IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae297

Dong Xia, Ying Chen, Xiang Fu, Hui-Yi Liu, Mu-Yan Sun, Fen Wang, Yong Zhang, Chun-Feng Liu, Jun-Yi Liu

{"title":"Overexpression of α-synuclein in Pigment Dispersing Factor neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila.","authors":"Dong Xia, Ying Chen, Xiang Fu, Hui-Yi Liu, Mu-Yan Sun, Fen Wang, Yong Zhang, Chun-Feng Liu, Jun-Yi Liu","doi":"10.1093/sleep/zsae297","DOIUrl":"10.1093/sleep/zsae297","url":null,"abstract":"Parkinson's disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research increasingly indicates the prevalence of sleep-wake disorders in early-stage PD, although the underlying pathogenic mechanisms remain unclear. In this study, transgenic Drosophila models were utilized to observe excessive daytime sleepiness and impaired anticipation in flies overexpressing α-syn in pan-neurons and circadian clock neurons. Additionally, deficits in projection of Pigment Dispersing Factor (PDF) neuron terminals, which are involved in Drosophila sleep and circadian rhythm, were identified. An imbalance in lipid metabolism homeostasis was detected in the brains of α-syn overexpressing mutants. Ultimately, the inhibition of Sterol Regulatory Element-Binding Protein (SREBP) activity led to an improvement in the reduced daytime sleep duration phenotype. Our results suggest that lipid pathways play a role in sleep-wake disorders triggered by α-syn mutation and aggregation, thereby providing valuable insights into potential therapeutic avenues for disrupted sleep patterns associated with PD.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian clock gene variants in two Japanese families with familial advanced sleep phase. 两个家族性睡眠阶段提前的日本家庭的生物钟基因变异。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae309

Motoki Ukai, Akiko Hida, Shingo Kitamura, Yuichi Inoue, Kazuo Mishima

引用次数: 0

Exploring the bidirectional relationship between chronic kidney disease and obstructive sleep apnea. 探讨慢性肾病与阻塞性睡眠呼吸暂停的双向关系。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsaf002

Yu-Hsiang Lin, Kuo-Jen Lin, Jau-Yuan Chen

引用次数: 0

Obstructive sleep apnea and chronic kidney disease: time to move from association to causality and intervention. 阻塞性睡眠呼吸暂停和慢性肾脏疾病：时间从关联到因果关系和干预。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae254

Patrick J Hanly, Sofia B Ahmed

引用次数: 0

Nocturnal blood pressure: the hidden link between sleep apnea and hypertensive disorders of pregnancy? 夜间血压：睡眠呼吸暂停与妊娠期高血压疾病之间的隐性联系？

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae303

Federica Piani, Martino F Pengo

引用次数: 0

Shaping the structural dynamics of motor learning through cueing during sleep. 通过睡眠中的线索塑造运动学习的结构动态。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsaf006

Whitney Stee, Antoine Legouhy, Michele Guerreri, Michael-Christopher Foti, Jean-Marc Lina, Hui Zhang, Philippe Peigneux

{"title":"Shaping the structural dynamics of motor learning through cueing during sleep.","authors":"Whitney Stee, Antoine Legouhy, Michele Guerreri, Michael-Christopher Foti, Jean-Marc Lina, Hui Zhang, Philippe Peigneux","doi":"10.1093/sleep/zsaf006","DOIUrl":"10.1093/sleep/zsaf006","url":null,"abstract":"Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted memory reactivation (TMR), involving cueing learned material during posttraining sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and posttraining sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during posttraining sleep affects performance gains and delayed microstructural remodeling, using both standard diffusion tensor imaging and advanced neurite orientation dispersion and density imaging. Sixty healthy young adults participated in a 5 days protocol, undergoing five diffusion-weighted imaging sessions, pre- and post-two motor sequence training sessions, and after a posttraining night of either regular sleep (RS) or TMR. Results demonstrated rapid skill acquisition on day 1, followed by performance stabilization on day 2, and improvement on day 5, in both RS and TMR groups. (Re)training induced widespread microstructural changes in motor-related areas, initially involving the hippocampus, followed by a delayed engagement of the caudate nucleus. Mean Diffusivity changes were accompanied by increased neurite density index in the putamen, suggesting increased neurite density, while free water fraction reduction indicated glial reorganization. TMR-related structural differences emerged in the dorsolateral prefrontal cortex on day 2 and the right cuneus on day 5, suggesting unique sleep TMR-related neural reorganization patterns. Persistence of practice-related structural changes, although moderated over time, suggests a lasting neural network reorganization, partially mediated by sleep TMR.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex. 睡眠是小鼠初级视觉皮层经验依赖序列可塑性的必要条件。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae262

