SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae254
Patrick J Hanly, Sofia B Ahmed
{"title":"Obstructive sleep apnea and chronic kidney disease: time to move from association to causality and intervention.","authors":"Patrick J Hanly, Sofia B Ahmed","doi":"10.1093/sleep/zsae254","DOIUrl":"10.1093/sleep/zsae254","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae303
Federica Piani, Martino F Pengo
{"title":"Nocturnal blood pressure: the hidden link between sleep apnea and hypertensive disorders of pregnancy?","authors":"Federica Piani, Martino F Pengo","doi":"10.1093/sleep/zsae303","DOIUrl":"10.1093/sleep/zsae303","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsaf006
Whitney Stee, Antoine Legouhy, Michele Guerreri, Michael-Christopher Foti, Jean-Marc Lina, Hui Zhang, Philippe Peigneux
{"title":"Shaping the structural dynamics of motor learning through cueing during sleep.","authors":"Whitney Stee, Antoine Legouhy, Michele Guerreri, Michael-Christopher Foti, Jean-Marc Lina, Hui Zhang, Philippe Peigneux","doi":"10.1093/sleep/zsaf006","DOIUrl":"10.1093/sleep/zsaf006","url":null,"abstract":"<p><p>Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted memory reactivation (TMR), involving cueing learned material during posttraining sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and posttraining sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during posttraining sleep affects performance gains and delayed microstructural remodeling, using both standard diffusion tensor imaging and advanced neurite orientation dispersion and density imaging. Sixty healthy young adults participated in a 5 days protocol, undergoing five diffusion-weighted imaging sessions, pre- and post-two motor sequence training sessions, and after a posttraining night of either regular sleep (RS) or TMR. Results demonstrated rapid skill acquisition on day 1, followed by performance stabilization on day 2, and improvement on day 5, in both RS and TMR groups. (Re)training induced widespread microstructural changes in motor-related areas, initially involving the hippocampus, followed by a delayed engagement of the caudate nucleus. Mean Diffusivity changes were accompanied by increased neurite density index in the putamen, suggesting increased neurite density, while free water fraction reduction indicated glial reorganization. TMR-related structural differences emerged in the dorsolateral prefrontal cortex on day 2 and the right cuneus on day 5, suggesting unique sleep TMR-related neural reorganization patterns. Persistence of practice-related structural changes, although moderated over time, suggests a lasting neural network reorganization, partially mediated by sleep TMR.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae262
Nishitha S Hosamane, Adam M Didouchevski, Ayse Malci, Jeffrey P Gavornik, Michael S Sidorov
{"title":"Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.","authors":"Nishitha S Hosamane, Adam M Didouchevski, Ayse Malci, Jeffrey P Gavornik, Michael S Sidorov","doi":"10.1093/sleep/zsae262","DOIUrl":"10.1093/sleep/zsae262","url":null,"abstract":"<p><strong>Study objectives: </strong>Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.</p><p><strong>Methods: </strong>Visually evoked potentials were recorded in awake, head-fixed mice viewing sequences of four visual stimuli. Each sequence was presented 200 times per session, across multiple sessions, to drive plasticity. The effects of sleep consolidation time and sleep deprivation on plasticity were assessed.</p><p><strong>Results: </strong>Sequence plasticity occurred in V1 following as little as 1 hour of ad libitum sleep and increased with longer periods of sleep. Sleep deprivation blocked sequence plasticity consolidation, which recovered following subsequent sleep.</p><p><strong>Conclusions: </strong>Sleep is required for the consolidation of sequence plasticity in mouse V1.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae299
Laura Hainke, James Dowsett, Manuel Spitschan, Josef Priller
{"title":"40 Hz visual stimulation during sleep evokes neuronal gamma activity in NREM and REM stages.","authors":"Laura Hainke, James Dowsett, Manuel Spitschan, Josef Priller","doi":"10.1093/sleep/zsae299","DOIUrl":"10.1093/sleep/zsae299","url":null,"abstract":"<p><strong>Study objectives: </strong>Visual stimulation (VS) at 40 Hz is being tested as a non-invasive approach against dementias such as Alzheimer's disease. Applying it during sleep could increase the convenience, duration, and efficacy of stimulation. Here, we tested the feasibility of 40 Hz VS during sleep in a proof-of-concept study.</p><p><strong>Methods: </strong>Thirty healthy participants underwent one control and one experimental night of polysomnography at the sleep laboratory. 40 Hz VS was delivered in wakefulness (W), NREM sleep stages 2 and 3, and REM sleep.</p><p><strong>Results: </strong>As expected, 40 Hz EEG spectral power was increased in all four stages in the experimental condition, compared to control. It was highest in W and similar across NREM 2, NREM 3, and REM, with large and medium effect sizes, respectively. Steady-state visually evoked potential (SSVEP) analyses in the time domain confirmed the specificity of the effect. Secondary analyses revealed that the intervention did not impair objective and subjective sleep quality beyond the first-night effect.</p><p><strong>Conclusions: </strong>40 Hz VS during sleep effectively evoked neuronal gamma activity at stimulation frequency without degrading sleep quality, supporting the feasibility of this approach. These findings lay the groundwork for optimizing gamma-band sensory stimulation as a tool to causally study cognitive functions and as a scalable, non-invasive intervention against dementias.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae292
