Sleep最新文献

{"title":"Opioid-related sleep-disordered breathing: correlates and conundrums.","authors":"Susmita Chowdhuri, M Safwan Badr","doi":"10.1093/sleep/zsae104","DOIUrl":"10.1093/sleep/zsae104","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of accelerometer-measured sleep duration with incident cardiovascular disease and cardiovascular mortality.","authors":"Mingqing Zhou, Yannis Yan Liang, Sizhi Ai, Hongliang Feng, Yujing Zhou, Yaping Liu, Jihui Zhang, Fujun Jia, Binbin Lei","doi":"10.1093/sleep/zsae157","DOIUrl":"10.1093/sleep/zsae157","url":null,"abstract":"<p><strong>Study objectives: </strong>This study aimed to determine the associations between accelerometer-measured sleep durations and the risks of incident cardiovascular disease (CVD) and CVD-related mortality.</p><p><strong>Methods: </strong>A total of 92 261 participants (mean age: 62.4 ± 7.8 years, 56.4% female) were included in UK Biobank between 2013 and 2015. Average daily sleep durations were measured using wrist-worn accelerometers over a 7-day period. Sleep durations were categorized as <7 hours/day, 7-9 hours/day (reference), and >9 hours/day. The incidence of CVD and CVD-related mortality were ascertained by hospital records and death registries.</p><p><strong>Results: </strong>During a median follow-up period of 7.0 years, a total of 13 167 participants developed CVD, and 1079 participants died of CVD. Compared with a sleep duration 7-9 hours/day, an accelerometer-measured sleep duration <7 hours/day but not >9 hours/day was associated with higher risks of incident CVD (HR 1.06, 95% CI: 1.02 to 1.10), CVD-related mortality (HR 1.29, 95% CI: 1.14 to 1.47), coronary heart disease (HR 1.11, 95% CI: 1.03 to 1.19), myocardial infarction (HR 1.14, 95% CI: 1.03 to 1.27), heart failure (HR 1.20, 95% CI: 1.08 to 1.34), and atrial fibrillation (HR 1.15, 95% CI: 1.07 to 1.24). A curvilinear dose‒response pattern was observed between accelerometer-measured sleep durations and incident CVD (poverall < .001), with L-shaped associations found for incident CVD and CVD-related mortality.</p><p><strong>Conclusions: </strong>An accelerometer-measured sleep duration of <7 hours/day but not >9 hours/day was associated with elevated risks of incident CVD and CVD-related mortality. Maintaining adequate sleep may help promote cardiovascular health.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the weekend sleep dilemma: the health impacts of catching up on sleep.","authors":"Chenlu Gao, Lei Gao, Kun Hu, Peng Li","doi":"10.1093/sleep/zsae159","DOIUrl":"10.1093/sleep/zsae159","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lighting the path forward: the value of sleep- and circadian-informed lighting interventions in shift work.","authors":"Prerna Varma, Shadab A Rahman","doi":"10.1093/sleep/zsae214","DOIUrl":"10.1093/sleep/zsae214","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatments in patients with chronic insomnia: which electroencephalographic markers of hyperarousal to evaluate?","authors":"Luigi Ferini-Strambi, Andrea Galbiati","doi":"10.1093/sleep/zsae223","DOIUrl":"10.1093/sleep/zsae223","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A circadian-informed lighting intervention accelerates circadian adjustment to a night work schedule in a submarine lighting environment.","authors":"Alisha Guyett, Nicole Lovato, Jack Manners, Nicole Stuart, Barbara Toson, Bastien Lechat, Leon Lack, Gorica Micic, Siobhan Banks, Jillian Dorrian, Eva Kemps, Andrew Vakulin, Robert Adams, Danny J Eckert, Hannah Scott, Peter Catcheside","doi":"10.1093/sleep/zsae146","DOIUrl":"10.1093/sleep/zsae146","url":null,"abstract":"<p><strong>Study objective: </strong>Night work has detrimental impacts on sleep and performance, primarily due to misalignment between sleep-wake schedules and underlying circadian rhythms. This study tested whether circadian-informed lighting accelerated circadian phase delay, and thus adjustment to night work, compared to blue-depleted standard lighting under simulated submariner work conditions.</p><p><strong>Methods: </strong>Nineteen healthy sleepers (12 males; mean ± SD aged 29 ± 10 years) participated in two separate 8-day visits approximately 1 month apart to receive, in random order, circadian-informed lighting (blue-enriched and dim, blue-depleted lighting at specific times) and standard lighting (dim, blue-depleted lighting). After an adaptation night (day 1), salivary dim-light melatonin onset (DLMO) assessment was undertaken from 18:00 to 02:00 on days 2-3. During days 3-7, participants completed simulated night work from 00:00 to 08:00 and a sleep period from 10:00 to 19:00. Post-condition DLMO assessment occurred from 21:00 to 13:00 on days 7-8. Ingestible capsules continuously sampled temperature to estimate daily core body temperature minimum (Tmin) time. Tmin and DLMO circadian delays were compared between conditions using mixed effects models.</p><p><strong>Results: </strong>There were significant condition-by-day interactions in Tmin and DLMO delays (both p < .001). After four simulated night shifts, circadian-informed lighting produced a mean [95% CI] 5.6 [3.0 to 8.2] hours greater delay in Tmin timing and a 4.2 [3.0 to 5.5] hours greater delay in DLMO timing compared to standard lighting.</p><p><strong>Conclusions: </strong>Circadian-informed lighting accelerates adjustment to shiftwork in a simulated submariner work environment. Circadian lighting interventions warrant consideration in any dimly lit and blue-depleted work environments where circadian adjustment is relevant to help enhance human performance, safety, and health.