Alejandro Roman-Gonzalez, Carlos Andrés Naranjo, Walter D Cardona-Maya, Dionis Vallejo, Francisco Garcia, Cesar Franco, Leonor Alvarez, Luis Ignacio Tobón, Marta Ibeth López, Carolina Rua, Gabriel Bedoya, Ángela Cadavid, José Domingo Torres
{"title":"哥伦比亚缺血性脑卒中患者和健康对照者阿司匹林抵抗频率","authors":"Alejandro Roman-Gonzalez, Carlos Andrés Naranjo, Walter D Cardona-Maya, Dionis Vallejo, Francisco Garcia, Cesar Franco, Leonor Alvarez, Luis Ignacio Tobón, Marta Ibeth López, Carolina Rua, Gabriel Bedoya, Ángela Cadavid, José Domingo Torres","doi":"10.1155/2021/9924710","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention.</p><p><strong>Materials and methods: </strong>Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test.</p><p><strong>Results: </strong>Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis (<i>p</i> = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia.</p><p><strong>Conclusion: </strong>Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.</p>","PeriodicalId":22054,"journal":{"name":"Stroke Research and Treatment","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164531/pdf/","citationCount":"1","resultStr":"{\"title\":\"Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia.\",\"authors\":\"Alejandro Roman-Gonzalez, Carlos Andrés Naranjo, Walter D Cardona-Maya, Dionis Vallejo, Francisco Garcia, Cesar Franco, Leonor Alvarez, Luis Ignacio Tobón, Marta Ibeth López, Carolina Rua, Gabriel Bedoya, Ángela Cadavid, José Domingo Torres\",\"doi\":\"10.1155/2021/9924710\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention.</p><p><strong>Materials and methods: </strong>Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test.</p><p><strong>Results: </strong>Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis (<i>p</i> = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia.</p><p><strong>Conclusion: </strong>Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.</p>\",\"PeriodicalId\":22054,\"journal\":{\"name\":\"Stroke Research and Treatment\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2021-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164531/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Stroke Research and Treatment\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2021/9924710\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stroke Research and Treatment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2021/9924710","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia.
Objective: To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention.
Materials and methods: Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test.
Results: Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis (p = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia.
Conclusion: Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.
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