Stroke Research and Treatment最新文献

{"title":"Does Action Observation of the Whole Task Influence Mirror Neuron System and Upper Limb Muscle Activity Better Than Part Task in People With Stroke?","authors":"A Sulfikar Ali, Mayur Bhat, Hari Prakash Palaniswamy, Selvam Ramachandran, Senthil D Kumaran","doi":"10.1155/2024/9967369","DOIUrl":"https://doi.org/10.1155/2024/9967369","url":null,"abstract":"<p><p><b>Background:</b> Task-based action observation and imitation (AOI) is a promising intervention to enhance upper limb (UL) motor function poststroke. However, whether whole/part task must be trained in the AOI therapy needs further substantiation. <b>Objective:</b> The objective of this study is to assess and compare the mirror neuron activity and UL muscle activity during AOI of reaching task in terms of whole task (complete movement) and part task (proximal arm movements and distal arm movements). <b>Methods:</b> In this cross-sectional study, 26 participants with first-time unilateral stroke were asked to observe the prerecorded videos of a reaching task in terms of a whole task and proximal and distal components, followed by imitation of the task, respectively. Electroencephalographic (EEG) mu rhythm suppression and electromyographic amplitude of six UL muscles were measured during the task. <b>Results:</b> The analysis of EEG revealed a statistically significant mu suppression score, indicating mirror neuron system activity, during AOI of the whole task in C3 (<i>p</i> = <0.001) and C4 (<i>p</i> = <0.001) electrodes compared to the part task. Percentage maximum voluntary contraction amplitudes of the deltoid (<i>p</i> = 0.002), supraspinatus (<i>p</i> = <0.001), triceps brachii (<i>p</i> = 0.002), brachioradialis (<i>p</i> = 0.006), and extensor carpi radialis (<i>p</i> = <0.001) muscles showed a significant increase in muscle activity during AOI of the whole task. Also, there seems to be a task observation-specific activation of muscles following AOI of proximal or distal tasks. <b>Conclusion:</b> The practice of the whole task should be given emphasis while framing the AOI treatment module to enhance reaching in people with stroke. <b>Trial registration:</b> Clinical Trials Registry-India (CTRI) identifier: CTRI/2018/04/013466.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2024 ","pages":"9967369"},"PeriodicalIF":1.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Contralateral Limb Cross Education and High-Frequency Repetitive Transcranial Magnetic Stimulation on Functional Indices of the Affected Upper Limb in Subacute Phase of Stroke","authors":"Katayoon Rezaei, Amin Kordi Yoosefinejad, Farzaneh Moslemi Haghighi, Mohsen Razeghi","doi":"10.1155/2023/4387667","DOIUrl":"https://doi.org/10.1155/2023/4387667","url":null,"abstract":"Background. Stroke is one of the causes of long-term morbidity. Despite rehabilitation strategies, most survivors live with motor deficits in the upper limbs. Objectives. The aim of the study was to compare the effect of contralateral cross education (CE) and high-frequency repetitive magnetic stimulation (HF-rTMS) on the function of upper extremity in subacute phase of stroke. Methods. Forty patients were randomly assigned into 4 groups. Group “A” received physical therapy (PT) for 10 sessions, 3 times per week. Group “B” received PT and HF-rTMS as follows: stimulation of 20 Hz for 5 s, intertrain interval for 50 s, 20 trains, 2000 pulses at 90% resting motor threshold, and conventional PT. Group “C” was treated with CE and PT. In group “D,” HF-rTMS, CE, and PT were administered. Results. Significant differences were found in the Fugl-Meyer scale between “A” and “C” (\u0000 \u0000 P\u0000 =\u0000 0.01\u0000 \u0000 ), “A” and “D” (\u0000 \u0000 P\u0000 =\u0000 0.02\u0000 \u0000 ), and “B” and “C” groups (\u0000 \u0000 P\u0000 =\u0000 0.01\u0000 \u0000 ). In the box-block test, there were significant differences between “A” and “B” (\u0000 \u0000 P\u0000 =\u0000 0.01\u0000 \u0000 ), “A” and “C” (\u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 ), “B” and “D” (\u0000 \u0000 P\u0000 =\u0000 0.001\u0000 \u0000 ), and “B” and “C” groups (\u0000 \u0000 P\u0000 =\u0000 0.01\u0000 \u0000 ). Statistical differences were observed in grip strength between “A” and “B” (\u0000 \u0000 P\u0000 =\u0000 0.01\u0000 \u0000 ) and “A” and “C” groups (\u0000 \u0000 P\u0000 =\u0000 0.02\u0000 \u0000 ). Conclusions. It is suggested that clinicians select the therapeutic methods in line with their expected goal. When the goal is to improve upper extremity function, CE+PT could be more effective than HF-rTMS+PT. Also, CE+PT and HF-rTMS+PT were more effective than CE+HF-rTMS+PT at improving grip strength. Therefore, combining several methods would not always lead to better results.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":" 1236","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation of SAFE Score to Predict Atrial Fibrillation Diagnosis after Ischemic Stroke: A Retrospective Multicenter Study","authors":"Miguel Quesada López, L. Amaya Pascasio, Sara Blanco Madera, Jorge Pagola, Diana Vidal de Francisco, Elena de Celis Ruiz, Inmaculada Villegas Rodríguez, Joaquín Carneado-Ruiz, J. García‐Carmona, Juan Manuel García Torrecillas, Ana López Ferreiro, Iker Elosua Bayes, Ricardo Jaime Rigual Bobillo, María Isabel López López, Íñigo Esain González, María Dolores Ortega Ortega, Marina Blanco Ruiz, Irene Pérez Ortega, Carlos Lázaro Hernández, Blanca Fuentes Gimeno, A. Arjona Padillo, Patricia Martínez Sánchez","doi":"10.1155/2023/6655772","DOIUrl":"https://doi.org/10.1155/2023/6655772","url":null,"abstract":"Introduction. The screening for atrial fibrillation (AF) scale (SAFE score) was recently developed to provide a prediction of the diagnosis of AF after an ischemic stroke. It includes 7 items: \u0000 \u0000 a\u0000 g\u0000 e\u0000 ≥\u0000 65\u0000 \u0000 years, bronchopathy, thyroid disease, cortical location of stroke, intracranial large vessel occlusion, NT-ProBNP ≥250 pg/mL, and left atrial enlargement. In the internal validation, a good performance was obtained, with an \u0000 \u0000 A\u0000 U\u0000 C\u0000 =\u0000 0.88\u0000 \u0000 (95% CI 0.84-0.91) and sensitivity and specificity of 83% and 80%, respectively, for \u0000 \u0000 s\u0000 c\u0000 o\u0000 r\u0000 e\u0000 s\u0000 ≥\u0000 5\u0000 \u0000 . The aim of this study is the external validation of the SAFE score in a multicenter cohort. Methods. A retrospective multicenter study, including consecutive patients with ischemic stroke or transient ischemic attack between 2020 and 2022 with at least 24 hours of cardiac monitoring. Patients with previous AF or AF diagnosed on admission ECG were excluded. Results. Overall, 395 patients were recruited for analysis. The SAFE score obtained an \u0000 \u0000 A\u0000 U\u0000 C\u0000 =\u0000 0.822\u0000 \u0000 (95% CI 0.778-0.866) with a sensitivity of 87.2%, a specificity of 65.4%, a positive predictive value of 44.1%, and a negative predictive value of 94.3% for a SAFE \u0000 \u0000 s\u0000 c\u0000 o\u0000 r\u0000 e\u0000 ≥\u0000 5\u0000 \u0000 , with no significant gender differences. Calibration analysis in the external cohort showed an absence of significant differences between the observed values and those predicted by the model (Hosmer-Lemeshow’s test 0.089). Conclusions. The SAFE score showed adequate discriminative ability and calibration, so its external validation is justified. Further validations in other external cohorts or specific subpopulations of stroke patients might be required.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"119 5","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Survival Time to Death among Stroke Patients at Jimma University Medical Center, Southwest Ethiopia: A Retrospective Cohort Study.","authors":"Bikiltu Wakuma Negasa, Teramaj Wongel Wotale, Mesfin Esayas Lelisho, Legesse Kassa Debusho, Kibrealem Sisay, Wubishet Gezimu","doi":"10.1155/2023/1557133","DOIUrl":"10.1155/2023/1557133","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a life-threatening condition that occurs due to impaired blood flow to brain tissues. Every year, about 15 million people worldwide suffer from a stroke, with five million of them suffering from some form of permanent physical disability. Globally, stroke is the second-leading cause of death following ischemic heart disease. It is a public health burden for both developed and developing nations, including Ethiopia.