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian transcriptome oscillations in human adipose tissue depend on napping status and link to metabolic and inflammatory pathways.","authors":"María Rodríguez-Martín, Fernando Pérez-Sanz, Carolina Zambrano, Juan Luján, Mikael Ryden, Frank A J L Scheer, Marta Garaulet","doi":"10.1093/sleep/zsae160","DOIUrl":"10.1093/sleep/zsae160","url":null,"abstract":"<p><strong>Study objectives: </strong>Napping is a common habit in many countries. Nevertheless, studies about the chronic effects of napping on obesity are contradictory, and the molecular link between napping and metabolic alterations has yet to be studied. We aim to identify molecular mechanisms in adipose tissue (AT) that may connect napping and abdominal obesity.</p><p><strong>Methods: </strong>In this cross-sectional study, we extracted the RNA repeatedly across 24 hours from cultured AT explants and performed RNA sequencing. Circadian rhythms were analyzed using six consecutive time points across 24 hours. We also assessed global gene expression in each group (nappers vs. non-nappers).</p><p><strong>Results: </strong>With napping, there was an 88% decrease in the number of rhythmic genes compared to that in non-nappers, a reduction in rhythm amplitudes of 29%, and significant phase changes from a coherent unimodal acrophase in non-nappers, towards a scattered and bimodal acrophase in nappers. Those genes that lost rhythmicity with napping were mainly involved in pathways of glucose and lipid metabolism, and of the circadian clock. Additionally, we found differential global gene expression between nappers and non-nappers with 34 genes down- and 32 genes upregulated in nappers. The top upregulated gene (IER3) and top down-regulated pseudogene (VDAC2P2) in nappers have been previously shown to be involved in inflammation.</p><p><strong>Conclusions: </strong>These new findings have implications for our understanding of napping's relationship with obesity and metabolic disorders.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is cataplexy?","authors":"Margaret S Blattner, Thomas E Scammell","doi":"10.1093/sleep/zsad261","DOIUrl":"10.1093/sleep/zsad261","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed school start time is associated with better sleep, mental health, and life satisfaction among residential high-school students: a prospective study.","authors":"Christian S Chan, Ming Chun Tang, Jacklyn C Y Leung, Cyanea Y S Poon, Esther Y Y Lau","doi":"10.1093/sleep/zsae171","DOIUrl":"10.1093/sleep/zsae171","url":null,"abstract":"<p><p>This study examined the longer-term individual- and school-level changes in students 7 months after a 1-hour delay in school start time (SST). Two cohorts of grade 11 students (N = 227; 60.8% female, age = 17.0 [0.85]) at a residential high school in Hong Kong completed a questionnaire assessing sleep duration, insomnia symptoms, depression, anxiety, stress, and subjective well-being in 2017 and 2018, respectively. One of the cohorts was reassessed 7 months after the implementation of a delay in SST, from 07:30 am to 08:30 am (n = 83, 65.1% female). School-level data on breakfast consumption, attendance, tardiness, and health clinic visits were collected. Between-group and within-group prospective comparisons suggest that the delay in SST was associated with improved sleep duration, mental health, and life satisfaction. School-level data revealed increased breakfast consumption and decreased unexcused absences, tardiness, and clinic visits.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major alteration of motor control during rapid eye movements sleep in mice models of sleep disorders.","authors":"Maxime Grenot, Alexis Roman, Manon Villalba, Anne-Laure Morel, Patrice Fort, Sébastien Arthaud, Paul-Antoine Libourel, Christelle Peyron","doi":"10.1093/sleep/zsae178","DOIUrl":"10.1093/sleep/zsae178","url":null,"abstract":"<p><p>Alteration of motor control during rapid eye movements (REM) sleep has been extensively described in sleep disorders, in particular in isolated REM sleep behavior disorder (iRBD) and narcolepsy type 1 (NT1). NT1 is caused by the loss of orexin/hypocretin (ORX) neurons. Unlike in iRBD, the RBD comorbid symptoms of NT1 are not associated with alpha-synucleinopathies. To determine whether the chronic absence of ORX neuropeptides is sufficient to induce RBD symptoms, we analyzed during REM sleep the EMG signal of the prepro-hypocretin knockout mice (ORX-/-), a recognized mouse model of NT1. Then, we evaluated the severity of motor alterations by comparing the EMG data of ORX-/- mice to those of mice with a targeted suppression of the sublaterodorsal glutamatergic neurotransmission, a recognized rodent model of iRBD. We found a significant alteration of tonic and phasic components of EMG during REM sleep in ORX-/- mice, with more phasic events and more REM sleep episodes without atonia compared to the control wild-type mice. However, these phasic events were fewer, shorter, and less complex in ORX-/- mice compared to the RBD-like ORX-/- mice. We thus show that ORX deficiency, as seen in NT1, is sufficient to impair muscle atonia during REM sleep with a moderate severity of alteration as compared to isolated RBD mice. As described in NT1 patients, we report a major interindividual variability in the severity and frequency of RBD symptoms in ORX-deficient mice.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}