Sleep最新文献

{"title":"Norwegian Excellence: High-Quality Research in a Healthy Population.","authors":"Lauren Hale, Dimitri A Christakis","doi":"10.1093/sleep/zsaf294","DOIUrl":"https://doi.org/10.1093/sleep/zsaf294","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity: A Safe Step Toward Better Quality of Life in Narcolepsy.","authors":"Vladimir Tuka, Karel Šonka","doi":"10.1093/sleep/zsaf293","DOIUrl":"https://doi.org/10.1093/sleep/zsaf293","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of an Automated Sleep Scoring Approach for Actigraphy Data in Children and Adolescents.","authors":"Pin-Wei Chen, Erica C Jansen, Christopher M Cielo, Ariel A Williamson, Margaret Banker, Michael Kaye, Peter X K Song, Karen E Peterson, Alejandra Cantoral, Martha María Téllez-Rojo, Cathy Goldstein, Khadija Zanna, Akane Sano, Jennette P Moreno, Heidi Kalkwarf, Babette S Zemel, Jonathan A Mitchell","doi":"10.1093/sleep/zsaf282","DOIUrl":"10.1093/sleep/zsaf282","url":null,"abstract":"<p><strong>Study objectives: </strong>GGIR is an R package for processing raw acceleration data to estimate sleep health parameters. We aimed to 1) assess the performance of three sleep algorithms within GGIR against PSG for detecting sleep/wake in clinically referred, typically-developing children (criterion validity); and 2) describe GGIR-derived sleep estimates from typically developing children enrolled in multiple cohort studies (face validity).</p><p><strong>Methods: </strong>For criterion evaluation, children (8-16y, N=30) wore an actigraphy device for one night during in-lab polysomnography with performance assessed using epoch-by-epoch analyses. For face validity evaluation, four community/free living datasets were used: 1) BMAYC (3-5y, N=310), 2) SSS (5-8y, N=118), 3) S-Grow2 (12-13y; N=291) and 4) ELEMENT (9-18y; N=543). All raw acceleration data were processed using GGIR (v.3.0-0) with the Cole-Kripke (CK), Sadeh (S), and van Hees (vH) algorithm settings.</p><p><strong>Results: </strong>Following the in-lab test, 60% of children were diagnosed with mild to severe obstructive sleep apnea (OSA). For criterion evaluation, the 30-s epoch-by-epoch analyses revealed that average balanced accuracies were 0.80 (Sensitivity=0.80; Specificity=0.79), 0.76 (Sensitivity=0.86; Specificity=0.65), and 0.67 (Sensitivity=0.95, Specificity=0.39) for GGIR-CK, GGIR-vH, and GGIR-S, respectively. For face validity evaluation, sleep estimates mirrored the in-lab performance metrics (e.g., sleep duration estimates were similar when using GGIR-CK and GGIR-VH but approximately one hour longer when using GGIR-S).</p><p><strong>Conclusions: </strong>The in-lab performance metrics, from typically-developing children with and without OSA, and cohort-based descriptive statistics from samples of typically-developing children, provide benchmark data to guide investigators on the suitability of GGIR for automated processing of raw acceleration data for pediatric sleep estimation.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations among nonrestorative sleep status, sleep apnea syndrome, and major adverse cardiac and cerebrovascular events: Health check-up and claims data in Japan.","authors":"Naomi Takahashi, Yoshimitsu Takahashi, Kimihiko Murase, Kazuma Nagata, Yuka Nakatani, Satoshi Hamada, Hironobu Sunadome, Jumpei Togawa, Toyohiro Hirai, Kazuo Chin, Takeo Nakayama, Susumu Sato","doi":"10.1093/sleep/zsaf290","DOIUrl":"https://doi.org/10.1093/sleep/zsaf290","url":null,"abstract":"<p><strong>Study objectives: </strong>Nonrestorative sleep (NRS) refers to the subjective experience of feeling unrefreshed upon awakening that is not attributed to a lack of sleep. NRS may lead to the development of various lifestyle-related diseases, including cardiovascular disease. We investigated the relationships among NRS status, major adverse cardiac and cerebrovascular events (MACCEs), and newly diagnosed sleep apnea syndrome (SAS) status among health check-up participants via the health insurance claims database.</p><p><strong>Methods: </strong>We followed 86009 participants who underwent health check-ups in 2014 and answered a sleep-related question for up to 6 years via health insurance claims and a health check-up database. MACCEs were defined as the initial recording of a diagnostic code for MACCEs that required hospitalization. Cox proportional hazards models were constructed to determine whether NRS status was significantly associated with MACCE risk.</p><p><strong>Results: </strong>The mean age of the participants was 50.7±15.8 years; 58.8% were male, and 32.9% had NRS status. Even after adjusting for other factors, NRS status was a significant risk factor for MACCE development (hazard ratio: 1.14, 95% CI: 1.07-1.23). A total of 75.9% of the participants who had both MACCEs and newly diagnosed SAS during the follow-up period had heart disease.</p><p><strong>Conclusions: </strong>NRS status is an important indicator of sleep hygiene, and improving NRS might reduce the risk of MACCE development. Further screening tests (e.g., home sleep apnea testing) and consequent appropriate treatment may reduce MACCE risk and maintain their health status in people with NRS identified during checkups.