.03) were independent predictors of poor treatment outcomes.</p><p><strong>Conclusion: </strong>Substantial numbers of stroke patients had poor treatment outcomes. Elderly patients, patients diagnosed with hemorrhagic stroke, patients with comorbidity, and those with delayed hospital admission were more likely to have poor treatment outcome. Hence, frequent monitoring and care should be given for the aforementioned patients. Awareness creation on the importance of early admission should be delivered particularly for patients who have risk factors of stroke (cardiovascular diseases).</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2020 ","pages":"8817948"},"PeriodicalIF":1.5,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38788515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Doppler for Early Prediction of Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage and the Associated Clinical Biomarkers.","authors":"Ahmed Esmael,&nbsp;Tamer Belal,&nbsp;Khaled Eltoukhy","doi":"10.1155/2020/8874605","DOIUrl":"https://doi.org/10.1155/2020/8874605","url":null,"abstract":"<p><strong>Methods: </strong>Prospective study included 40 cases with acute aSAH. Initial evaluation by Glasgow Coma Scale (GCS) and the severity of aSAH was detected by both the clinical Hunt and Hess and radiological Fisher's grading scales. TCD was done for all patients five times within 10 days measuring the mean flow velocities (MFVs) of cerebral arteries. At the 3-month follow-up, patients were classified into two groups according to Montreal Cognitive Assessment (MoCA) scale: the first group was 31 cases (77.5%) with intact cognitive functions and the other group was 9 cases (22.5%) with impaired cognition.</p><p><strong>Results: </strong>Patients with impaired cognitive functions showed significantly lower mean GCS (<i>p</i> = 0.03), significantly higher mean Hunt and Hess scale grades (<i>p</i> = 0.04), significantly higher mean diabetes mellitus (DM) (<i>p</i> = 0.03), significantly higher mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) (<i>p</i> = 0.02 and <i>p</i> = 0.005, respectively), and significantly higher MFVs measured within the first 10 days. The patients with cognitive impairment were accompanied by a higher incidence of hydrocephalus (<i>p</i> = 0.01) and a higher incidence of delayed cerebral ischemia (DCI) (<i>p</i> < 0.001). Logistic regression analysis detected that MFV ≥ 86  cm/s in the middle cerebral artery (MCA), MFV ≥ 68  cm/s in the anterior cerebral artery (ACA), and MFV ≥ 45  cm/s in the posterior cerebral artery (PCA) were significantly associated with increased risk of cognitive impairment.</p><p><strong>Conclusion: </strong>Cognitive impairment after the 3-month follow-up phase in aSAH patients was 22.5%. Acute hydrocephalus and DCI are highly associated with poor cognitive function in aSAH. Increased MFV is a strong predictor for poor cognitive function in aSAH. This trial is registered with NCT04329208.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2020 ","pages":"8874605"},"PeriodicalIF":1.5,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8874605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38705794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Preexisting Psychotropic Medication Use on a Cohort of Patients with Ischemic Stroke Outcome.","authors":"Adalia H Jun-O'Connell, Dilip K Jayaraman, Nils Henninger, Brian Silver, Majaz Moonis, Anthony J Rothschild","doi":"10.1155/2020/9070486","DOIUrl":"10.1155/2020/9070486","url":null,"abstract":"<p><strong>Background: </strong>Several studies investigated the use of selective serotonin reuptake inhibitors (SSRI) after ischemic stroke to improve motor recovery. However, little is known about the effects of preexisting psychotropic medication use (PPMU), such as antidepressants, on a long-term ischemic stroke functional disability.</p><p><strong>Objective: </strong>We sought to determine the prevalence of PPMU and whether PPMU relates to the long-term clinical outcome in a cohort of patients presenting with acute ischemic strokes.</p><p><strong>Methods: </strong>We retrospectively analyzed 323 consecutive patients who presented with an acute ischemic stroke in a single institution between January 2015 and December 2017. Baseline characteristics, functional disability as measured by the modified Rankin Scale (mRS), and major adverse cardiovascular complications (MACE) within 365 days were recorded. The comparison groups included a control group of ischemic stroke patients who were not on psychotropic medications before and after the index ischemic stroke and a second group of poststroke psychotropic medication use (PoMU), which consisted of patients started on psychotropic medication during the index admission.