Sleep最新文献

{"title":"The case for considering irregular sleep as a clinical sleep disorder.","authors":"Hannah Scott, Bastien Lechat, Kelly Sansom, Tracey L Sletten, Robert Adams, Andrew J K Phillips","doi":"10.1093/sleep/zsag221","DOIUrl":"https://doi.org/10.1093/sleep/zsag221","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An actigraphy-based algorithm to assess daytime napping in people with narcolepsy type 1.","authors":"Raul Torres, Rahul Ghosal, Melissa Naylor, Simerpal K Gill, Yelena Pyatkevich, Sarah L Bermingham, Derek L Buhl, Brian Tracey, Marta Karas, Francesco Onorati, Vadim Zipunnikov, Dmitri Volfson","doi":"10.1093/sleep/zsag219","DOIUrl":"https://doi.org/10.1093/sleep/zsag219","url":null,"abstract":"<p><strong>Study objectives: </strong>Excessive daytime sleepiness is a defining symptom of narcolepsy, affecting daily functioning and quality of life. We developed and evaluated an actigraphy-based nap detection algorithm to objectively estimate daytime naps, a key manifestation of excessive daytime sleepiness.</p><p><strong>Methods: </strong>The nap detection algorithm was developed using data from the Multi-Ethnic Study of Atherosclerosis. This dataset included manually annotated naps from 2237 participants with 7 days of wrist-worn actigraphy. The nap detection algorithm was then applied in studies of participants with narcolepsy type 1 (NT1).</p><p><strong>Results: </strong>Our final nap detection algorithm yielded high specificity (Tau B: 93.2%) and accuracy (F1 Area: 83.9%). Applying our algorithm in an observational study (NCT04445129), participants with NT1 experienced 12.8 fewer nap-free days (p < .001) over 28 days and slept 34 min more (p < .001) during the day than controls. In a randomized clinical trial (NCT05687903), our algorithm demonstrated that participants with NT1 treated with an orexin receptor 2- selective agonist, oveporexton (TAK-861), experienced 6.1-11.9 additional nap-free days and slept 12-33 min fewer versus baseline.</p><p><strong>Conclusions: </strong>Overall, our nap detection algorithm retained sensitivity while minimizing false positives. It reliably identified nap-based phenotypes that differentiate individuals with NT1 from age and sex-matched healthy controls, and it demonstrated that an orexin receptor 2-selective agonist reduces napping in participants with NT1 to normative levels near those of healthy controls.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better sleep now, better cognition later? Predicting cognitive function using a machine learning-based sleep EEG brain health score.","authors":"Francesca R Marino, Wolfgang Ganglberger, Haoqi Sun, Yulin Liu, Huitong Ding, Robert J Thomas, Rhoda Au, M Brandon Westover","doi":"10.1093/sleep/zsag100","DOIUrl":"10.1093/sleep/zsag100","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep state electrocortical activity measured using electroencephalograms (EEG) is linked with cognitive function and dementia risk. The rich information in overnight EEG can be condensed into integrated scores using machine learning. The Brain Health Score (BHS) was derived in prior work using an end-to-end deep learning model trained to jointly optimize higher cognitive function and lower disease risk from raw EEG. However, it is unknown whether the BHS predicts future neuropsychological (NP) performance.</p><p><strong>Methods: </strong>This study included 426 Framingham Heart Study (FHS) Generation 2 or Omni 1 participants with BHS values from in-home polysomnography in mid-to-late life, and subsequent digital clock drawing (dCDT) and NP testing an average of 12.6 years later. Linear regression models estimated associations between BHS and dCDT, memory, language, or executive function scores, adjusting for age, sex, race, education, smoking, body mass index, and FHS cohort. To enable comparisons across outcomes, the independent variables were centered and rescaled, and then the model was refitted to generate standardized estimates.</p><p><strong>Results: </strong>Participants were on average 56 years at sleep assessment, 55% female, and 86% non-Hispanic White. Each 1-SD higher BHS was associated with higher dCDT, memory, language, and executive function scores (dCDT: β = 0.16, 95% CI = 0.06-0.26; memory: β = 0.13, 95% CI = 0.03-0.23; language: β = 0.13, 95% CI = 0.03-0.23; executive: β = 0.10, 95% CI = 0.01-0.19).</p><p><strong>Conclusions: </strong>Higher BHS in mid-to-late life was associated with better digital and traditional NP performance more than a decade later. These findings support the potential of EEG-derived, data-driven scores as a biomarker of future cognitive health.