Sleep最新文献_第3页

Is it time to revisit the scoring of Slow Wave (N3) Sleep?

IF 5.6 2区医学

Sleep Pub Date : 2025-03-13 DOI: 10.1093/sleep/zsaf063

Shaun Davidson, Rachel Sharman, Simon D Kyle, Lionel Tarassenko

{"title":"Is it time to revisit the scoring of Slow Wave (N3) Sleep?","authors":"Shaun Davidson, Rachel Sharman, Simon D Kyle, Lionel Tarassenko","doi":"10.1093/sleep/zsaf063","DOIUrl":"https://doi.org/10.1093/sleep/zsaf063","url":null,"abstract":"The use of a fixed electroencephalogram (EEG) amplitude threshold of 75 µV for labelling slow waves is a subject of ongoing discussion given EEG amplitude is known to vary with age and sex. This paper investigates the impact of this amplitude threshold on age- and sex-related trends in visually-annotated SWS. Automated methods for labelling SWS using data-driven thresholds and amplitude- or frequency-based inputs are developed. Age- and sex-related trends in SWS derived from visual annotation and automated labelling are then compared across a cohort of 2,913 participants from the Sleep Heart Health Study. In the selected cohort, males exhibit an age-related decrease in visually-annotated SWS, which is preserved when using automated labelling. In contrast, females exhibit a mild age-related increase in visually-annotated and amplitude-labelled SWS, but an age-related decrease in frequency-labelled SWS. Further, using frequency-labelled SWS results in a reduction in SWS in females to a level comparable to that of males. Overall, the consistency of age-related trends in SWS in males between visual annotation and automated labelling, as well as the lack of consistency in these trends in females, is striking. Given that the 75 µV amplitude threshold was established using data acquired primarily from young males, these results suggest that observed sex-based differences in visually-annotated SWS may be artefactual rather than physiological, and a result of the 75 µV amplitude criterion. This sex-related disparity highlights the need for the AASM guidelines for scoring SWS to be reviewed and updated to provide equivalent performance for males and females.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of estimated glomerular filtration rate with the incidence of sleep apnea syndrome. 估计肾小球滤过率与睡眠呼吸暂停综合征发病率的关系。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae302

Tatsuhiko Azegami, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Toshiyuki Ko, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Norihiko Takeda, Takashi Yokoo, Hideo Yasunaga, Masaomi Nangaku, Kaori Hayashi

{"title":"Association of estimated glomerular filtration rate with the incidence of sleep apnea syndrome.","authors":"Tatsuhiko Azegami, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Toshiyuki Ko, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Norihiko Takeda, Takashi Yokoo, Hideo Yasunaga, Masaomi Nangaku, Kaori Hayashi","doi":"10.1093/sleep/zsae302","DOIUrl":"10.1093/sleep/zsae302","url":null,"abstract":"Study objectives: Sleep apnea syndrome (SAS) is potentially linked to life-threatening conditions. The decline in kidney function is involved in the development of various diseases; however, it remains unclear whether it is implicated in the onset of SAS. Therefore, this study aimed to investigate the relationship between kidney function and the incidence of SAS.Methods: The association of estimated glomerular filtration rate (eGFR) with the incidence of SAS was assessed retrospectively using real-world administrative claims and health checkup data collected between April 2014 and November 2022. To strengthen robustness, three stratified analyses and four sensitivity analyses were conducted.Results: We assessed 1 589 259 individuals for the analysis. During a median (interquartile range) follow-up of 1167 (652-1699) days, 11 054 cases of SAS events were documented. Multivariable Cox regression analyses after adjusting for potential confounders, including age, sex, body mass index, hypertension, diabetes, dyslipidemia, cigarette smoking, alcohol drinking, and physical inactivity, demonstrated that the decrease in eGFR (eGFR ≥ 90, 60-89, 45-59, 30-44, and <30 mL/min/1.73 m2) was associated with a higher risk of SAS (hazard ratio [95% confidence intervals]; 1 [reference value], 1.13 [1.06-1.20], 1.22 [1.13-1.32], 1.34 [1.17-1.52], 1.82 [1.43-2.33]). In the restricted cubic spline regression model, the risk of developing SAS increased with the reduction in eGFR. The results of the sensitivity analyses were consistent with the primary findings.Conclusion: Our analysis utilizing a large-scale population-based cohort concluded that reduced eGFR is associated with the risk of developing SAS in a dose-dependent manner.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae311