</p><p><strong>Results: </strong>The prevalence of PPMU in the studied cohort was 21.4% (69/323). There was a greater proportion of females in the PPMU than in the comparison groups (<i>P</i> < 0.001), while vascular risk factors were similar in all groups, except for an increased presence of posterior circulation infarcts in the PPMU (37.4% vs. 18.8%, <i>P</i> < 0.001). Among the patients with available 1-year follow-up data (<i>n</i> = 246), we noted significantly greater improvement in stroke deficits, measured by National Institute of Health Stroke Scale (NIHSS) between PPMU and PoMU vs. control (3 (0-7) versus 1 (0-4), <i>P</i> = 0.041). The 1-year mRS was worse in PPMU and PoMU compared to the control group (2 (IQ 1-3) vs. 2 (IQ 0-3) vs. 1 (IQ 0-2), respectively, <i>P</i> = 0.013), but delta mRS reflecting the degree of mRS improvement showed no significant difference between any PMU and control patients (<i>P</i> = 0.76). There was no statistically significant difference in MACE.</p><p><strong>Conclusion: </strong>PPMU in ischemic stroke is common; it can be beneficial in ischemic stroke in the long-term clinical outcome and is not associated with increased risks of MACE.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2020 ","pages":"9070486"},"PeriodicalIF":1.5,"publicationDate":"2020-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38567040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study.","authors":"Derya Uluduz,&nbsp;Sevki Sahin,&nbsp;Taskin Duman,&nbsp;Serefnur Ozturk,&nbsp;Vildan Yayla,&nbsp;Nazire Afsar,&nbsp;Nevzat Uzuner,&nbsp;Ipek Midi,&nbsp;Nilgun Cinar,&nbsp;Mehmet Ali Sungur,&nbsp;Fusun Mayda Domac,&nbsp;Birsen Ince,&nbsp;Baki Goksan,&nbsp;Cemile Handan Misirli,&nbsp;Mustafa Bakar,&nbsp;Hasan Huseyin Kozak,&nbsp;Sena Colakoglu,&nbsp;Ali Yavuz Karahan,&nbsp;Eylem Ozaydin Goksu,&nbsp;Fatih Ozdag,&nbsp;Mehmet Guney Senol,&nbsp;Vedat Ali Yurekli,&nbsp;Ufuk Aluclu,&nbsp;Serkan Demir,&nbsp;Hayriye Kucukoglu,&nbsp;Serdar Oruc,&nbsp;Nilufer Yesilot,&nbsp;Ozge Yimaz Kusbeci,&nbsp;Bijen Nazliel,&nbsp;Firdevs Ezgi Ucan Tokuc,&nbsp;Hesna Bektas,&nbsp;Fatma Nida Tascilar,&nbsp;Emrah Aytac,&nbsp;Mustafa Gokce,&nbsp;Hale Zeynep Batur Caglayan,&nbsp;Ahmet Tufekci,&nbsp;Gulnur Uzuner,&nbsp;Dilek Necioglu Orken,&nbsp;Osman Ozgur Yalin,&nbsp;Uygar Utku,&nbsp;Arda Yilmaz,&nbsp;Hamit Genc,&nbsp;Murat Cabalar,&nbsp;Aysel Milanlioglu,&nbsp;Hakan Ekmekci,&nbsp;Burcu Zeydan,&nbsp;Sevim Baybas,&nbsp;Yuksel Kablan,&nbsp;Basak Karakurum Goksel,&nbsp;Mustafa Acikgoz,&nbsp;Hatice Kurucu,&nbsp;Seden Demirci,&nbsp;Taskin Gunes","doi":"10.1155/2020/8610903","DOIUrl":"https://doi.org/10.1155/2020/8610903","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group.</p><p><strong>Methods: </strong>Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF.</p><p><strong>Results: </strong>The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34 ± 9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38 ± 9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%).</p><p><strong>Conclusion: </strong>The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2020 ","pages":"8610903"},"PeriodicalIF":1.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8610903","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38400442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Thai Version of the Gait Assessment and Intervention Tool (G.A.I.T.)","authors":"Jittima Saengsuwan, P. Sirasaporn","doi":"10.1155/2020/1710534","DOIUrl":"https://doi.org/10.1155/2020/1710534","url":null,"abstract":"Introduction. The Gait Assessment and Intervention Tool (G.A.I.T.) is well-accepted for determining changes in gait quality in neurological patients. This study is aimed at translating the G.A.I.T. to Thai and to examine its validity and reliability. Methods. The Thai translation and back-translation into English were done according to international guidelines. Sixty-eight patients with subacute to chronic stroke were recruited. Concurrent validity was determined by the correlation coefficient between the Thai G.A.I.T. scale and a comfortable vs. fast gait speed. The convergent validity was determined by the correlation coefficient between the Thai G.A.I.T. and the lower extremity Motricity Index, the Functional Ambulation Category (FAC), and the National Institutes of Health Stroke Scale (NIHSS). Interrater reliability was assessed using videos of 68 patients analysed by two independent raters. Each rater was randomly assigned to rescore the Thai G.A.I.T. for each patient over at least two weeks to assess intrarater reliability. Results. The concurrent validity of the Thai G.A.I.T. vs. the respective comfortable and fast gait speeds was excellent (Rs=−0.79 and Rs=−0.68, p<0.001). The respective convergent validity with the lower extremity Motricity Index, NIHSS, and FAC was Rs=−0.62, 0.57, and -0.51, respectively. The respective inter- and intrarater reliabilities were excellent (ICC=0.93, 95% CI 0.88-0.96 and 0.95, 95% CI 0.91-0.97). Conclusion. A Thai version of the G.A.I.T. was developed, and its validity and reliability for use among patients with subacute to chronic stroke were established. Further work regarding the responsiveness of the tool is needed.