</p><p><strong>Objectives: </strong>This study is aimed at estimating the time to death among stroke patients at Jimma University Medical Center, Southwest Ethiopia.</p><p><strong>Methods: </strong>A facility-based retrospective cohort study was conducted among 432 patients. The data were collected from stroke patients under follow-up at Jimma University Medical Center from January 1, 2016, to January 30, 2019. A log-rank test was used to compare the survival experiences of different categories of patients. The Cox proportional hazard model and the accelerated failure time model were used to analyze the survival analysis of stroke patients using R software. An Akaike's information criterion was used to compare the fitted models.</p><p><strong>Results: </strong>Of the 432 stroke patients followed, 223 (51.6%) experienced the event of death. The median time to death among the patients was 15 days. According to the results of the Weibull accelerated failure time model, the age of patients, atrial fibrillation, alcohol consumption, types of stroke diagnosed, hypertension, and diabetes mellitus were found to be the significant prognostic factors that contribute to shorter survival times among stroke patients.</p><p><strong>Conclusion: </strong>The Weibull accelerated failure time model better described the time to death of the stroke patients' data set than other distributions used in this study. Patients' age, atrial fibrillation, alcohol consumption, being diagnosed with hemorrhagic types of stroke, having hypertension, and having diabetes mellitus were found to be factors shortening survival time to death for stroke patients. Hence, healthcare professionals need to thoroughly follow the patients who pass risk factors. Moreover, patients need to be educated about lifestyle modifications.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2023 ","pages":"1557133"},"PeriodicalIF":1.5,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Self-Directed Home Therapy Adherence Combined with TheraBracelet on Poststroke Hand Recovery: A Pilot Study.","authors":"Gabrielle Scronce, Viswanathan Ramakrishnan, Amanda A Vatinno, Na Jin Seo","doi":"10.1155/2023/3682898","DOIUrl":"10.1155/2023/3682898","url":null,"abstract":"<p><p>Hand impairment is a common consequence of stroke, resulting in long-term disability and reduced quality of life. Recovery may be augmented through self-directed therapy activities at home, complemented by the use of rehabilitation devices such as peripheral sensory stimulation. The objective of this study was to determine the effect of adherence to self-directed therapy and the use of TheraBracelet (subsensory random-frequency vibratory stimulation) on hand function for stroke survivors. In a double-blind, randomized controlled pilot trial, 12 chronic stroke survivors were assigned to a treatment or control group (<i>n</i> = 6/group). All participants were instructed to perform 200 repetitions of therapeutic hand tasks 5 days/week while wearing a wrist-worn device 8 hours/day for 4 weeks. The treatment group received TheraBracelet vibration from the device, while the control group received no vibration. Home task repetition adherence and device wear logs, as well as hand function assessment (Stroke Impact Scale Hand domain), were obtained weekly. Repetition adherence was comparable between groups but varied among participants. Participants wore the device to a greater extent than adhering to completing repetitions. A linear mixed model analysis showed a significant interaction between repetition and group (<i>p</i> = 0.01), with greater adherence resulting in greater hand function change for the treatment group (<i>r</i> = 0.94; <i>R</i> ² = 0.88), but not for the control group. Secondary analysis revealed that repetition adherence was greater for those with lower motor capacity and greater self-efficacy at baseline. This pilot study suggests that adherence to self-directed therapy at home combined with subsensory stimulation may affect recovery outcomes in stroke survivors. This trial is registered with NCT04026399.