Giuseppe Lanza, Maria P Mogavero, Raffaele Ferri

引用次数: 0

Spectral dynamics prior to motor events differ between NREM sleep parasomnias and healthy sleepers. NREM 睡眠妄想症患者与健康睡眠者在运动事件发生前的频谱动态存在差异。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae252

Anna Castelnovo, Greta Mainieri, Giuseppe Loddo, Spyros Balafas, Chiara Brombin, Giulia Balella, Angelica Montini, Clelia Di Serio, Mauro Manconi, Federica Provini

{"title":"Spectral dynamics prior to motor events differ between NREM sleep parasomnias and healthy sleepers.","authors":"Anna Castelnovo, Greta Mainieri, Giuseppe Loddo, Spyros Balafas, Chiara Brombin, Giulia Balella, Angelica Montini, Clelia Di Serio, Mauro Manconi, Federica Provini","doi":"10.1093/sleep/zsae252","DOIUrl":"10.1093/sleep/zsae252","url":null,"abstract":"Study objectives: The umbrella term \"Disorders of Arousal\" (DoA), encompassing sleepwalking, confusional arousals, and sleep terrors, refers to parasomnias manifesting during nonrapid eye movement (NREM) sleep, commonly thought to arise from an aberrant arousal process. While previous studies have detailed electroencephalographic (EEG) changes linked to DoA episodes, it remains uncertain how these alterations differ from a physiological arousal process. This study directly compared brain activity between DoA episodes and arousals associated with physiological movements (motor arousal) in individuals with DoA and healthy sleepers.Methods: Fifty-three adult participants with DoA (25 males, 32.2 ± 15.5 years) and 33 control participants (14 males, 31.4 ± 11.4 years) underwent one or more home EEG recordings. A semiparametric regression model was employed to elucidate the complex relationship between EEG activity across channels, within and across different groups, including motor arousals in DoA (n = 169), parasomnia episodes in DoA (n = 361), and motor arousals in healthy sleepers (n = 137).Results: Parasomnia episodes and motor arousals in both groups were preceded by a diffuse increase in slow-wave activity (SWA) and beta power, and a widespread decrease in sigma power. However, motor arousals in DoA displayed lower beta and central sigma than in healthy sleepers. Within participants with DoA, episodes were preceded by lower beta, frontal sigma, and higher SWA than motor arousals.Conclusions: Our findings suggest that the arousal process is altered in participants with DoA, and that specific EEG patterns are required for DoA episodes to emerge. These insights will help guide future research into the underlying circuits and objective markers of DoA.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpression of α-synuclein in Pigment Dispersing Factor neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila. 果蝇PDF神经元α-突触核蛋白过表达通过调节脂质代谢改变睡眠-觉醒模式。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae297

Dong Xia, Ying Chen, Xiang Fu, Hui-Yi Liu, Mu-Yan Sun, Fen Wang, Yong Zhang, Chun-Feng Liu, Jun-Yi Liu