Nishitha S Hosamane, Adam M Didouchevski, Ayse Malci, Jeffrey P Gavornik, Michael S Sidorov

{"title":"Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.","authors":"Nishitha S Hosamane, Adam M Didouchevski, Ayse Malci, Jeffrey P Gavornik, Michael S Sidorov","doi":"10.1093/sleep/zsae262","DOIUrl":"10.1093/sleep/zsae262","url":null,"abstract":"Study objectives: Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.Methods: Visually evoked potentials were recorded in awake, head-fixed mice viewing sequences of four visual stimuli. Each sequence was presented 200 times per session, across multiple sessions, to drive plasticity. The effects of sleep consolidation time and sleep deprivation on plasticity were assessed.Results: Sequence plasticity occurred in V1 following as little as 1 hour of ad libitum sleep and increased with longer periods of sleep. Sleep deprivation blocked sequence plasticity consolidation, which recovered following subsequent sleep.Conclusions: Sleep is required for the consolidation of sequence plasticity in mouse V1.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

40 Hz visual stimulation during sleep evokes neuronal gamma activity in NREM and REM stages. 40赫兹的视觉刺激在睡眠中唤醒非快速眼动和快速眼动阶段的神经元伽马活动。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae299

Laura Hainke, James Dowsett, Manuel Spitschan, Josef Priller

{"title":"40 Hz visual stimulation during sleep evokes neuronal gamma activity in NREM and REM stages.","authors":"Laura Hainke, James Dowsett, Manuel Spitschan, Josef Priller","doi":"10.1093/sleep/zsae299","DOIUrl":"10.1093/sleep/zsae299","url":null,"abstract":"Study objectives: Visual stimulation (VS) at 40 Hz is being tested as a non-invasive approach against dementias such as Alzheimer's disease. Applying it during sleep could increase the convenience, duration, and efficacy of stimulation. Here, we tested the feasibility of 40 Hz VS during sleep in a proof-of-concept study.Methods: Thirty healthy participants underwent one control and one experimental night of polysomnography at the sleep laboratory. 40 Hz VS was delivered in wakefulness (W), NREM sleep stages 2 and 3, and REM sleep.Results: As expected, 40 Hz EEG spectral power was increased in all four stages in the experimental condition, compared to control. It was highest in W and similar across NREM 2, NREM 3, and REM, with large and medium effect sizes, respectively. Steady-state visually evoked potential (SSVEP) analyses in the time domain confirmed the specificity of the effect. Secondary analyses revealed that the intervention did not impair objective and subjective sleep quality beyond the first-night effect.Conclusions: 40 Hz VS during sleep effectively evoked neuronal gamma activity at stimulation frequency without degrading sleep quality, supporting the feasibility of this approach. These findings lay the groundwork for optimizing gamma-band sensory stimulation as a tool to causally study cognitive functions and as a scalable, non-invasive intervention against dementias.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: a case-control study. 特发性嗜睡症患者核心体温昼夜节律的振幅和相位没有失调：病例对照研究