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2023 ","pages":"3682898"},"PeriodicalIF":1.8,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9377934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden and In-Hospital Mortality of Stroke Admissions at a Tertiary Level Hospital in Namibia: A Retrospective Cohort Study.","authors":"Saara Ndinelago Neshuku,&nbsp;Jessica Kirchner-Frankle,&nbsp;Maria Nangolo,&nbsp;Maria Moses,&nbsp;Chalese Olivia Einbeck,&nbsp;Percy Kumire,&nbsp;Vaja Zatjirua,&nbsp;Justor Banda","doi":"10.1155/2023/1978536","DOIUrl":"https://doi.org/10.1155/2023/1978536","url":null,"abstract":"<p><strong>Background: </strong>Despite stroke being a leading cause of morbidity and mortality globally, there is a dearth of information on the burden and outcomes of stroke in sub-Saharan Africa and Namibia in particular.</p><p><strong>Methods: </strong>A hospital-based, retrospective cohort study was conducted to analyse non-electronic medical records of all consecutive stroke patients who were admitted to one of the highest tertiary-level hospitals in Namibia for 12 months (2019-2020). The primary outcome of the study was to establish the in-hospital mortality, stroke subtypes, and associated complications.</p><p><strong>Results: </strong>In total, 220 patients were included in the study, their mean age was 53 (SD13.8) years, and 55.5% were males. 61.0% had an ischaemic stroke (IS), and 39.0% had a haemorrhagic stroke (HS). The mean age was significantly lower in patients with HS vs. IS (48.2 ± 12.2 vs. 56.1 ± 13.3, <i>p</i> < 0.001). Of the IS patients, the majority (29.0%) had total anterior circulation infarct (TACI), while in the HS group, 34.0% had basal ganglia haemorrhage with or without intraventricular extension. Hypertension (<i>p</i> = 0.015), dyslipidaemia (<i>p</i> = 0.001), alcohol consumption (<i>p</i> = 0.022), and other cardiovascular diseases (<i>p</i> = 0.007) were more prevalent in patients with IS compared to those with HS. The prevalence rate of intravenous thrombolysis was 2.2% in IS and use of intravenous antihypertensives in 25.9% of patients with HS than IS. The in-hospital mortality was 26.4% with complications such as raised ICP, aspiration pneumonia, hydrocephalus, and sepsis significantly high in those that died. Aspiration pneumonia (OR 2.79, 95% CI 1.63-4.76, <i>p</i> < 0.001) and increased ICP (OR 0.30, 95% CI 0.16-057, <i>p</i> < 0.001) were independent predictors of in-hospital mortality on the multivariate analysis.</p><p><strong>Conclusion: </strong>Our findings showed a younger mean age for stroke and mortality rate comparable to other low- to middle-income countries (LMICs). Hypertension and alcohol consumption were the main risk factors for both stroke subtypes, while aspiration pneumonia and raised intracranial pressure predicted in-hospital mortality.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2023 ","pages":"1978536"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10707567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional Mirror Therapy versus Immersive Virtual Reality Mirror Therapy: The Perceived Usability after Stroke.","authors":"Eliana da Silva Jaques,&nbsp;Anelise Ineu Figueiredo,&nbsp;Aniuska Schiavo,&nbsp;Bianca Pacheco Loss,&nbsp;Gabriel Hoff da Silveira,&nbsp;Vicenzo Abichequer Sangalli,&nbsp;Denizar Alberto da Silva Melo,&nbsp;Léder Leal Xavier,&nbsp;Márcio Sarroglia Pinho,&nbsp;Régis Gemerasca Mestriner","doi":"10.1155/2023/5080699","DOIUrl":"https://doi.org/10.1155/2023/5080699","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a widespread and complex health issue, with many survivors requiring long-term rehabilitation due to upper-limb impairment. This study is aimed at comparing the perceived usability of two feedback-based stroke therapies: conventional mirror therapy (MT) and immersive virtual reality mirror therapy (VR).