{"title":"Overexpression of α-synuclein in Pigment Dispersing Factor neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila.","authors":"Dong Xia, Ying Chen, Xiang Fu, Hui-Yi Liu, Mu-Yan Sun, Fen Wang, Yong Zhang, Chun-Feng Liu, Jun-Yi Liu","doi":"10.1093/sleep/zsae297","DOIUrl":"10.1093/sleep/zsae297","url":null,"abstract":"Parkinson's disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research increasingly indicates the prevalence of sleep-wake disorders in early-stage PD, although the underlying pathogenic mechanisms remain unclear. In this study, transgenic Drosophila models were utilized to observe excessive daytime sleepiness and impaired anticipation in flies overexpressing α-syn in pan-neurons and circadian clock neurons. Additionally, deficits in projection of Pigment Dispersing Factor (PDF) neuron terminals, which are involved in Drosophila sleep and circadian rhythm, were identified. An imbalance in lipid metabolism homeostasis was detected in the brains of α-syn overexpressing mutants. Ultimately, the inhibition of Sterol Regulatory Element-Binding Protein (SREBP) activity led to an improvement in the reduced daytime sleep duration phenotype. Our results suggest that lipid pathways play a role in sleep-wake disorders triggered by α-syn mutation and aggregation, thereby providing valuable insights into potential therapeutic avenues for disrupted sleep patterns associated with PD.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian clock gene variants in two Japanese families with familial advanced sleep phase. 两个家族性睡眠阶段提前的日本家庭的生物钟基因变异。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae309

Motoki Ukai, Akiko Hida, Shingo Kitamura, Yuichi Inoue, Kazuo Mishima

引用次数: 0

Exploring the bidirectional relationship between chronic kidney disease and obstructive sleep apnea. 探讨慢性肾病与阻塞性睡眠呼吸暂停的双向关系。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsaf002

Yu-Hsiang Lin, Kuo-Jen Lin, Jau-Yuan Chen

引用次数: 0

Obstructive sleep apnea and chronic kidney disease: time to move from association to causality and intervention. 阻塞性睡眠呼吸暂停和慢性肾脏疾病：时间从关联到因果关系和干预。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae254

Patrick J Hanly, Sofia B Ahmed

引用次数: 0

Nocturnal blood pressure: the hidden link between sleep apnea and hypertensive disorders of pregnancy? 夜间血压：睡眠呼吸暂停与妊娠期高血压疾病之间的隐性联系？

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae303

Federica Piani, Martino F Pengo

引用次数: 0

Shaping the structural dynamics of motor learning through cueing during sleep. 通过睡眠中的线索塑造运动学习的结构动态。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsaf006

Whitney Stee, Antoine Legouhy, Michele Guerreri, Michael-Christopher Foti, Jean-Marc Lina, Hui Zhang, Philippe Peigneux

{"title":"Shaping the structural dynamics of motor learning through cueing during sleep.","authors":"Whitney Stee, Antoine Legouhy, Michele Guerreri, Michael-Christopher Foti, Jean-Marc Lina, Hui Zhang, Philippe Peigneux","doi":"10.1093/sleep/zsaf006","DOIUrl":"10.1093/sleep/zsaf006","url":null,"abstract":"Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted memory reactivation (TMR), involving cueing learned material during posttraining sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and posttraining sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during posttraining sleep affects performance gains and delayed microstructural remodeling, using both standard diffusion tensor imaging and advanced neurite orientation dispersion and density imaging. Sixty healthy young adults participated in a 5 days protocol, undergoing five diffusion-weighted imaging sessions, pre- and post-two motor sequence training sessions, and after a posttraining night of either regular sleep (RS) or TMR. Results demonstrated rapid skill acquisition on day 1, followed by performance stabilization on day 2, and improvement on day 5, in both RS and TMR groups. (Re)training induced widespread microstructural changes in motor-related areas, initially involving the hippocampus, followed by a delayed engagement of the caudate nucleus. Mean Diffusivity changes were accompanied by increased neurite density index in the putamen, suggesting increased neurite density, while free water fraction reduction indicated glial reorganization. TMR-related structural differences emerged in the dorsolateral prefrontal cortex on day 2 and the right cuneus on day 5, suggesting unique sleep TMR-related neural reorganization patterns. Persistence of practice-related structural changes, although moderated over time, suggests a lasting neural network reorganization, partially mediated by sleep TMR.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0