Aristotle G Leonhard, Vishesh K Kapur
{"title":"Beyond traditional hypoxemia metrics: hypoxic burden as a predictor of cognitive dysfunction in sleep apnea.","authors":"Aristotle G Leonhard, Vishesh K Kapur","doi":"10.1093/sleep/zsae292","DOIUrl":"10.1093/sleep/zsae292","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae290
Helen J Burgess, Allie A Rodgers, Muneer Rizvydeen, Gabriel Mongefranco, Zainab Fayyaz, Agnes Fejer, Ashlyn Johnson, Cathy A Goldstein
{"title":"Lessons learned on the road to improve sleep data extracted from a Fitbit device.","authors":"Helen J Burgess, Allie A Rodgers, Muneer Rizvydeen, Gabriel Mongefranco, Zainab Fayyaz, Agnes Fejer, Ashlyn Johnson, Cathy A Goldstein","doi":"10.1093/sleep/zsae290","DOIUrl":"10.1093/sleep/zsae290","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: a case-control study.","authors":"Tugdual Adam, Lucie Barateau, Jérôme Tanty, Yves Dauvilliers","doi":"10.1093/sleep/zsae246","DOIUrl":"10.1093/sleep/zsae246","url":null,"abstract":"<p><strong>Study objectives: </strong>To investigate the amplitude and phase of the circadian rhythm of core body temperature (CBT) via the continuous measure of the gastrointestinal temperature in participants with idiopathic hypersomnia (IH), non-specified hypersomnia (NSH) compared to healthy controls (HC) in a constant routine standardized bedrest (BR) protocol.</p><p><strong>Methods: </strong>Consecutive participants evaluated in a National Reference Center for Rare Hypersomnias benefited from an extensive evaluation with one-night polysomnography, followed by a modified Multiple Sleep Latency Test (mMSLT), and a continuous 32-hour BR recording in standardized conditions. CBT was recorded via a telemetry pill (e-Celsius) during the BR, modeled by a Cosinor, with extraction of MESOR, amplitude, and phase. Participants with IH, diagnosed according to the International Classification of Sleep Disorders-3, were compared with participants with NSH (complaint of hypersomnolence but normal mMSLT and BR), and HC. Participants were divided into four groups based on their mMSLT mean sleep latency (mMSLT+,≤8 minutes) and their BR total sleep time (BR+, ≥19 hours).</p><p><strong>Results: </strong>A total of 108 participants (80% women, 28.3 ± 7.8 years old) were included in the analyses, 81 IH (83% women), 16 NSH (75% women), and 11 HC (64% women). Cosinor amplitude and phase of CBT did not differ between IH, NSH, and HC, nor in the subgroup analysis (37 BR+/mMSLT+, 35 BR+/mMSLT-, 9 BR-/mMSLT+, 27 BR-/mMSLT-). No difference in chronotypes was observed between groups. Women had a greater MESOR and reduced CBT amplitude compared to men.</p><p><strong>Conclusions: </strong>The circadian rhythm of CBT showed no difference in amplitude or phase between IH, NSH, and HC, and was not related to prolonged sleep time or objective daytime sleepiness.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsae307
Shahrokh Javaheri, Alberto Giannoni, Virend K Somers, Atul Malhotra, Michele Emdin, Maria R Costanzo
{"title":"Central sleep apnea and cardiovascular disease state-of-the-art.","authors":"Shahrokh Javaheri, Alberto Giannoni, Virend K Somers, Atul Malhotra, Michele Emdin, Maria R Costanzo","doi":"10.1093/sleep/zsae307","DOIUrl":"10.1093/sleep/zsae307","url":null,"abstract":"<p><p>Central sleep apnea, a rare polysomnographic finding in the general population, is prevalent in certain cardiovascular conditions including systolic and diastolic left ventricular dysfunction, atrial fibrillation, coronary artery disease, carotid artery stenosis, stroke, and use of certain cardiac-related medications. Polysomnographic findings of central sleep apnea with adverse cardiovascular impacts include nocturnal hypoxemia and arousals, which can lead to increased sympathetic activity both at night and in the daytime. Among cardiovascular diseases, central sleep apnea is most prevalent in patients with left ventricular systolic dysfunction; a large study of more than 900 treated patients has shown a dose-dependent relationship between nocturnal desaturation and mortality. Multiple small randomized controlled trials have shown mitigation of sympathetic activity when central sleep apnea is treated with nocturnal oxygen, continuous positive airway pressure, and adaptive servoventilation. However, two early randomized controlled trials with positive airway pressure devices have shown either a neutral effect on survival or excess premature mortality in the active treatment arm, compared to untreated central sleep apnea. In contrast, the results of the most recent trial using an advanced adaptive servoventilation device showed improved quality of life and no signal for mortality suggesting that treatment of central sleep apnea was at least safe. In addition to positive airway pressure devices, multiple medications have been shown to improve central sleep apnea, but no long-term trials of pharmacologic therapy have been published. Currently, phrenic nerve stimulation is approved for the treatment of central sleep apnea, and the results of a randomized controlled trial showed significant improvement in sleep metrics and quality of life.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SleepPub Date : 2025-03-11DOI: 10.1093/sleep/zsaf016
Shawn D Youngstedt, Giselle Soares Passos, Ryan S Falck, Marcos Gonçalves Santana
{"title":"Inter-individual differences and reliability of the acute effects of exercise on actigraphic sleep measures.","authors":"Shawn D Youngstedt, Giselle Soares Passos, Ryan S Falck, Marcos Gonçalves Santana","doi":"10.1093/sleep/zsaf016","DOIUrl":"10.1093/sleep/zsaf016","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}