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nightmares and suicide risk: broadening the therapeutic frame beyond Imagery Rehearsal Therapy.","authors":"Baris Olten, William V McCall","doi":"10.1093/sleep/zsag129","DOIUrl":"10.1093/sleep/zsag129","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quest for automated pediatric sleep scoring: are we there yet?","authors":"Alex Gileles-Hillel, Joachim A Behar","doi":"10.1093/sleep/zsag174","DOIUrl":"10.1093/sleep/zsag174","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk stratification in obstructive sleep apnea: a potential role for cardiac troponins.","authors":"Bhajan Singh","doi":"10.1093/sleep/zsag138","DOIUrl":"10.1093/sleep/zsag138","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive airway pressure therapy for cognitive enhancement in Parkinson's disease: from statistical signals to clinical practice.","authors":"Wenjun Li, Shuping Ni","doi":"10.1093/sleep/zsag072","DOIUrl":"10.1093/sleep/zsag072","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of chronic insomnia in elderly adults with dual orexin receptor antagonists: a systematic review and meta-analysis.","authors":"Eleonora Rollo, Annibale Antonioni, Lamberto Manzoli, Francesco Di Lorenzo, Maria Elena Flacco","doi":"10.1093/sleep/zsag135","DOIUrl":"10.1093/sleep/zsag135","url":null,"abstract":"<p><strong>Study objectives: </strong>Chronic insomnia is common among older adults, and its management is particularly challenging due to changes in sleep architecture, multimorbidity, and increased vulnerability to adverse drug effects. Dual orexin receptor antagonists have emerged as a novel therapeutic class with promising efficacy and tolerability profiles. However, evidence specific to older adults remains limited. Here, we performed the first systematic review and meta-analysis specifically evaluating the efficacy and safety of dual orexin receptor antagonists in elderly patients with chronic insomnia (PROSPERO CRD42024565687).</p><p><strong>Methods: </strong>Randomized controlled trials were identified from MEDLINE, Scopus, and ClinicalTrials.gov. Objective polysomnographic outcomes, including latency to persistent sleep, total sleep time, and wake after sleep onset, as well as subjective sleep measures, were analyzed, along with safety outcomes.</p><p><strong>Results: </strong>Ten studies met the inclusion criteria for the systematic review, with five studies contributing to the meta-analysis. The quantitative synthesis comprised 2235 patients in the experimental group and 1409 patients in the control group. Overall, compared with placebo dual orexin receptor antagonists reduced wake after sleep onset and latency to persistent sleep while increasing total sleep time after 1 month and 3 months of treatment. Importantly, dual orexin receptor antagonists increased subjective total sleep time. Finally, daridorexant showed a favorable safety profile, whereas lemborexant and suvorexant were associated with higher rates of treatment-emergent adverse events than placebo, without an increase in serious adverse events.</p><p><strong>Conclusions: </strong>Despite limited evidence, dual orexin receptor antagonists appear effective and generally safe for treating chronic insomnia in the elderly, supporting their role as a valuable therapeutic option.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting the identification of glutamatergic inputs to the sublaterodorsal tegmental nucleus and their role in REM sleep control: insights and limitations.","authors":"Pengyu Zhao, Wioletta Rozpędek-Kamińska","doi":"10.1093/sleep/zsag033","DOIUrl":"10.1093/sleep/zsag033","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of major adverse cardiovascular events with the apnea-hypopnea index, desaturation severity parameters, and cardiac troponins in participants of the Akershus Sleep APnea cohort.","authors":"Xin Feng, Fjola Sigurdardottir, Erna Sif Arnardottir, Toril Dammen, Gunnar Einvik, Henri Korkalainen, Ole Klungsøyr, Timo Leppänen, Inger Hilde Nordhus, Sami Nikkonen, Juha Töyräs, Thea Thorshov, Tonje Caroline Øverby, Torbjørn Omland, Harald Hrubos-Strøm","doi":"10.1093/sleep/zsag013","DOIUrl":"10.1093/sleep/zsag013","url":null,"abstract":"<p><strong>Study objectives: </strong>To examine the prognostic value of the apnea-hypopnea index (AHI), desaturation severity parameters, and cardiac troponins alone and combined for major cardiovascular events (MACEs).</p><p><strong>Methods: </strong>MACE data were retrieved in 2021 from the Norwegian Patient Registry for 518 participants in the Akershus Sleep APnea (ASAP) cohort. Baseline polysomnography and fasting blood samples were collected between June 2006 and January 2008. Desaturation duration (DesDur) and severity (DesSev) were calculated using Automatic Blood Oxygen Saturation Analysis software. Cox regression models estimated hazard ratios (HRs) for MACE. Predictive properties of combining troponins and obstructive sleep apnea severity were calculated by comparing established clinical thresholds for cardiac troponin I (cTnI) and T (cTnT) with AHI clinical thresholds of ≥15 and ≥30, respectively.</p><p><strong>Results: </strong>High AHI, DesDur, DesSev, cTnI, and cTnT were associated with increased MACE risk. However, only cTnI independently predicted MACE after adjustment (HR: 1.74, 95% CI: 1.32-2.29). The HR for MACE was 2.68 (95% CI: 1.03-6.97) in patients with both high cTnI and AHI ≥30 events/h.</p><p><strong>Conclusion: </strong>In this 15-year follow-up, cTnI was independently associated with risk of MACE, whereas the AHI, desaturation parameters, and cTnT were not independent predictors. cTnI, especially when combined with AHI, was a stronger MACE predictor than cTnT. Provided our findings are validated in clinical obstructive sleep apnea populations, the measurement of cTnI may be considered for cardiovascular risk stratification.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}