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae246

Tugdual Adam, Lucie Barateau, Jérôme Tanty, Yves Dauvilliers

{"title":"Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: a case-control study.","authors":"Tugdual Adam, Lucie Barateau, Jérôme Tanty, Yves Dauvilliers","doi":"10.1093/sleep/zsae246","DOIUrl":"10.1093/sleep/zsae246","url":null,"abstract":"Study objectives: To investigate the amplitude and phase of the circadian rhythm of core body temperature (CBT) via the continuous measure of the gastrointestinal temperature in participants with idiopathic hypersomnia (IH), non-specified hypersomnia (NSH) compared to healthy controls (HC) in a constant routine standardized bedrest (BR) protocol.Methods: Consecutive participants evaluated in a National Reference Center for Rare Hypersomnias benefited from an extensive evaluation with one-night polysomnography, followed by a modified Multiple Sleep Latency Test (mMSLT), and a continuous 32-hour BR recording in standardized conditions. CBT was recorded via a telemetry pill (e-Celsius) during the BR, modeled by a Cosinor, with extraction of MESOR, amplitude, and phase. Participants with IH, diagnosed according to the International Classification of Sleep Disorders-3, were compared with participants with NSH (complaint of hypersomnolence but normal mMSLT and BR), and HC. Participants were divided into four groups based on their mMSLT mean sleep latency (mMSLT+,≤8 minutes) and their BR total sleep time (BR+, ≥19 hours).Results: A total of 108 participants (80% women, 28.3 ± 7.8 years old) were included in the analyses, 81 IH (83% women), 16 NSH (75% women), and 11 HC (64% women). Cosinor amplitude and phase of CBT did not differ between IH, NSH, and HC, nor in the subgroup analysis (37 BR+/mMSLT+, 35 BR+/mMSLT-, 9 BR-/mMSLT+, 27 BR-/mMSLT-). No difference in chronotypes was observed between groups. Women had a greater MESOR and reduced CBT amplitude compared to men.Conclusions: The circadian rhythm of CBT showed no difference in amplitude or phase between IH, NSH, and HC, and was not related to prolonged sleep time or objective daytime sleepiness.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central sleep apnea and cardiovascular disease state-of-the-art. 中枢性睡眠呼吸暂停和心血管疾病。

IF 5.6 2区医学

Sleep Pub Date : 2025-03-11 DOI: 10.1093/sleep/zsae307

Shahrokh Javaheri, Alberto Giannoni, Virend K Somers, Atul Malhotra, Michele Emdin, Maria R Costanzo

{"title":"Central sleep apnea and cardiovascular disease state-of-the-art.","authors":"Shahrokh Javaheri, Alberto Giannoni, Virend K Somers, Atul Malhotra, Michele Emdin, Maria R Costanzo","doi":"10.1093/sleep/zsae307","DOIUrl":"10.1093/sleep/zsae307","url":null,"abstract":"Central sleep apnea, a rare polysomnographic finding in the general population, is prevalent in certain cardiovascular conditions including systolic and diastolic left ventricular dysfunction, atrial fibrillation, coronary artery disease, carotid artery stenosis, stroke, and use of certain cardiac-related medications. Polysomnographic findings of central sleep apnea with adverse cardiovascular impacts include nocturnal hypoxemia and arousals, which can lead to increased sympathetic activity both at night and in the daytime. Among cardiovascular diseases, central sleep apnea is most prevalent in patients with left ventricular systolic dysfunction; a large study of more than 900 treated patients has shown a dose-dependent relationship between nocturnal desaturation and mortality. Multiple small randomized controlled trials have shown mitigation of sympathetic activity when central sleep apnea is treated with nocturnal oxygen, continuous positive airway pressure, and adaptive servoventilation. However, two early randomized controlled trials with positive airway pressure devices have shown either a neutral effect on survival or excess premature mortality in the active treatment arm, compared to untreated central sleep apnea. In contrast, the results of the most recent trial using an advanced adaptive servoventilation device showed improved quality of life and no signal for mortality suggesting that treatment of central sleep apnea was at least safe. In addition to positive airway pressure devices, multiple medications have been shown to improve central sleep apnea, but no long-term trials of pharmacologic therapy have been published. Currently, phrenic nerve stimulation is approved for the treatment of central sleep apnea, and the results of a randomized controlled trial showed significant improvement in sleep metrics and quality of life.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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