</p><p><strong>Methods: </strong>The study involved 45 participants, divided into three groups: the stroke survivors (<i>n</i> = 15), stroke-free older adults (<i>n</i> = 15), and young controls (<i>n</i> = 15). Participants performed two tasks using both MT and VR in a semirandom sequence. Usability instruments (SUS and NASA-TLX) were applied at the end of the activities, along with two experience-related questions.</p><p><strong>Results: </strong>The results indicated that both MT and VR had similar levels of perceived usability, with MT being more adaptable and causing less overall discomfort. Conversely, VR increased the perception of task difficulty and prevented participants from diverting their attention from the mirror-based feedback.</p><p><strong>Conclusion: </strong>While VR was found to be less comfortable than MT, both systems exhibited similar perceived usability. The comfort levels of the goggles may play a crucial role in determining the usability of VR for upper limb rehabilitation after stroke.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2023 ","pages":"5080699"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9575856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Lymphocyte-to-Monocyte Ratio as a Possible Predictor of an Unfavourable Clinical Outcome in Patients with Acute Ischemic Stroke after Mechanical Thrombectomy.","authors":"Katarína Pinčáková, Georgi Krastev, Jozef Haring, Miroslav Mako, Viktória Mikulášková, Vladimír Bošák","doi":"10.1155/2022/9243080","DOIUrl":"10.1155/2022/9243080","url":null,"abstract":"<p><strong>Background: </strong>Although considerable progress has been made in the treatment of acute ischemic stroke (AIS), the clinical outcome of patients is still significantly influenced by the inflammatory response that follows stroke-induced brain injury. The aim of this study was to evaluate the potential use of complete blood count parameters, including indices and ratios, for predicting the clinical outcome in AIS patients undergoing mechanical thrombectomy (MT).</p><p><strong>Methods: </strong>This single-centre retrospective study is consisted of 179 patients. Patient data including demographic characteristics, risk factors, clinical data, laboratory parameters on admission, and clinical outcome were collected. Based on the clinical outcome assessed at 3 months after MT by the modified Rankin Scale (mRS), patients were divided into two groups: the favourable group (mRS 0-2) and unfavourable group (mRS 3-6). Stepwise multivariate logistic regression analysis was used to detect an independent predictor of the unfavourable clinical outcome.</p><p><strong>Results: </strong>An unfavourable clinical outcome was detected after 3 months in 101 patients (54.4%). Multivariate logistic regression analysis confirmed that the lymphocyte-to-monocyte ratio (LMR) was an independent predictor of unfavourable clinical outcome at 3 months (odds ratio = 0.761, 95% confidence interval 0.625-0.928, and <i>P</i> = 0.007). The value of 3.27 was chosen to be the optimal cut-off value of LMR. This value could predict the unfavourable clinical outcome with a 74.0% sensitivity and a 54.4% specificity.</p><p><strong>Conclusion: </strong>The LMR at the time of hospital admission is a predictor of an unfavourable clinical outcome at 3 months in AIS patients after MT.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2022 ","pages":"9243080"},"PeriodicalIF":1.8,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10400575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and Predictors of In-Hospital Stroke Mortality in Ethiopia: A Systematic Review and Meta-Analysis","authors":"Amare Abera Tareke, Masrie Getnet Abate, A. Alem, Y. Alamneh, Alehegn Aderaw Alamneh, Yikeber Argachew Deml, M. Shiferaw, Woldeteklehaymanot Kassahun, Abraham Teym","doi":"10.1155/2022/7202657","DOIUrl":"https://doi.org/10.1155/2022/7202657","url":null,"abstract":"Introduction Stroke is the second leading cause of mortality worldwide, accounting for approximately 5.5 million deaths each year. Due to demographic and health changes, the epidemiology of stroke is shifting from industrialized to low- and middle-income nations. Ethiopia is a developing country with a population that reflects this shift. Therefore, this