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-shift work chronotype matters: resilience as a mediator to shift work tolerance.","authors":"Jee Hyun Kim","doi":"10.1093/sleep/zsaf281","DOIUrl":"https://doi.org/10.1093/sleep/zsaf281","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between insufficient sleep, exposure to violence, and violent behaviors in adolescents.","authors":"Cornelia L Griggs, Reagan A Collins, Josélio R de Oliveira Filho, Peter T Masiakos, Chana A Sacks, Rebecca Robbins","doi":"10.1093/sleep/zsaf283","DOIUrl":"https://doi.org/10.1093/sleep/zsaf283","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Sleep in Dementia Prevention: Building the Case for Causality.","authors":"Kening Jiang, Daniel D Callow, Adam P Spira","doi":"10.1093/sleep/zsaf285","DOIUrl":"https://doi.org/10.1093/sleep/zsaf285","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporation of complex narratives into dreaming.","authors":"Jessica Palmieri, Deniz Kumral, Sammy-Jo Wymer, Susanne Kirchner, Maximilian Schneider, Steffen Gais, Monika Schönauer","doi":"10.1093/sleep/zsaf280","DOIUrl":"https://doi.org/10.1093/sleep/zsaf280","url":null,"abstract":"<p><p>Reactivation of waking neuronal activity during sleep holds a functional role in memory consolidation. Reprocessing of daytime memory in dreams might aid later memory performance in a similar way. Numerous findings hint at a link between dreaming and sleep-dependent memory processing, however, studies investigating day-residue incorporation in dreaming led to mixed results so far. In this study, we used a naturalistic learning paradigm aimed at biasing dream content by manipulating pre-sleep experience. Participants listened to one of four different audiobooks while falling asleep and were awoken several times during the night to report their dreams. Afterwards, we tested how well they remembered the content of the audiobook. We then asked three blind raters to guess, based solely on anonymized dream reports, which audiobook someone had listened to before experiencing a dream. Our findings show that dreams across the whole night and from both NREM and REM awakenings contain specific information about the content of narratives studied before sleep. Moreover, participants with stronger incorporation of the audiobook in their dreams showed a tendency to recognize more audiobook content across the sleep period. Together, these findings suggest that salient day-time experiences resurface in dreams and that content selected for consolidation during sleep is more strongly incorporated.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Central Sleep Apnea: The past, the present and the future.","authors":"Lee K Brown, Shahrokh Javaheri","doi":"10.1093/sleep/zsaf286","DOIUrl":"https://doi.org/10.1093/sleep/zsaf286","url":null,"abstract":"<p><p>Idiopathic Central Sleep Apnea/Primary Central Sleep Apnea (ICSA) has been an officially recognized sleep disorder since the 2005 International Classification of Sleep Disorders 2nd edition (ICSD-2) and remains in the International Classification of Sleep Disorders 3rd edition (ICSD-3). The literature supports the etiology as \"high loop gain/increased controller gain,\" along with central sleep apnea (CSA) associated with common diagnoses (e.g. heart failure). Available data place the adult population prevalence at about 0.05% (men) and 0.003% (women), while up to 11% of patients diagnosed with CSA may be classified as ICSA. Symptoms may include nocturnal choking, witnessed apneas, awakenings with the sensation of shortness of breath, restless sleep, insomnia, non-restorative sleep, daytime sleepiness, fatigue, and variable degrees of snoring. Per the ICSD-3, ICSA may only be diagnosed if \"The disorder [CSA] is not better explained by another current sleep disorder, medical or neurologic disorder, medication use, or substance use disorder.\" However, a putative diagnosis of ICSA should prompt a comprehensive search for asymptomatic left ventricular dysfunction without heart failure, atrial fibrillation, carotid artery disease, ischemic central nervous system pathology, acromegaly, and licit or illicit respiratory depressant drug use, which could be a potential cause of CSA. Systematic studies are needed to determine the cost effectiveness of this approach. However, if present, ICSA is excluded and intervention can be initiated for the underlying diagnosis, which may resolve CSA and, importantly, improve outcomes specific to the causative disease. Treatment options for ICSA include devices such as adaptive servo-ventilation or transvenous phrenic nerve stimulation, medications such as acetazolamide, and sleep position training.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA methylation and multi-omics profiling of T cells uncovers chemotactic pathways and proliferation-linked hypomethylation in narcolepsy type 1.","authors":"Mihoko Shimada, Makoto Honda, Yoshiko Honda, Tohru Kodama, Yuki Hitomi, Katsushi Tokunaga, Taku Miyagawa","doi":"10.1093/sleep/zsaf278","DOIUrl":"https://doi.org/10.1093/sleep/zsaf278","url":null,"abstract":"<p><p>Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a loss of orexin-producing cells in the brain and involves autoimmune mechanisms, including the presence of autoreactive T cells. In this study, we performed genome-wide DNA methylation analysis using both CD4+/CD8+ T cells from 42 NT1 patients and 42 controls across discovery and replication cohorts. To identify methylation changes more robustly associated with the disease, we prioritized differentially methylated regions (DMRs) over single-site differentially methylated positions (DMPs). Furthermore, to validate and interpret DMP-level associations, we integrated genome-wide genotype and gene expression data obtained from the same individuals. As a result, the DMR analysis identified 15 reproducible DMRs in CD4+ T cells and 5 in CD8+ T cells, with most DMRs shared between the two cell types. Shared DMRs included regions associated with CCL5 (p=2.1.E-02) and CCR4 (p=8.3.E-03). Integrative analysis with genotype and gene expression data also showed that the DMP related to S100A4, which promotes lymphocyte migration through CCR5 and CXCR3 receptors, was associated with the disease in CD4+ T cells. Pathway analysis of genes identified through both the DMR and integrative analyses indicated enrichment in cell chemotaxis-related pathways, suggesting that aberrant chemokine-mediated cell migration plays a central role in NT1 pathogenesis. Further, NT1-associated methylation changes were predominantly hypomethylation events, significantly enriched in non-promoter, non-CpG island regions (p=1.74E-102). We further observed that global hypomethylation levels were correlated with hypoSC, a mitotic index estimated from methylation data, highlighting increased T cell proliferation in NT1.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}