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"10 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82078324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Use of Standardized Outcome Measures for Stroke Rehabilitation among Physiotherapists in Ghana.","authors":"Seth Kwame Agyenkwa,&nbsp;Cosmos Yarfi,&nbsp;Adjoa Nkrumah Banson,&nbsp;Woyram Abla Kofi-Bediako,&nbsp;Ulric Sena Abonie,&nbsp;Seth Kwadjo Angmorterh,&nbsp;Eric Kwasi Ofori","doi":"10.1155/2020/9259017","DOIUrl":"https://doi.org/10.1155/2020/9259017","url":null,"abstract":"<p><strong>Background: </strong>The use of standardized outcome measures is an aspect of good clinical practice and essential to the rehabilitation of patients suffering from stroke. Literature reports regarding the extent of usage of outcome measures in stroke rehabilitation by physiotherapists globally are inconsistent. In addition, the patronage of outcome measures in stroke rehabilitation in low-resourced countries is uncertain.</p><p><strong>Objective: </strong>This study was conducted to assess the current practice of physiotherapists in Ghana regarding the use of standardized outcome measures in the rehabilitation of stroke patients.</p><p><strong>Method: </strong>A descriptive cross-sectional survey, was used involving 105 registered physiotherapists in Ghana. A 35-item adapted questionnaire was used to collect data on some commonly used outcome measures and frequency of use by physiotherapists for stroke patients.</p><p><strong>Results: </strong>A total of 55 (52.4%) physiotherapists did not use outcome measures in their clinical practice. Physiotherapists below 40 years of age use outcome measures (64.7%) more than those 41 years and above (6.7%). Physiotherapists working in public facilities in Ghana are more likely to use outcome measures (56.2%) than those in private facilities (16.2%). Physiotherapists who attend to 1-10 patients in a week used outcome measures more (32.4%) than physiotherapists who attend to more than 30 patients (3.8%) in a week.</p><p><strong>Conclusion: </strong>There is poor usage of outcome measures by Ghanaian physiotherapists, with more than half of the participants not using any standardized outcome measures for rehabilitation of patients in their practice. Physiotherapists who attends to fewer number of patients in a week are more likely to use outcome measures. There is the need for implementation of policy and guidelines on the use of outcome measures by the Allied Health Professions Council and the Ghana Physiotherapy Association.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2020 ","pages":"9259017"},"PeriodicalIF":1.5,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9259017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38153007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Parafascicular Surgery (MIPS) for Spontaneous Intracerebral Hemorrhage Compared to Medical Management: A Case Series Comparison for a Single Institution.","authors":"Victoria L Phillips, Anil K Roy, Jonathan Ratcliff, Gustavo Pradilla","doi":"10.1155/2020/6503038","DOIUrl":"10.1155/2020/6503038","url":null,"abstract":"<p><strong>Objective: </strong>We compared the safety and effectiveness of minimally invasive parafascicular surgery (MIPS) as a frontline treatment for spontaneous supratentorial ICH to medical management. <i>Patients</i>. The sample consisted of 17 patients who underwent MIPS from January 2014 to December 2016 and a comparison group of 23 patients who were medically managed from June 2012 to December 2013. All had an International Classification of Disease (ICD) diagnosis of 431 and were treated at Grady Memorial Hospital, an urban, public, safety-net hospital.</p><p><strong>Methods: </strong>The primary endpoint was risk of inpatient mortality. Secondary endpoints were rates of inpatient infection and favorable discharge status, defined as discharge to home or rehabilitation facility. Demographics and pre- and postclinical outcomes were compared using <i>t</i>-tests, the Mann-Whitney test, and chi-squared tests for continuous, ordinal and categorical measures, respectively. Cox proportional hazard models were used to estimate the time to inpatient death. Logistic regression analyses were used to determine treatment effects on secondary outcomes. We also conducted exploratory subgroup analyses which compared MIPS to two medical management subgroups: those who had surgery during their hospitalization and those that did not.</p><p><strong>Results: </strong>Two patients (12%) died in the MIPS group compared to three (12%) in the medical management group. MIPS did not increase the risk of inpatient mortality relative to medical management. Rates of inpatient infection did not differ significantly between the two groups; eight MIPS patients (47%) and 13 medically managed patients (50%) contracted infections. MIPS significantly increased the likelihood of favorable discharge status (odds ratio (OR) 1.77; 95% CI, 1.12-21.9) compared to medical management. No outcome measures were significantly different between MIPS and the medical management subgroup without surgery, while rates of favorable discharge were higher among the MIPS patients compared to the medical management group with surgery.</p><p><strong>Conclusions: </strong>These data suggest that MIPS, as a frontline treatment for spontaneous ICH, versus medical management for spontaneous ICH warrants further investigation.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2020 ","pages":"6503038"},"PeriodicalIF":1.8,"publicationDate":"2020-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38082288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}