systematic review and meta-analysis are aimed at evaluating the extent of in-hospital mortality of both ischemic and hemorrhagic stroke in Ethiopia and determining relevant factors associated with the mortality. Methods Observational studies published as of July 15, 2020, that reported the magnitude, predictors, and causes of in-hospital mortality of stroke were systematically and comprehensively retrieved using the PRISMA 2020 criteria from databases such as PubMed/MEDLINE, Science Direct, and Google Scholar. The review papers were chosen based on the study methodology (facility-based observational), the study area (Ethiopia), the study population (adult patients with stroke), the outcome (in-hospital mortality), and the fact that they were published in English. Result A total of 3709 patients with stroke were included in this systematic review and meta-analysis, which included 19 publications. In-hospital mortality was 14.03 percent on average in the studies, with reports ranging from 6.04 percent to 37.37 percent. Patients with hemorrhagic type stroke, admission Glasgow Coma Scale less than or equal to 12, impaired mental status, National Institutes of Health Stroke Scale stroke level greater than 13, prolonged hospital stay, any incontinence, pneumonia, and/or swallowing trouble had an increased risk of death after stroke. Conclusion The magnitude of in-hospital mortality of patients with stroke in Ethiopia is high. The assessment of the level of consciousness is vital for clinical management and as an indicator of prognosis. Patients with unfavorable prognostic signs, such as entry Glasgow Coma Scale, National Institutes of Health Stroke Scale stroke level > 13, hemorrhagic stroke, pneumonia, incontinence, and dysphagia, should be given priority.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"109 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83414313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are the Predictors of Intracranial Aneurysm Rupture in Indonesian Population Based on Angiographic Findings? Insight from Intracranial Aneurysm Registry on Three Comprehensive Stroke Centres in Indonesia","authors":"J. P. Swatan, A. F. Sani, Dedy Kurniawan, H. Swatan, S. Husain","doi":"10.1155/2022/4787048","DOIUrl":"https://doi.org/10.1155/2022/4787048","url":null,"abstract":"Objectives What are the Predictors of Intracranial Aneurysm (IA) Rupture based on angiographic findings among patients in Indonesia's Population Based on Angiographic Findings. Materials and Methods We conducted a cross-sectional study on subjects with IA not caused by congenital aetiologies or other vascular malformations with cerebral angiography performed from January 2017 to January 2021. Demographic data and aneurysm profile, which include aneurysm count, size, location, and rupture event, were collected. The correlation between risk factors and IA rupture events was determined using bivariate and multivariate analysis. Results From 100 angiography data (33 males and 67 females), the mean subject age is 51.94 ± 10.78. We observe a total of 121 IAs from all subjects. Most of the IAs are in the anterior circulation (104 aneurysms, 85.96%), have small size (77 aneurysms, 63.64%), and are found in ruptured conditions (90 aneurysms, 74.38%). Males have a greater aneurysm count (1.36 ± 0.74 vs. 1.13 ± 0.55, p = 0.036) and larger aneurysm size (p = 0.002). Aneurysm size is significantly correlated with its location (p = 0.008). Medium size (p = 0.019; OR 2.62, 95% CI 1.08-6.36) and location other than the internal carotid artery are associated with increased rupture event. Multivariate analysis revealed that gender (p = 0.031; aOR 5.37, 95% CI 1.17-24.70) is a significant risk factor of IA rupture event. Conclusion IA profiling will enable clinicians to determine the risk of rupture and treatment plans for the Indonesian population. Further studies with a larger sample size are required to confirm these findings.","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":"2 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77787677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}